EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000168827 (Gene tree)
Gene ID: 85476
Gene Symbol: GFM1
Alias: EFGM|GFM|EGF1|mtEF-G1
Full Name: G elongation factor mitochondrial 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 48,298 bases
Position: chr3:158,644,278-158,692,575
Accession: 13780
RBP type: canonical RBP
Summary: Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000418755	GTP_EFTU	PF00009.27	2.7e-63	1	1
ENSP00000419038	GTP_EFTU	PF00009.27	4.6e-63	1	1
ENSP00000264263	GTP_EFTU	PF00009.27	7.1e-63	1	1
ENSP00000417532	GTP_EFTU	PF00009.27	3e-18	1	1
ENSP00000418755	GTP_EFTU_D2	PF03144.25	5.6e-16	1	1
ENSP00000419038	GTP_EFTU_D2	PF03144.25	6e-16	1	1
ENSP00000264263	GTP_EFTU_D2	PF03144.25	6.4e-16	1	1
ENSP00000419038	EFG_IV	PF03764.18	2.7e-34	1	1
ENSP00000264263	EFG_IV	PF03764.18	2.9e-34	1	1
ENSP00000418755	EFG_IV	PF03764.18	1.8e-14	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000490261	GFM1-211	591	-	-	- (aa)	-	-
ENST00000478576	GFM1-208	2147	-	ENSP00000418755	591 (aa)	-	C9IZ01
ENST00000477721	GFM1-205	739	-	-	- (aa)	-	-
ENST00000312756	GFM1-202	2006	-	-	- (aa)	-	-
ENST00000478251	GFM1-206	2040	-	-	- (aa)	-	-
ENST00000472383	GFM1-204	656	-	ENSP00000420272	17 (aa)	-	H7C5M4
ENST00000264263	GFM1-201	3453	-	ENSP00000264263	770 (aa)	-	Q96RP9
ENST00000478254	GFM1-207	3470	-	ENSP00000417225	453 (aa)	-	F8WAU4
ENST00000481468	GFM1-209	842	-	-	- (aa)	-	-
ENST00000486715	GFM1-210	3721	XM_006713795	ENSP00000419038	751 (aa)	XP_006713858	Q96RP9
ENST00000464732	GFM1-203	502	-	ENSP00000417532	60 (aa)	-	C9JA25

Gene Model

Click here to download ENSG00000168827's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000168827	Platelet Function Tests	9.5806851E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000168827's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000168827	GFM1	74	38.926	ENSG00000167658	EEF2	75	38.926
ENSG00000168827	GFM1	80	44.231	ENSG00000151806	GUF1	56	33.173
ENSG00000168827	GFM1	73	68.182	ENSG00000164347	GFM2	98	51.515
ENSG00000168827	GFM1	61	30.986	ENSG00000108883	EFTUD2	54	30.986

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000168827	GFM1	100	91.667	ENSAPOG00000016489	gfm1	97	78.394	Acanthochromis_polyacanthus
ENSG00000168827	GFM1	100	100.000	ENSAMEG00000013542	GFM1	98	92.391	Ailuropoda_melanoleuca
ENSG00000168827	GFM1	98	74.797	ENSACIG00000014465	gfm1	94	75.758	Amphilophus_citrinellus
ENSG00000168827	GFM1	100	91.667	ENSAOCG00000006023	gfm1	97	79.178	Amphiprion_ocellaris
ENSG00000168827	GFM1	100	91.667	ENSAPEG00000024499	gfm1	99	79.777	Amphiprion_percula
ENSG00000168827	GFM1	100	93.333	ENSATEG00000013789	gfm1	98	79.184	Anabas_testudineus
ENSG00000168827	GFM1	100	96.667	ENSAPLG00000005022	GFM1	100	83.058	Anas_platyrhynchos
ENSG00000168827	GFM1	100	98.333	ENSACAG00000006829	GFM1	99	81.326	Anolis_carolinensis
ENSG00000168827	GFM1	100	98.333	ENSANAG00000035983	GFM1	98	94.694	Aotus_nancymaae
ENSG00000168827	GFM1	100	93.333	ENSACLG00000016586	gfm1	99	80.082	Astatotilapia_calliptera
