EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000168826 (Gene tree)
Gene ID: 166793
Gene Symbol: ZBTB49
Alias: FLJ38559|ZNF509
Full Name: zinc finger and BTB domain containing 49
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 31,590 bases
Position: chr4:4,290,197-4,321,786
Accession: 19883
RBP type: canonical RBP
Summary: ZBTB49 (Zinc Finger And BTB Domain Containing 49) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription factor binding. An important paralog of this gene is BCL6.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000338807	zf-C2H2	PF00096.26	7.5e-36	1	7
ENSP00000338807	zf-C2H2	PF00096.26	7.5e-36	2	7
ENSP00000338807	zf-C2H2	PF00096.26	7.5e-36	3	7
ENSP00000338807	zf-C2H2	PF00096.26	7.5e-36	4	7
ENSP00000338807	zf-C2H2	PF00096.26	7.5e-36	5	7
ENSP00000338807	zf-C2H2	PF00096.26	7.5e-36	6	7
ENSP00000338807	zf-C2H2	PF00096.26	7.5e-36	7	7
ENSP00000421654	zf-C2H2	PF00096.26	2.1e-09	1	1
ENSP00000338807	zf-met	PF12874.7	5.5e-12	1	2
ENSP00000338807	zf-met	PF12874.7	5.5e-12	2	2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000337872	ZBTB49-201	2889	XM_005247951	ENSP00000338807	765 (aa)	XP_005248008	Q6ZSB9
ENST00000515012	ZBTB49-206	2380	-	ENSP00000422321	453 (aa)	-	D6RC96
ENST00000511458	ZBTB49-205	492	-	ENSP00000426765	122 (aa)	-	H0YAD4
ENST00000504302	ZBTB49-204	523	-	ENSP00000421654	174 (aa)	-	H0Y8P2
ENST00000502918	ZBTB49-202	502	-	ENSP00000425747	146 (aa)	-	D6RJ00
ENST00000503703	ZBTB49-203	2520	-	ENSP00000424525	144 (aa)	-	D6RB16

Gene Model

Click here to download ENSG00000168826's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000168826	Platelet Function Tests	3.0775000E-005	-
ENSG00000168826	Platelet Function Tests	1.8954400E-005	-
ENSG00000168826	Child Development Disorders, Pervasive	3.7567400E-005	-
ENSG00000168826	Child Development Disorders, Pervasive	2.4838900E-005	-
ENSG00000168826	Child Development Disorders, Pervasive	2.8252000E-005	-
ENSG00000168826	Child Development Disorders, Pervasive	4.9248100E-005	-
ENSG00000168826	Child Development Disorders, Pervasive	4.2888700E-005	-
ENSG00000168826	Child Development Disorders, Pervasive	1.9900000E-005	-
ENSG00000168826	Child Development Disorders, Pervasive	3.3016500E-005	-
ENSG00000168826	Child Development Disorders, Pervasive	1.6690200E-005	-
ENSG00000168826	Child Development Disorders, Pervasive	5.8858300E-005	-
ENSG00000168826	Child Development Disorders, Pervasive	2.9260000E-005	-
ENSG00000168826	Child Development Disorders, Pervasive	4.3372000E-005	-
ENSG00000168826	Child Development Disorders, Pervasive	3.9763000E-006	-
ENSG00000168826	Child Development Disorders, Pervasive	2.8139000E-005	-
ENSG00000168826	Psychotic Disorders	5E-6	26821981
ENSG00000168826	Schizophrenia	5E-6	26821981
ENSG00000168826	Antipsychotic Agents	5E-6	26821981

