EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000168724 (Gene tree)
Gene ID: 134218
Gene Symbol: DNAJC21
Alias: GS3|DNAJA5|JJJ1
Full Name: DnaJ heat shock protein family (Hsp40) member C21
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 29,406 bases
Position: chr5:34,929,559-34,958,964
Accession: 27030
RBP type: canonical RBP
Summary: This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the precursor 45S ribosomal RNA and may be involved in early nuclear ribosomal RNA biogenesis and maturation of the 60S ribosomal subunit. Mutations in this gene result in Bone marrow failure syndrome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000494173	zf-met	PF12874.7	7e-08	1	1
ENSP00000493850	zf-met	PF12874.7	9.2e-08	1	1
ENSP00000493883	zf-met	PF12874.7	9.6e-08	1	1
ENSP00000343728	zf-met	PF12874.7	1.2e-07	1	1
ENSP00000497410	zf-met	PF12874.7	1.2e-07	1	1
ENSP00000496545	zf-met	PF12874.7	1.3e-07	1	1
ENSP00000371451	zf-met	PF12874.7	1.4e-07	1	1
ENSP00000493850	zf-C2H2_jaz	PF12171.8	5.4e-11	1	1
ENSP00000494173	zf-C2H2_jaz	PF12171.8	6.6e-11	1	1
ENSP00000493883	zf-C2H2_jaz	PF12171.8	7.8e-11	1	1
ENSP00000343728	zf-C2H2_jaz	PF12171.8	8.9e-11	1	1
ENSP00000497410	zf-C2H2_jaz	PF12171.8	8.9e-11	1	1
ENSP00000496545	zf-C2H2_jaz	PF12171.8	9.2e-11	1	1
ENSP00000371451	zf-C2H2_jaz	PF12171.8	9.8e-11	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000382021	DNAJC21-202	6208	XM_011513965	ENSP00000371451	576 (aa)	XP_011512267	Q5F1R6
ENST00000642851	DNAJC21-209	2788	XM_005248250	ENSP00000496545	544 (aa)	XP_005248307	Q5F1R6
ENST00000644357	DNAJC21-210	1682	-	ENSP00000493850	353 (aa)	-	A0A2R8Y4N5
ENST00000646714	DNAJC21-211	2989	-	ENSP00000495883	89 (aa)	-	A0A2R8YET8
ENST00000509626	DNAJC21-204	779	-	-	- (aa)	-	-
ENST00000648817	DNAJC21-212	6107	-	ENSP00000497410	531 (aa)	-	UPI000020C957
ENST00000506762	DNAJC21-203	402	-	-	- (aa)	-	-
ENST00000512136	DNAJC21-205	2516	-	-	- (aa)	-	-
ENST00000642675	DNAJC21-208	2338	-	ENSP00000494173	415 (aa)	-	A0A2R8Y534
ENST00000342382	DNAJC21-201	2309	-	ENSP00000343728	531 (aa)	-	Q5F1R6
ENST00000642285	DNAJC21-207	2276	-	ENSP00000493883	473 (aa)	-	A0A2R8Y4Q0
ENST00000514237	DNAJC21-206	1022	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000168724's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000168724	candesartan	9E-6	22566498
ENSG00000168724	Hypertension	9E-6	22566498

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000168724	rs37439	5	34951045	A	Response to angiotensin II receptor blocker therapy	22566498	[0.53-1.47] unit decrease	1	GO_1901556\|EFO_0000537

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000168724's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000168724	DNAJC21	73	76.099	ENSAPOG00000020475	dnajc21	91	70.976	Acanthochromis_polyacanthus
ENSG00000168724	DNAJC21	100	90.789	ENSAMEG00000003283	DNAJC21	100	90.789	Ailuropoda_melanoleuca
ENSG00000168724	DNAJC21	76	78.056	ENSACIG00000016953	dnajc21	97	75.192	Amphilophus_citrinellus
