EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000169375 (Gene tree)
Gene ID: 25942
Gene Symbol: SIN3A
Alias: KIAA0700|DKFZP434K2235
Full Name: SIN3 transcription regulator family member A
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 86,464 bases
Position: chr15:75,369,379-75,455,842
Accession: 19353
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24063527	Increased binding of stroke-induced long non-coding RNAs to the transcriptional corepressors Sin3A and coREST.	ASN Neuro	2013 Oct 23	Dharap A	doi: 10.1042/AN20130029.
28461394	Mrhl Long Noncoding RNA Mediates Meiotic Commitment of Mouse Spermatogonial Cells by Regulating Sox8 Expression.	Mol Cell Biol	2017 Jun 29	Kataruka S	doi: 10.1128/MCB.00632-16

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000568190	SIN3A-209	567	-	ENSP00000456997	98 (aa)	-	H3BT34
ENST00000568309	SIN3A-210	549	-	ENSP00000455644	107 (aa)	-	H3BQ76
ENST00000567289	SIN3A-208	4078	-	ENSP00000455834	156 (aa)	-	H3BQL7
ENST00000566640	SIN3A-207	944	-	-	- (aa)	-	-
ENST00000564778	SIN3A-205	617	-	ENSP00000455204	176 (aa)	-	H3BP90
ENST00000360439	SIN3A-201	5050	-	ENSP00000353622	1273 (aa)	-	Q96ST3
ENST00000562776	SIN3A-204	590	-	ENSP00000455072	142 (aa)	-	H3BNZ3
ENST00000565264	SIN3A-206	510	-	ENSP00000454296	18 (aa)	-	H3BMA2
ENST00000568431	SIN3A-211	565	-	ENSP00000454750	130 (aa)	-	H3BNA0
ENST00000570115	SIN3A-214	554	-	ENSP00000455662	123 (aa)	-	H3BQ88
ENST00000570021	SIN3A-213	600	-	-	- (aa)	-	-
ENST00000394947	SIN3A-202	6737	XM_006720465	ENSP00000378402	1273 (aa)	XP_006720528	Q96ST3
ENST00000568919	SIN3A-212	455	-	-	- (aa)	-	-
ENST00000394949	SIN3A-203	4930	-	ENSP00000378403	1273 (aa)	-	Q96ST3
ENST00000570124	SIN3A-215	593	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000169375's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04919	Thyroid hormone signaling pathway	KEGG
hsa05016	Huntington disease	KEGG
hsa05169	Epstein-Barr virus infection	KEGG
hsa05202	Transcriptional misregulation in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000169375	Death, Sudden, Cardiac	3E-6	21658281

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000169375	rs8028182	15	75426328	?	Sudden cardiac arrest	21658281	[1.19-1.54]	1.36	EFO_0004278

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169375's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000169375	SIN3A	100	100.000	ENSMUSG00000042557	Sin3a	100	98.038	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	22783022.	IMP	Process
GO:0000776	kinetochore	-	IEA	Component
GO:0000785	chromatin	21873635.	IBA	Component
GO:0000976	transcription regulatory region sequence-specific DNA binding	-	ISS	Function
GO:0001102	RNA polymerase II activating transcription factor binding	22783022.	IPI	Function
GO:0001103	RNA polymerase II repressing transcription factor binding	-	IEA	Function
GO:0001701	in utero embryonic development	-	IEA	Process
GO:0002218	activation of innate immune response	22783022.	IMP	Process
GO:0002230	positive regulation of defense response to virus by host	22783022.	IMP	Process