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000168826	rs6446601	4	4298683	?	Coronary artery calcified atherosclerotic plaque score in type 2 diabetes	29221444	[0.16-0.7] unit increase	0.428	EFO_0004723\|EFO_0001360

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000168826's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000168826	ZBTB49	81	77.119	ENSAPOG00000018248	zbtb49	100	46.503	Acanthochromis_polyacanthus
ENSG00000168826	ZBTB49	100	89.041	ENSAMEG00000013670	ZBTB49	100	80.261	Ailuropoda_melanoleuca
ENSG00000168826	ZBTB49	81	77.966	ENSACIG00000003247	zbtb49	100	46.992	Amphilophus_citrinellus
ENSG00000168826	ZBTB49	81	77.966	ENSAOCG00000006995	zbtb49	100	46.455	Amphiprion_ocellaris
ENSG00000168826	ZBTB49	81	77.966	ENSAPEG00000001834	zbtb49	100	46.210	Amphiprion_percula
ENSG00000168826	ZBTB49	98	44.800	ENSATEG00000023519	zbtb49	100	42.308	Anabas_testudineus
ENSG00000168826	ZBTB49	100	82.313	ENSAPLG00000003489	ZBTB49	100	73.272	Anas_platyrhynchos
ENSG00000168826	ZBTB49	100	75.510	ENSACAG00000010957	ZBTB49	100	58.625	Anolis_carolinensis
ENSG00000168826	ZBTB49	100	95.890	ENSANAG00000024606	ZBTB49	100	93.734	Aotus_nancymaae
ENSG00000168826	ZBTB49	73	82.075	ENSACLG00000013174	zbtb49	100	46.350	Astatotilapia_calliptera
ENSG00000168826	ZBTB49	81	71.186	ENSAMXG00000008432	zbtb49	100	55.000	Astyanax_mexicanus
ENSG00000168826	ZBTB49	100	92.466	ENSBTAG00000014680	ZBTB49	100	80.260	Bos_taurus
ENSG00000168826	ZBTB49	100	95.890	ENSCJAG00000000119	ZBTB49	100	92.820	Callithrix_jacchus
ENSG00000168826	ZBTB49	100	89.041	ENSCAFG00000015688	ZBTB49	100	81.462	Canis_familiaris
ENSG00000168826	ZBTB49	100	89.041	ENSCAFG00020010909	ZBTB49	95	81.593	Canis_lupus_dingo
ENSG00000168826	ZBTB49	100	92.466	ENSCHIG00000015069	ZBTB49	98	79.870	Capra_hircus
ENSG00000168826	ZBTB49	100	95.205	ENSTSYG00000010894	ZBTB49	100	86.945	Carlito_syrichta
ENSG00000168826	ZBTB49	100	87.671	ENSCAPG00000004847	ZBTB49	100	74.122	Cavia_aperea
ENSG00000168826	ZBTB49	100	87.671	ENSCPOG00000007981	ZBTB49	100	74.252	Cavia_porcellus
ENSG00000168826	ZBTB49	99	100.000	ENSCATG00000011176	ZBTB49	100	96.736	Cercocebus_atys
ENSG00000168826	ZBTB49	100	91.096	ENSCLAG00000014857	ZBTB49	100	80.364	Chinchilla_lanigera
ENSG00000168826	ZBTB49	100	98.630	ENSCSAG00000016270	ZBTB49	100	96.867	Chlorocebus_sabaeus
ENSG00000168826	ZBTB49	98	82.500	ENSCHOG00000012751	ZBTB49	96	85.510	Choloepus_hoffmanni
ENSG00000168826	ZBTB49	100	82.313	ENSCPBG00000005715	ZBTB49	100	77.253	Chrysemys_picta_bellii
ENSG00000168826	ZBTB49	100	98.630	ENSCANG00000036923	ZBTB49	100	96.997	Colobus_angolensis_palliatus
ENSG00000168826	ZBTB49	100	87.671	ENSCGRG00001001097	Zbtb49	100	74.967	Cricetulus_griseus_chok1gshd
ENSG00000168826	ZBTB49	100	87.671	ENSCGRG00000012996	Zbtb49	100	74.837	Cricetulus_griseus_crigri
ENSG00000168826	ZBTB49	81	73.729	ENSDARG00000102111	zbtb49	92	44.944	Danio_rerio
