EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000169371 (Gene tree)
Gene ID: 10073
Gene Symbol: SNUPN
Alias: SNURPORTIN-1|Snurportin1|RNUT1
Full Name: snurportin 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 28,387 bases
Position: chr15:75,598,083-75,626,469
Accession: 14245
RBP type: canonical RBP
Summary: The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000455894	Snurportin1	PF11538.8	1e-18	1	1
ENSP00000457093	Snurportin1	PF11538.8	1.9e-18	1	1
ENSP00000456742	Snurportin1	PF11538.8	3.5e-18	1	1
ENSP00000456260	Snurportin1	PF11538.8	6.9e-18	1	1
ENSP00000309831	Snurportin1	PF11538.8	1.2e-17	1	1
ENSP00000454852	Snurportin1	PF11538.8	1.2e-17	1	1
ENSP00000456224	Snurportin1	PF11538.8	1.2e-17	1	1
ENSP00000458053	Snurportin1	PF11538.8	1.2e-17	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24326307	Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination.	Nat Commun	2013	Yoon JH	doi: 10.1038/ncomms3939.
15920472	Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1.	EMBO J	2005 Jul 6	Strasser A	-
19619473	Molecular determinants of snurportin 1 ligand affinity and structural response upon binding.	Biophys J	2009 Jul 22	Goette M	doi: 10.1016/j.bpj.2009.04.049.
23952175	Chemical synthesis of U1 snRNA derivatives.	Org Lett	2013 Sep 6	Ohkubo A	doi: 10.1021/ol401917r

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000567134	SNUPN-207	1641	-	ENSP00000456224	360 (aa)	-	O95149
ENST00000564644	SNUPN-205	1931	-	ENSP00000454852	360 (aa)	-	O95149
ENST00000564675	SNUPN-206	1682	-	ENSP00000458053	360 (aa)	-	O95149
ENST00000308588	SNUPN-201	1513	-	ENSP00000309831	360 (aa)	-	O95149
ENST00000568162	SNUPN-210	759	-	ENSP00000457093	100 (aa)	-	H3BTA6
ENST00000563875	SNUPN-203	406	-	ENSP00000455649	2 (aa)	-	UPI000011EBE6
ENST00000569817	SNUPN-211	1023	-	ENSP00000456260	209 (aa)	-	H3BRI5
ENST00000564086	SNUPN-204	644	-	ENSP00000456742	136 (aa)	-	H3BSK1
ENST00000563793	SNUPN-202	661	-	ENSP00000455894	63 (aa)	-	H3BQR0
ENST00000567437	SNUPN-208	470	-	-	- (aa)	-	-
ENST00000568078	SNUPN-209	920	-	ENSP00000457562	200 (aa)	-	H3BUB4

Gene Model

Click here to download ENSG00000169371's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000169371	Prostatic Neoplasms	4E-6	27515689
ENSG00000169371	Electromagnetic Radiation	4E-6	27515689

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169371's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000169371	SNUPN	100	76.190	ENSAPOG00000016953	snupn	94	65.266	Acanthochromis_polyacanthus
ENSG00000169371	SNUPN	100	96.825	ENSAMEG00000008291	SNUPN	99	93.094	Ailuropoda_melanoleuca
ENSG00000169371	SNUPN	100	71.429	ENSACIG00000012409	snupn	94	64.146	Amphilophus_citrinellus
ENSG00000169371	SNUPN	100	76.190	ENSAOCG00000018096	snupn	94	64.986	Amphiprion_ocellaris
ENSG00000169371	SNUPN	100	76.190	ENSAPEG00000008834	snupn	94	64.986	Amphiprion_percula
ENSG00000169371	SNUPN	100	74.603	ENSATEG00000021019	snupn	94	64.986	Anabas_testudineus
