EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000168374 (Gene tree)
Gene ID: 378
Gene Symbol: ARF4
Alias: ARF2
Full Name: ADP ribosylation factor 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 26,858 bases
Position: chr3:57,571,363-57,598,220
Accession: 655
RBP type: canonical RBP
Summary: This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000420254	MMR_HSR1	PF01926.23	0.00012	1	1
ENSP00000306010	MMR_HSR1	PF01926.23	0.00036	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000303436	ARF4-201	1660	-	ENSP00000306010	180 (aa)	-	P18085
ENST00000486310	ARF4-204	1601	-	ENSP00000420655	59 (aa)	-	F8WDB3
ENST00000489843	ARF4-206	1360	-	ENSP00000475828	71 (aa)	-	U3KQF2
ENST00000493378	ARF4-207	548	-	-	- (aa)	-	-
ENST00000495354	ARF4-208	495	-	-	- (aa)	-	-
ENST00000463880	ARF4-202	641	-	ENSP00000420254	127 (aa)	-	C9JPM4
ENST00000483848	ARF4-203	404	-	-	- (aa)	-	-
ENST00000488156	ARF4-205	732	-	ENSP00000418388	22 (aa)	-	C9J6P1
ENST00000496292	ARF4-209	1467	-	ENSP00000417501	153 (aa)	-	C9JAK5

Gene Model

Click here to download ENSG00000168374's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000168374's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000168374	ARF4	100	100.000	ENSAMEG00000011813	ARF4	100	96.667	Ailuropoda_melanoleuca
ENSG00000168374	ARF4	100	100.000	ENSACAG00000002890	ARF4	100	96.667	Anolis_carolinensis
ENSG00000168374	ARF4	100	100.000	ENSANAG00000037339	ARF4	100	100.000	Aotus_nancymaae
ENSG00000168374	ARF4	100	100.000	ENSBTAG00000016069	ARF4	100	96.667	Bos_taurus
ENSG00000168374	ARF4	100	90.909	ENSBTAG00000053459	-	99	84.659	Bos_taurus
ENSG00000168374	ARF4	100	100.000	ENSCJAG00000040282	ARF4	100	100.000	Callithrix_jacchus
ENSG00000168374	ARF4	100	100.000	ENSCAFG00000029086	ARF4	100	96.667	Canis_familiaris
ENSG00000168374	ARF4	100	100.000	ENSCAFG00020006698	ARF4	100	96.667	Canis_lupus_dingo
ENSG00000168374	ARF4	100	100.000	ENSCHIG00000005883	-	100	96.667	Capra_hircus
ENSG00000168374	ARF4	100	100.000	ENSCHIG00000017997	-	100	96.667	Capra_hircus
ENSG00000168374	ARF4	100	100.000	ENSTSYG00000009748	ARF4	100	94.444	Carlito_syrichta
ENSG00000168374	ARF4	100	100.000	ENSCATG00000044002	ARF4	100	100.000	Cercocebus_atys
ENSG00000168374	ARF4	100	100.000	ENSCSAG00000012271	ARF4	100	100.000	Chlorocebus_sabaeus
ENSG00000168374	ARF4	100	100.000	ENSCPBG00000012354	ARF4	100	96.667	Chrysemys_picta_bellii
ENSG00000168374	ARF4	100	100.000	ENSCANG00000032405	ARF4	100	100.000	Colobus_angolensis_palliatus
ENSG00000168374	ARF4	100	100.000	ENSDNOG00000046406	ARF4	100	96.667	Dasypus_novemcinctus
ENSG00000168374	ARF4	100	100.000	ENSETEG00000010424	ARF4	100	96.111	Echinops_telfairi
ENSG00000168374	ARF4	100	100.000	ENSEASG00005000663	ARF4	100	96.667	Equus_asinus_asinus
ENSG00000168374	ARF4	100	100.000	ENSECAG00000005229	ARF4	100	96.667	Equus_caballus
ENSG00000168374	ARF4	100	100.000	ENSFCAG00000040365	ARF4	100	96.111	Felis_catus
ENSG00000168374	ARF4	100	97.183	ENSFALG00000008385	ARF4	100	88.398	Ficedula_albicollis