ENSG00000168827	GFM1	100	93.333	ENSAMXG00000013435	gfm1	96	80.833	Astyanax_mexicanus
ENSG00000168827	GFM1	100	100.000	ENSBTAG00000027795	GFM1	98	92.663	Bos_taurus
ENSG00000168827	GFM1	100	81.667	WBGene00009246	gfm-1	99	55.526	Caenorhabditis_elegans
ENSG00000168827	GFM1	100	96.667	ENSCJAG00000000363	GFM1	98	94.837	Callithrix_jacchus
ENSG00000168827	GFM1	100	100.000	ENSCAFG00000009006	GFM1	100	93.195	Canis_familiaris
ENSG00000168827	GFM1	100	100.000	ENSCAFG00020005878	GFM1	99	93.223	Canis_lupus_dingo
ENSG00000168827	GFM1	100	100.000	ENSCHIG00000015220	GFM1	98	92.935	Capra_hircus
ENSG00000168827	GFM1	100	100.000	ENSTSYG00000002013	GFM1	98	94.429	Carlito_syrichta
ENSG00000168827	GFM1	97	80.769	ENSCAPG00000005699	GFM1	98	80.743	Cavia_aperea
ENSG00000168827	GFM1	100	100.000	ENSCPOG00000001194	GFM1	98	92.391	Cavia_porcellus
ENSG00000168827	GFM1	100	98.333	ENSCCAG00000025561	GFM1	98	94.687	Cebus_capucinus
ENSG00000168827	GFM1	100	100.000	ENSCATG00000037622	GFM1	100	96.937	Cercocebus_atys
ENSG00000168827	GFM1	100	98.333	ENSCLAG00000002503	GFM1	98	91.316	Chinchilla_lanigera
ENSG00000168827	GFM1	100	100.000	ENSCSAG00000012162	GFM1	100	96.671	Chlorocebus_sabaeus
ENSG00000168827	GFM1	100	98.333	ENSCHOG00000004867	GFM1	98	83.696	Choloepus_hoffmanni
ENSG00000168827	GFM1	100	98.333	ENSCPBG00000018367	GFM1	98	82.337	Chrysemys_picta_bellii
ENSG00000168827	GFM1	100	81.667	ENSCING00000011960	-	94	59.254	Ciona_intestinalis
ENSG00000168827	GFM1	100	80.000	ENSCSAVG00000008514	-	99	59.778	Ciona_savignyi
ENSG00000168827	GFM1	100	100.000	ENSCANG00000031714	GFM1	100	96.937	Colobus_angolensis_palliatus
ENSG00000168827	GFM1	100	98.333	ENSCGRG00001022095	GFM1	98	92.799	Cricetulus_griseus_chok1gshd
ENSG00000168827	GFM1	100	98.333	ENSCGRG00000012043	GFM1	98	92.799	Cricetulus_griseus_crigri
ENSG00000168827	GFM1	100	91.667	ENSCSEG00000017088	gfm1	98	76.217	Cynoglossus_semilaevis
ENSG00000168827	GFM1	100	93.333	ENSCVAG00000004126	gfm1	99	81.268	Cyprinodon_variegatus
ENSG00000168827	GFM1	100	91.667	ENSDARG00000063624	gfm1	97	79.722	Danio_rerio
ENSG00000168827	GFM1	54	89.976	ENSDNOG00000016385	-	100	89.976	Dasypus_novemcinctus
ENSG00000168827	GFM1	100	96.667	ENSDORG00000014165	Gfm1	98	89.674	Dipodomys_ordii
ENSG00000168827	GFM1	100	90.000	FBgn0263133	mEFG1	95	67.465	Drosophila_melanogaster
ENSG00000168827	GFM1	100	96.667	ENSETEG00000019197	GFM1	90	90.610	Echinops_telfairi
ENSG00000168827	GFM1	100	83.333	ENSEBUG00000012794	gfm1	99	66.222	Eptatretus_burgeri
ENSG00000168827	GFM1	96	68.276	ENSEEUG00000000429	GFM1	99	68.276	Erinaceus_europaeus
ENSG00000168827	GFM1	100	93.333	ENSELUG00000014728	gfm1	98	77.174	Esox_lucius
ENSG00000168827	GFM1	100	100.000	ENSFCAG00000013291	GFM1	98	93.207	Felis_catus
ENSG00000168827	GFM1	100	96.667	ENSFALG00000007619	GFM1	100	83.136	Ficedula_albicollis
ENSG00000168827	GFM1	100	100.000	ENSFDAG00000016559	GFM1	98	92.120	Fukomys_damarensis
ENSG00000168827	GFM1	100	91.667	ENSFHEG00000006091	gfm1	98	80.136	Fundulus_heteroclitus
