EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000169249 (Gene tree)
Gene ID: 8233
Gene Symbol: ZRSR2
Alias: U2AF1-RS2|URP|ZC3H22|U2AF1L2
Full Name: zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 32,992 bases
Position: chrX:15,790,269-15,823,260
Accession: 23019
RBP type: canonical RBP
Summary: This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000303015	zf-CCCH	PF00642.24	7.9e-13	1	2
ENSP00000303015	zf-CCCH	PF00642.24	7.9e-13	2	2
ENSP00000303015	RRM_1	PF00076.22	8e-05	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31124956	Effect of RNA splicing machinery gene mutations on prognosis of patients with MDS: A meta-analysis.	Medicine (Baltimore)	2019 May	Wang X	doi: 10.1097/MD.0000000000015743.
29069007	Successful eltrombopag treatment of severe refractory thrombocytopenia in chronic myelomonocytic leukemia: Two cases reports: A CARE-compliant article.	Medicine (Baltimore)	2017 Oct	Gao Y	doi: 10.1097/MD.0000000000008337.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000307771	ZRSR2-201	1491	XM_005274597	ENSP00000303015	482 (aa)	XP_005274654	Q15696
ENST00000380308	ZRSR2-202	744	-	ENSP00000369664	147 (aa)	-	A6NDW0
ENST00000468028	ZRSR2-203	365	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000169249's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000169249	Child Development Disorders, Pervasive	8.5437400E-006	-
ENSG00000169249	Child Development Disorders, Pervasive	8.5437400E-006	-
ENSG00000169249	Child Development Disorders, Pervasive	3.8711800E-005	-
ENSG00000169249	Child Development Disorders, Pervasive	3.8711800E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169249's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000169249	ZRSR2	74	57.660	ENSAPOG00000004712	zrsr2	77	64.532	Acanthochromis_polyacanthus
ENSG00000169249	ZRSR2	85	89.806	ENSAMEG00000017716	ZRSR2	89	86.493	Ailuropoda_melanoleuca
ENSG00000169249	ZRSR2	71	60.174	ENSACIG00000004601	zrsr2	80	53.155	Amphilophus_citrinellus
ENSG00000169249	ZRSR2	57	68.327	ENSAOCG00000024102	zrsr2	58	60.274	Amphiprion_ocellaris
ENSG00000169249	ZRSR2	73	62.185	ENSAPEG00000024673	zrsr2	66	57.246	Amphiprion_percula
ENSG00000169249	ZRSR2	76	61.067	ENSATEG00000016753	zrsr2	67	56.373	Anabas_testudineus
ENSG00000169249	ZRSR2	96	68.842	ENSACAG00000017034	ZRSR2	97	69.427	Anolis_carolinensis
ENSG00000169249	ZRSR2	100	96.680	ENSANAG00000019297	ZRSR2	100	96.680	Aotus_nancymaae
ENSG00000169249	ZRSR2	70	63.768	ENSACLG00000019635	zrsr2	77	56.115	Astatotilapia_calliptera