GO:0002244	hematopoietic progenitor cell differentiation	-	IEA	Process
GO:0003682	chromatin binding	-	IEA	Function
GO:0003700	DNA-binding transcription factor activity	-	IEA	Function
GO:0003714	transcription corepressor activity	21873635.	IBA	Function
GO:0003723	RNA binding	-	IEA	Function
GO:0004407	histone deacetylase activity	21873635.	IBA	Function
GO:0005515	protein binding	10049357.10220385.10823891.11238380.11259580.11359905.12150998.12670868.14525983.16254079.17803295.17956988.18451802.21258344.23752268.23770565.25314079.26496610.	IPI	Function
GO:0005634	nucleus	22783022.	IDA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005667	transcription factor complex	-	IEA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0006260	DNA replication	-	IEA	Process
GO:0006476	protein deacetylation	22783022.	IMP	Process
GO:0007568	aging	-	IEA	Process
GO:0010817	regulation of hormone levels	-	IEA	Process
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	-	IEA	Process
GO:0016575	histone deacetylation	21873635.	IBA	Process
GO:0016580	Sin3 complex	21873635.	IBA	Component
GO:0016580	Sin3 complex	14966270.17827154.	IDA	Component
GO:0016580	Sin3 complex	22783022.	NAS	Component
GO:0017053	transcriptional repressor complex	-	IEA	Component
GO:0019216	regulation of lipid metabolic process	-	TAS	Process
GO:0031937	positive regulation of chromatin silencing	22783022.	IMP	Process
GO:0033558	protein deacetylase activity	22783022.	IMP	Function
GO:0034613	cellular protein localization	-	IEA	Process
GO:0042754	negative regulation of circadian rhythm	-	ISS	Process
GO:0043066	negative regulation of apoptotic process	-	IEA	Process
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	-	IEA	Process
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	Process
GO:0045892	negative regulation of transcription, DNA-templated	-	ISS	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	22783022.	IMP	Process
GO:0048511	rhythmic process	-	IEA	Process
GO:0051595	response to methylglyoxal	-	IEA	Process
GO:0071333	cellular response to glucose stimulus	-	IEA	Process
GO:1900181	negative regulation of protein localization to nucleus	22783022.	IMP	Process
GO:1901675	negative regulation of histone H3-K27 acetylation	22783022.	IMP	Process
GO:1903351	cellular response to dopamine	-	IEA	Process
GO:2000678	negative regulation of transcription regulatory region DNA binding	22783022.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28805661	The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer.	J Clin Invest	2017 Sep 1	Li W	doi: 10.1172/JCI94233
26118188	Expression Analysis of p16, c-Myc, and mSin3A in Non-small Cell Lung Cancer by Computer Aided Scoring and Analysis (CASA).	Clin Lab	2015	Salmaninejad A	-
20920219	Maximum growth and survival of estrogen receptor-alpha positive breast cancer cells requires the Sin3A transcriptional repressor.	Mol Cancer	2010 Sep 29	Ellison-Zelski SJ	doi: 10.1186/1476-4598-9-263.
17854949	Decreased expression of the SIN3A gene, a candidate tumor suppressor located at the prevalent allelic loss region 15q23 in non-small cell lung cancer.	Lung Cancer	2008 Jan	Suzuki H	-