ENSG00000168826	ZBTB49	100	91.837	ENSDNOG00000016261	ZBTB49	100	81.995	Dasypus_novemcinctus
ENSG00000168826	ZBTB49	100	90.411	ENSEASG00005005309	ZBTB49	100	84.183	Equus_asinus_asinus
ENSG00000168826	ZBTB49	100	89.726	ENSECAG00000013694	ZBTB49	95	83.922	Equus_caballus
ENSG00000168826	ZBTB49	97	52.101	ENSEEUG00000010840	-	77	70.968	Erinaceus_europaeus
ENSG00000168826	ZBTB49	94	68.116	ENSELUG00000011132	zbtb49	100	45.476	Esox_lucius
ENSG00000168826	ZBTB49	100	89.726	ENSFCAG00000015510	ZBTB49	100	72.526	Felis_catus
ENSG00000168826	ZBTB49	100	82.993	ENSFALG00000009426	ZBTB49	100	68.359	Ficedula_albicollis
ENSG00000168826	ZBTB49	81	72.881	ENSFHEG00000004314	zbtb49	99	45.610	Fundulus_heteroclitus
ENSG00000168826	ZBTB49	81	78.814	ENSGMOG00000009091	zbtb49	99	46.526	Gadus_morhua
ENSG00000168826	ZBTB49	100	81.633	ENSGALG00000015009	ZBTB49	100	75.751	Gallus_gallus
ENSG00000168826	ZBTB49	81	75.424	ENSGAFG00000020512	zbtb49	99	45.665	Gambusia_affinis
ENSG00000168826	ZBTB49	81	77.966	ENSGACG00000009172	zbtb49	100	47.519	Gasterosteus_aculeatus
ENSG00000168826	ZBTB49	100	82.313	ENSGAGG00000014086	ZBTB49	100	74.707	Gopherus_agassizii
ENSG00000168826	ZBTB49	100	100.000	ENSGGOG00000013012	ZBTB49	100	99.216	Gorilla_gorilla
ENSG00000168826	ZBTB49	73	82.075	ENSHBUG00000020719	zbtb49	100	46.691	Haplochromis_burtoni
ENSG00000168826	ZBTB49	84	74.797	ENSHCOG00000013830	zbtb49	92	77.119	Hippocampus_comes
ENSG00000168826	ZBTB49	86	67.460	ENSIPUG00000000380	zbtb49	63	73.516	Ictalurus_punctatus
ENSG00000168826	ZBTB49	100	92.466	ENSSTOG00000000550	ZBTB49	100	83.529	Ictidomys_tridecemlineatus
ENSG00000168826	ZBTB49	73	81.132	ENSKMAG00000009855	zbtb49	100	46.098	Kryptolebias_marmoratus
ENSG00000168826	ZBTB49	81	77.966	ENSLBEG00000027629	zbtb49	100	45.618	Labrus_bergylta
ENSG00000168826	ZBTB49	100	75.000	ENSLACG00000007886	ZBTB49	99	57.468	Latimeria_chalumnae
ENSG00000168826	ZBTB49	92	70.588	ENSLOCG00000009974	zbtb49	100	58.936	Lepisosteus_oculatus
ENSG00000168826	ZBTB49	100	88.435	ENSLAFG00000016590	ZBTB49	100	81.462	Loxodonta_africana
ENSG00000168826	ZBTB49	99	100.000	ENSMFAG00000043670	ZBTB49	100	97.258	Macaca_fascicularis
ENSG00000168826	ZBTB49	100	98.630	ENSMMUG00000023394	ZBTB49	100	97.258	Macaca_mulatta
ENSG00000168826	ZBTB49	99	100.000	ENSMNEG00000038781	ZBTB49	100	97.258	Macaca_nemestrina
ENSG00000168826	ZBTB49	100	98.630	ENSMLEG00000042466	ZBTB49	100	97.128	Mandrillus_leucophaeus
ENSG00000168826	ZBTB49	81	78.814	ENSMAMG00000019729	zbtb49	100	47.596	Mastacembelus_armatus
ENSG00000168826	ZBTB49	73	82.075	ENSMZEG00005026824	zbtb49	100	47.421	Maylandia_zebra
ENSG00000168826	ZBTB49	100	82.313	ENSMGAG00000012706	ZBTB49	100	73.142	Meleagris_gallopavo
ENSG00000168826	ZBTB49	100	88.356	ENSMAUG00000018552	Zbtb49	100	70.143	Mesocricetus_auratus
ENSG00000168826	ZBTB49	100	95.890	ENSMICG00000042304	ZBTB49	100	87.582	Microcebus_murinus
