EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000169288 (Gene tree)
Gene ID: 65008
Gene Symbol: MRPL1
Alias: BM022
Full Name: mitochondrial ribosomal protein L1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 90,836 bases
Position: chr4:77,861,955-77,952,790
Accession: 14275
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000315017	Ribosomal_L1	PF00687.21	5.2e-16	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000504901	MRPL1-203	535	-	-	- (aa)	-	-
ENST00000511521	MRPL1-205	580	-	-	- (aa)	-	-
ENST00000506674	MRPL1-204	832	-	-	- (aa)	-	-
ENST00000502384	MRPL1-202	898	-	ENSP00000421616	231 (aa)	-	H0Y8N7
ENST00000515625	MRPL1-206	307	-	-	- (aa)	-	-
ENST00000315567	MRPL1-201	1490	-	ENSP00000315017	325 (aa)	-	Q9BYD6

Gene Model

Click here to download ENSG00000169288's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000169288	rs35648590	4	77922761	C	Menstruation quality of life impact (headache)	29855537	[0.096-0.212] unit decrease	0.15414548	EFO_0009366\|HP_0002315

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169288's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000169288	MRPL1	78	56.667	ENSAPOG00000005831	mrpl1	82	51.938	Acanthochromis_polyacanthus
ENSG00000169288	MRPL1	94	50.228	ENSACIG00000002298	mrpl1	84	52.174	Amphilophus_citrinellus
ENSG00000169288	MRPL1	98	45.768	ENSAOCG00000006715	mrpl1	80	51.779	Amphiprion_ocellaris
ENSG00000169288	MRPL1	78	57.222	ENSAPEG00000020020	mrpl1	84	52.174	Amphiprion_percula
ENSG00000169288	MRPL1	98	47.516	ENSATEG00000008760	mrpl1	100	47.205	Anabas_testudineus
ENSG00000169288	MRPL1	79	57.923	ENSAPLG00000003428	MRPL1	92	54.688	Anas_platyrhynchos
ENSG00000169288	MRPL1	96	48.243	ENSACAG00000012069	MRPL1	82	46.341	Anolis_carolinensis
ENSG00000169288	MRPL1	99	88.580	ENSANAG00000035463	-	99	88.580	Aotus_nancymaae
ENSG00000169288	MRPL1	99	76.636	ENSANAG00000020317	-	99	76.636	Aotus_nancymaae
ENSG00000169288	MRPL1	98	47.040	ENSACLG00000001464	mrpl1	88	47.040	Astatotilapia_calliptera
ENSG00000169288	MRPL1	90	47.393	ENSAMXG00000033077	mrpl1	74	47.843	Astyanax_mexicanus
ENSG00000169288	MRPL1	97	82.857	ENSCPOG00000031686	MRPL1	97	81.905	Cavia_porcellus
ENSG00000169288	MRPL1	99	81.424	ENSCLAG00000005041	MRPL1	98	82.609	Chinchilla_lanigera
ENSG00000169288	MRPL1	99	85.759	ENSCANG00000033966	MRPL1	99	85.759	Colobus_angolensis_palliatus
ENSG00000169288	MRPL1	98	75.692	ENSCGRG00001005376	-	99	75.077	Cricetulus_griseus_chok1gshd
ENSG00000169288	MRPL1	98	75.385	ENSCGRG00000003658	-	99	74.769	Cricetulus_griseus_crigri
ENSG00000169288	MRPL1	97	43.671	ENSCSEG00000014014	mrpl1	100	43.210	Cynoglossus_semilaevis
ENSG00000169288	MRPL1	98	45.820	ENSCVAG00000021636	mrpl1	99	45.820	Cyprinodon_variegatus
ENSG00000169288	MRPL1	97	41.956	ENSDARG00000054606	mrpl1	76	46.800	Danio_rerio
ENSG00000169288	MRPL1	100	81.231	ENSDNOG00000001665	MRPL1	99	80.000	Dasypus_novemcinctus
ENSG00000169288	MRPL1	99	79.141	ENSDORG00000015752	Mrpl1	97	79.141	Dipodomys_ordii
ENSG00000169288	MRPL1	97	32.416	ENSEBUG00000004815	mrpl1	77	33.465	Eptatretus_burgeri
ENSG00000169288	MRPL1	79	54.945	ENSELUG00000013391	mrpl1	74	52.083	Esox_lucius
ENSG00000169288	MRPL1	100	80.615	ENSFCAG00000013776	MRPL1	100	80.615	Felis_catus
ENSG00000169288	MRPL1	90	51.923	ENSFALG00000008527	MRPL1	89	51.953	Ficedula_albicollis
ENSG00000169288	MRPL1	96	81.847	ENSFDAG00000011113	MRPL1	96	80.892	Fukomys_damarensis
