EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000168298 (Gene tree)
Gene ID: 3008
Gene Symbol: HIST1H1E
Alias: H1.4|H1e|H1s-4|H1F4
Full Name: histone cluster 1 H1 family member e
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 785 bases
Position: chr6:26,156,331-26,157,115
Accession: 4718
RBP type: non-canonical RBP
Summary: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23682076	Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells.	Cancer Prev Res (Phila)	2013 Jul	Lee LR	doi: 10.1158/1940-6207.CAPR-12-0493

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000304218	HIST1H1E-201	754	-	ENSP00000307705	219 (aa)	-	P10412

Gene Model

Click here to download ENSG00000168298's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000168298	Body Height	8E-22	25282103

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000168298's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000168298	HIST1H1E	53	97.391	ENSMUSG00000051627	Hist1h1e	53	97.391	Mus_musculus
ENSG00000168298	HIST1H1E	53	93.966	ENSMUSG00000052565	Hist1h1d	52	94.828	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000788	nuclear nucleosome	21873635.	IBA	Component
GO:0003690	double-stranded DNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005509	calcium ion binding	21873635.	IBA	Function
GO:0005515	protein binding	21873635.	IBA	Function
GO:0005515	protein binding	15469825.17474147.17540172.	IPI	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005525	GTP binding	21873635.	IBA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	17540172.	IDA	Component
GO:0005720	nuclear heterochromatin	21873635.	IBA	Component
GO:0005720	nuclear heterochromatin	15911621.	IDA	Component
GO:0006334	nucleosome assembly	-	IEA	Process
GO:0006355	regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0016208	AMP binding	21873635.	IBA	Function
GO:0016584	nucleosome positioning	21873635.	IBA	Process
GO:0030261	chromosome condensation	21873635.	IBA	Process
GO:0031490	chromatin DNA binding	15911621.	IMP	Function
GO:0031492	nucleosomal DNA binding	21873635.	IBA	Function
GO:0031936	negative regulation of chromatin silencing	21873635.	IBA	Process
GO:0032564	dATP binding	-	IEA	Function
GO:0043531	ADP binding	21873635.	IBA	Function
GO:0045910	negative regulation of DNA recombination	21873635.	IBA	Process
GO:0080182	histone H3-K4 trimethylation	21873635.	IBA	Process
GO:0098532	histone H3-K27 trimethylation	21873635.	IBA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26209608	Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence.	Mol Cell Proteomics	2016 Mar	Chen Y	doi: 10.1074/mcp.M114.046441