ENSG00000168827	GFM1	100	95.000	ENSGMOG00000010161	gfm1	99	78.838	Gadus_morhua
ENSG00000168827	GFM1	100	95.000	ENSGALG00000009634	GFM1	99	82.128	Gallus_gallus
ENSG00000168827	GFM1	100	93.333	ENSGAFG00000012527	gfm1	98	81.224	Gambusia_affinis
ENSG00000168827	GFM1	100	93.333	ENSGACG00000009864	gfm1	97	79.172	Gasterosteus_aculeatus
ENSG00000168827	GFM1	100	98.333	ENSGAGG00000002769	-	91	89.950	Gopherus_agassizii
ENSG00000168827	GFM1	100	100.000	ENSGGOG00000003085	GFM1	100	99.734	Gorilla_gorilla
ENSG00000168827	GFM1	100	93.333	ENSHBUG00000002120	gfm1	97	81.267	Haplochromis_burtoni
ENSG00000168827	GFM1	100	98.333	ENSHGLG00000016855	GFM1	98	93.071	Heterocephalus_glaber_female
ENSG00000168827	GFM1	100	98.333	ENSHGLG00100013049	GFM1	98	93.071	Heterocephalus_glaber_male
ENSG00000168827	GFM1	100	95.000	ENSHCOG00000007638	gfm1	98	80.274	Hippocampus_comes
ENSG00000168827	GFM1	100	95.000	ENSIPUG00000005873	gfm1	97	80.165	Ictalurus_punctatus
ENSG00000168827	GFM1	100	100.000	ENSSTOG00000010150	GFM1	99	91.033	Ictidomys_tridecemlineatus
ENSG00000168827	GFM1	100	100.000	ENSJJAG00000016447	Gfm1	98	91.168	Jaculus_jaculus
ENSG00000168827	GFM1	100	91.667	ENSKMAG00000020768	gfm1	98	78.367	Kryptolebias_marmoratus
ENSG00000168827	GFM1	100	93.333	ENSLBEG00000021315	gfm1	100	79.915	Labrus_bergylta
ENSG00000168827	GFM1	100	93.333	ENSLACG00000012295	GFM1	99	80.548	Latimeria_chalumnae
ENSG00000168827	GFM1	97	75.034	ENSLOCG00000003778	gfm1	99	75.034	Lepisosteus_oculatus
ENSG00000168827	GFM1	100	98.333	ENSLAFG00000010945	GFM1	100	89.655	Loxodonta_africana
ENSG00000168827	GFM1	100	100.000	ENSMFAG00000035731	GFM1	100	96.937	Macaca_fascicularis
ENSG00000168827	GFM1	100	100.000	ENSMMUG00000004961	GFM1	98	100.000	Macaca_mulatta
ENSG00000168827	GFM1	100	100.000	ENSMNEG00000033245	GFM1	98	100.000	Macaca_nemestrina
ENSG00000168827	GFM1	100	100.000	ENSMLEG00000030908	GFM1	100	97.039	Mandrillus_leucophaeus
ENSG00000168827	GFM1	100	93.333	ENSMAMG00000011760	gfm1	98	80.136	Mastacembelus_armatus
ENSG00000168827	GFM1	100	93.333	ENSMZEG00005016639	gfm1	97	81.267	Maylandia_zebra
ENSG00000168827	GFM1	100	95.000	ENSMGAG00000010641	GFM1	97	82.069	Meleagris_gallopavo
ENSG00000168827	GFM1	100	98.333	ENSMAUG00000000611	Gfm1	98	93.207	Mesocricetus_auratus
ENSG00000168827	GFM1	100	100.000	ENSMICG00000049086	GFM1	98	94.022	Microcebus_murinus
ENSG00000168827	GFM1	100	98.333	ENSMOCG00000000465	Gfm1	98	92.255	Microtus_ochrogaster
ENSG00000168827	GFM1	100	95.000	ENSMMOG00000012538	gfm1	98	79.589	Mola_mola
ENSG00000168827	GFM1	100	100.000	ENSMODG00000015673	GFM1	98	86.639	Monodelphis_domestica
ENSG00000168827	GFM1	100	91.667	ENSMALG00000012508	gfm1	95	80.223	Monopterus_albus
ENSG00000168827	GFM1	100	98.333	MGP_CAROLIEiJ_G0025052	Gfm1	98	91.033	Mus_caroli
ENSG00000168827	GFM1	100	98.333	ENSMUSG00000027774	Gfm1	98	91.304	Mus_musculus
ENSG00000168827	GFM1	100	98.333	MGP_PahariEiJ_G0026495	Gfm1	98	91.304	Mus_pahari
ENSG00000168827	GFM1	100	98.333	MGP_SPRETEiJ_G0025994	Gfm1	98	91.304	Mus_spretus
