EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000168439 (Gene tree)
Gene ID: 10963
Gene Symbol: STIP1
Alias: HOP|STI1
Full Name: stress induced phosphoprotein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 19,277 bases
Position: chr11:64,185,272-64,204,548
Accession: 11387
RBP type: non-canonical RBP
Summary: STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
2410268	Identification of a 60-kDa phosphoprotein that binds stored messenger RNA of Xenopus oocytes.	Eur J Biochem	1985 Jul 1	Dearsly AL	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000537479	STIP1-205	601	-	-	- (aa)	-	-
ENST00000544739	STIP1-212	562	-	-	- (aa)	-	-
ENST00000538497	STIP1-206	582	-	-	- (aa)	-	-
ENST00000540736	STIP1-209	399	-	-	- (aa)	-	-
ENST00000540501	STIP1-208	880	-	-	- (aa)	-	-
ENST00000543847	STIP1-211	772	-	ENSP00000442704	236 (aa)	-	F5H783
ENST00000358794	STIP1-203	2743	-	ENSP00000351646	590 (aa)	-	P31948
ENST00000305218	STIP1-201	2196	-	ENSP00000305958	543 (aa)	-	P31948
ENST00000540887	STIP1-210	877	-	ENSP00000443416	137 (aa)	-	H0YGI8
ENST00000355603	STIP1-202	528	-	-	- (aa)	-	-
ENST00000536973	STIP1-204	738	-	ENSP00000441036	138 (aa)	-	F5GXD8
ENST00000538945	STIP1-207	1900	-	ENSP00000445957	519 (aa)	-	P31948

Gene Model

Click here to download ENSG00000168439's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05020	Prion diseases	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000168439	Attention Deficit Disorder with Hyperactivity	4E-6	21784300

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000168439	rs11607165	11	64196475	?	Attention deficit hyperactivity disorder	21784300			EFO_0003888
ENSG00000168439	rs2236647	11	64197133	?	Reaction time	29844566	[0.0057-0.0126] unit increase	0.0091312	EFO_0008393

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000168439's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000168439	STIP1	100	97.422	ENSMUSG00000024966	Stip1	100	97.422	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	20029029.21044950.21170051.21360678.23349634.23431407.24880080.25036637.27353360.28330616.	IPI	Function
GO:0005634	nucleus	16130169.	TAS	Component
GO:0005794	Golgi apparatus	1569099.	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0008022	protein C-terminus binding	-	IEA	Function
GO:0030544	Hsp70 protein binding	-	IEA	Function
GO:0032991	protein-containing complex	23349634.	IDA	Component
GO:0051087	chaperone binding	-	IEA	Function
GO:0051879	Hsp90 protein binding	21873635.	IBA	Function
GO:0051879	Hsp90 protein binding	29127155.	IPI	Function
GO:0098761	cellular response to interleukin-7	-	IEA	Process
GO:0101031	chaperone complex	29127155.	IDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20501939	Stress-induced phosphoprotein 1 as a secreted biomarker for human ovarian cancer promotes cancer cell proliferation.	Mol Cell Proteomics	2010 Sep	Wang TH	doi: 10.1074/mcp.M110.000802
29596884	STIP1 is over-expressed in hepatocellular carcinoma and promotes the growth and migration of cancer cells.	Gene	2018 Jul 1	Luo X	doi: 10.1016/j.gene.2018.03.076
30076803	Prognostic significance of STIP1 expression in human cancer: A meta-analysis.	Clin Chim Acta	2018 Nov	Zhang S	doi: 10.1016/j.cca.2018.07.037
22824801	C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances.	Oncogene	2013 Jun 20	Muller P	doi: 10.1038/onc.2012.314
23915849	Immunohistological analysis of stress-induced phosphoprotein 1 in ovarian cancer patients with low serum cancer antigen 125 levels.	Taiwan J Obstet Gynecol	2013 Jun	Chao A	doi: 10.1016/j.tjog.2013.04.006.