ENSG00000169371	SNUPN	100	97.129	ENSANAG00000025568	SNUPN	100	94.722	Aotus_nancymaae
ENSG00000169371	SNUPN	100	73.016	ENSACLG00000025155	snupn	94	64.146	Astatotilapia_calliptera
ENSG00000169371	SNUPN	100	74.603	ENSAMXG00000038311	snupn	96	65.634	Astyanax_mexicanus
ENSG00000169371	SNUPN	100	95.238	ENSBTAG00000021293	SNUPN	100	88.950	Bos_taurus
ENSG00000169371	SNUPN	99	43.396	WBGene00017746	F23F1.5	88	42.034	Caenorhabditis_elegans
ENSG00000169371	SNUPN	100	96.825	ENSCJAG00000003005	SNUPN	100	94.722	Callithrix_jacchus
ENSG00000169371	SNUPN	100	95.261	ENSCAFG00000018035	SNUPN	100	90.055	Canis_familiaris
ENSG00000169371	SNUPN	100	95.238	ENSCHIG00000018047	SNUPN	100	89.779	Capra_hircus
ENSG00000169371	SNUPN	100	94.118	ENSTSYG00000037224	SNUPN	100	88.920	Carlito_syrichta
ENSG00000169371	SNUPN	100	86.029	ENSCAPG00000005061	SNUPN	100	73.961	Cavia_aperea
ENSG00000169371	SNUPN	100	96.825	ENSCPOG00000034772	SNUPN	100	87.535	Cavia_porcellus
ENSG00000169371	SNUPN	100	96.324	ENSCCAG00000016169	-	100	94.722	Cebus_capucinus
ENSG00000169371	SNUPN	100	92.063	ENSCCAG00000023343	-	87	85.714	Cebus_capucinus
ENSG00000169371	SNUPN	100	100.000	ENSCATG00000039783	SNUPN	100	97.500	Cercocebus_atys
ENSG00000169371	SNUPN	100	93.651	ENSCLAG00000016968	SNUPN	100	87.258	Chinchilla_lanigera
ENSG00000169371	SNUPN	100	96.825	ENSCSAG00000019246	-	100	95.556	Chlorocebus_sabaeus
ENSG00000169371	SNUPN	100	98.413	ENSCSAG00000014576	-	89	96.944	Chlorocebus_sabaeus
ENSG00000169371	SNUPN	100	98.413	ENSCHOG00000005403	SNUPN	100	70.994	Choloepus_hoffmanni
ENSG00000169371	SNUPN	100	93.651	ENSCPBG00000022172	SNUPN	95	78.846	Chrysemys_picta_bellii
ENSG00000169371	SNUPN	100	100.000	ENSCANG00000029707	SNUPN	100	97.222	Colobus_angolensis_palliatus
ENSG00000169371	SNUPN	100	93.810	ENSCGRG00001004622	Snupn	100	90.859	Cricetulus_griseus_chok1gshd
ENSG00000169371	SNUPN	100	93.810	ENSCGRG00000002515	Snupn	100	90.859	Cricetulus_griseus_crigri
ENSG00000169371	SNUPN	100	71.429	ENSCSEG00000003160	snupn	86	61.308	Cynoglossus_semilaevis
ENSG00000169371	SNUPN	100	73.016	ENSCVAG00000010502	snupn	94	64.507	Cyprinodon_variegatus
ENSG00000169371	SNUPN	100	76.190	ENSDARG00000008395	snupn	98	63.085	Danio_rerio
ENSG00000169371	SNUPN	100	96.825	ENSDNOG00000044304	SNUPN	94	87.258	Dasypus_novemcinctus
ENSG00000169371	SNUPN	100	98.413	ENSDORG00000009051	Snupn	100	91.713	Dipodomys_ordii
ENSG00000169371	SNUPN	84	94.340	ENSETEG00000013792	SNUPN	100	74.033	Echinops_telfairi
ENSG00000169371	SNUPN	100	58.411	ENSEBUG00000006682	snupn	93	53.955	Eptatretus_burgeri
ENSG00000169371	SNUPN	100	100.000	ENSEASG00005015697	SNUPN	97	94.737	Equus_asinus_asinus
ENSG00000169371	SNUPN	100	100.000	ENSECAG00000017726	SNUPN	100	94.737	Equus_caballus
ENSG00000169371	SNUPN	100	98.413	ENSEEUG00000000981	-	70	90.964	Erinaceus_europaeus
ENSG00000169371	SNUPN	100	69.841	ENSELUG00000023305	snupn	93	65.318	Esox_lucius