ENSG00000168827	GFM1	100	100.000	ENSMPUG00000002859	GFM1	98	92.391	Mustela_putorius_furo
ENSG00000168827	GFM1	100	100.000	ENSMLUG00000000452	GFM1	98	93.478	Myotis_lucifugus
ENSG00000168827	GFM1	100	98.333	ENSNGAG00000012375	Gfm1	98	92.098	Nannospalax_galili
ENSG00000168827	GFM1	100	93.333	ENSNBRG00000004631	gfm1	99	81.379	Neolamprologus_brichardi
ENSG00000168827	GFM1	100	100.000	ENSNLEG00000004176	GFM1	100	98.802	Nomascus_leucogenys
ENSG00000168827	GFM1	100	98.333	ENSMEUG00000007784	GFM1	100	78.394	Notamacropus_eugenii
ENSG00000168827	GFM1	100	96.667	ENSOPRG00000009860	GFM1	99	91.168	Ochotona_princeps
ENSG00000168827	GFM1	100	100.000	ENSODEG00000004316	GFM1	98	93.071	Octodon_degus
ENSG00000168827	GFM1	100	93.333	ENSONIG00000003772	gfm1	97	81.267	Oreochromis_niloticus
ENSG00000168827	GFM1	100	98.333	ENSOANG00000013873	-	88	92.547	Ornithorhynchus_anatinus
ENSG00000168827	GFM1	51	79.476	ENSOANG00000021192	-	93	81.467	Ornithorhynchus_anatinus
ENSG00000168827	GFM1	100	100.000	ENSOCUG00000013561	GFM1	98	93.478	Oryctolagus_cuniculus
ENSG00000168827	GFM1	100	93.333	ENSORLG00000006487	gfm1	100	81.523	Oryzias_latipes
ENSG00000168827	GFM1	100	93.333	ENSORLG00020003362	gfm1	97	80.854	Oryzias_latipes_hni
ENSG00000168827	GFM1	100	93.333	ENSORLG00015005829	gfm1	97	80.441	Oryzias_latipes_hsok
ENSG00000168827	GFM1	100	93.333	ENSOMEG00000012894	gfm1	97	81.267	Oryzias_melastigma
ENSG00000168827	GFM1	100	98.333	ENSOGAG00000008298	GFM1	98	92.391	Otolemur_garnettii
ENSG00000168827	GFM1	100	100.000	ENSOARG00000002409	GFM1	100	92.445	Ovis_aries
ENSG00000168827	GFM1	100	100.000	ENSPPAG00000033881	GFM1	100	99.740	Pan_paniscus
ENSG00000168827	GFM1	100	100.000	ENSPPRG00000009281	GFM1	98	93.071	Panthera_pardus
ENSG00000168827	GFM1	100	100.000	ENSPTIG00000012416	GFM1	98	92.935	Panthera_tigris_altaica
ENSG00000168827	GFM1	100	100.000	ENSPTRG00000015570	GFM1	100	99.740	Pan_troglodytes
ENSG00000168827	GFM1	100	100.000	ENSPANG00000016512	GFM1	98	100.000	Papio_anubis
ENSG00000168827	GFM1	100	93.333	ENSPKIG00000004876	gfm1	97	81.129	Paramormyrops_kingsleyae
ENSG00000168827	GFM1	100	98.333	ENSPSIG00000012567	GFM1	99	82.661	Pelodiscus_sinensis
ENSG00000168827	GFM1	100	91.667	ENSPMGG00000014068	gfm1	99	79.612	Periophthalmus_magnuspinnatus
ENSG00000168827	GFM1	100	98.333	ENSPEMG00000008942	Gfm1	98	92.255	Peromyscus_maniculatus_bairdii
ENSG00000168827	GFM1	100	100.000	ENSPCIG00000020195	GFM1	96	86.504	Phascolarctos_cinereus
ENSG00000168827	GFM1	100	93.333	ENSPFOG00000011022	gfm1	98	81.361	Poecilia_formosa
ENSG00000168827	GFM1	100	93.333	ENSPLAG00000019585	gfm1	98	80.401	Poecilia_latipinna
ENSG00000168827	GFM1	100	91.667	ENSPMEG00000012376	gfm1	98	81.224	Poecilia_mexicana
ENSG00000168827	GFM1	100	91.667	ENSPREG00000001332	gfm1	93	80.952	Poecilia_reticulata
ENSG00000168827	GFM1	100	100.000	ENSPPYG00000014244	GFM1	100	98.402	Pongo_abelii
ENSG00000168827	GFM1	100	96.667	ENSPCAG00000008934	GFM1	100	87.340	Procavia_capensis