21470770	RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation.	Cancer Lett	2011 Jul 28	Walsh N	doi: 10.1016/j.canlet.2011.03.004
24488757	Expression of stress-induced phosphoprotein1 (STIP1) is associated with tumor progression and poor prognosis in epithelial ovarian cancer.	Genes Chromosomes Cancer	2014 Apr	Cho H	doi: 10.1002/gcc.22136
29559743	Stress-induced phosphoprotein 1 mediates hepatocellular carcinoma metastasis after insufficient radiofrequency ablation.	Oncogene	2018 Jun	Su T	doi: 10.1038/s41388-018-0169-4

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	64203599	Silent	NA	Q512Q	0.18
BLCA	chr11	64203582	Missense_Mutation	novel	I507V	0.07
BLCA	chr11	64194293	Silent	novel	L108L	0.08
BLCA	chr11	64200209	Missense_Mutation	novel	I387M	0.15
BLCA	chr11	64194582	Silent	novel	L155L	0.32
BLCA	chr11	64202882	Missense_Mutation	NA	E418K	0.25
BLCA	chr11	64203594	Missense_Mutation	novel	M511V	0.17
BLCA	chr11	64203614	Silent	novel	A517A	0.21
BLCA	chr11	64204202	3'UTR	novel		0.36
BRCA	chr11	64197943	Missense_Mutation	NA	R331Q	0.17
BRCA	chr11	64194493	Missense_Mutation	novel	N126D	0.09
BRCA	chr11	64193267	Missense_Mutation	NA	L67V	0.15
BRCA	chr11	64186226	5'UTR	novel		0.23
BRCA	chr11	64204236	3'UTR	novel		0.29
BRCA	chr11	64203208	Missense_Mutation	NA	D456H	0.17
CESC	chr11	64195662	Missense_Mutation	rs769710155	R174Q	0.11
CESC	chr11	64197493	Missense_Mutation	novel	A267V	0.39
CESC	chr11	64194501	Missense_Mutation	NA	F128L	0.18
COAD	chr11	64195820	Splice_Region	novel		0.36
COAD	chr11	64197539	Nonsense_Mutation	NA	C282*	0.1
COAD	chr11	64200020	Silent	NA	N368N	0.25
COAD	chr11	64195726	Missense_Mutation	novel	E195D	0.43
COAD	chr11	64195681	Silent	rs373218763	S180S	0.24
COAD	chr11	64199999	In_Frame_Del	NA	E363del	0.43
COAD	chr11	64203454	Missense_Mutation	NA	A464V	0.46
COAD	chr11	64203525	Nonsense_Mutation	NA	R488*	0.46
COAD	chr11	64203525	Nonsense_Mutation	NA	R488*	0.35
COAD	chr11	64197326	Missense_Mutation	rs747004405	T243I	0.07
COAD	chr11	64194195	Missense_Mutation	NA	S76P	0.43
COAD	chr11	64200201	Nonsense_Mutation	NA	E385*	0.11
COAD	chr11	64203484	Missense_Mutation	novel	A474V	0.45
COAD	chr11	64203447	Splice_Region	novel		0.26
ESCA	chr11	64186259	5'UTR	novel		0.35
ESCA	chr11	64202904	Missense_Mutation	novel	P425L	0.11
GBM	chr11	64194246	Nonsense_Mutation	novel	R93*	0.38
GBM	chr11	64197375	Missense_Mutation	novel	M259I	0.13
HNSC	chr11	64200168	Splice_Site	novel	X374_splice	0.43
HNSC	chr11	64195742	Missense_Mutation	novel	P201S	0.3
HNSC	chr11	64197298	Missense_Mutation	rs149913210	D234N	0.12
HNSC	chr11	64203484	Missense_Mutation	novel	A474V	0.5
KIRP	chr11	64204186	3'UTR	novel		0.51
LAML	chr11	64200183	Missense_Mutation	novel	A379T	0.05
LGG	chr11	64193110	Silent	novel	A14A	0.37
LGG	chr11	64204182	3'UTR	novel		0.38
LIHC	chr11	64197571	Missense_Mutation	novel	R293Q	0.12
LIHC	chr11	64195803	Missense_Mutation	novel	N221S	0.42
LIHC	chr11	64186118	5'UTR	novel		0.46
LIHC	chr11	64197517	Missense_Mutation	NA	Y275C	0.2