ENSG00000169288	MRPL1	98	45.483	ENSFHEG00000012375	mrpl1	99	45.483	Fundulus_heteroclitus
ENSG00000169288	MRPL1	91	52.133	ENSGALG00000010324	MRPL1	73	55.691	Gallus_gallus
ENSG00000169288	MRPL1	98	45.794	ENSGAFG00000006089	mrpl1	86	45.483	Gambusia_affinis
ENSG00000169288	MRPL1	96	56.604	ENSGAGG00000015092	MRPL1	98	54.268	Gopherus_agassizii
ENSG00000169288	MRPL1	100	99.385	ENSGGOG00000001304	MRPL1	100	99.385	Gorilla_gorilla
ENSG00000169288	MRPL1	98	47.040	ENSHBUG00000004985	mrpl1	100	47.040	Haplochromis_burtoni
ENSG00000169288	MRPL1	99	78.328	ENSHGLG00000006127	MRPL1	99	81.056	Heterocephalus_glaber_female
ENSG00000169288	MRPL1	99	78.328	ENSHGLG00100004303	MRPL1	99	81.056	Heterocephalus_glaber_male
ENSG00000169288	MRPL1	85	48.980	ENSIPUG00000009866	mrpl1	88	47.308	Ictalurus_punctatus
ENSG00000169288	MRPL1	97	82.019	ENSSTOG00000001415	MRPL1	98	84.227	Ictidomys_tridecemlineatus
ENSG00000169288	MRPL1	98	76.471	ENSJJAG00000012571	Mrpl1	98	75.542	Jaculus_jaculus
ENSG00000169288	MRPL1	96	47.964	ENSKMAG00000004236	mrpl1	77	52.049	Kryptolebias_marmoratus
ENSG00000169288	MRPL1	73	54.438	ENSLBEG00000013686	-	81	49.784	Labrus_bergylta
ENSG00000169288	MRPL1	85	52.551	ENSLBEG00000017454	-	70	52.055	Labrus_bergylta
ENSG00000169288	MRPL1	96	49.842	ENSLACG00000008208	MRPL1	95	50.000	Latimeria_chalumnae
ENSG00000169288	MRPL1	93	51.835	ENSLOCG00000007408	mrpl1	97	48.113	Lepisosteus_oculatus
ENSG00000169288	MRPL1	65	93.168	ENSMFAG00000030593	MRPL1	98	93.168	Macaca_fascicularis
ENSG00000169288	MRPL1	93	89.767	ENSMLEG00000030203	MRPL1	99	78.328	Mandrillus_leucophaeus
ENSG00000169288	MRPL1	98	48.137	ENSMAMG00000016943	mrpl1	99	46.729	Mastacembelus_armatus
ENSG00000169288	MRPL1	98	47.040	ENSMZEG00005020288	mrpl1	100	47.040	Maylandia_zebra
ENSG00000169288	MRPL1	92	50.943	ENSMGAG00000005136	MRPL1	86	56.667	Meleagris_gallopavo
ENSG00000169288	MRPL1	98	57.188	ENSMAUG00000019228	Mrpl1	99	57.188	Mesocricetus_auratus
ENSG00000169288	MRPL1	93	82.791	ENSMICG00000032729	-	89	85.088	Microcebus_murinus
ENSG00000169288	MRPL1	98	77.090	ENSMOCG00000017395	Mrpl1	99	75.542	Microtus_ochrogaster
ENSG00000169288	MRPL1	93	69.444	ENSMODG00000011704	MRPL1	92	71.483	Monodelphis_domestica
ENSG00000169288	MRPL1	98	46.154	ENSMALG00000006393	mrpl1	100	45.483	Monopterus_albus
ENSG00000169288	MRPL1	96	79.180	ENSMUSG00000029486	Mrpl1	98	77.508	Mus_musculus
ENSG00000169288	MRPL1	96	78.864	MGP_PahariEiJ_G0017208	Mrpl1	98	77.204	Mus_pahari
ENSG00000169288	MRPL1	96	79.114	MGP_SPRETEiJ_G0028427	Mrpl1	98	77.439	Mus_spretus
ENSG00000169288	MRPL1	99	78.947	ENSMPUG00000006794	MRPL1	98	78.947	Mustela_putorius_furo
ENSG00000169288	MRPL1	95	73.955	ENSNGAG00000015669	Mrpl1	98	75.241	Nannospalax_galili
ENSG00000169288	MRPL1	94	48.693	ENSNBRG00000016660	mrpl1	95	48.693	Neolamprologus_brichardi
ENSG00000169288	MRPL1	99	76.780	ENSODEG00000004206	MRPL1	99	77.950	Octodon_degus
ENSG00000169288	MRPL1	98	47.516	ENSONIG00000014024	mrpl1	99	47.516	Oreochromis_niloticus
ENSG00000169288	MRPL1	91	70.755	ENSOANG00000003564	MRPL1	90	71.937	Ornithorhynchus_anatinus
ENSG00000169288	MRPL1	99	81.424	ENSOCUG00000003852	MRPL1	99	84.211	Oryctolagus_cuniculus
ENSG00000169288	MRPL1	92	48.837	ENSORLG00000018859	mrpl1	69	51.082	Oryzias_latipes
ENSG00000169288	MRPL1	89	46.377	ENSOMEG00000010049	mrpl1	76	47.967	Oryzias_melastigma
ENSG00000169288	MRPL1	89	81.724	ENSOGAG00000012126	MRPL1	99	80.731	Otolemur_garnettii
