EuRBPDB

Description

Ensembl ID: ENSG00000168291 (Gene tree)
Gene ID: 5162
Gene Symbol: PDHB
Alias: PDHE1B
Full Name: pyruvate dehydrogenase E1 beta subunit
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 6,228 bases
Position: chr3:58,427,630-58,433,857
Accession: 8808
RBP type: non-canonical RBP
Summary: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000461692	PDHB-203	1535	NR_033384	-	- (aa)	-	-
ENST00000485460	PDHB-210	1397	-	ENSP00000417267	341 (aa)	-	P11177
ENST00000479945	PDHB-207	4459	-	-	- (aa)	-	-
ENST00000302746	PDHB-201	1527	-	ENSP00000307241	359 (aa)	-	P11177
ENST00000480626	PDHB-208	710	-	-	- (aa)	-	-
ENST00000482894	PDHB-209	581	-	-	- (aa)	-	-
ENST00000383714	PDHB-202	1478	-	ENSP00000373220	341 (aa)	-	P11177
ENST00000469364	PDHB-204	1616	-	ENSP00000419580	251 (aa)	-	F8WF02
ENST00000469827	PDHB-205	586	-	-	- (aa)	-	-
ENST00000474765	PDHB-206	1503	-	ENSP00000418448	350 (aa)	-	C9J634

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00010	Glycolysis / Gluconeogenesis	KEGG
hsa00020	Citrate cycle (TCA cycle)	KEGG
hsa00620	Pyruvate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa04066	HIF-1 signaling pathway	KEGG
hsa04922	Glucagon signaling pathway	KEGG
hsa05230	Central carbon metabolism in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000168291	Hepcidins	7E-7	27846281

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000168291	PDHB	100	66.569	WBGene00015413	pdhb-1	99	66.189	Caenorhabditis_elegans
ENSG00000168291	PDHB	96	70.031	FBgn0039635	CG11876	97	67.139	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004738	pyruvate dehydrogenase activity	19081061.	IDA	Function
GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	-	IEA	Function
GO:0005515	protein binding	12651851.18206651.19081061.29128334.	IPI	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006006	glucose metabolic process	-	IEA	Process
GO:0006086	acetyl-CoA biosynthetic process from pyruvate	19081061.	IDA	Process
GO:0006090	pyruvate metabolic process	-	TAS	Process
GO:0006099	tricarboxylic acid cycle	19081061.	IDA	Process
GO:0034604	pyruvate dehydrogenase (NAD+) activity	18164639.	IDA	Function
GO:0045254	pyruvate dehydrogenase complex	19081061.	IDA	Component
GO:0061732	mitochondrial acetyl-CoA biosynthetic process from pyruvate	18164639.	IC	Process