EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000169188 (Gene tree)
Gene ID: 27301
Gene Symbol: APEX2
Alias: APEXL2|APE2|XTH2|ZGRF2
Full Name: apurinic/apyrimidinic endodeoxyribonuclease 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 8,735 bases
Position: chrX:55,000,323-55,009,057
Accession: 17889
RBP type: canonical RBP
Summary: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000364126	Exo_endo_phos	PF03372.23	3.3e-19	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30478324	Proximity-CLIP provides a snapshot of protein-occupied RNA elements in subcellular compartments.	Nat Methods	2018 Dec	Benhalevy D	doi: 10.1038/s41592-018-0220-y
31350943	Proximity labeling to detect RNA-protein interactions in live cells.	FEBS Open Bio	2019 Jul 27	Lu M	doi: 10.1002/2211-5463.12706

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000471758	APEX2-202	728	-	-	- (aa)	-	-
ENST00000374987	APEX2-201	3245	-	ENSP00000364126	518 (aa)	-	Q9UBZ4

Gene Model

Click here to download ENSG00000169188's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03410	Base excision repair	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169188's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000169188	APEX2	99	44.755	ENSAPOG00000005805	apex2	99	44.755	Acanthochromis_polyacanthus
ENSG00000169188	APEX2	100	86.320	ENSAMEG00000003608	APEX2	100	86.320	Ailuropoda_melanoleuca
ENSG00000169188	APEX2	99	45.819	ENSACIG00000010000	apex2	99	45.819	Amphilophus_citrinellus
ENSG00000169188	APEX2	99	44.406	ENSAOCG00000021774	apex2	99	44.755	Amphiprion_ocellaris
ENSG00000169188	APEX2	99	44.231	ENSAPEG00000020890	apex2	93	44.580	Amphiprion_percula
ENSG00000169188	APEX2	99	43.814	ENSATEG00000023600	apex2	99	43.814	Anabas_testudineus
ENSG00000169188	APEX2	99	51.158	ENSACAG00000011201	APEX2	99	51.351	Anolis_carolinensis
ENSG00000169188	APEX2	97	83.101	ENSANAG00000020845	-	100	83.101	Aotus_nancymaae
ENSG00000169188	APEX2	100	95.367	ENSANAG00000021907	-	100	95.367	Aotus_nancymaae
ENSG00000169188	APEX2	99	44.718	ENSAMXG00000007422	apex2	99	45.070	Astyanax_mexicanus
ENSG00000169188	APEX2	100	85.135	ENSBTAG00000013177	APEX2	100	85.135	Bos_taurus
ENSG00000169188	APEX2	100	94.981	ENSCJAG00000016584	APEX2	100	94.981	Callithrix_jacchus
ENSG00000169188	APEX2	100	85.135	ENSCAFG00000014310	APEX2	100	85.135	Canis_familiaris
ENSG00000169188	APEX2	100	86.486	ENSCAFG00020013818	APEX2	100	86.486	Canis_lupus_dingo
ENSG00000169188	APEX2	100	84.556	ENSCHIG00000019916	APEX2	100	84.556	Capra_hircus
ENSG00000169188	APEX2	100	86.873	ENSTSYG00000005612	APEX2	100	86.873	Carlito_syrichta
ENSG00000169188	APEX2	100	77.799	ENSCPOG00000007265	APEX2	100	77.799	Cavia_porcellus
ENSG00000169188	APEX2	97	80.800	ENSCCAG00000025405	-	99	80.800	Cebus_capucinus
ENSG00000169188	APEX2	100	96.718	ENSCATG00000044854	APEX2	100	96.718	Cercocebus_atys
ENSG00000169188	APEX2	100	79.537	ENSCLAG00000017315	APEX2	100	79.537	Chinchilla_lanigera
ENSG00000169188	APEX2	100	96.525	ENSCSAG00000012124	APEX2	100	96.525	Chlorocebus_sabaeus
ENSG00000169188	APEX2	99	47.719	ENSCPBG00000016631	APEX2	99	48.256	Chrysemys_picta_bellii