ENSG00000169249	ZRSR2	94	54.466	ENSAMXG00000018502	zrsr2	70	56.659	Astyanax_mexicanus
ENSG00000169249	ZRSR2	100	96.266	ENSCJAG00000047941	ZRSR2	100	96.266	Callithrix_jacchus
ENSG00000169249	ZRSR2	86	90.168	ENSCAFG00000012201	ZRSR2	91	87.290	Canis_familiaris
ENSG00000169249	ZRSR2	73	72.159	ENSCAFG00020016674	-	87	64.000	Canis_lupus_dingo
ENSG00000169249	ZRSR2	73	86.610	ENSCHIG00000023069	-	93	84.789	Capra_hircus
ENSG00000169249	ZRSR2	83	81.203	ENSCHIG00000024109	-	93	80.451	Capra_hircus
ENSG00000169249	ZRSR2	54	86.397	ENSTSYG00000005278	-	80	87.160	Carlito_syrichta
ENSG00000169249	ZRSR2	87	86.698	ENSCPOG00000004227	ZRSR2	91	87.685	Cavia_porcellus
ENSG00000169249	ZRSR2	100	96.266	ENSCCAG00000023937	ZRSR2	100	96.266	Cebus_capucinus
ENSG00000169249	ZRSR2	89	90.046	ENSCATG00000020687	-	87	91.924	Cercocebus_atys
ENSG00000169249	ZRSR2	100	99.378	ENSCATG00000034085	ZRSR2	100	99.378	Cercocebus_atys
ENSG00000169249	ZRSR2	71	89.244	ENSCLAG00000002087	ZRSR2	97	88.352	Chinchilla_lanigera
ENSG00000169249	ZRSR2	100	98.347	ENSCSAG00000014897	ZRSR2	100	98.347	Chlorocebus_sabaeus
ENSG00000169249	ZRSR2	70	77.778	ENSCHOG00000007907	ZRSR2	87	65.517	Choloepus_hoffmanni
ENSG00000169249	ZRSR2	63	35.447	ENSCING00000022974	-	56	39.510	Ciona_intestinalis
ENSG00000169249	ZRSR2	100	91.286	ENSCANG00000030333	ZRSR2	100	91.494	Colobus_angolensis_palliatus
ENSG00000169249	ZRSR2	89	74.419	ENSCGRG00001007132	Zrsr1	95	73.031	Cricetulus_griseus_chok1gshd
ENSG00000169249	ZRSR2	100	76.803	ENSCGRG00001006948	-	82	84.726	Cricetulus_griseus_chok1gshd
ENSG00000169249	ZRSR2	100	79.755	ENSCGRG00000009725	-	86	83.373	Cricetulus_griseus_crigri
ENSG00000169249	ZRSR2	89	74.419	ENSCGRG00000019269	Zrsr1	95	73.031	Cricetulus_griseus_crigri
ENSG00000169249	ZRSR2	87	57.981	ENSCSEG00000009682	zrsr2	67	63.218	Cynoglossus_semilaevis
ENSG00000169249	ZRSR2	96	53.996	ENSCVAG00000020877	zrsr2	76	56.019	Cyprinodon_variegatus
ENSG00000169249	ZRSR2	73	65.352	ENSDARG00000058448	zrsr2	65	60.000	Danio_rerio
ENSG00000169249	ZRSR2	82	90.909	ENSDNOG00000015008	ZRSR2	80	92.199	Dasypus_novemcinctus
ENSG00000169249	ZRSR2	81	32.432	FBgn0031628	CG3294	77	31.048	Drosophila_melanogaster
ENSG00000169249	ZRSR2	97	69.723	ENSETEG00000005141	-	88	73.892	Echinops_telfairi
ENSG00000169249	ZRSR2	51	92.742	ENSECAG00000006454	ZRSR2	83	92.578	Equus_caballus
ENSG00000169249	ZRSR2	100	81.405	ENSEEUG00000002115	ZRSR2	89	84.524	Erinaceus_europaeus
ENSG00000169249	ZRSR2	85	85.714	ENSFCAG00000025255	-	86	83.373	Felis_catus
ENSG00000169249	ZRSR2	85	91.463	ENSFCAG00000009333	-	90	88.333	Felis_catus