20547842	Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer cells.	Proc Natl Acad Sci U S A	2010 Jun 29	Farias EF	doi: 10.1073/pnas.1006737107
27780928	SIN3A and SIN3B differentially regulate breast cancer metastasis.	Oncotarget	2016 Nov 29	Lewis MJ	doi: 10.18632/oncotarget.12805.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr15	75381633	Missense_Mutation	novel	D1090Y	0.18
BLCA	chr15	75392438	Silent	novel	L885L	0.12
BLCA	chr15	75411502	Missense_Mutation	novel	H333R	0.12
BLCA	chr15	75409884	Missense_Mutation	novel	N423K	0.23
BLCA	chr15	75375859	Missense_Mutation	rs749092824	I1133V	0.18
BLCA	chr15	75384313	Missense_Mutation	NA	T1049K	0.06
BLCA	chr15	75409871	Missense_Mutation	novel	R428C	0.12
BLCA	chr15	75375812	Missense_Mutation	novel	K1148N	0.23
BLCA	chr15	75400849	Missense_Mutation	NA	E540K	0.44
BLCA	chr15	75401966	Missense_Mutation	NA	R471Q	0.46
BLCA	chr15	75400930	Missense_Mutation	novel	E513Q	0.38
BLCA	chr15	75422713	Missense_Mutation	NA	Q100H	0.31
BLCA	chr15	75372179	Missense_Mutation	novel	Q1208E	0.3
BLCA	chr15	75422614	Intron	novel		0.16
BRCA	chr15	75371878	3'UTR	rs62029732		0.46
BRCA	chr15	75412872	Frame_Shift_Del	novel	*H214Pfs71**	0.06
BRCA	chr15	75400051	Nonsense_Mutation	novel	E615*	0.07
BRCA	chr15	75380681	Missense_Mutation	NA	T1111A	0.19
BRCA	chr15	75396453	Missense_Mutation	NA	L633P	0.45
BRCA	chr15	75392640	Missense_Mutation	NA	H818R	0.47
BRCA	chr15	75411584	Missense_Mutation	NA	H306Y	0.3
BRCA	chr15	75409887	Silent	NA	Q422Q	0.5
BRCA	chr15	75401937	Missense_Mutation	NA	E481K	0.15
BRCA	chr15	75384304	Missense_Mutation	NA	R1052P	0.73
BRCA	chr15	75384374	In_Frame_Del	novel	L1023_N1029delinsH	0.3
BRCA	chr15	75410192	Frame_Shift_Del	NA	*N368Tfs22**	0.42
CESC	chr15	75396279	Missense_Mutation	novel	A691V	0.19
CESC	chr15	75400063	Missense_Mutation	NA	R611G	0.19
CESC	chr15	75400125	Missense_Mutation	novel	S590L	0.07
CESC	chr15	75412789	Missense_Mutation	NA	Q244E	0.29
CESC	chr15	75400809	Missense_Mutation	NA	R553Q	0.31
CESC	chr15	75375823	Frame_Shift_Ins	novel	*K1145Gfs20**	0.04
CESC	chr15	75400858	Nonsense_Mutation	NA	R537*	0.47
CESC	chr15	75409903	Missense_Mutation	rs376704049	P417L	0.45
CESC	chr15	75392513	Silent	novel	S860S	0.06
CESC	chr15	75371878	3'UTR	rs62029732		0.18
CESC	chr15	75410243	Missense_Mutation	novel	P351L	0.41
CESC	chr15	75389670	Silent	NA	I1001I	0.19
CESC	chr15	75400110	Missense_Mutation	novel	S595C	0.29
CHOL	chr15	75396401	Silent	novel	K650K	0.09
COAD	chr15	75394702	Missense_Mutation	NA	E752V	0.33
COAD	chr15	75401937	Missense_Mutation	NA	E481K	0.43
COAD	chr15	75392462	Silent	NA	R877R	0.44
COAD	chr15	75407091	Silent	novel	K457K	0.34
COAD	chr15	75384399	Silent	novel	V1020V	0.29
COAD	chr15	75400075	Nonsense_Mutation	novel	E607*	0.05
COAD	chr15	75412832	Silent	novel	Q229Q	0.06
COAD	chr15	75401937	Missense_Mutation	NA	E481K	0.2
COAD	chr15	75412895	Silent	rs758937437	V208V	0.24
COAD	chr15	75430221	Missense_Mutation	NA	T52M	0.22
COAD	chr15	75400810	Nonsense_Mutation	novel	R553*	0.18
COAD	chr15	75409842	Silent	novel	P437P	0.34