LUAD	chr11	64200180	Nonsense_Mutation	NA	Q378*	0.13
LUAD	chr11	64193281	Missense_Mutation	novel	W71C	0.36
LUAD	chr11	64204269	3'UTR	novel		0.13
LUAD	chr11	64203560	Missense_Mutation	NA	M499I	0.09
LUAD	chr11	64195854	Intron	novel		0.1
LUAD	chr11	64197573	Missense_Mutation	NA	E294Q	0.19
LUAD	chr11	64200032	Silent	NA	Q372Q	0.15
LUAD	chr11	64203564	Missense_Mutation	NA	D501N	0.15
LUAD	chr11	64197292	Missense_Mutation	NA	G232R	0.36
LUAD	chr11	64194196	Missense_Mutation	NA	S76L	0.22
LUSC	chr11	64204155	3'UTR	novel		0.46
LUSC	chr11	64193117	Missense_Mutation	rs769617573	V17M	0.1
LUSC	chr11	64203584	Missense_Mutation	novel	I507M	0.09
LUSC	chr11	64197549	Missense_Mutation	rs762737538	I286V	0.44
LUSC	chr11	64195666	Silent	NA	I175I	0.26
LUSC	chr11	64193105	Nonsense_Mutation	novel	K13*	0.18
LUSC	chr11	64195774	Silent	novel	P211P	0.33
LUSC	chr11	64197281	Missense_Mutation	novel	E228V	0.26
LUSC	chr11	64200225	Missense_Mutation	novel	D393H	0.2
LUSC	chr11	64195698	Missense_Mutation	NA	D186V	0.14
LUSC	chr11	64200244	Missense_Mutation	rs780822146	N399S	0.31
OV	chr11	64195847	Intron	novel		0.04
OV	chr11	64202886	Missense_Mutation	NA	E419V	0.14
OV	chr11	64194195	Frame_Shift_Ins	novel	*S76Cfs14**	0.08
OV	chr11	64194200	Silent	NA	R77R	0.17
OV	chr11	64204060	Missense_Mutation	novel	L522F	0.11
OV	chr11	64194595	Nonsense_Mutation	NA	R160*	0.45
OV	chr11	64194506	Missense_Mutation	novel	M130R	0.17
OV	chr11	64195852	Intron	novel		0.49
OV	chr11	64193156	Frame_Shift_Ins	novel	*A30Vfs42**	0.06
PAAD	chr11	64203578	Silent	novel	R505R	0.29
PAAD	chr11	64194210	Missense_Mutation	novel	A81T	0.18
PAAD	chr11	64203153	Silent	rs2070232	A437A	0.21
READ	chr11	64197512	Silent	rs774373870	G273G	0.16
READ	chr11	64204092	Missense_Mutation	novel	K533R	0.17
READ	chr11	64197552	Nonsense_Mutation	novel	E287*	0.46
SARC	chr11	64186159	5'UTR	novel		0.08
SARC	chr11	64197971	Silent	novel	Q340Q	0.1
SARC	chr11	64204409	3'UTR	novel		0.74
SKCM	chr11	64203508	Missense_Mutation	NA	P482L	0.16
SKCM	chr11	64203494	Silent	rs768299155	N477N	0.23
SKCM	chr11	64203495	Missense_Mutation	novel	R478W	0.23
SKCM	chr11	64195773	Missense_Mutation	novel	P211Q	0.42
SKCM	chr11	64194251	Silent	novel	T94T	0.28
SKCM	chr11	64197948	Missense_Mutation	novel	P333S	0.23
STAD	chr11	64197967	Missense_Mutation	novel	C339Y	0.05
STAD	chr11	64193196	Missense_Mutation	NA	N43S	0.04
STAD	chr11	64197340	Missense_Mutation	novel	Y248H	0.15
STAD	chr11	64195820	Splice_Region	novel		0.16
STAD	chr11	64194482	Missense_Mutation	NA	R122I	0.27
STAD	chr11	64203493	Missense_Mutation	NA	N477S	0.14
STAD	chr11	64203140	Missense_Mutation	NA	R433Q	0.14
STAD	chr11	64197582	Nonsense_Mutation	NA	R297*	0.29
UCEC	chr11	64194595	Nonsense_Mutation	NA	R160*	0.37
UCEC	chr11	64197357	Silent	NA	E253E	0.49
UCEC	chr11	64203621	Missense_Mutation	novel	E520K	0.56
UCEC	chr11	64204323	3'UTR	rs761832631		0.33
UCEC	chr11	64197558	Missense_Mutation	novel	G289R	0.39
UCEC	chr11	64203545	Missense_Mutation	novel	E494D	0.33
UCEC	chr11	64204153	3'UTR	novel		0.33