ENSG00000169249	ZRSR2	82	74.074	ENSFALG00000004373	ZRSR2	88	71.596	Ficedula_albicollis
ENSG00000169249	ZRSR2	85	90.049	ENSFDAG00000011766	ZRSR2	88	89.286	Fukomys_damarensis
ENSG00000169249	ZRSR2	73	63.510	ENSFHEG00000006093	zrsr2	63	59.367	Fundulus_heteroclitus
ENSG00000169249	ZRSR2	59	58.904	ENSGMOG00000008189	zrsr2	68	54.494	Gadus_morhua
ENSG00000169249	ZRSR2	54	79.845	ENSGALG00000016552	ZRSR2	83	76.703	Gallus_gallus
ENSG00000169249	ZRSR2	96	52.008	ENSGACG00000015069	zrsr2	71	54.034	Gasterosteus_aculeatus
ENSG00000169249	ZRSR2	79	75.066	ENSGAGG00000016402	ZRSR2	85	72.346	Gopherus_agassizii
ENSG00000169249	ZRSR2	100	98.755	ENSGGOG00000011962	ZRSR2	100	98.755	Gorilla_gorilla
ENSG00000169249	ZRSR2	79	71.169	ENSGGOG00000025707	-	87	67.013	Gorilla_gorilla
ENSG00000169249	ZRSR2	73	63.636	ENSHBUG00000000797	zrsr2	76	56.306	Haplochromis_burtoni
ENSG00000169249	ZRSR2	85	89.024	ENSHGLG00000003790	ZRSR2	89	86.715	Heterocephalus_glaber_female
ENSG00000169249	ZRSR2	85	88.136	ENSHGLG00100010131	ZRSR2	88	86.747	Heterocephalus_glaber_male
ENSG00000169249	ZRSR2	70	60.117	ENSHCOG00000020661	zrsr2	61	60.058	Hippocampus_comes
ENSG00000169249	ZRSR2	74	59.331	ENSIPUG00000012642	zrsr2	80	63.816	Ictalurus_punctatus
ENSG00000169249	ZRSR2	89	87.126	ENSSTOG00000008492	ZRSR2	89	89.762	Ictidomys_tridecemlineatus
ENSG00000169249	ZRSR2	85	87.835	ENSJJAG00000020365	-	84	87.192	Jaculus_jaculus
ENSG00000169249	ZRSR2	73	63.099	ENSKMAG00000009969	zrsr2	71	57.381	Kryptolebias_marmoratus
ENSG00000169249	ZRSR2	80	62.975	ENSLBEG00000024627	zrsr2	67	61.272	Labrus_bergylta
ENSG00000169249	ZRSR2	79	69.634	ENSLACG00000013483	ZRSR2	67	66.993	Latimeria_chalumnae
ENSG00000169249	ZRSR2	80	65.885	ENSLOCG00000007427	zrsr2	74	64.573	Lepisosteus_oculatus
ENSG00000169249	ZRSR2	83	82.663	ENSLAFG00000009326	-	91	82.759	Loxodonta_africana
ENSG00000169249	ZRSR2	85	73.608	ENSLAFG00000018654	-	94	73.397	Loxodonta_africana
ENSG00000169249	ZRSR2	100	98.755	ENSMFAG00000039674	ZRSR2	100	98.755	Macaca_fascicularis
ENSG00000169249	ZRSR2	100	98.755	ENSMNEG00000043293	ZRSR2	100	98.755	Macaca_nemestrina
ENSG00000169249	ZRSR2	100	92.975	ENSMLEG00000028125	ZRSR2	100	92.975	Mandrillus_leucophaeus
ENSG00000169249	ZRSR2	75	63.271	ENSMAMG00000010779	zrsr2	63	59.686	Mastacembelus_armatus
ENSG00000169249	ZRSR2	73	63.361	ENSMZEG00005006531	zrsr2	71	57.245	Maylandia_zebra
ENSG00000169249	ZRSR2	82	74.065	ENSMGAG00000014689	ZRSR2	88	72.986	Meleagris_gallopavo
ENSG00000169249	ZRSR2	86	84.058	ENSMAUG00000009754	-	89	80.387	Mesocricetus_auratus