ENSG00000169188	APEX2	99	38.390	ENSCSAVG00000006052	-	99	38.390	Ciona_savignyi
ENSG00000169188	APEX2	100	95.753	ENSCANG00000003053	APEX2	100	95.753	Colobus_angolensis_palliatus
ENSG00000169188	APEX2	100	80.888	ENSCGRG00001008132	Apex2	100	80.888	Cricetulus_griseus_chok1gshd
ENSG00000169188	APEX2	100	80.888	ENSCGRG00000009667	Apex2	100	80.888	Cricetulus_griseus_crigri
ENSG00000169188	APEX2	99	44.655	ENSCSEG00000019900	apex2	98	44.655	Cynoglossus_semilaevis
ENSG00000169188	APEX2	99	44.254	ENSCVAG00000021583	apex2	99	43.878	Cyprinodon_variegatus
ENSG00000169188	APEX2	99	44.930	ENSDARG00000008472	apex2	99	45.503	Danio_rerio
ENSG00000169188	APEX2	100	82.046	ENSDNOG00000038901	APEX2	100	82.046	Dasypus_novemcinctus
ENSG00000169188	APEX2	99	46.035	ENSEBUG00000015654	apex2	99	46.035	Eptatretus_burgeri
ENSG00000169188	APEX2	100	87.452	ENSEASG00005011694	APEX2	91	87.452	Equus_asinus_asinus
ENSG00000169188	APEX2	100	87.452	ENSECAG00000026921	APEX2	91	87.452	Equus_caballus
ENSG00000169188	APEX2	100	78.077	ENSEEUG00000013172	APEX2	100	78.077	Erinaceus_europaeus
ENSG00000169188	APEX2	99	43.316	ENSELUG00000021417	apex2	99	43.316	Esox_lucius
ENSG00000169188	APEX2	100	85.135	ENSFCAG00000021990	APEX2	100	85.135	Felis_catus
ENSG00000169188	APEX2	100	80.695	ENSFDAG00000008076	APEX2	100	80.695	Fukomys_damarensis
ENSG00000169188	APEX2	99	40.426	ENSFHEG00000021411	apex2	99	40.426	Fundulus_heteroclitus
ENSG00000169188	APEX2	53	56.164	ENSGMOG00000019681	apex2	79	55.721	Gadus_morhua
ENSG00000169188	APEX2	99	44.755	ENSGAFG00000005829	apex2	99	45.105	Gambusia_affinis
ENSG00000169188	APEX2	90	44.668	ENSGAGG00000011520	APEX2	92	44.668	Gopherus_agassizii
ENSG00000169188	APEX2	100	99.035	ENSGGOG00000002056	APEX2	100	99.035	Gorilla_gorilla
ENSG00000169188	APEX2	99	46.555	ENSHBUG00000009938	apex2	99	45.203	Haplochromis_burtoni
ENSG00000169188	APEX2	100	80.502	ENSHGLG00000000273	APEX2	100	80.502	Heterocephalus_glaber_female
ENSG00000169188	APEX2	99	47.664	ENSHCOG00000010165	apex2	99	47.664	Hippocampus_comes
ENSG00000169188	APEX2	99	43.529	ENSIPUG00000000352	APEX2	99	43.697	Ictalurus_punctatus
ENSG00000169188	APEX2	100	83.784	ENSSTOG00000025121	APEX2	100	83.784	Ictidomys_tridecemlineatus
ENSG00000169188	APEX2	100	81.118	ENSJJAG00000019611	Apex2	100	81.118	Jaculus_jaculus
ENSG00000169188	APEX2	99	48.043	ENSKMAG00000006985	apex2	99	48.043	Kryptolebias_marmoratus
ENSG00000169188	APEX2	99	43.599	ENSLBEG00000012139	apex2	99	43.426	Labrus_bergylta
ENSG00000169188	APEX2	99	41.373	ENSLACG00000000865	APEX2	99	41.373	Latimeria_chalumnae
ENSG00000169188	APEX2	99	45.675	ENSLOCG00000014467	apex2	99	46.367	Lepisosteus_oculatus
ENSG00000169188	APEX2	100	83.977	ENSLAFG00000018312	APEX2	100	83.977	Loxodonta_africana
ENSG00000169188	APEX2	100	96.332	ENSMFAG00000002486	APEX2	100	96.332	Macaca_fascicularis
ENSG00000169188	APEX2	100	96.139	ENSMMUG00000008428	APEX2	100	96.139	Macaca_mulatta
ENSG00000169188	APEX2	100	96.332	ENSMNEG00000036783	APEX2	100	96.332	Macaca_nemestrina
ENSG00000169188	APEX2	100	96.718	ENSMLEG00000028208	APEX2	100	96.718	Mandrillus_leucophaeus
ENSG00000169188	APEX2	99	43.973	ENSMAMG00000024220	apex2	99	43.973	Mastacembelus_armatus