COAD	chr15	75389797	Missense_Mutation	NA	Y959C	0.29
COAD	chr15	75375837	Missense_Mutation	rs754243706	R1140Q	0.23
COAD	chr15	75380702	Nonsense_Mutation	NA	R1104*	0.24
COAD	chr15	75410237	Nonsense_Mutation	NA	L353*	0.19
COAD	chr15	75422594	Intron	novel		0.4
COAD	chr15	75412869	Missense_Mutation	novel	Q217R	0.19
COAD	chr15	75430187	Missense_Mutation	NA	Q63H	0.39
COAD	chr15	75392371	Missense_Mutation	novel	R908W	0.26
COAD	chr15	75410183	Missense_Mutation	NA	D371V	0.46
COAD	chr15	75372093	Silent	NA	G1236G	0.32
COAD	chr15	75396375	Frame_Shift_Del	NA	*G659Afs26**	0.14
COAD	chr15	75409882	Missense_Mutation	novel	G424D	0.08
COAD	chr15	75422518	Intron	novel		0.18
COAD	chr15	75412891	Nonsense_Mutation	NA	Q210*	0.34
COAD	chr15	75372100	Missense_Mutation	novel	L1234R	0.08
COAD	chr15	75375694	Missense_Mutation	NA	R1188W	0.12
COAD	chr15	75411567	Silent	NA	V311V	0.18
COAD	chr15	75430308	Missense_Mutation	NA	S23N	0.25
COAD	chr15	75384351	Silent	novel	Q1036Q	0.07
COAD	chr15	75392626	Missense_Mutation	NA	L823V	0.33
COAD	chr15	75396275	Silent	NA	V692V	0.25
COAD	chr15	75372187	Missense_Mutation	rs747873220	R1205H	0.44
DLBC	chr15	75400092	Missense_Mutation	novel	K601R	0.1
ESCA	chr15	75371325	3'UTR	novel		0.33
ESCA	chr15	75400121	Missense_Mutation	novel	W591C	0.21
ESCA	chr15	75375723	Missense_Mutation	novel	Y1178C	0.15
ESCA	chr15	75371794	3'UTR	novel		0.12
ESCA	chr15	75422473	Intron	novel		0.21
ESCA	chr15	75412841	Silent	novel	H226H	0.16
GBM	chr15	75389774	Missense_Mutation	novel	R967W	0.5
GBM	chr15	75384334	Nonsense_Mutation	novel	S1042*	0.18
GBM	chr15	75410151	Missense_Mutation	novel	D382N	0.1
GBM	chr15	75410141	Missense_Mutation	novel	S385I	0.17
GBM	chr15	75380710	Nonsense_Mutation	novel	Y1101*	0.45
GBM	chr15	75430320	Missense_Mutation	NA	R19Q	0.6
GBM	chr15	75409860	Silent	novel	P431P	0.1
GBM	chr15	75400749	Missense_Mutation	NA	R573Q	0.34
HNSC	chr15	75384416	Missense_Mutation	novel	E1015Q	0.14
HNSC	chr15	75375662	Splice_Region	novel		0.23
HNSC	chr15	75412973	Missense_Mutation	novel	F182L	0.17
HNSC	chr15	75400732	Missense_Mutation	novel	E579K	0.42
HNSC	chr15	75389732	Missense_Mutation	rs767869086	D981H	0.34
HNSC	chr15	75409902	Silent	rs142678572	P417P	0.11
HNSC	chr15	75411710	Missense_Mutation	NA	Q264K	0.22
HNSC	chr15	75375787	Missense_Mutation	novel	E1157Q	0.04
HNSC	chr15	75375797	Silent	novel	K1153K	0.21
HNSC	chr15	75410208	Missense_Mutation	novel	A363T	0.07
HNSC	chr15	75410157	Silent	rs139503359	L380L	0.18
KIRC	chr15	75389762	Missense_Mutation	NA	D971Y	0.29
KIRC	chr15	75400118	In_Frame_Del	novel	W591_S592del	0.03
KIRP	chr15	75412789	Nonsense_Mutation	NA	Q244*	0.13
KIRP	chr15	75407076	Silent	novel	T462T	0.39
KIRP	chr15	75372192	Silent	NA	S1203S	0.36
KIRP	chr15	75400124	Silent	rs373830836	S590S	0.35
LAML	chr15	75412956	Missense_Mutation	novel	P188L	0.03
LAML	chr15	75394806	Missense_Mutation	novel	W717C	0.07
LGG	chr15	75389730	Frame_Shift_Del	novel	*D975Vfs33**	0.12
LGG	chr15	75396498	Splice_Site	NA	X619_splice	0.1
LGG	chr15	75394699	Missense_Mutation	novel	I753T	0.27
LIHC	chr15	75412804	Missense_Mutation	NA	A239T	0.5
