EuRBPDB

Description

Ensembl ID: ENSG00000169223 (Gene tree)
Gene ID: 10960
Gene Symbol: LMAN2
Alias: GP36B|VIP36|C5orf8
Full Name: lectin, mannose binding 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 20,323 bases
Position: chr5:177,331,562-177,351,884
Accession: 16986
RBP type: non-canonical RBP
Summary: This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000502560	LMAN2-202	876	-	ENSP00000425229	288 (aa)	-	D6RDX1
ENST00000504071	LMAN2-204	562	-	-	- (aa)	-	-
ENST00000506310	LMAN2-205	564	-	-	- (aa)	-	-
ENST00000502721	LMAN2-203	639	-	-	- (aa)	-	-
ENST00000303127	LMAN2-201	1800	-	ENSP00000303366	356 (aa)	-	Q12907
ENST00000515209	LMAN2-208	1149	-	ENSP00000423998	325 (aa)	-	D6RBV2
ENST00000513877	LMAN2-206	823	-	ENSP00000427377	191 (aa)	-	D6RIU4
ENST00000514458	LMAN2-207	616	-	ENSP00000424132	203 (aa)	-	D6RBH1

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000169223	Platelet Function Tests	1.7248500E-005	-
ENSG00000169223	Platelet Function Tests	1.3622400E-005	-
ENSG00000169223	Parathyroid Hormone	5.1430000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000169223	rs4976686	5	177345735	G	Anthropometric traits	30166351	[0.024-0.031] unit increase	0.02757	EFO_0004324\|EFO_0004339
ENSG00000169223	rs4976686	5	177345735	?	Anthropometric traits (multi-trait analysis)	30166351			EFO_0004324

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000169223	LMAN2	100	99.476	ENSMUSG00000021484	Lman2	100	94.413	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	21873635.	IBA	Component
GO:0005515	protein binding	20477988.	IPI	Function
GO:0005537	mannose binding	21873635.	IBA	Function
GO:0005537	mannose binding	20477988.	IMP	Function
GO:0005615	extracellular space	22016386.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	21873635.	IBA	Component
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	15308636.20477988.	IDA	Component
GO:0005794	Golgi apparatus	20477988.	IDA	Component
GO:0005887	integral component of plasma membrane	22016386.	IDA	Component
GO:0006888	ER to Golgi vesicle-mediated transport	21873635.	IBA	Process
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	20477988.	IMP	Process
GO:0007029	endoplasmic reticulum organization	21873635.	IBA	Process
GO:0007030	Golgi organization	21873635.	IBA	Process
GO:0009986	cell surface	22016386.	IDA	Component
GO:0015031	protein transport	-	IEA	Process
GO:0030134	COPII-coated ER to Golgi transport vesicle	21873635.	IBA	Component
GO:0030246	carbohydrate binding	23701871.	IDA	Function
GO:0031072	heat shock protein binding	20477988.	IPI	Function
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	-	IEA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0050766	positive regulation of phagocytosis	22016386.	IMP	Process
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component