ENSG00000168374	ARF4	100	100.000	ENSFDAG00000007614	ARF4	100	94.444	Fukomys_damarensis
ENSG00000168374	ARF4	100	100.000	ENSGALG00000005622	ARF4	100	96.667	Gallus_gallus
ENSG00000168374	ARF4	100	100.000	ENSGAGG00000010263	ARF4	100	96.667	Gopherus_agassizii
ENSG00000168374	ARF4	100	100.000	ENSGGOG00000000294	ARF4	100	100.000	Gorilla_gorilla
ENSG00000168374	ARF4	100	100.000	ENSHGLG00100004350	ARF4	100	95.000	Heterocephalus_glaber_male
ENSG00000168374	ARF4	100	100.000	ENSSTOG00000019470	-	100	95.556	Ictidomys_tridecemlineatus
ENSG00000168374	ARF4	100	95.455	ENSLACG00000015381	ARF4	100	92.308	Latimeria_chalumnae
ENSG00000168374	ARF4	100	100.000	ENSLOCG00000013270	ARF4	100	93.889	Lepisosteus_oculatus
ENSG00000168374	ARF4	100	95.455	ENSLOCG00000016776	-	100	91.667	Lepisosteus_oculatus
ENSG00000168374	ARF4	100	100.000	ENSLAFG00000006203	ARF4	100	96.667	Loxodonta_africana
ENSG00000168374	ARF4	100	100.000	ENSMFAG00000000830	ARF4	100	100.000	Macaca_fascicularis
ENSG00000168374	ARF4	100	100.000	ENSMNEG00000034663	ARF4	100	100.000	Macaca_nemestrina
ENSG00000168374	ARF4	100	100.000	ENSMLEG00000038341	ARF4	100	100.000	Mandrillus_leucophaeus
ENSG00000168374	ARF4	100	97.183	ENSMGAG00000006460	ARF4	97	88.701	Meleagris_gallopavo
ENSG00000168374	ARF4	100	100.000	ENSMICG00000002015	-	100	96.111	Microcebus_murinus
ENSG00000168374	ARF4	100	100.000	ENSMODG00000000185	ARF4	100	96.667	Monodelphis_domestica
ENSG00000168374	ARF4	100	100.000	ENSMPUG00000016871	ARF4	100	96.667	Mustela_putorius_furo
ENSG00000168374	ARF4	100	100.000	ENSMLUG00000007990	ARF4	100	96.111	Myotis_lucifugus
ENSG00000168374	ARF4	100	100.000	ENSNLEG00000027374	ARF4	100	100.000	Nomascus_leucogenys
ENSG00000168374	ARF4	100	100.000	ENSMEUG00000001015	ARF4	100	96.667	Notamacropus_eugenii
ENSG00000168374	ARF4	100	100.000	ENSOCUG00000000824	ARF4	100	95.000	Oryctolagus_cuniculus
ENSG00000168374	ARF4	100	100.000	ENSOGAG00000012034	ARF4	100	96.111	Otolemur_garnettii
ENSG00000168374	ARF4	100	100.000	ENSOARG00000013565	ARF4	100	96.667	Ovis_aries
ENSG00000168374	ARF4	100	100.000	ENSPPAG00000036638	ARF4	100	100.000	Pan_paniscus
ENSG00000168374	ARF4	100	100.000	ENSPPRG00000011774	ARF4	100	96.111	Panthera_pardus
ENSG00000168374	ARF4	100	100.000	ENSPTIG00000018850	ARF4	100	96.111	Panthera_tigris_altaica
ENSG00000168374	ARF4	100	100.000	ENSPTRG00000015051	ARF4	100	100.000	Pan_troglodytes
ENSG00000168374	ARF4	100	100.000	ENSPANG00000006704	ARF4	100	100.000	Papio_anubis
ENSG00000168374	ARF4	100	100.000	ENSPSIG00000004867	ARF4	100	96.667	Pelodiscus_sinensis
ENSG00000168374	ARF4	100	100.000	ENSPCIG00000027320	ARF4	100	96.667	Phascolarctos_cinereus
ENSG00000168374	ARF4	100	100.000	ENSPPYG00000013768	ARF4	100	100.000	Pongo_abelii
ENSG00000168374	ARF4	100	100.000	ENSPCAG00000005717	ARF4	100	96.111	Procavia_capensis
ENSG00000168374	ARF4	100	100.000	ENSPCOG00000001896	ARF4	100	96.111	Propithecus_coquereli
ENSG00000168374	ARF4	100	100.000	ENSPVAG00000008882	ARF4	100	96.111	Pteropus_vampyrus