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr6	26156694	Missense_Mutation	novel	S102T	0.52
ACC	chr6	26156817	Missense_Mutation	novel	G143W	0.27
BLCA	chr6	26156957	Silent	novel	A189A	0.11
BLCA	chr6	26156698	Missense_Mutation	rs776601380	G103A	0.1
BLCA	chr6	26156453	Silent	rs201889498	K21K	0.23
BLCA	chr6	26156717	Missense_Mutation	NA	K109N	0.28
BLCA	chr6	26157041	Missense_Mutation	novel	K217N	0.61
BLCA	chr6	26157026	Missense_Mutation	novel	K212N	0.13
BLCA	chr6	26156602	Missense_Mutation	NA	Y71C	0.31
BLCA	chr6	26156717	Missense_Mutation	NA	K109N	0.24
BLCA	chr6	26156957	Silent	NA	A189A	0.37
BRCA	chr6	26156572	Missense_Mutation	rs768767088	A61V	0.34
BRCA	chr6	26157011	In_Frame_Del	novel	A208_A214del	0.31
BRCA	chr6	26156657	Missense_Mutation	NA	S89R	0.29
BRCA	chr6	26156675	Silent	novel	Q95Q	0.1
CESC	chr6	26156864	Silent	rs781387925	A158A	0.14
CESC	chr6	26156514	Missense_Mutation	NA	E42Q	0.86
CESC	chr6	26156695	Missense_Mutation	rs766257287	S102L	0.19
CESC	chr6	26156436	Nonsense_Mutation	NA	E16*	0.2
CESC	chr6	26156543	Silent	rs762056816	S51S	0.36
CESC	chr6	26156456	Silent	rs780842942	K22K	0.36
COAD	chr6	26156406	Missense_Mutation	novel	P6T	0.75
COAD	chr6	26156872	In_Frame_Del	novel	A163_A165del	0.15
COAD	chr6	26156922	Missense_Mutation	NA	A178T	0.14
COAD	chr6	26156933	Frame_Shift_Del	NA	*K183Rfs?**	0.28
COAD	chr6	26157009	In_Frame_Del	novel	A208_K212del	0.47
COAD	chr6	26156976	Missense_Mutation	NA	P196A	0.11
COAD	chr6	26156849	Silent	rs759116050	K153K	0.46
COAD	chr6	26156959	Missense_Mutation	NA	K190R	0.33
COAD	chr6	26156910	Frame_Shift_Del	novel	*K175Rfs?**	0.22
DLBC	chr6	26156672	Silent	rs549787183	V94V	0.26
DLBC	chr6	26156701	Missense_Mutation	novel	S104C	0.22
DLBC	chr6	26156880	Missense_Mutation	rs201935674	A164T	0.31
DLBC	chr6	26156802	Missense_Mutation	novel	P138S	0.24
DLBC	chr6	26156757	Missense_Mutation	novel	A123P	0.27
DLBC	chr6	26156880	Missense_Mutation	rs201935674	A164T	0.32
DLBC	chr6	26156529	Missense_Mutation	rs547695315	A47P	0.12
DLBC	chr6	26156784	Missense_Mutation	novel	A132T	0.21
DLBC	chr6	26156517	Missense_Mutation	NA	L43V	0.22
DLBC	chr6	26156756	Silent	rs200272831	K122K	0.38
ESCA	chr6	26156592	Missense_Mutation	novel	A68S	0.1
HNSC	chr6	26156398	Missense_Mutation	novel	E3V	0.54
HNSC	chr6	26156577	In_Frame_Del	novel	K64del	0.28
HNSC	chr6	26156971	Missense_Mutation	NA	V194A	0.39
HNSC	chr6	26156546	Silent	rs753419578	K52K	0.11
HNSC	chr6	26156942	Silent	novel	A184A	0.2
LGG	chr6	26156755	Frame_Shift_Del	novel	*K122Sfs73**	0.13
LGG	chr6	26156498	Silent	novel	S36S	0.32
LGG	chr6	26156536	Missense_Mutation	rs776712433	A49V	0.2
LGG	chr6	26157046	Nonstop_Mutation	novel	220delext?	0.1
LIHC	chr6	26156713	Missense_Mutation	novel	N108T	0.38
LIHC	chr6	26156539	In_Frame_Del	novel	S51del	0.32
LUAD	chr6	26156469	Missense_Mutation	novel	S27T	0.08
LUAD	chr6	26156857	Missense_Mutation	NA	K156R	0.4
LUAD	chr6	26157050	Silent	NA	*220*	0.2
LUAD	chr6	26157048	Nonstop_Mutation	novel	220Kext?	0.18
LUAD	chr6	26156579	Silent	rs535188796	K63K	0.1
LUAD	chr6	26156464	Missense_Mutation	NA	R25P	0.77
LUAD	chr6	26156569	Missense_Mutation	novel	A60D	0.16