ENSG00000168827	GFM1	100	100.000	ENSPCOG00000022259	GFM1	98	94.429	Propithecus_coquereli
ENSG00000168827	GFM1	100	100.000	ENSPVAG00000013605	GFM1	98	93.207	Pteropus_vampyrus
ENSG00000168827	GFM1	100	93.333	ENSPNYG00000006037	gfm1	100	80.108	Pundamilia_nyererei
ENSG00000168827	GFM1	100	93.333	ENSPNAG00000001237	gfm1	97	80.556	Pygocentrus_nattereri
ENSG00000168827	GFM1	100	98.333	ENSRNOG00000012873	Gfm1	98	91.440	Rattus_norvegicus
ENSG00000168827	GFM1	100	100.000	ENSRBIG00000031363	GFM1	100	96.671	Rhinopithecus_bieti
ENSG00000168827	GFM1	100	100.000	ENSRROG00000031081	GFM1	100	96.804	Rhinopithecus_roxellana
ENSG00000168827	GFM1	100	68.750	YLR069C	-	90	57.184	Saccharomyces_cerevisiae
ENSG00000168827	GFM1	100	98.333	ENSSBOG00000023252	GFM1	98	95.109	Saimiri_boliviensis_boliviensis
ENSG00000168827	GFM1	100	100.000	ENSSHAG00000017772	GFM1	98	86.957	Sarcophilus_harrisii
ENSG00000168827	GFM1	100	91.667	ENSSFOG00015003117	gfm1	99	80.907	Scleropages_formosus
ENSG00000168827	GFM1	100	91.667	ENSSMAG00000013221	gfm1	98	77.415	Scophthalmus_maximus
ENSG00000168827	GFM1	100	91.667	ENSSDUG00000018665	gfm1	98	78.776	Seriola_dumerili
ENSG00000168827	GFM1	100	91.667	ENSSLDG00000020606	gfm1	98	78.776	Seriola_lalandi_dorsalis
ENSG00000168827	GFM1	100	95.000	ENSSPUG00000018686	GFM1	98	80.220	Sphenodon_punctatus
ENSG00000168827	GFM1	100	93.333	ENSSPAG00000008800	gfm1	98	79.048	Stegastes_partitus
ENSG00000168827	GFM1	100	98.333	ENSSSCG00000025651	GFM1	97	92.255	Sus_scrofa
ENSG00000168827	GFM1	100	93.333	ENSTRUG00000009244	gfm1	97	80.028	Takifugu_rubripes
ENSG00000168827	GFM1	100	91.667	ENSTNIG00000007729	gfm1	97	80.579	Tetraodon_nigroviridis
ENSG00000168827	GFM1	95	100.000	ENSTBEG00000017404	GFM1	82	96.053	Tupaia_belangeri
ENSG00000168827	GFM1	100	100.000	ENSTTRG00000001735	GFM1	97	92.391	Tursiops_truncatus
ENSG00000168827	GFM1	100	100.000	ENSUAMG00000026381	GFM1	98	92.663	Ursus_americanus
ENSG00000168827	GFM1	100	100.000	ENSUMAG00000011268	GFM1	98	92.527	Ursus_maritimus
ENSG00000168827	GFM1	100	100.000	ENSVPAG00000009444	GFM1	98	88.995	Vicugna_pacos
ENSG00000168827	GFM1	100	100.000	ENSVVUG00000020091	GFM1	100	92.751	Vulpes_vulpes
ENSG00000168827	GFM1	100	98.333	ENSXETG00000032551	GFM1	97	83.584	Xenopus_tropicalis
ENSG00000168827	GFM1	100	93.333	ENSXCOG00000012590	gfm1	95	77.053	Xiphophorus_couchianus
ENSG00000168827	GFM1	100	93.333	ENSXMAG00000000261	gfm1	98	80.952	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003746	translation elongation factor activity	21873635.	IBA	Function
GO:0003746	translation elongation factor activity	19716793.	IDA	Function
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0003924	GTPase activity	19716793.	IDA	Function
GO:0005515	protein binding	18157088.28169297.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0070125	mitochondrial translational elongation	21873635.	IBA	Process
GO:0070125	mitochondrial translational elongation	19716793.	IDA	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process