ENSG00000169371	SNUPN	100	100.000	ENSFCAG00000040981	SNUPN	100	92.818	Felis_catus
ENSG00000169371	SNUPN	100	98.413	ENSFDAG00000011599	SNUPN	100	88.643	Fukomys_damarensis
ENSG00000169371	SNUPN	100	73.016	ENSFHEG00000017627	snupn	94	64.426	Fundulus_heteroclitus
ENSG00000169371	SNUPN	100	69.841	ENSGMOG00000009272	snupn	100	63.202	Gadus_morhua
ENSG00000169371	SNUPN	96	72.449	ENSGALG00000029537	SNUPN	100	68.852	Gallus_gallus
ENSG00000169371	SNUPN	100	76.190	ENSGAFG00000004954	snupn	94	64.507	Gambusia_affinis
ENSG00000169371	SNUPN	100	76.190	ENSGACG00000007450	snupn	100	65.352	Gasterosteus_aculeatus
ENSG00000169371	SNUPN	100	92.063	ENSGAGG00000022470	SNUPN	100	77.869	Gopherus_agassizii
ENSG00000169371	SNUPN	100	85.714	ENSGGOG00000004581	-	100	99.379	Gorilla_gorilla
ENSG00000169371	SNUPN	100	73.016	ENSHBUG00000006950	snupn	94	64.426	Haplochromis_burtoni
ENSG00000169371	SNUPN	100	96.825	ENSHGLG00000000536	SNUPN	99	88.268	Heterocephalus_glaber_female
ENSG00000169371	SNUPN	100	96.825	ENSHGLG00100016161	SNUPN	99	88.268	Heterocephalus_glaber_male
ENSG00000169371	SNUPN	100	74.603	ENSHCOG00000007262	snupn	95	65.193	Hippocampus_comes
ENSG00000169371	SNUPN	100	66.667	ENSIPUG00000014460	Snupn	98	63.812	Ictalurus_punctatus
ENSG00000169371	SNUPN	100	98.413	ENSSTOG00000005904	SNUPN	100	95.014	Ictidomys_tridecemlineatus
ENSG00000169371	SNUPN	100	73.016	ENSKMAG00000009957	snupn	93	63.559	Kryptolebias_marmoratus
ENSG00000169371	SNUPN	100	73.016	ENSLBEG00000020694	snupn	94	64.365	Labrus_bergylta
ENSG00000169371	SNUPN	100	79.365	ENSLACG00000015801	SNUPN	96	71.839	Latimeria_chalumnae
ENSG00000169371	SNUPN	100	82.540	ENSLOCG00000015064	snupn	96	66.102	Lepisosteus_oculatus
ENSG00000169371	SNUPN	100	98.413	ENSLAFG00000004422	SNUPN	100	92.244	Loxodonta_africana
ENSG00000169371	SNUPN	100	100.000	ENSMFAG00000003706	SNUPN	100	96.410	Macaca_fascicularis
ENSG00000169371	SNUPN	100	100.000	ENSMMUG00000004784	SNUPN	100	97.778	Macaca_mulatta
ENSG00000169371	SNUPN	100	100.000	ENSMLEG00000041966	SNUPN	100	88.889	Mandrillus_leucophaeus
ENSG00000169371	SNUPN	100	77.778	ENSMAMG00000023109	snupn	94	66.106	Mastacembelus_armatus
ENSG00000169371	SNUPN	100	73.016	ENSMZEG00005010806	snupn	94	64.426	Maylandia_zebra
ENSG00000169371	SNUPN	100	93.810	ENSMAUG00000020426	Snupn	100	91.690	Mesocricetus_auratus
ENSG00000169371	SNUPN	100	96.825	ENSMICG00000016438	SNUPN	100	92.244	Microcebus_murinus
ENSG00000169371	SNUPN	100	95.238	ENSMOCG00000014238	Snupn	100	91.413	Microtus_ochrogaster
ENSG00000169371	SNUPN	100	74.603	ENSMMOG00000001321	snupn	94	64.706	Mola_mola
ENSG00000169371	SNUPN	100	93.651	ENSMODG00000008852	SNUPN	100	82.289	Monodelphis_domestica
ENSG00000169371	SNUPN	100	77.778	ENSMALG00000015058	snupn	94	65.819	Monopterus_albus
ENSG00000169371	SNUPN	100	95.261	MGP_CAROLIEiJ_G0032259	Snupn	100	91.436	Mus_caroli
ENSG00000169371	SNUPN	100	95.261	ENSMUSG00000055334	Snupn	100	91.713	Mus_musculus