ENSG00000168724	DNAJC21	73	77.869	ENSAOCG00000014500	dnajc21	100	62.063	Amphiprion_ocellaris
ENSG00000168724	DNAJC21	67	75.676	ENSAPEG00000017159	dnajc21	100	62.749	Amphiprion_percula
ENSG00000168724	DNAJC21	99	65.094	ENSAPLG00000006757	DNAJC21	100	68.738	Anas_platyrhynchos
ENSG00000168724	DNAJC21	100	67.949	ENSACAG00000021095	DNAJC21	100	69.231	Anolis_carolinensis
ENSG00000168724	DNAJC21	100	96.992	ENSANAG00000029512	DNAJC21	100	96.992	Aotus_nancymaae
ENSG00000168724	DNAJC21	97	64.571	ENSACLG00000005203	dnajc21	91	78.431	Astatotilapia_calliptera
ENSG00000168724	DNAJC21	100	62.316	ENSAMXG00000008099	dnajc21	100	63.686	Astyanax_mexicanus
ENSG00000168724	DNAJC21	100	89.869	ENSBTAG00000015648	DNAJC21	86	89.493	Bos_taurus
ENSG00000168724	DNAJC21	100	96.805	ENSCJAG00000018495	DNAJC21	100	96.014	Callithrix_jacchus
ENSG00000168724	DNAJC21	100	91.353	ENSCAFG00000018794	DNAJC21	100	91.353	Canis_familiaris
ENSG00000168724	DNAJC21	66	75.899	ENSCAFG00020005023	-	92	79.286	Canis_lupus_dingo
ENSG00000168724	DNAJC21	100	91.353	ENSCAFG00020016768	-	100	91.353	Canis_lupus_dingo
ENSG00000168724	DNAJC21	100	89.493	ENSCHIG00000012397	DNAJC21	100	89.118	Capra_hircus
ENSG00000168724	DNAJC21	100	92.565	ENSTSYG00000006288	DNAJC21	100	92.565	Carlito_syrichta
ENSG00000168724	DNAJC21	100	96.429	ENSCCAG00000038110	DNAJC21	100	96.429	Cebus_capucinus
ENSG00000168724	DNAJC21	100	91.681	ENSCATG00000029357	DNAJC21	100	91.681	Cercocebus_atys
ENSG00000168724	DNAJC21	100	87.740	ENSCLAG00000011176	DNAJC21	100	89.379	Chinchilla_lanigera
ENSG00000168724	DNAJC21	100	97.368	ENSCSAG00000017112	DNAJC21	100	97.368	Chlorocebus_sabaeus
ENSG00000168724	DNAJC21	100	77.337	ENSCHOG00000001798	DNAJC21	100	80.309	Choloepus_hoffmanni
ENSG00000168724	DNAJC21	100	71.165	ENSCPBG00000021311	DNAJC21	95	70.795	Chrysemys_picta_bellii
ENSG00000168724	DNAJC21	100	96.429	ENSCANG00000009741	DNAJC21	100	96.429	Colobus_angolensis_palliatus
ENSG00000168724	DNAJC21	100	88.180	ENSCGRG00001020440	Dnajc21	86	87.805	Cricetulus_griseus_chok1gshd
ENSG00000168724	DNAJC21	100	86.091	ENSCGRG00000008326	Dnajc21	90	87.226	Cricetulus_griseus_crigri
ENSG00000168724	DNAJC21	98	59.328	ENSCSEG00000019817	dnajc21	100	61.020	Cynoglossus_semilaevis
ENSG00000168724	DNAJC21	100	60.584	ENSCVAG00000016740	dnajc21	100	61.081	Cyprinodon_variegatus
ENSG00000168724	DNAJC21	100	60.465	ENSDARG00000105195	dnajc21	100	61.733	Danio_rerio
ENSG00000168724	DNAJC21	99	80.964	ENSDNOG00000041523	DNAJC21	99	78.748	Dasypus_novemcinctus
ENSG00000168724	DNAJC21	100	87.850	ENSDORG00000009370	Dnajc21	100	87.477	Dipodomys_ordii
ENSG00000168724	DNAJC21	100	92.857	ENSEASG00005014955	DNAJC21	100	92.857	Equus_asinus_asinus
ENSG00000168724	DNAJC21	100	93.045	ENSECAG00000024728	DNAJC21	78	93.045	Equus_caballus
ENSG00000168724	DNAJC21	100	86.331	ENSEEUG00000012676	DNAJC21	100	80.000	Erinaceus_europaeus
ENSG00000168724	DNAJC21	98	59.823	ENSELUG00000009111	dnajc21	100	59.375	Esox_lucius
ENSG00000168724	DNAJC21	100	89.662	ENSFCAG00000029775	DNAJC21	100	89.662	Felis_catus