ENSG00000169249	ZRSR2	85	92.233	ENSMICG00000003211	ZRSR2	88	92.344	Microcebus_murinus
ENSG00000169249	ZRSR2	100	80.328	ENSMOCG00000011340	-	91	83.254	Microtus_ochrogaster
ENSG00000169249	ZRSR2	59	66.552	ENSMMOG00000018572	zrsr2	74	59.659	Mola_mola
ENSG00000169249	ZRSR2	83	77.307	ENSMODG00000017202	ZRSR2	89	75.714	Monodelphis_domestica
ENSG00000169249	ZRSR2	83	50.000	ENSMALG00000013132	zrsr2	60	56.358	Monopterus_albus
ENSG00000169249	ZRSR2	89	75.701	MGP_CAROLIEiJ_G0016133	Zrsr1	95	75.779	Mus_caroli
ENSG00000169249	ZRSR2	89	75.000	ENSMUSG00000044068	Zrsr1	95	75.060	Mus_musculus
ENSG00000169249	ZRSR2	89	75.935	MGP_PahariEiJ_G0016759	Zrsr1	95	76.019	Mus_pahari
ENSG00000169249	ZRSR2	89	75.000	MGP_SPRETEiJ_G0016976	Zrsr1	95	75.060	Mus_spretus
ENSG00000169249	ZRSR2	85	88.780	ENSMPUG00000002739	ZRSR2	90	85.238	Mustela_putorius_furo
ENSG00000169249	ZRSR2	73	57.670	ENSMLUG00000002201	-	75	59.091	Myotis_lucifugus
ENSG00000169249	ZRSR2	99	82.292	ENSMLUG00000009780	-	86	84.892	Myotis_lucifugus
ENSG00000169249	ZRSR2	89	85.847	ENSNGAG00000008809	-	88	86.429	Nannospalax_galili
ENSG00000169249	ZRSR2	78	74.599	ENSNGAG00000011974	Zrsr1	99	72.632	Nannospalax_galili
ENSG00000169249	ZRSR2	67	64.438	ENSNBRG00000021146	zrsr2	82	55.227	Neolamprologus_brichardi
ENSG00000169249	ZRSR2	100	92.116	ENSNLEG00000018892	-	87	91.885	Nomascus_leucogenys
ENSG00000169249	ZRSR2	100	98.548	ENSNLEG00000009496	ZRSR2	100	98.548	Nomascus_leucogenys
ENSG00000169249	ZRSR2	65	74.038	ENSMEUG00000015318	-	65	74.038	Notamacropus_eugenii
ENSG00000169249	ZRSR2	89	88.811	ENSODEG00000004944	ZRSR2	88	87.204	Octodon_degus
ENSG00000169249	ZRSR2	71	64.857	ENSONIG00000000228	zrsr2	87	59.512	Oreochromis_niloticus
ENSG00000169249	ZRSR2	84	77.262	ENSOANG00000002571	ZRSR2	89	75.060	Ornithorhynchus_anatinus
ENSG00000169249	ZRSR2	51	32.114	ENSOANG00000006463	-	97	34.440	Ornithorhynchus_anatinus
ENSG00000169249	ZRSR2	88	89.252	ENSOCUG00000004295	ZRSR2	85	86.052	Oryctolagus_cuniculus
ENSG00000169249	ZRSR2	67	62.691	ENSORLG00000003476	zrsr2	60	59.322	Oryzias_latipes
ENSG00000169249	ZRSR2	67	62.385	ENSORLG00020020707	zrsr2	64	56.000	Oryzias_latipes_hni
ENSG00000169249	ZRSR2	67	62.691	ENSORLG00015019831	zrsr2	63	56.952	Oryzias_latipes_hsok
ENSG00000169249	ZRSR2	60	66.327	ENSOMEG00000011857	zrsr2	63	59.270	Oryzias_melastigma
ENSG00000169249	ZRSR2	88	83.726	ENSOGAG00000031648	-	85	81.146	Otolemur_garnettii
ENSG00000169249	ZRSR2	88	90.187	ENSOGAG00000011340	-	95	87.678	Otolemur_garnettii
ENSG00000169249	ZRSR2	88	87.943	ENSOGAG00000033259	-	85	86.603	Otolemur_garnettii