ENSG00000169188	APEX2	99	46.555	ENSMZEG00005026322	apex2	99	45.556	Maylandia_zebra
ENSG00000169188	APEX2	100	84.363	ENSMICG00000043181	APEX2	100	84.363	Microcebus_murinus
ENSG00000169188	APEX2	100	79.923	ENSMOCG00000004339	Apex2	100	79.923	Microtus_ochrogaster
ENSG00000169188	APEX2	99	44.387	ENSMMOG00000017340	apex2	99	44.923	Mola_mola
ENSG00000169188	APEX2	99	55.447	ENSMODG00000005341	APEX2	99	55.447	Monodelphis_domestica
ENSG00000169188	APEX2	99	43.002	ENSMALG00000014179	apex2	99	42.424	Monopterus_albus
ENSG00000169188	APEX2	100	79.344	MGP_CAROLIEiJ_G0033484	Apex2	100	81.132	Mus_caroli
ENSG00000169188	APEX2	100	79.344	ENSMUSG00000025269	Apex2	99	81.132	Mus_musculus
ENSG00000169188	APEX2	100	79.344	MGP_PahariEiJ_G0032023	Apex2	94	88.785	Mus_pahari
ENSG00000169188	APEX2	100	79.537	MGP_SPRETEiJ_G0034654	Apex2	100	81.132	Mus_spretus
ENSG00000169188	APEX2	100	86.100	ENSMPUG00000003293	APEX2	100	86.100	Mustela_putorius_furo
ENSG00000169188	APEX2	100	78.571	ENSMLUG00000004562	-	100	78.571	Myotis_lucifugus
ENSG00000169188	APEX2	100	81.081	ENSMLUG00000016298	-	100	81.081	Myotis_lucifugus
ENSG00000169188	APEX2	100	79.923	ENSNGAG00000013576	Apex2	100	79.923	Nannospalax_galili
ENSG00000169188	APEX2	99	43.531	ENSNBRG00000010099	apex2	99	43.531	Neolamprologus_brichardi
ENSG00000169188	APEX2	81	98.814	ENSNLEG00000032067	-	100	98.814	Nomascus_leucogenys
ENSG00000169188	APEX2	99	46.816	ENSONIG00000016881	apex2	99	47.753	Oreochromis_niloticus
ENSG00000169188	APEX2	89	52.156	ENSOANG00000000689	-	95	52.156	Ornithorhynchus_anatinus
ENSG00000169188	APEX2	100	72.031	ENSOCUG00000000570	APEX2	100	72.031	Oryctolagus_cuniculus
ENSG00000169188	APEX2	99	45.811	ENSORLG00000014053	apex2	99	45.811	Oryzias_latipes
ENSG00000169188	APEX2	99	45.276	ENSORLG00020013253	apex2	99	45.276	Oryzias_latipes_hni
ENSG00000169188	APEX2	99	45.633	ENSORLG00015007515	apex2	99	45.633	Oryzias_latipes_hsok
ENSG00000169188	APEX2	99	44.385	ENSOMEG00000003655	apex2	99	44.385	Oryzias_melastigma
ENSG00000169188	APEX2	99	86.187	ENSOGAG00000007797	APEX2	99	86.187	Otolemur_garnettii
ENSG00000169188	APEX2	100	84.363	ENSOARG00000005742	APEX2	100	84.363	Ovis_aries
ENSG00000169188	APEX2	100	99.035	ENSPPAG00000035747	APEX2	100	99.035	Pan_paniscus
ENSG00000169188	APEX2	100	85.328	ENSPPRG00000002440	APEX2	100	85.328	Panthera_pardus
ENSG00000169188	APEX2	100	84.942	ENSPTIG00000021651	APEX2	100	84.942	Panthera_tigris_altaica
ENSG00000169188	APEX2	100	99.228	ENSPTRG00000021946	APEX2	100	99.228	Pan_troglodytes
ENSG00000169188	APEX2	100	96.525	ENSPANG00000003595	APEX2	100	96.525	Papio_anubis
ENSG00000169188	APEX2	99	46.087	ENSPKIG00000007752	apex2	99	46.235	Paramormyrops_kingsleyae
ENSG00000169188	APEX2	99	44.186	ENSPMGG00000009151	apex2	99	44.186	Periophthalmus_magnuspinnatus
ENSG00000169188	APEX2	100	80.309	ENSPEMG00000016475	Apex2	100	80.309	Peromyscus_maniculatus_bairdii
ENSG00000169188	APEX2	99	55.534	ENSPCIG00000007633	APEX2	98	55.728	Phascolarctos_cinereus
ENSG00000169188	APEX2	99	45.009	ENSPFOG00000000408	apex2	99	45.009	Poecilia_formosa
ENSG00000169188	APEX2	99	45.009	ENSPLAG00000023814	apex2	99	45.009	Poecilia_latipinna