ENSG00000169288	MRPL1	100	99.692	ENSPPAG00000041378	MRPL1	100	99.692	Pan_paniscus
ENSG00000169288	MRPL1	100	80.308	ENSPPRG00000009221	MRPL1	100	80.308	Panthera_pardus
ENSG00000169288	MRPL1	100	80.615	ENSPTIG00000015465	MRPL1	100	80.615	Panthera_tigris_altaica
ENSG00000169288	MRPL1	100	100.000	ENSPTRG00000016199	MRPL1	100	100.000	Pan_troglodytes
ENSG00000169288	MRPL1	99	93.189	ENSPANG00000007832	MRPL1	99	93.189	Papio_anubis
ENSG00000169288	MRPL1	92	49.770	ENSPKIG00000019299	mrpl1	78	51.351	Paramormyrops_kingsleyae
ENSG00000169288	MRPL1	68	67.089	ENSPSIG00000015906	MRPL1	96	65.000	Pelodiscus_sinensis
ENSG00000169288	MRPL1	92	48.039	ENSPMGG00000004020	mrpl1	94	48.089	Periophthalmus_magnuspinnatus
ENSG00000169288	MRPL1	98	75.851	ENSPEMG00000018072	-	99	74.303	Peromyscus_maniculatus_bairdii
ENSG00000169288	MRPL1	98	62.696	ENSPCIG00000029496	-	95	61.755	Phascolarctos_cinereus
ENSG00000169288	MRPL1	98	44.860	ENSPFOG00000013095	mrpl1	98	44.860	Poecilia_formosa
ENSG00000169288	MRPL1	85	48.980	ENSPLAG00000019871	mrpl1	78	49.407	Poecilia_latipinna
ENSG00000169288	MRPL1	98	44.860	ENSPMEG00000015846	mrpl1	99	44.860	Poecilia_mexicana
ENSG00000169288	MRPL1	98	44.237	ENSPREG00000003524	mrpl1	99	44.237	Poecilia_reticulata
ENSG00000169288	MRPL1	100	97.231	ENSPPYG00000014870	MRPL1	100	97.231	Pongo_abelii
ENSG00000169288	MRPL1	98	46.106	ENSPNYG00000006464	mrpl1	98	46.106	Pundamilia_nyererei
ENSG00000169288	MRPL1	84	52.577	ENSPNAG00000018662	mrpl1	79	50.588	Pygocentrus_nattereri
ENSG00000169288	MRPL1	98	76.708	ENSRNOG00000002070	Mrpl1	99	74.224	Rattus_norvegicus
ENSG00000169288	MRPL1	98	76.636	ENSRNOG00000045785	LOC100359687	99	74.920	Rattus_norvegicus
ENSG00000169288	MRPL1	99	92.879	ENSRBIG00000040801	MRPL1	99	92.879	Rhinopithecus_bieti
ENSG00000169288	MRPL1	99	93.189	ENSRROG00000041586	MRPL1	99	93.189	Rhinopithecus_roxellana
ENSG00000169288	MRPL1	99	65.538	ENSSHAG00000001696	MRPL1	99	65.538	Sarcophilus_harrisii
ENSG00000169288	MRPL1	86	51.515	ENSSFOG00015014444	mrpl1	75	51.394	Scleropages_formosus
ENSG00000169288	MRPL1	99	46.933	ENSSMAG00000015530	mrpl1	99	47.077	Scophthalmus_maximus
ENSG00000169288	MRPL1	99	44.582	ENSSDUG00000018458	mrpl1	100	44.582	Seriola_dumerili
ENSG00000169288	MRPL1	99	44.272	ENSSLDG00000000399	mrpl1	93	44.272	Seriola_lalandi_dorsalis
ENSG00000169288	MRPL1	77	59.777	ENSSPUG00000002005	MRPL1	82	58.400	Sphenodon_punctatus
ENSG00000169288	MRPL1	89	41.869	ENSSPAG00000022922	mrpl1	87	42.612	Stegastes_partitus
ENSG00000169288	MRPL1	79	55.191	ENSTGUG00000001739	MRPL1	83	52.060	Taeniopygia_guttata
ENSG00000169288	MRPL1	93	51.152	ENSTRUG00000004229	mrpl1	98	46.835	Takifugu_rubripes
ENSG00000169288	MRPL1	93	51.152	ENSTNIG00000016716	mrpl1	86	52.893	Tetraodon_nigroviridis
ENSG00000169288	MRPL1	99	81.988	ENSUMAG00000007973	MRPL1	97	85.551	Ursus_maritimus
ENSG00000169288	MRPL1	97	46.201	ENSXETG00000000373	mrpl1	95	47.256	Xenopus_tropicalis
ENSG00000169288	MRPL1	85	48.980	ENSXMAG00000002920	mrpl1	99	44.444	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000470	maturation of LSU-rRNA	21873635.	IBA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003735	structural constituent of ribosome	-	IEA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005739	mitochondrion	-	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0022625	cytosolic large ribosomal subunit	21873635.	IBA	Component
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process