ENSG00000169371	SNUPN	100	96.825	MGP_PahariEiJ_G0015126	Snupn	100	91.989	Mus_pahari
ENSG00000169371	SNUPN	100	95.261	MGP_SPRETEiJ_G0033399	Snupn	100	91.713	Mus_spretus
ENSG00000169371	SNUPN	100	96.825	ENSMPUG00000017324	SNUPN	100	90.884	Mustela_putorius_furo
ENSG00000169371	SNUPN	96	90.674	ENSMLUG00000027485	-	100	85.359	Myotis_lucifugus
ENSG00000169371	SNUPN	100	78.000	ENSMLUG00000000038	-	100	77.168	Myotis_lucifugus
ENSG00000169371	SNUPN	100	94.118	ENSMLUG00000027517	-	100	89.779	Myotis_lucifugus
ENSG00000169371	SNUPN	100	93.651	ENSNGAG00000018735	Snupn	100	91.690	Nannospalax_galili
ENSG00000169371	SNUPN	100	73.016	ENSNBRG00000017919	snupn	96	63.760	Neolamprologus_brichardi
ENSG00000169371	SNUPN	83	100.000	ENSNLEG00000035240	-	100	68.144	Nomascus_leucogenys
ENSG00000169371	SNUPN	100	98.413	ENSOPRG00000015889	-	100	72.928	Ochotona_princeps
ENSG00000169371	SNUPN	78	92.949	ENSODEG00000014491	SNUPN	100	73.529	Octodon_degus
ENSG00000169371	SNUPN	100	73.016	ENSONIG00000012855	snupn	96	65.266	Oreochromis_niloticus
ENSG00000169371	SNUPN	100	92.063	ENSOANG00000029361	-	91	79.817	Ornithorhynchus_anatinus
ENSG00000169371	SNUPN	100	98.413	ENSOCUG00000008801	SNUPN	99	89.694	Oryctolagus_cuniculus
ENSG00000169371	SNUPN	100	74.603	ENSORLG00000001836	snupn	94	65.181	Oryzias_latipes
ENSG00000169371	SNUPN	100	74.603	ENSORLG00020021175	snupn	94	65.460	Oryzias_latipes_hni
ENSG00000169371	SNUPN	100	74.603	ENSORLG00015014444	snupn	94	65.460	Oryzias_latipes_hsok
ENSG00000169371	SNUPN	100	77.778	ENSOMEG00000004853	snupn	94	67.908	Oryzias_melastigma
ENSG00000169371	SNUPN	100	77.778	ENSOMEG00000015313	-	93	59.836	Oryzias_melastigma
ENSG00000169371	SNUPN	100	98.413	ENSOGAG00000004915	SNUPN	100	89.503	Otolemur_garnettii
ENSG00000169371	SNUPN	100	95.238	ENSOARG00000001991	SNUPN	97	90.055	Ovis_aries
ENSG00000169371	SNUPN	100	100.000	ENSPPAG00000034351	SNUPN	100	99.444	Pan_paniscus
ENSG00000169371	SNUPN	100	100.000	ENSPPRG00000023192	SNUPN	100	92.541	Panthera_pardus
ENSG00000169371	SNUPN	100	100.000	ENSPTIG00000003528	SNUPN	100	92.541	Panthera_tigris_altaica
ENSG00000169371	SNUPN	100	100.000	ENSPTRG00000007302	SNUPN	100	99.722	Pan_troglodytes
ENSG00000169371	SNUPN	100	100.000	ENSPANG00000034514	SNUPN	100	88.611	Papio_anubis
ENSG00000169371	SNUPN	100	68.254	ENSPKIG00000012444	snupn	99	65.546	Paramormyrops_kingsleyae
ENSG00000169371	SNUPN	100	88.889	ENSPSIG00000015229	SNUPN	100	78.022	Pelodiscus_sinensis
ENSG00000169371	SNUPN	100	77.778	ENSPMGG00000023843	snupn	94	64.820	Periophthalmus_magnuspinnatus
ENSG00000169371	SNUPN	100	92.063	ENSPCIG00000007854	SNUPN	100	82.825	Phascolarctos_cinereus
ENSG00000169371	SNUPN	100	76.190	ENSPFOG00000014221	snupn	93	63.944	Poecilia_formosa
ENSG00000169371	SNUPN	100	76.190	ENSPLAG00000002339	snupn	93	64.225	Poecilia_latipinna
ENSG00000169371	SNUPN	100	76.190	ENSPMEG00000012436	snupn	93	63.944	Poecilia_mexicana
ENSG00000169371	SNUPN	100	74.603	ENSPREG00000012683	snupn	93	64.225	Poecilia_reticulata