ENSG00000169249	ZRSR2	85	88.675	ENSOARG00000012713	ZRSR2	91	87.059	Ovis_aries
ENSG00000169249	ZRSR2	100	98.548	ENSPPAG00000022429	ZRSR2	100	98.548	Pan_paniscus
ENSG00000169249	ZRSR2	90	93.981	ENSPPAG00000008683	-	87	91.885	Pan_paniscus
ENSG00000169249	ZRSR2	99	81.573	ENSPPRG00000012485	-	90	83.373	Panthera_pardus
ENSG00000169249	ZRSR2	85	91.707	ENSPPRG00000016585	-	90	88.571	Panthera_pardus
ENSG00000169249	ZRSR2	82	91.919	ENSPTIG00000016363	-	87	88.670	Panthera_tigris_altaica
ENSG00000169249	ZRSR2	99	81.366	ENSPTIG00000006398	-	90	83.135	Panthera_tigris_altaica
ENSG00000169249	ZRSR2	90	93.981	ENSPTRG00000017138	-	87	91.885	Pan_troglodytes
ENSG00000169249	ZRSR2	100	98.548	ENSPTRG00000021693	ZRSR2	100	98.548	Pan_troglodytes
ENSG00000169249	ZRSR2	89	66.977	ENSPTRG00000045685	-	95	67.062	Pan_troglodytes
ENSG00000169249	ZRSR2	100	98.963	ENSPANG00000016331	ZRSR2	100	98.963	Papio_anubis
ENSG00000169249	ZRSR2	100	89.485	ENSPANG00000009346	-	87	92.654	Papio_anubis
ENSG00000169249	ZRSR2	77	62.803	ENSPKIG00000013433	zrsr2	65	61.347	Paramormyrops_kingsleyae
ENSG00000169249	ZRSR2	82	77.273	ENSPSIG00000008915	ZRSR2	88	74.402	Pelodiscus_sinensis
ENSG00000169249	ZRSR2	71	60.580	ENSPMGG00000000771	zrsr2	58	65.667	Periophthalmus_magnuspinnatus
ENSG00000169249	ZRSR2	89	76.512	ENSPEMG00000013373	Zrsr1	95	76.134	Peromyscus_maniculatus_bairdii
ENSG00000169249	ZRSR2	73	55.028	ENSPMAG00000008152	zrsr2	83	52.010	Petromyzon_marinus
ENSG00000169249	ZRSR2	71	64.348	ENSPLAG00000019869	zrsr2	59	61.157	Poecilia_latipinna
ENSG00000169249	ZRSR2	71	64.348	ENSPMEG00000024070	zrsr2	59	61.157	Poecilia_mexicana
ENSG00000169249	ZRSR2	59	65.517	ENSPREG00000019201	zrsr2	58	56.825	Poecilia_reticulata
ENSG00000169249	ZRSR2	100	98.755	ENSPPYG00000020150	ZRSR2	100	98.755	Pongo_abelii
ENSG00000169249	ZRSR2	85	93.171	ENSPCOG00000027178	ZRSR2	88	92.823	Propithecus_coquereli
ENSG00000169249	ZRSR2	85	81.159	ENSPVAG00000010216	ZRSR2	90	81.132	Pteropus_vampyrus
ENSG00000169249	ZRSR2	70	64.058	ENSPNYG00000018426	zrsr2	80	56.000	Pundamilia_nyererei
ENSG00000169249	ZRSR2	60	72.664	ENSPNAG00000012282	zrsr2	62	66.372	Pygocentrus_nattereri
ENSG00000169249	ZRSR2	88	74.941	ENSRNOG00000009639	Zrsr1	95	74.580	Rattus_norvegicus
ENSG00000169249	ZRSR2	89	80.796	ENSRBIG00000033960	-	88	78.759	Rhinopithecus_bieti
ENSG00000169249	ZRSR2	100	77.366	ENSRBIG00000035472	ZRSR2	86	76.611	Rhinopithecus_bieti
ENSG00000169249	ZRSR2	100	98.340	ENSRROG00000030588	ZRSR2	100	98.340	Rhinopithecus_roxellana
ENSG00000169249	ZRSR2	92	82.883	ENSRROG00000041659	-	92	83.055	Rhinopithecus_roxellana