ENSG00000168374	ARF4	100	100.000	ENSRROG00000034971	ARF4	100	100.000	Rhinopithecus_roxellana
ENSG00000168374	ARF4	100	100.000	ENSSBOG00000020707	ARF4	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000168374	ARF4	100	100.000	ENSSHAG00000017434	ARF4	100	96.667	Sarcophilus_harrisii
ENSG00000168374	ARF4	100	100.000	ENSSARG00000009272	ARF4	100	79.444	Sorex_araneus
ENSG00000168374	ARF4	100	100.000	ENSSSCG00000031791	ARF4	100	96.667	Sus_scrofa
ENSG00000168374	ARF4	100	97.183	ENSTGUG00000007295	ARF4	100	92.771	Taeniopygia_guttata
ENSG00000168374	ARF4	100	100.000	ENSUAMG00000020632	ARF4	100	96.667	Ursus_americanus
ENSG00000168374	ARF4	100	100.000	ENSUMAG00000021908	ARF4	100	96.667	Ursus_maritimus
ENSG00000168374	ARF4	100	100.000	ENSVPAG00000003891	ARF4	100	96.667	Vicugna_pacos
ENSG00000168374	ARF4	100	100.000	ENSVVUG00000020333	ARF4	100	96.667	Vulpes_vulpes
ENSG00000168374	ARF4	100	100.000	ENSXETG00000008654	arf4	100	95.556	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003924	GTPase activity	-	TAS	Function
GO:0005086	ARF guanyl-nucleotide exchange factor activity	-	TAS	Function
GO:0005154	epidermal growth factor receptor binding	12446727.	IDA	Function
GO:0005515	protein binding	17956946.21988832.25416956.26258637.	IPI	Function
GO:0005525	GTP binding	21873635.	IBA	Function
GO:0005525	GTP binding	12446727.	IDA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005794	Golgi apparatus	21873635.	IBA	Component
GO:0005829	cytosol	12446727.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0006471	protein ADP-ribosylation	1899243.	IDA	Process
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	21873635.	IBA	Process
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	24768165.	IGI	Process
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	-	TAS	Process
GO:0006893	Golgi to plasma membrane transport	21873635.	IBA	Process
GO:0007173	epidermal growth factor receptor signaling pathway	-	IEA	Process
GO:0007420	brain development	-	IEA	Process
GO:0007612	learning	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016192	vesicle-mediated transport	21873635.	IBA	Process
GO:0016477	cell migration	22004728.	IDA	Process
GO:0031584	activation of phospholipase D activity	12446727.	IDA	Process
GO:0032587	ruffle membrane	12446727.	IDA	Component
GO:0043066	negative regulation of apoptotic process	19041174.	IDA	Process
GO:0043197	dendritic spine	23050017.	IDA	Component
GO:0045176	apical protein localization	-	IEA	Process
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	-	IEA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	12446727.	IDA	Process
GO:0048678	response to axon injury	-	IEA	Process
GO:0060996	dendritic spine development	23050017.	IDA	Process
GO:0061512	protein localization to cilium	-	IEA	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:0099175	regulation of postsynapse organization	-	IEA	Process
GO:2000377	regulation of reactive oxygen species metabolic process	19041174.	IDA	Process