ENSG00000168724	DNAJC21	99	64.608	ENSFALG00000002105	DNAJC21	98	66.994	Ficedula_albicollis
ENSG00000168724	DNAJC21	99	90.892	ENSFDAG00000013492	DNAJC21	100	90.892	Fukomys_damarensis
ENSG00000168724	DNAJC21	100	59.108	ENSFHEG00000004599	dnajc21	100	59.176	Fundulus_heteroclitus
ENSG00000168724	DNAJC21	79	68.668	ENSGMOG00000003347	dnajc21	74	73.066	Gadus_morhua
ENSG00000168724	DNAJC21	100	61.101	ENSGAFG00000011978	dnajc21	99	61.931	Gambusia_affinis
ENSG00000168724	DNAJC21	71	72.131	ENSGACG00000016480	dnajc21	100	59.058	Gasterosteus_aculeatus
ENSG00000168724	DNAJC21	100	69.982	ENSGAGG00000011966	DNAJC21	100	70.534	Gopherus_agassizii
ENSG00000168724	DNAJC21	100	99.150	ENSGGOG00000024744	DNAJC21	100	98.899	Gorilla_gorilla
ENSG00000168724	DNAJC21	97	64.381	ENSHBUG00000017885	dnajc21	91	78.431	Haplochromis_burtoni
ENSG00000168724	DNAJC21	100	90.414	ENSHGLG00000003933	-	100	90.414	Heterocephalus_glaber_female
ENSG00000168724	DNAJC21	100	69.663	ENSHGLG00000006827	-	100	70.599	Heterocephalus_glaber_female
ENSG00000168724	DNAJC21	100	88.462	ENSHGLG00100002047	DNAJC21	100	89.780	Heterocephalus_glaber_male
ENSG00000168724	DNAJC21	76	73.669	ENSHCOG00000011669	dnajc21	82	75.071	Hippocampus_comes
ENSG00000168724	DNAJC21	100	63.031	ENSIPUG00000017629	dnajc21	100	65.492	Ictalurus_punctatus
ENSG00000168724	DNAJC21	100	85.714	ENSSTOG00000009616	DNAJC21	97	94.180	Ictidomys_tridecemlineatus
ENSG00000168724	DNAJC21	100	83.453	ENSJJAG00000019642	Dnajc21	100	79.182	Jaculus_jaculus
ENSG00000168724	DNAJC21	73	73.829	ENSKMAG00000014422	dnajc21	98	68.510	Kryptolebias_marmoratus
ENSG00000168724	DNAJC21	72	76.323	ENSLBEG00000018026	dnajc21	92	76.471	Labrus_bergylta
ENSG00000168724	DNAJC21	98	65.076	ENSLACG00000005081	DNAJC21	99	65.129	Latimeria_chalumnae
ENSG00000168724	DNAJC21	100	63.620	ENSLOCG00000011784	dnajc21	100	64.750	Lepisosteus_oculatus
ENSG00000168724	DNAJC21	71	80.743	ENSLAFG00000007251	-	100	80.743	Loxodonta_africana
ENSG00000168724	DNAJC21	100	97.734	ENSMFAG00000001345	DNAJC21	100	97.574	Macaca_fascicularis
ENSG00000168724	DNAJC21	100	97.368	ENSMMUG00000000446	DNAJC21	100	97.368	Macaca_mulatta
ENSG00000168724	DNAJC21	100	97.232	ENSMNEG00000035975	DNAJC21	100	97.232	Macaca_nemestrina
ENSG00000168724	DNAJC21	100	96.884	ENSMLEG00000011252	DNAJC21	100	96.875	Mandrillus_leucophaeus
ENSG00000168724	DNAJC21	67	76.230	ENSMAMG00000015040	dnajc21	100	61.071	Mastacembelus_armatus
ENSG00000168724	DNAJC21	97	64.571	ENSMZEG00005019816	dnajc21	100	64.457	Maylandia_zebra
ENSG00000168724	DNAJC21	71	71.032	ENSMGAG00000003141	DNAJC21	100	61.176	Meleagris_gallopavo
ENSG00000168724	DNAJC21	100	87.805	ENSMAUG00000009009	Dnajc21	100	87.617	Mesocricetus_auratus
ENSG00000168724	DNAJC21	100	92.308	ENSMICG00000005679	DNAJC21	100	91.932	Microcebus_murinus
ENSG00000168724	DNAJC21	100	84.652	ENSMOCG00000011153	Dnajc21	100	86.400	Microtus_ochrogaster
ENSG00000168724	DNAJC21	74	69.444	ENSMMOG00000000864	dnajc21	100	54.461	Mola_mola
ENSG00000168724	DNAJC21	100	78.987	ENSMODG00000020382	DNAJC21	100	78.987	Monodelphis_domestica