LIHC	chr15	75413020	Missense_Mutation	novel	R167C	0.32
LIHC	chr15	75400896	Missense_Mutation	novel	Y524F	0.3
LUAD	chr15	75422693	Frame_Shift_Del	novel	*P107Hfs15**	0.34
LUAD	chr15	75394802	Missense_Mutation	NA	E719K	0.14
LUAD	chr15	75412906	Missense_Mutation	NA	P205A	0.17
LUAD	chr15	75394860	Silent	novel	L699L	0.08
LUAD	chr15	75394793	Nonsense_Mutation	novel	E722*	0.23
LUAD	chr15	75413034	Frame_Shift_Del	novel	*P162Rfs4**	0.1
LUAD	chr15	75372130	Missense_Mutation	rs148486660	R1224H	0.11
LUAD	chr15	75400055	Missense_Mutation	novel	E613D	0.23
LUAD	chr15	75380708	Missense_Mutation	rs754902352	V1102M	0.23
LUAD	chr15	75392552	Frame_Shift_Del	novel	*T848Qfs29**	0.32
LUAD	chr15	75430312	Missense_Mutation	novel	G22C	0.32
LUAD	chr15	75389739	Missense_Mutation	novel	Q978H	0.18
LUAD	chr15	75409858	Missense_Mutation	novel	T432I	0.16
LUAD	chr15	75381635	Missense_Mutation	novel	S1089W	0.04
LUAD	chr15	75422623	Intron	novel		0.13
LUAD	chr15	75392296	Missense_Mutation	NA	I933V	0.18
LUSC	chr15	75396262	Nonsense_Mutation	novel	K697*	0.25
LUSC	chr15	75409879	Missense_Mutation	NA	C425F	0.05
LUSC	chr15	75392263	Missense_Mutation	novel	Q944E	0.23
LUSC	chr15	75392778	Missense_Mutation	novel	P772L	0.35
LUSC	chr15	75372153	Silent	novel	K1216K	0.19
LUSC	chr15	75392322	Missense_Mutation	NA	R924T	0.3
LUSC	chr15	75411697	Frame_Shift_Del	novel	*P268Hfs19**	0.4
LUSC	chr15	75392252	Silent	novel	L947L	0.08
LUSC	chr15	75414260	Missense_Mutation	novel	Q140K	0.1
LUSC	chr15	75412823	Silent	novel	A232A	0.28
LUSC	chr15	75392510	Silent	novel	P861P	0.46
LUSC	chr15	75392678	Missense_Mutation	novel	Q805H	0.22
LUSC	chr15	75412771	Missense_Mutation	novel	V250I	0.09
LUSC	chr15	75430390	5'UTR	novel		0.2
LUSC	chr15	75409951	Missense_Mutation	novel	R401T	0.17
LUSC	chr15	75371991	Missense_Mutation	novel	F1270L	0.14
LUSC	chr15	75401966	Missense_Mutation	NA	R471Q	0.08
OV	chr15	75384412	Missense_Mutation	novel	I1016N	0.15
OV	chr15	75401891	Missense_Mutation	novel	S496C	0.3
OV	chr15	75422764	In_Frame_Ins	novel	S83_S84insGTTSNLRY	0.11
OV	chr15	75384338	Missense_Mutation	novel	N1041D	0.19
OV	chr15	75401935	Silent	novel	E481E	0.2
OV	chr15	75411617	Missense_Mutation	novel	S295A	0.08
OV	chr15	75411618	Silent	novel	P294P	0.07
OV	chr15	75412836	Missense_Mutation	novel	S228F	0.05
OV	chr15	75422719	Silent	NA	V98V	0.26
OV	chr15	75400794	Missense_Mutation	NA	Y558C	0.27
PAAD	chr15	75372137	Missense_Mutation	novel	V1222M	0.14
PAAD	chr15	75389692	Missense_Mutation	novel	A994D	0.16
PAAD	chr15	75392274	Missense_Mutation	novel	S940I	0.21
PAAD	chr15	75392311	Missense_Mutation	novel	R928W	0.19
PRAD	chr15	75430369	Missense_Mutation	novel	R3W	0.44
READ	chr15	75401937	Missense_Mutation	NA	E481K	0.15
READ	chr15	75412990	Missense_Mutation	NA	D177N	0.16
READ	chr15	75411540	Silent	NA	G320G	0.39
READ	chr15	75411541	Missense_Mutation	NA	G320D	0.39
READ	chr15	75412955	Frame_Shift_Ins	NA	*G189Wfs5**	0.29
READ	chr15	75409878	Silent	novel	C425C	0.44
READ	chr15	75396345	Missense_Mutation	novel	L669P	0.25
READ	chr15	75412832	Silent	novel	Q229Q	0.05
READ	chr15	75372208	Missense_Mutation	NA	S1198F	0.47