UCEC	chr11	64193129	Missense_Mutation	rs764983786	D21N	0.16
UCEC	chr11	64195860	Intron	novel		0.2
UCEC	chr11	64194191	Splice_Region	novel	G74G	0.09
UCEC	chr11	64204409	3'UTR	novel		0.53
UCEC	chr11	64195860	Intron	novel		0.08
UCEC	chr11	64203201	Missense_Mutation	novel	K453N	0.39
UCEC	chr11	64194478	Splice_Site	NA	X121_splice	0.34
UCEC	chr11	64203180	Missense_Mutation	novel	K446N	0.2
UCEC	chr11	64204153	3'UTR	novel		0.12
UCEC	chr11	64194589	Nonsense_Mutation	novel	Q158*	0.11
UCEC	chr11	64204409	3'UTR	novel		0.33
UCEC	chr11	64195865	Intron	novel		0.17
UCEC	chr11	64203500	Silent	rs773881149	H479H	0.32
UCEC	chr11	64197361	Missense_Mutation	NA	D255H	0.34
UCEC	chr11	64197865	Missense_Mutation	novel	R305Q	0.34
UCEC	chr11	64194574	Missense_Mutation	novel	R153W	0.49
UCEC	chr11	64204118	Missense_Mutation	rs766923089	I542V	0.46
UCEC	chr11	64204409	3'UTR	novel		0.34
UCEC	chr11	64204409	3'UTR	novel		0.37
UCEC	chr11	64204409	3'UTR	novel		0.39
UCEC	chr11	64203188	Missense_Mutation	novel	D449G	0.38
UCEC	chr11	64195865	Intron	novel		0.3
UCEC	chr11	64204153	3'UTR	novel		0.48
UCEC	chr11	64197522	Nonsense_Mutation	novel	K277*	0.42
UCEC	chr11	64204409	3'UTR	novel		0.32
UCEC	chr11	64197547	Missense_Mutation	rs775263263	A285V	0.08
UCEC	chr11	64204051	Splice_Region	novel		0.29
UCEC	chr11	64194260	Missense_Mutation	novel	E97D	0.38
UCEC	chr11	64204180	3'UTR	rs145110088		0.35
UCEC	chr11	64197512	Silent	rs774373870	G273G	0.2
UCEC	chr11	64204063	Silent	novel	K523K	0.05
UCEC	chr11	64204409	3'UTR	novel		0.36
UCEC	chr11	64200285	Missense_Mutation	novel	A413T	0.2
UCEC	chr11	64194505	Missense_Mutation	novel	M130V	0.39
UCEC	chr11	64197330	Silent	novel	A244A	0.24
UCEC	chr11	64197922	Missense_Mutation	novel	N324S	0.18
UCEC	chr11	64204129	3'UTR	novel		0.24
UCEC	chr11	64194241	Missense_Mutation	NA	A91D	0.29
UCEC	chr11	64204139	3'UTR	novel		0.17
UCEC	chr11	64204409	3'UTR	novel		0.44
UCEC	chr11	64193134	Silent	novel	D22D	0.33
UCEC	chr11	64193214	Missense_Mutation	novel	A49V	0.41
UVM	chr11	64204073	Missense_Mutation	novel	I527V	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.1957	0.018342
TGCT	DEL	0.7133	0.21504
UCS	AMP	0.25	0.0089022

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0037	Kaplan-Meier Survival Analysis
MESO	0.00017	Kaplan-Meier Survival Analysis
ACC	0.002	Kaplan-Meier Survival Analysis
HNSC	0.00012	Kaplan-Meier Survival Analysis
PRAD	0.01	Kaplan-Meier Survival Analysis
BRCA	0.0074	Kaplan-Meier Survival Analysis
ESCA	0.017	Kaplan-Meier Survival Analysis
KIRP	0.00053	Kaplan-Meier Survival Analysis
PAAD	0.029	Kaplan-Meier Survival Analysis
BLCA	0.023	Kaplan-Meier Survival Analysis
CESC	0.025	Kaplan-Meier Survival Analysis
LAML	0.0001	Kaplan-Meier Survival Analysis
KICH	0.01	Kaplan-Meier Survival Analysis
UCEC	0.043	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.0018	Kaplan-Meier Survival Analysis
UVM	0.0024	Kaplan-Meier Survival Analysis
OV	0.031	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742