ENSG00000168826	ZBTB49	100	86.301	ENSMOCG00000020948	Zbtb49	100	74.771	Microtus_ochrogaster
ENSG00000168826	ZBTB49	92	67.143	ENSMMOG00000012651	zbtb49	99	67.143	Mola_mola
ENSG00000168826	ZBTB49	99	83.333	ENSMODG00000001516	ZBTB49	100	75.911	Monodelphis_domestica
ENSG00000168826	ZBTB49	100	66.438	ENSMALG00000002941	zbtb49	99	49.782	Monopterus_albus
ENSG00000168826	ZBTB49	100	86.301	MGP_CAROLIEiJ_G0027176	Zbtb49	100	74.021	Mus_caroli
ENSG00000168826	ZBTB49	100	86.301	ENSMUSG00000029127	Zbtb49	100	74.282	Mus_musculus
ENSG00000168826	ZBTB49	95	88.406	MGP_PahariEiJ_G0016960	Zbtb49	100	72.454	Mus_pahari
ENSG00000168826	ZBTB49	100	86.301	MGP_SPRETEiJ_G0028173	Zbtb49	100	73.890	Mus_spretus
ENSG00000168826	ZBTB49	100	86.301	ENSMLUG00000009904	ZBTB49	100	76.863	Myotis_lucifugus
ENSG00000168826	ZBTB49	100	90.411	ENSNGAG00000018432	Zbtb49	100	78.329	Nannospalax_galili
ENSG00000168826	ZBTB49	73	75.000	ENSNBRG00000019459	zbtb49	100	45.642	Neolamprologus_brichardi
ENSG00000168826	ZBTB49	100	99.315	ENSNLEG00000016142	ZBTB49	100	97.911	Nomascus_leucogenys
ENSG00000168826	ZBTB49	100	84.932	ENSOPRG00000009045	ZBTB49	100	70.443	Ochotona_princeps
ENSG00000168826	ZBTB49	100	89.041	ENSODEG00000010729	ZBTB49	100	77.285	Octodon_degus
ENSG00000168826	ZBTB49	73	82.075	ENSONIG00000020365	zbtb49	100	46.276	Oreochromis_niloticus
ENSG00000168826	ZBTB49	100	89.041	ENSOCUG00000007993	ZBTB49	100	75.880	Oryctolagus_cuniculus
ENSG00000168826	ZBTB49	81	77.119	ENSOMEG00000002926	zbtb49	100	45.290	Oryzias_melastigma
ENSG00000168826	ZBTB49	100	93.151	ENSOGAG00000000988	ZBTB49	100	85.359	Otolemur_garnettii
ENSG00000168826	ZBTB49	100	92.466	ENSOARG00000007577	ZBTB49	100	62.437	Ovis_aries
ENSG00000168826	ZBTB49	100	100.000	ENSPPAG00000028054	ZBTB49	100	99.608	Pan_paniscus
ENSG00000168826	ZBTB49	100	89.041	ENSPPRG00000009152	ZBTB49	100	72.026	Panthera_pardus
ENSG00000168826	ZBTB49	100	89.726	ENSPTIG00000005893	-	80	87.273	Panthera_tigris_altaica
ENSG00000168826	ZBTB49	100	100.000	ENSPTRG00000015868	ZBTB49	100	99.739	Pan_troglodytes
ENSG00000168826	ZBTB49	99	100.000	ENSPANG00000015665	ZBTB49	100	96.997	Papio_anubis
ENSG00000168826	ZBTB49	100	67.808	ENSPKIG00000004091	zbtb49	100	50.125	Paramormyrops_kingsleyae
ENSG00000168826	ZBTB49	100	82.993	ENSPSIG00000015554	ZBTB49	100	74.707	Pelodiscus_sinensis
ENSG00000168826	ZBTB49	100	86.986	ENSPEMG00000014043	Zbtb49	100	74.771	Peromyscus_maniculatus_bairdii
ENSG00000168826	ZBTB49	99	82.639	ENSPCIG00000028213	ZBTB49	100	75.911	Phascolarctos_cinereus
ENSG00000168826	ZBTB49	81	77.119	ENSPFOG00000010840	zbtb49	99	45.878	Poecilia_formosa
ENSG00000168826	ZBTB49	81	77.119	ENSPLAG00000002647	zbtb49	99	45.933	Poecilia_latipinna
ENSG00000168826	ZBTB49	81	77.119	ENSPMEG00000023317	zbtb49	99	45.813	Poecilia_mexicana
ENSG00000168826	ZBTB49	81	76.271	ENSPREG00000019585	zbtb49	99	45.639	Poecilia_reticulata