READ	chr15	75392712	Missense_Mutation	novel	I794S	0.41
READ	chr15	75400828	Missense_Mutation	novel	D547Y	0.42
READ	chr15	75407142	Missense_Mutation	NA	K440N	0.48
READ	chr15	75411622	Missense_Mutation	novel	A293V	0.38
READ	chr15	75414228	Silent	novel	I150I	0.33
READ	chr15	75422501	Intron	novel		0.07
READ	chr15	75422769	Missense_Mutation	novel	H82N	0.38
READ	chr15	75375838	Nonsense_Mutation	NA	R1140*	0.3
READ	chr15	75380702	Nonsense_Mutation	NA	R1104*	0.32
READ	chr15	75392600	Silent	NA	L831L	0.29
SARC	chr15	75392473	Missense_Mutation	novel	Q874E	0.27
SARC	chr15	75372030	Silent	novel	V1257V	0.4
SARC	chr15	75430331	Silent	novel	A15A	0.55
SKCM	chr15	75392435	Silent	NA	F886F	0.24
SKCM	chr15	75371984	Missense_Mutation	NA	P1273T	0.38
SKCM	chr15	75396343	Nonsense_Mutation	novel	Q670*	0.4
SKCM	chr15	75375738	Missense_Mutation	novel	S1173F	0.16
SKCM	chr15	75394793	Missense_Mutation	NA	E722K	0.43
SKCM	chr15	75400054	Missense_Mutation	novel	D614N	0.2
SKCM	chr15	75392527	Missense_Mutation	NA	G856S	0.39
SKCM	chr15	75389802	Missense_Mutation	NA	D957E	0.3
SKCM	chr15	75392598	Missense_Mutation	NA	S832L	0.96
SKCM	chr15	75384283	Missense_Mutation	NA	S1059L	0.28
SKCM	chr15	75375842	Silent	novel	R1138R	0.08
SKCM	chr15	75392311	Missense_Mutation	novel	R928W	0.33
SKCM	chr15	75392312	Silent	novel	E927E	0.32
SKCM	chr15	75381626	Missense_Mutation	NA	P1092L	0.31
SKCM	chr15	75400063	Missense_Mutation	NA	R611C	0.12
SKCM	chr15	75401968	Splice_Region	NA	V470V	0.31
SKCM	chr15	75400772	Silent	NA	Y565Y	0.39
SKCM	chr15	75401889	Missense_Mutation	rs755980650	R497C	0.51
SKCM	chr15	75381663	Missense_Mutation	NA	E1080K	0.21
SKCM	chr15	75430303	Missense_Mutation	NA	E25K	0.35
SKCM	chr15	75412807	Missense_Mutation	NA	P238S	0.46
SKCM	chr15	75380634	Silent	novel	L1126L	0.69
SKCM	chr15	75414279	Silent	novel	V133V	0.27
SKCM	chr15	75392329	Missense_Mutation	NA	R922G	0.16
SKCM	chr15	75396428	Silent	NA	S641S	0.36
SKCM	chr15	75400095	Missense_Mutation	rs369940927	S600F	0.63
SKCM	chr15	75384420	Missense_Mutation	novel	S1013R	0.36
SKCM	chr15	75430235	Silent	rs370139085	T47T	0.43
SKCM	chr15	75407120	Nonsense_Mutation	novel	K448*	0.36
STAD	chr15	75372143	Nonsense_Mutation	NA	E1220*	0.36
STAD	chr15	75384408	Silent	NA	C1017C	0.26
STAD	chr15	75371910	3'UTR	novel		0.42
STAD	chr15	75392705	Silent	NA	H796H	0.05
STAD	chr15	75400062	Missense_Mutation	NA	R611H	0.31
STAD	chr15	75372014	Missense_Mutation	rs374431322	R1263C	0.3
STAD	chr15	75396460	Missense_Mutation	novel	R631W	0.38
STAD	chr15	75372168	Missense_Mutation	NA	Q1211H	0.41
STAD	chr15	75401908	Frame_Shift_Del	novel	*F490Lfs5**	0.33
STAD	chr15	75413014	Missense_Mutation	NA	S169P	0.21
STAD	chr15	75394805	Nonsense_Mutation	NA	R718*	0.32
STAD	chr15	75394838	Nonsense_Mutation	NA	R707*	0.41
STAD	chr15	75414301	Missense_Mutation	NA	A126V	0.27
STAD	chr15	75410266	Missense_Mutation	novel	K343N	0.14
STAD	chr15	75384404	Nonsense_Mutation	NA	Q1019*	0.21
STAD	chr15	75411680	Frame_Shift_Del	novel	*S274Pfs13**	0.14
STAD	chr15	75411633	Silent	rs769881227	S289S	0.41
STAD	chr15	75407060	Frame_Shift_Ins	novel	D468*	0.17