ENSG00000169188	APEX2	99	45.184	ENSPMEG00000023222	apex2	99	45.184	Poecilia_mexicana
ENSG00000169188	APEX2	100	98.842	ENSPPYG00000020388	APEX2	100	98.842	Pongo_abelii
ENSG00000169188	APEX2	100	87.259	ENSPCOG00000016083	APEX2	100	87.259	Propithecus_coquereli
ENSG00000169188	APEX2	90	85.591	ENSPVAG00000007851	APEX2	100	85.591	Pteropus_vampyrus
ENSG00000169188	APEX2	99	44.035	ENSPNYG00000015698	apex2	99	44.035	Pundamilia_nyererei
ENSG00000169188	APEX2	99	44.013	ENSPNAG00000011666	apex2	99	44.013	Pygocentrus_nattereri
ENSG00000169188	APEX2	100	79.344	ENSRNOG00000000166	Apex2	100	79.344	Rattus_norvegicus
ENSG00000169188	APEX2	100	96.332	ENSRBIG00000036500	APEX2	100	96.332	Rhinopithecus_bieti
ENSG00000169188	APEX2	100	96.525	ENSRROG00000032674	APEX2	100	96.525	Rhinopithecus_roxellana
ENSG00000169188	APEX2	96	75.000	ENSSBOG00000003489	-	99	75.000	Saimiri_boliviensis_boliviensis
ENSG00000169188	APEX2	100	95.174	ENSSBOG00000030500	-	100	95.174	Saimiri_boliviensis_boliviensis
ENSG00000169188	APEX2	99	54.581	ENSSHAG00000007846	APEX2	99	54.581	Sarcophilus_harrisii
ENSG00000169188	APEX2	99	48.263	ENSSFOG00015010354	apex2	99	49.543	Scleropages_formosus
ENSG00000169188	APEX2	99	44.503	ENSSMAG00000012753	apex2	99	44.231	Scophthalmus_maximus
ENSG00000169188	APEX2	99	45.487	ENSSDUG00000022892	apex2	99	45.841	Seriola_dumerili
ENSG00000169188	APEX2	99	45.290	ENSSLDG00000024347	apex2	99	45.652	Seriola_lalandi_dorsalis
ENSG00000169188	APEX2	100	77.927	ENSSARG00000010297	APEX2	100	77.927	Sorex_araneus
ENSG00000169188	APEX2	99	46.341	ENSSPAG00000016279	apex2	99	46.516	Stegastes_partitus
ENSG00000169188	APEX2	100	83.591	ENSSSCG00000012348	-	100	83.591	Sus_scrofa
ENSG00000169188	APEX2	99	45.679	ENSTRUG00000015660	apex2	99	45.679	Takifugu_rubripes
ENSG00000169188	APEX2	81	45.952	ENSTNIG00000003725	apex2	100	45.952	Tetraodon_nigroviridis
ENSG00000169188	APEX2	90	85.161	ENSTBEG00000010520	APEX2	100	85.161	Tupaia_belangeri
ENSG00000169188	APEX2	100	86.293	ENSUAMG00000004720	APEX2	100	86.293	Ursus_americanus
ENSG00000169188	APEX2	100	81.467	ENSUMAG00000002892	APEX2	100	81.467	Ursus_maritimus
ENSG00000169188	APEX2	100	85.907	ENSVVUG00000005989	APEX2	100	85.907	Vulpes_vulpes
ENSG00000169188	APEX2	99	45.966	ENSXETG00000022026	apex2	98	45.966	Xenopus_tropicalis
ENSG00000169188	APEX2	99	45.167	ENSXMAG00000025740	apex2	99	45.343	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001650	fibrillar center	-	IDA	Component
GO:0003677	DNA binding	-	IEA	Function
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	21873635.	IBA	Function
GO:0004519	endonuclease activity	-	IEA	Function
GO:0004528	phosphodiesterase I activity	21873635.	IBA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0006284	base-excision repair	21873635.	IBA	Process
GO:0006310	DNA recombination	-	IEA	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0008311	double-stranded DNA 3'-5' exodeoxyribonuclease activity	21873635.	IBA	Function
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0090305	nucleic acid phosphodiester bond hydrolysis	-	IEA	Process
GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	-	IEA	Function