ENSG00000169371	SNUPN	100	100.000	ENSPPYG00000006663	SNUPN	100	89.444	Pongo_abelii
ENSG00000169371	SNUPN	100	98.413	ENSPCOG00000025482	SNUPN	100	92.521	Propithecus_coquereli
ENSG00000169371	SNUPN	100	96.825	ENSPVAG00000010035	SNUPN	100	91.413	Pteropus_vampyrus
ENSG00000169371	SNUPN	100	73.016	ENSPNYG00000008752	snupn	94	64.426	Pundamilia_nyererei
ENSG00000169371	SNUPN	100	77.778	ENSPNAG00000026875	snupn	98	65.363	Pygocentrus_nattereri
ENSG00000169371	SNUPN	100	96.825	ENSRNOG00000005426	Snupn	99	92.655	Rattus_norvegicus
ENSG00000169371	SNUPN	100	100.000	ENSRBIG00000038665	SNUPN	100	97.222	Rhinopithecus_bieti
ENSG00000169371	SNUPN	100	100.000	ENSRROG00000043625	SNUPN	100	97.500	Rhinopithecus_roxellana
ENSG00000169371	SNUPN	100	96.825	ENSSBOG00000029086	-	100	94.167	Saimiri_boliviensis_boliviensis
ENSG00000169371	SNUPN	100	77.778	ENSSFOG00015022264	snupn	66	71.118	Scleropages_formosus
ENSG00000169371	SNUPN	100	77.778	ENSSMAG00000005485	snupn	94	69.275	Scophthalmus_maximus
ENSG00000169371	SNUPN	100	77.778	ENSSDUG00000023461	snupn	94	65.826	Seriola_dumerili
ENSG00000169371	SNUPN	100	77.778	ENSSLDG00000001425	snupn	94	66.011	Seriola_lalandi_dorsalis
ENSG00000169371	SNUPN	100	96.825	ENSSARG00000005585	SNUPN	100	72.727	Sorex_araneus
ENSG00000169371	SNUPN	100	90.476	ENSSPUG00000014331	SNUPN	95	76.554	Sphenodon_punctatus
ENSG00000169371	SNUPN	100	74.603	ENSSPAG00000001216	snupn	94	65.266	Stegastes_partitus
ENSG00000169371	SNUPN	100	98.413	ENSSSCG00000001877	SNUPN	100	93.370	Sus_scrofa
ENSG00000169371	SNUPN	100	76.190	ENSTRUG00000016085	snupn	92	65.546	Takifugu_rubripes
ENSG00000169371	SNUPN	100	74.603	ENSTNIG00000008456	snupn	100	57.550	Tetraodon_nigroviridis
ENSG00000169371	SNUPN	100	96.825	ENSTBEG00000002434	SNUPN	100	86.704	Tupaia_belangeri
ENSG00000169371	SNUPN	100	100.000	ENSTTRG00000011484	SNUPN	100	85.083	Tursiops_truncatus
ENSG00000169371	SNUPN	100	96.825	ENSUAMG00000022723	SNUPN	100	93.094	Ursus_americanus
ENSG00000169371	SNUPN	100	96.825	ENSUMAG00000003738	SNUPN	100	92.818	Ursus_maritimus
ENSG00000169371	SNUPN	100	96.825	ENSVPAG00000001768	-	61	92.453	Vicugna_pacos
ENSG00000169371	SNUPN	100	93.651	ENSVVUG00000019574	SNUPN	100	90.331	Vulpes_vulpes
ENSG00000169371	SNUPN	100	80.952	ENSXETG00000015280	snupn	99	67.622	Xenopus_tropicalis
ENSG00000169371	SNUPN	100	76.190	ENSXMAG00000006634	snupn	94	64.507	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000339	RNA cap binding	9670026.	TAS	Function
GO:0000387	spliceosomal snRNP assembly	-	TAS	Process
GO:0005515	protein binding	19339969.19339972.20972448.23850451.26673895.	IPI	Function
GO:0005643	nuclear pore	9670026.	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006606	protein import into nucleus	-	IEA	Process
GO:0051170	import into nucleus	-	TAS	Process
GO:0061015	snRNA import into nucleus	-	IEA	Process
GO:0061608	nuclear import signal receptor activity	-	IEA	Function