EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000168393 (Gene tree)
Gene ID: 1841
Gene Symbol: DTYMK
Alias: CDC8|TYMK|TMPK
Full Name: deoxythymidylate kinase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 11,250 bases
Position: chr2:241,675,742-241,686,991
Accession: 3061
RBP type: non-canonical RBP
Summary: (Deoxythymidylate Kinase) is a Protein Coding gene. Diseases associated with DTYMK include Gaucher Disease, Type Iii. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include kinase activity and thymidylate kinase activity. An important paralog of this gene is CMPK2.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
14671117	The genome of canarypox virus.	J Virol	2004 Jan	Tulman ER	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000305784	DTYMK-201	1232	-	ENSP00000304802	212 (aa)	-	P23919
ENST00000400770	DTYMK-202	1089	-	ENSP00000383581	83 (aa)	-	G5E9E9
ENST00000420144	DTYMK-203	575	-	ENSP00000387379	192 (aa)	-	H7BZ20
ENST00000432348	DTYMK-204	926	-	ENSP00000410647	101 (aa)	-	H7C3A4
ENST00000493095	DTYMK-207	322	-	-	- (aa)	-	-
ENST00000464603	DTYMK-206	890	-	-	- (aa)	-	-
ENST00000445261	DTYMK-205	518	-	ENSP00000408939	170 (aa)	-	H7C312

Gene Model

Click here to download ENSG00000168393's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00240	Pyrimidine metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000168393's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000168393	DTYMK	99	39.450	WBGene00011272	dtmk-1	97	39.450	Caenorhabditis_elegans

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004550	nucleoside diphosphate kinase activity	21873635.	IBA	Function
GO:0004798	thymidylate kinase activity	21873635.	IBA	Function
GO:0004798	thymidylate kinase activity	8845311.	IDA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005758	mitochondrial intermembrane space	-	IEA	Component
GO:0005759	mitochondrial matrix	-	IEA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006165	nucleoside diphosphate phosphorylation	-	IEA	Process
GO:0006227	dUDP biosynthetic process	21873635.	IBA	Process
GO:0006233	dTDP biosynthetic process	21873635.	IBA	Process
GO:0006235	dTTP biosynthetic process	21873635.	IBA	Process
GO:0006235	dTTP biosynthetic process	-	IEA	Process
GO:0008283	cell proliferation	8024690.	TAS	Process
GO:0009041	uridylate kinase activity	21873635.	IBA	Function
GO:0015949	nucleobase-containing small molecule interconversion	-	TAS	Process
GO:0043627	response to estrogen	-	IEA	Process
GO:0045445	myoblast differentiation	-	IEA	Process
GO:0046686	response to cadmium ion	-	IEA	Process
GO:0046940	nucleoside monophosphate phosphorylation	-	IEA	Process
GO:0071363	cellular response to growth factor stimulus	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18413751	Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status.	Cancer Res	2008 Apr 15	Hu CM	doi: 10.1158/0008-5472.CAN-07-3069.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BRCA	chr2	241680289	Silent	NA	G90G	0.13
BRCA	chr2	241676084	3'UTR	rs200764696		0.28
BRCA	chr2	241685796	Missense_Mutation	NA	L71P	0.41
CESC	chr2	241680226	Splice_Region	rs761881458		0.19
CESC	chr2	241678617	Silent	rs188663113	D121D	0.39
COAD	chr2	241678617	Silent	rs188663113	D121D	0.32
ESCA	chr2	241678532	Missense_Mutation	rs762448283	R150C	0.15
GBM	chr2	241678510	Missense_Mutation	novel	Q157L	0.22
GBM	chr2	241676177	Missense_Mutation	novel	D197N	0.25
GBM	chr2	241678484	Frame_Shift_Del	novel	*Q166Sfs3**	0.42
GBM	chr2	241678474	Missense_Mutation	novel	K169T	0.09
HNSC	chr2	241678461	Silent	novel	L173L	0.11
LIHC	chr2	241676034	3'UTR	novel		0.33
OV	chr2	241678544	Missense_Mutation	novel	F146I	0.09
PAAD	chr2	241685824	Missense_Mutation	novel	D62N	0.2
PRAD	chr2	241685822	Silent	novel	D62D	0.35
READ	chr2	241680300	Missense_Mutation	novel	L87M	0.48
SARC	chr2	241676165	Missense_Mutation	novel	T201A	0.52
SKCM	chr2	241676097	3'UTR	novel		0.5
STAD	chr2	241678617	Silent	rs188663113	D121D	0.07
THCA	chr2	241678538	Missense_Mutation	NA	H148N	0.45
UCEC	chr2	241676069	3'UTR	novel		0.38
UCEC	chr2	241676146	Missense_Mutation	novel	L207P	0.5
UCEC	chr2	241678502	Missense_Mutation	novel	A160T	0.34
UCEC	chr2	241680265	Silent	novel	Y98Y	0.4
UCEC	chr2	241678644	Missense_Mutation	novel	F112L	0.57
UCEC	chr2	241680265	Silent	novel	Y98Y	0.15
UCEC	chr2	241676191	Missense_Mutation	NA	R192H	0.43
UCEC	chr2	241680317	Missense_Mutation	novel	P81L	0.31
UCEC	chr2	241680277	Silent	rs774620496	V94V	0.36
UCEC	chr2	241676193	Silent	rs758962690	I191I	0.16
UCEC	chr2	241680265	Silent	novel	Y98Y	0.26
UCEC	chr2	241678546	Missense_Mutation	rs766664417	A145V	0.46
UCEC	chr2	241678531	Missense_Mutation	rs149828739	R150H	0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2222	0.032456
BLCA	DEL	0.424	2.0711e-36
BRCA	DEL	0.2148	2.4898e-11
CESC	DEL	0.3458	3.4658e-41
HNSC	DEL	0.2165	1.278e-25
KIRC	DEL	0.0928	5.6049e-16
KIRP	DEL	0.0382	5.174e-05
LGG	DEL	0.1189	1.4015e-20
LIHC	DEL	0.1297	0.0022356
LUSC	DEL	0.2595	1.3904e-19
OV	DEL	0.2556	7.0161e-09
PAAD	AMP	0.0598	0.1091
PAAD	DEL	0.0435	0.2014
SARC	DEL	0.3891	7.1647e-24
TGCT	DEL	0.0733	0.062762
THCA	DEL	0.024	0.040844
UCEC	DEL	0.0798	0.00045104
UVM	DEL	0.025	0.024639

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.0002	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
SKCM	0.0082	Kaplan-Meier Survival Analysis
LUSC	0.013	Kaplan-Meier Survival Analysis
PAAD	0.019	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.0089	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.00022	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742