ENSG00000168826	ZBTB49	100	100.000	ENSPPYG00000014601	ZBTB49	100	97.911	Pongo_abelii
ENSG00000168826	ZBTB49	100	94.521	ENSPCOG00000017347	ZBTB49	99	86.894	Propithecus_coquereli
ENSG00000168826	ZBTB49	100	86.986	ENSPVAG00000015185	ZBTB49	100	78.824	Pteropus_vampyrus
ENSG00000168826	ZBTB49	81	76.271	ENSPNYG00000002658	zbtb49	93	59.386	Pundamilia_nyererei
ENSG00000168826	ZBTB49	100	64.626	ENSPNAG00000002376	zbtb49	94	57.846	Pygocentrus_nattereri
ENSG00000168826	ZBTB49	100	84.932	ENSRNOG00000005633	Zbtb49	100	72.324	Rattus_norvegicus
ENSG00000168826	ZBTB49	100	97.945	ENSRBIG00000039747	ZBTB49	100	97.128	Rhinopithecus_bieti
ENSG00000168826	ZBTB49	100	97.945	ENSRROG00000016491	ZBTB49	100	96.997	Rhinopithecus_roxellana
ENSG00000168826	ZBTB49	100	95.890	ENSSBOG00000023351	ZBTB49	100	93.342	Saimiri_boliviensis_boliviensis
ENSG00000168826	ZBTB49	97	81.818	ENSSHAG00000008414	ZBTB49	100	68.742	Sarcophilus_harrisii
ENSG00000168826	ZBTB49	81	76.271	ENSSMAG00000010370	zbtb49	100	46.867	Scophthalmus_maximus
ENSG00000168826	ZBTB49	81	77.966	ENSSDUG00000022170	zbtb49	87	77.966	Seriola_dumerili
ENSG00000168826	ZBTB49	100	78.082	ENSSARG00000007633	ZBTB49	100	72.089	Sorex_araneus
ENSG00000168826	ZBTB49	98	54.032	ENSSPUG00000007609	ZBTB49	100	74.464	Sphenodon_punctatus
ENSG00000168826	ZBTB49	81	77.966	ENSSPAG00000001212	zbtb49	82	77.966	Stegastes_partitus
ENSG00000168826	ZBTB49	100	86.301	ENSSSCG00000008728	ZBTB49	100	77.184	Sus_scrofa
ENSG00000168826	ZBTB49	100	82.313	ENSTGUG00000009920	ZBTB49	100	71.521	Taeniopygia_guttata
ENSG00000168826	ZBTB49	96	44.981	ENSTRUG00000020880	zbtb49	100	44.888	Takifugu_rubripes
ENSG00000168826	ZBTB49	100	67.808	ENSTNIG00000000411	zbtb49	100	48.106	Tetraodon_nigroviridis
ENSG00000168826	ZBTB49	98	86.667	ENSTBEG00000005000	ZBTB49	100	87.955	Tupaia_belangeri
ENSG00000168826	ZBTB49	100	93.151	ENSTTRG00000012820	ZBTB49	100	82.115	Tursiops_truncatus
ENSG00000168826	ZBTB49	100	89.041	ENSVVUG00000014967	ZBTB49	100	81.201	Vulpes_vulpes
ENSG00000168826	ZBTB49	95	79.286	ENSXETG00000016041	zbtb49	92	58.650	Xenopus_tropicalis
ENSG00000168826	ZBTB49	81	75.424	ENSXMAG00000021595	zbtb49	97	45.949	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0001223	transcription coactivator binding	25245946.	IPI	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005634	nucleus	25245946.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	25245946.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0007050	cell cycle arrest	25245946.	IDA	Process
GO:0008134	transcription factor binding	25245946.	IPI	Function
GO:0008285	negative regulation of cell proliferation	25245946.	IDA	Process
GO:0015630	microtubule cytoskeleton	-	IDA	Component
GO:0043565	sequence-specific DNA binding	25245946.	IDA	Function
GO:0045944	positive regulation of transcription by RNA polymerase II	25245946.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function