STAD	chr15	75396343	Nonsense_Mutation	novel	Q670*	0.28
STAD	chr15	75396415	Missense_Mutation	novel	E646K	0.3
STAD	chr15	75372078	Silent	NA	G1241G	0.05
STAD	chr15	75392408	Frame_Shift_Del	novel	*F895Lfs10**	0.3
STAD	chr15	75400048	Missense_Mutation	NA	R616C	0.28
THCA	chr15	75411728	Missense_Mutation	novel	A258S	0.01
THYM	chr15	75400065	Missense_Mutation	novel	Y610C	0.11
THYM	chr15	75371193	3'UTR	novel		0.2
THYM	chr15	75414301	Missense_Mutation	NA	A126V	0.41
THYM	chr15	75384359	Missense_Mutation	rs761480300	G1034R	0.08
UCEC	chr15	75392403	Missense_Mutation	NA	R897Q	0.49
UCEC	chr15	75392724	Missense_Mutation	NA	A790V	0.48
UCEC	chr15	75392389	Missense_Mutation	NA	L902I	0.32
UCEC	chr15	75410168	Missense_Mutation	NA	F376C	0.37
UCEC	chr15	75422536	Intron	rs372510391		0.42
UCEC	chr15	75371790	3'UTR	novel		0.38
UCEC	chr15	75392248	Nonsense_Mutation	novel	E949*	0.39
UCEC	chr15	75400849	Missense_Mutation	NA	E540K	0.29
UCEC	chr15	75381704	Missense_Mutation	NA	L1066R	0.52
UCEC	chr15	75412876	Missense_Mutation	rs754112981	G215S	0.44
UCEC	chr15	75407060	Missense_Mutation	novel	D468Y	0.38
UCEC	chr15	75396374	Frame_Shift_Ins	novel	*T660Hfs7**	0.45
UCEC	chr15	75380702	Nonsense_Mutation	NA	R1104*	0.43
UCEC	chr15	75372165	Silent	novel	A1212A	0.41
UCEC	chr15	75384411	Silent	NA	I1016I	0.34
UCEC	chr15	75400803	Missense_Mutation	novel	G555D	0.41
UCEC	chr15	75372187	Missense_Mutation	rs747873220	R1205H	0.24
UCEC	chr15	75400769	Silent	novel	Q566Q	0.1
UCEC	chr15	75409903	Missense_Mutation	rs376704049	P417L	0.33
UCEC	chr15	75412905	Missense_Mutation	novel	P205L	0.06
UCEC	chr15	75407060	Frame_Shift_Ins	novel	D468*	0.45
UCEC	chr15	75401931	In_Frame_Del	NA	Y480_N482del	0.77
UCEC	chr15	75384380	Nonsense_Mutation	novel	E1027*	0.19
UCEC	chr15	75392501	Silent	NA	S864S	0.24
UCEC	chr15	75396433	Missense_Mutation	NA	L640F	0.2
UCEC	chr15	75411633	Silent	rs769881227	S289S	0.42
UCEC	chr15	75389725	Missense_Mutation	NA	L983P	0.34
UCEC	chr15	75401925	Missense_Mutation	NA	R485C	0.3
UCEC	chr15	75411501	Silent	rs564686234	H333H	0.32
UCEC	chr15	75422501	Intron	novel		0.48
UCEC	chr15	75392461	Nonsense_Mutation	NA	G878*	0.41
UCEC	chr15	75394838	Nonsense_Mutation	NA	R707*	0.35
UCEC	chr15	75401938	Silent	rs148031099	Y480Y	0.24
UCEC	chr15	75392435	Missense_Mutation	NA	F886L	0.36
UCEC	chr15	75430365	Missense_Mutation	rs749564136	R4H	0.41
UCEC	chr15	75372038	Missense_Mutation	novel	H1255N	0.26
UCEC	chr15	75389728	Nonsense_Mutation	novel	S982*	0.39
UCEC	chr15	75407067	Missense_Mutation	novel	L465F	0.44
UCEC	chr15	75381633	Missense_Mutation	novel	D1090N	0.32
UCEC	chr15	75392713	Missense_Mutation	rs779075582	I794V	0.26
UCEC	chr15	75400047	Missense_Mutation	NA	R616H	0.3
UCEC	chr15	75371193	3'UTR	novel		0.38
UCEC	chr15	75422541	Intron	novel		0.23
UCEC	chr15	75380724	Splice_Site	novel	X1097_splice	0.16
UCEC	chr15	75371798	3'UTR	novel		0.36
UCEC	chr15	75372003	Silent	rs768298196	Y1266Y	0.43
UCEC	chr15	75372210	Splice_Site	novel	X1198_splice	0.36
UCEC	chr15	75380702	Nonsense_Mutation	NA	R1104*	0.32
UCEC	chr15	75392440	Missense_Mutation	novel	L885I	0.07
UCEC	chr15	75407061	Frame_Shift_Del	NA	*F467Lfs28**	0.32