ENSG00000168724	DNAJC21	69	76.839	ENSMALG00000020368	dnajc21	99	61.343	Monopterus_albus
ENSG00000168724	DNAJC21	91	84.252	MGP_CAROLIEiJ_G0019664	-	100	83.727	Mus_caroli
ENSG00000168724	DNAJC21	100	85.178	ENSMUSG00000044224	Dnajc21	100	84.398	Mus_musculus
ENSG00000168724	DNAJC21	100	85.553	MGP_PahariEiJ_G0016044	Dnajc21	100	85.178	Mus_pahari
ENSG00000168724	DNAJC21	100	83.271	MGP_SPRETEiJ_G0020561	Dnajc21	100	83.271	Mus_spretus
ENSG00000168724	DNAJC21	100	90.226	ENSMPUG00000015133	DNAJC21	86	90.226	Mustela_putorius_furo
ENSG00000168724	DNAJC21	100	85.612	ENSMLUG00000000230	DNAJC21	100	87.026	Myotis_lucifugus
ENSG00000168724	DNAJC21	100	88.555	ENSNGAG00000021213	Dnajc21	100	88.368	Nannospalax_galili
ENSG00000168724	DNAJC21	73	71.429	ENSNBRG00000008882	dnajc21	86	69.091	Neolamprologus_brichardi
ENSG00000168724	DNAJC21	100	90.368	ENSNLEG00000014463	DNAJC21	98	92.110	Nomascus_leucogenys
ENSG00000168724	DNAJC21	89	86.533	ENSOPRG00000012894	DNAJC21	100	75.551	Ochotona_princeps
ENSG00000168724	DNAJC21	50	76.571	ENSODEG00000012748	-	98	76.571	Octodon_degus
ENSG00000168724	DNAJC21	97	62.857	ENSONIG00000007724	dnajc21	91	78.431	Oreochromis_niloticus
ENSG00000168724	DNAJC21	99	70.071	ENSOANG00000014526	DNAJC21	100	74.111	Ornithorhynchus_anatinus
ENSG00000168724	DNAJC21	100	91.182	ENSOCUG00000005257	DNAJC21	88	90.994	Oryctolagus_cuniculus
ENSG00000168724	DNAJC21	97	58.287	ENSORLG00000005913	dnajc21	100	59.313	Oryzias_latipes
ENSG00000168724	DNAJC21	97	59.099	ENSORLG00020005159	dnajc21	100	60.145	Oryzias_latipes_hni
ENSG00000168724	DNAJC21	97	60.038	ENSORLG00015011626	dnajc21	100	59.783	Oryzias_latipes_hsok
ENSG00000168724	DNAJC21	97	59.273	ENSOMEG00000007657	dnajc21	86	73.077	Oryzias_melastigma
ENSG00000168724	DNAJC21	100	89.904	ENSOGAG00000001468	DNAJC21	100	88.433	Otolemur_garnettii
ENSG00000168724	DNAJC21	100	89.513	ENSOARG00000011506	DNAJC21	100	89.139	Ovis_aries
ENSG00000168724	DNAJC21	100	99.717	ENSPPAG00000042627	DNAJC21	99	99.448	Pan_paniscus
ENSG00000168724	DNAJC21	100	87.260	ENSPPRG00000023534	DNAJC21	94	86.965	Panthera_pardus
ENSG00000168724	DNAJC21	100	87.260	ENSPTIG00000002442	DNAJC21	94	86.965	Panthera_tigris_altaica
ENSG00000168724	DNAJC21	100	99.717	ENSPTRG00000016785	DNAJC21	100	99.479	Pan_troglodytes
ENSG00000168724	DNAJC21	100	97.368	ENSPANG00000002427	DNAJC21	100	97.054	Papio_anubis
ENSG00000168724	DNAJC21	96	63.289	ENSPKIG00000005946	dnajc21	100	62.177	Paramormyrops_kingsleyae
ENSG00000168724	DNAJC21	75	76.860	ENSPMGG00000022993	dnajc21	90	73.402	Periophthalmus_magnuspinnatus
ENSG00000168724	DNAJC21	100	85.132	ENSPEMG00000016806	Dnajc21	100	86.400	Peromyscus_maniculatus_bairdii
ENSG00000168724	DNAJC21	100	60.036	ENSPFOG00000008317	dnajc21	99	61.051	Poecilia_formosa
ENSG00000168724	DNAJC21	100	60.256	ENSPLAG00000006826	dnajc21	99	61.191	Poecilia_latipinna
ENSG00000168724	DNAJC21	100	60.036	ENSPMEG00000020264	dnajc21	99	60.688	Poecilia_mexicana
ENSG00000168724	DNAJC21	100	62.044	ENSPREG00000017568	dnajc21	99	62.113	Poecilia_reticulata