LUAD	chr6	26156849	Silent	rs759116050	K153K	0.16
LUSC	chr6	26156550	Missense_Mutation	NA	R54C	0.13
LUSC	chr6	26156436	Nonsense_Mutation	NA	E16*	0.82
LUSC	chr6	26156919	Nonsense_Mutation	NA	K177*	0.33
MESO	chr6	26156430	Missense_Mutation	novel	P14S	0.19
OV	chr6	26156562	Missense_Mutation	NA	S58P	0.92
OV	chr6	26156572	Missense_Mutation	NA	A61D	0.36
PAAD	chr6	26156955	Missense_Mutation	rs372876447	A189T	0.16
PAAD	chr6	26156753	Missense_Mutation	novel	K121N	0.1
PAAD	chr6	26156754	Nonsense_Mutation	novel	K122*	0.11
SKCM	chr6	26157033	Missense_Mutation	novel	A215T	0.12
SKCM	chr6	26156580	Missense_Mutation	novel	K64E	0.29
SKCM	chr6	26156656	In_Frame_Ins	novel	L93_T99dup	0.09
SKCM	chr6	26156717	Silent	novel	K109K	0.35
SKCM	chr6	26156760	Missense_Mutation	novel	G124S	0.85
SKCM	chr6	26156761	Missense_Mutation	novel	G124D	0.84
SKCM	chr6	26156459	Frame_Shift_Del	novel	*A24Pfs65**	0.21
SKCM	chr6	26156669	Silent	rs752928702	L93L	0.23
SKCM	chr6	26156503	Missense_Mutation	rs771979983	P38L	0.22
SKCM	chr6	26156747	Silent	NA	K119K	0.27
STAD	chr6	26156713	Missense_Mutation	NA	N108S	0.24
STAD	chr6	26156898	Missense_Mutation	NA	A170S	0.2
STAD	chr6	26156748	Missense_Mutation	rs777376445	A120T	0.39
STAD	chr6	26156867	Missense_Mutation	novel	K159N	0.28
STAD	chr6	26156472	Missense_Mutation	NA	A28S	0.29
STAD	chr6	26156922	Missense_Mutation	NA	A178T	0.31
STAD	chr6	26156470	Missense_Mutation	rs766435782	S27F	0.1
STAD	chr6	26156971	Missense_Mutation	NA	V194A	0.15
STAD	chr6	26156988	Missense_Mutation	NA	K200E	0.21
STAD	chr6	26156414	Silent	rs760212562	A8A	0.16
THCA	chr6	26156519	Silent	rs756055232	L43L	0.24
THCA	chr6	26156480	Silent	NA	A30A	0.38
UCEC	chr6	26156670	Missense_Mutation	NA	V94L	0.39
UCEC	chr6	26156862	Missense_Mutation	NA	A158T	0.2
UCEC	chr6	26156849	Missense_Mutation	novel	K153N	0.21
UCEC	chr6	26157033	Missense_Mutation	novel	A215T	0.71
UCEC	chr6	26156464	Missense_Mutation	rs761734336	R25H	0.87
UCEC	chr6	26156587	Missense_Mutation	novel	L66P	0.31
UCEC	chr6	26157025	Missense_Mutation	novel	K212R	0.25
UCEC	chr6	26156620	Missense_Mutation	novel	N77S	0.45
UCEC	chr6	26156785	Missense_Mutation	rs373468962	A132V	0.16
UCEC	chr6	26156501	Frame_Shift_Ins	novel	*V40Gfs7**	0.36
UCEC	chr6	26156676	Missense_Mutation	NA	T96S	0.24
UCEC	chr6	26156565	Missense_Mutation	novel	L59V	0.23
UCEC	chr6	26156685	Missense_Mutation	novel	T99A	0.51
UCEC	chr6	26156526	Missense_Mutation	rs778623700	K46E	0.22

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.1153	0.046699

Survival Analysis

Cancer	P-value	Q-value
STAD	0.011	Kaplan-Meier Survival Analysis
SARC	0.0081	Kaplan-Meier Survival Analysis
ACC	0.00014	Kaplan-Meier Survival Analysis
ESCA	0.00027	Kaplan-Meier Survival Analysis
KIRP	0.00057	Kaplan-Meier Survival Analysis
COAD	0.0093	Kaplan-Meier Survival Analysis
PAAD	0.046	Kaplan-Meier Survival Analysis
BLCA	0.039	Kaplan-Meier Survival Analysis
LIHC	0.017	Kaplan-Meier Survival Analysis
DLBC	0.045	Kaplan-Meier Survival Analysis
LGG	0.0023	Kaplan-Meier Survival Analysis
LUAD	0.0099	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742