UCEC	chr15	75381635	Missense_Mutation	novel	S1089L	0.44
UCEC	chr15	75392353	Missense_Mutation	rs745676137	E914K	0.53
UCEC	chr15	75410151	Missense_Mutation	novel	D382Y	0.39
UCEC	chr15	75400803	Missense_Mutation	NA	G555V	0.47
UCEC	chr15	75413019	Missense_Mutation	rs752788557	R167H	0.4
UCEC	chr15	75372200	Missense_Mutation	rs747451113	R1201C	0.15
UCEC	chr15	75392290	Nonsense_Mutation	NA	R935*	0.3
UCEC	chr15	75372172	Missense_Mutation	novel	F1210C	0.31
UCEC	chr15	75411526	Missense_Mutation	rs760260844	Y325C	0.29
UCEC	chr15	75411568	Missense_Mutation	NA	V311D	0.07
UCEC	chr15	75422519	Intron	rs763545869		0.48
UCEC	chr15	75396258	Missense_Mutation	NA	R698T	0.49
UCEC	chr15	75392428	Missense_Mutation	novel	N889D	0.15
UCEC	chr15	75400905	Missense_Mutation	novel	F521C	0.31
UCEC	chr15	75410159	Missense_Mutation	novel	F379S	0.2
UCEC	chr15	75401967	Nonsense_Mutation	NA	R471*	0.44
UCEC	chr15	75372003	Silent	rs768298196	Y1266Y	0.4
UCEC	chr15	75411579	Frame_Shift_Del	novel	*I308Sfs46**	0.34
UCEC	chr15	75392408	Frame_Shift_Del	novel	*F895Lfs10**	0.39
UCEC	chr15	75370930	3'Flank	novel		0.33
UCEC	chr15	75371948	3'UTR	novel		0.33
UCEC	chr15	75371193	3'UTR	novel		0.37
UCEC	chr15	75400844	Silent	NA	G541G	0.16
UCEC	chr15	75411663	Silent	rs535260527	P279P	0.4
UCEC	chr15	75389814	Silent	novel	V953V	0.27
UCEC	chr15	75392302	Silent	novel	L931L	0.44
UCEC	chr15	75396487	Missense_Mutation	novel	V622F	0.22
UCEC	chr15	75413005	Missense_Mutation	novel	F172V	0.33
UCEC	chr15	75384312	Frame_Shift_Del	novel	*Y1050Ifs8**	0.17
UCEC	chr15	75422603	Intron	novel		0.1
UCEC	chr15	75380702	Nonsense_Mutation	NA	R1104*	0.37
UCEC	chr15	75392404	Nonsense_Mutation	NA	R897*	0.47
UCEC	chr15	75380702	Nonsense_Mutation	NA	R1104*	0.16
UCEC	chr15	75392572	Nonsense_Mutation	novel	E841*	0.35
UCEC	chr15	75396339	Missense_Mutation	novel	R671M	0.53
UCEC	chr15	75410211	Missense_Mutation	novel	V362F	0.26
UCEC	chr15	75400158	Splice_Site	novel	X580_splice	0.3
UCEC	chr15	75396401	Missense_Mutation	NA	K650N	0.46
UCEC	chr15	75394843	Missense_Mutation	NA	E705A	0.2
UCEC	chr15	75410287	Splice_Site	novel	X337_splice	0.08
UCEC	chr15	75394804	Missense_Mutation	novel	R718Q	0.34
UCEC	chr15	75384356	Missense_Mutation	novel	G1035C	0.13
UCEC	chr15	75392354	Silent	rs138048130	A913A	0.26
UCEC	chr15	75400090	Missense_Mutation	novel	K602E	0.44
UCEC	chr15	75407102	Missense_Mutation	novel	D454Y	0.18
UCEC	chr15	75409989	Splice_Region	novel	L388L	0.4
UCEC	chr15	75422418	Intron	novel		0.21
UCEC	chr15	75422608	Intron	novel		0.19
UCEC	chr15	75375686	Silent	novel	T1190T	0.08
UCEC	chr15	75412990	Missense_Mutation	NA	D177N	0.42
UCS	chr15	75392395	Nonsense_Mutation	novel	Q900*	0.24

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.1966	0.0058042
LGG	AMP	0.0136	0.19963
PAAD	AMP	0.0652	0.20695
PAAD	DEL	0.1087	0.13216

Survival Analysis

Cancer	P-value	Q-value
THYM	0.041	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.011	Kaplan-Meier Survival Analysis
KIRP	0.041	Kaplan-Meier Survival Analysis
READ	0.034	Kaplan-Meier Survival Analysis
LAML	0.003	Kaplan-Meier Survival Analysis