ENSG00000168724	DNAJC21	100	97.180	ENSPPYG00000015391	DNAJC21	85	97.180	Pongo_abelii
ENSG00000168724	DNAJC21	59	80.000	ENSPCAG00000009732	-	55	80.000	Procavia_capensis
ENSG00000168724	DNAJC21	100	89.850	ENSPCOG00000019875	DNAJC21	100	94.974	Propithecus_coquereli
ENSG00000168724	DNAJC21	100	85.352	ENSPVAG00000013255	DNAJC21	100	87.179	Pteropus_vampyrus
ENSG00000168724	DNAJC21	97	64.381	ENSPNYG00000007690	dnajc21	91	78.431	Pundamilia_nyererei
ENSG00000168724	DNAJC21	100	61.664	ENSPNAG00000023349	dnajc21	100	62.633	Pygocentrus_nattereri
ENSG00000168724	DNAJC21	100	85.366	ENSRNOG00000017876	Dnajc21	100	84.991	Rattus_norvegicus
ENSG00000168724	DNAJC21	100	89.425	ENSRBIG00000034952	DNAJC21	100	89.074	Rhinopithecus_bieti
ENSG00000168724	DNAJC21	100	95.677	ENSRROG00000037577	DNAJC21	100	95.677	Rhinopithecus_roxellana
ENSG00000168724	DNAJC21	100	95.673	ENSSBOG00000035312	-	100	95.992	Saimiri_boliviensis_boliviensis
ENSG00000168724	DNAJC21	52	87.432	ENSSBOG00000028616	-	93	87.432	Saimiri_boliviensis_boliviensis
ENSG00000168724	DNAJC21	100	79.775	ENSSHAG00000010525	DNAJC21	100	79.775	Sarcophilus_harrisii
ENSG00000168724	DNAJC21	76	74.859	ENSSFOG00015022418	dnajc21	84	74.857	Scleropages_formosus
ENSG00000168724	DNAJC21	95	63.550	ENSSMAG00000005935	dnajc21	100	63.406	Scophthalmus_maximus
ENSG00000168724	DNAJC21	67	75.815	ENSSDUG00000016254	dnajc21	92	72.405	Seriola_dumerili
ENSG00000168724	DNAJC21	67	76.087	ENSSLDG00000007020	dnajc21	92	72.658	Seriola_lalandi_dorsalis
ENSG00000168724	DNAJC21	56	76.923	ENSSARG00000009903	-	100	63.222	Sorex_araneus
ENSG00000168724	DNAJC21	88	77.222	ENSSPAG00000006348	dnajc21	100	58.333	Stegastes_partitus
ENSG00000168724	DNAJC21	98	70.321	ENSTGUG00000001971	DNAJC21	100	69.017	Taeniopygia_guttata
ENSG00000168724	DNAJC21	97	57.615	ENSTRUG00000011587	dnajc21	100	61.818	Takifugu_rubripes
ENSG00000168724	DNAJC21	99	60.000	ENSTNIG00000007518	dnajc21	84	76.685	Tetraodon_nigroviridis
ENSG00000168724	DNAJC21	78	89.744	ENSTBEG00000011821	DNAJC21	82	93.407	Tupaia_belangeri
ENSG00000168724	DNAJC21	100	85.615	ENSTTRG00000003250	DNAJC21	100	85.615	Tursiops_truncatus
ENSG00000168724	DNAJC21	100	87.828	ENSUAMG00000022482	DNAJC21	100	87.828	Ursus_americanus
ENSG00000168724	DNAJC21	100	85.783	ENSUMAG00000012891	DNAJC21	99	87.751	Ursus_maritimus
ENSG00000168724	DNAJC21	100	75.271	ENSVPAG00000010130	DNAJC21	100	78.676	Vicugna_pacos
ENSG00000168724	DNAJC21	100	89.183	ENSVVUG00000022084	-	97	90.619	Vulpes_vulpes
ENSG00000168724	DNAJC21	66	78.832	ENSVVUG00000002401	-	97	79.197	Vulpes_vulpes
ENSG00000168724	DNAJC21	100	62.177	ENSXETG00000000706	dnajc21	100	63.100	Xenopus_tropicalis
ENSG00000168724	DNAJC21	67	75.683	ENSXMAG00000004317	dnajc21	99	60.980	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	17500595.20195357.	IPI	Function
GO:0005730	nucleolus	-	IEA	Component
GO:0005840	ribosome	16952052.	NAS	Component
GO:0006457	protein folding	16952052.	NAS	Process
GO:0008270	zinc ion binding	-	IEA	Function