ENSG00000169249	ZRSR2	85	77.616	ENSSBOG00000017836	ZRSR2	84	79.064	Saimiri_boliviensis_boliviensis
ENSG00000169249	ZRSR2	83	82.250	ENSSHAG00000013271	ZRSR2	89	81.146	Sarcophilus_harrisii
ENSG00000169249	ZRSR2	79	61.917	ENSSFOG00015009363	zrsr2	68	53.830	Scleropages_formosus
ENSG00000169249	ZRSR2	79	60.925	ENSSMAG00000013874	zrsr2	62	58.537	Scophthalmus_maximus
ENSG00000169249	ZRSR2	73	62.363	ENSSDUG00000002784	zrsr2	66	56.338	Seriola_dumerili
ENSG00000169249	ZRSR2	79	74.084	ENSSPUG00000007432	ZRSR2	90	72.208	Sphenodon_punctatus
ENSG00000169249	ZRSR2	71	58.721	ENSSPAG00000010595	zrsr2	57	57.143	Stegastes_partitus
ENSG00000169249	ZRSR2	85	85.612	ENSSSCG00000030283	-	88	83.372	Sus_scrofa
ENSG00000169249	ZRSR2	56	79.044	ENSSSCG00000026864	-	99	75.646	Sus_scrofa
ENSG00000169249	ZRSR2	79	74.740	ENSTGUG00000007964	ZRSR2	88	73.086	Taeniopygia_guttata
ENSG00000169249	ZRSR2	98	51.844	ENSTRUG00000023769	U2AF1-RS2	66	57.002	Takifugu_rubripes
ENSG00000169249	ZRSR2	75	62.162	ENSTNIG00000009495	zrsr2	67	57.908	Tetraodon_nigroviridis
ENSG00000169249	ZRSR2	68	93.558	ENSTBEG00000008533	ZRSR2	69	93.558	Tupaia_belangeri
ENSG00000169249	ZRSR2	58	90.265	ENSTTRG00000012433	ZRSR2	59	93.333	Tursiops_truncatus
ENSG00000169249	ZRSR2	51	94.309	ENSUAMG00000016637	ZRSR2	85	93.359	Ursus_americanus
ENSG00000169249	ZRSR2	51	94.309	ENSUMAG00000008698	ZRSR2	85	93.359	Ursus_maritimus
ENSG00000169249	ZRSR2	76	91.105	ENSVPAG00000007641	ZRSR2	79	91.761	Vicugna_pacos
ENSG00000169249	ZRSR2	73	71.388	ENSVVUG00000009615	-	77	68.839	Vulpes_vulpes
ENSG00000169249	ZRSR2	85	65.459	ENSXETG00000031542	ZRSR2	86	66.422	Xenopus_tropicalis
ENSG00000169249	ZRSR2	62	65.116	ENSXCOG00000000318	zrsr2	60	58.974	Xiphophorus_couchianus
ENSG00000169249	ZRSR2	62	65.116	ENSXMAG00000015258	zrsr2	57	58.127	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000245	spliceosomal complex assembly	21041408.	IMP	Process
GO:0000398	mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000398	mRNA splicing, via spliceosome	9237760.	IMP	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0005515	protein binding	9237760.23602568.25416956.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	21873635.	IBA	Component
GO:0005689	U12-type spliceosomal complex	15146077.21041408.	IDA	Component
GO:0008380	RNA splicing	15146077.	IC	Process
GO:0030628	pre-mRNA 3'-splice site binding	21873635.	IBA	Function
GO:0030628	pre-mRNA 3'-splice site binding	21041408.	IDA	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0089701	U2AF	21873635.	IBA	Component