EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000169385 (Gene tree)
Gene ID: 6036
Gene Symbol: RNASE2
Alias: EDN|RAF3|RNS2
Full Name: ribonuclease A family member 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 985 bases
Position: chr14:20,955,452-20,956,436
Accession: 10045
RBP type: canonical RBP
Summary: The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000303276	RnaseA	PF00074.20	6.2e-35	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000304625	RNASE2-201	755	-	ENSP00000303276	161 (aa)	-	P10153

Gene Model

Click here to download ENSG00000169385's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169385's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000169385	RNASE2	88	41.844	ENSG00000173431	RNASE8	87	41.844
ENSG00000169385	RNASE2	85	45.255	ENSG00000169413	RNASE6	87	45.255
ENSG00000169385	RNASE2	88	39.716	ENSG00000165799	RNASE7	87	39.716
ENSG00000169385	RNASE2	77	33.077	ENSG00000129538	RNASE1	89	33.621
ENSG00000169385	RNASE2	100	68.944	ENSG00000169397	RNASE3	100	68.944

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000169385	RNASE2	100	73.292	ENSANAG00000014479	-	100	73.292	Aotus_nancymaae
ENSG00000169385	RNASE2	100	54.658	ENSBTAG00000049914	-	86	54.658	Bos_taurus
ENSG00000169385	RNASE2	86	57.971	ENSBTAG00000025664	-	86	56.522	Bos_taurus
ENSG00000169385	RNASE2	100	70.186	ENSCJAG00000009638	-	100	70.186	Callithrix_jacchus
ENSG00000169385	RNASE2	86	53.623	ENSCHIG00000006998	-	100	53.416	Capra_hircus
ENSG00000169385	RNASE2	100	71.429	ENSCCAG00000008336	-	100	71.429	Cebus_capucinus
ENSG00000169385	RNASE2	100	65.839	ENSCATG00000021993	RNASE3	100	65.839	Cercocebus_atys
ENSG00000169385	RNASE2	100	83.230	ENSCSAG00000000344	RNASE2	100	83.230	Chlorocebus_sabaeus
ENSG00000169385	RNASE2	99	74.375	ENSCANG00000041784	RNASE2	99	74.375	Colobus_angolensis_palliatus
ENSG00000169385	RNASE2	89	48.276	ENSCGRG00001015465	Ear11	99	49.689	Cricetulus_griseus_chok1gshd
ENSG00000169385	RNASE2	90	54.110	ENSCGRG00001015384	Ear7	100	54.938	Cricetulus_griseus_chok1gshd
ENSG00000169385	RNASE2	55	48.864	ENSCGRG00001009946	-	71	47.009	Cricetulus_griseus_chok1gshd
ENSG00000169385	RNASE2	99	49.068	ENSCGRG00001015041	Ear10	99	49.068	Cricetulus_griseus_chok1gshd
ENSG00000169385	RNASE2	55	48.864	ENSCGRG00000013872	-	71	47.009	Cricetulus_griseus_crigri
ENSG00000169385	RNASE2	89	48.276	ENSCGRG00000013443	Ear10	99	49.689	Cricetulus_griseus_crigri
ENSG00000169385	RNASE2	90	54.110	ENSCGRG00000006180	Ear7	100	54.938	Cricetulus_griseus_crigri
ENSG00000169385	RNASE2	89	48.276	ENSCGRG00000003290	Ear11	99	49.689	Cricetulus_griseus_crigri
ENSG00000169385	RNASE2	99	55.000	ENSDNOG00000033465	-	99	55.000	Dasypus_novemcinctus
ENSG00000169385	RNASE2	99	48.125	ENSDNOG00000043774	-	99	48.125	Dasypus_novemcinctus
ENSG00000169385	RNASE2	86	49.275	ENSDORG00000028426	-	84	50.000	Dipodomys_ordii
ENSG00000169385	RNASE2	85	54.348	ENSEASG00005010211	-	85	54.545	Equus_asinus_asinus
ENSG00000169385	RNASE2	99	54.037	ENSECAG00000002332	-	99	54.037	Equus_caballus
ENSG00000169385	RNASE2	100	99.379	ENSGGOG00000043975	RNASE2	100	99.379	Gorilla_gorilla
ENSG00000169385	RNASE2	100	68.944	ENSGGOG00000037139	RNASE3	100	68.944	Gorilla_gorilla
ENSG00000169385	RNASE2	88	47.887	ENSSTOG00000030965	-	87	46.203	Ictidomys_tridecemlineatus
ENSG00000169385	RNASE2	99	50.000	ENSSTOG00000020133	-	99	50.000	Ictidomys_tridecemlineatus
ENSG00000169385	RNASE2	98	50.633	ENSSTOG00000024645	-	98	50.633	Ictidomys_tridecemlineatus
ENSG00000169385	RNASE2	100	68.944	ENSMFAG00000014172	-	100	68.944	Macaca_fascicularis
ENSG00000169385	RNASE2	100	65.217	ENSMFAG00000014110	-	100	65.217	Macaca_fascicularis
ENSG00000169385	RNASE2	100	68.944	ENSMMUG00000037666	-	100	68.944	Macaca_mulatta
ENSG00000169385	RNASE2	100	81.988	ENSMMUG00000046252	RNASE2	100	81.988	Macaca_mulatta
ENSG00000169385	RNASE2	100	66.460	ENSMMUG00000040314	-	100	66.460	Macaca_mulatta
ENSG00000169385	RNASE2	100	68.944	ENSMNEG00000001455	-	100	68.944	Macaca_nemestrina
ENSG00000169385	RNASE2	100	67.081	ENSMNEG00000038266	-	100	67.081	Macaca_nemestrina
ENSG00000169385	RNASE2	100	64.596	ENSMLEG00000002481	RNASE3	100	64.596	Mandrillus_leucophaeus
ENSG00000169385	RNASE2	83	55.970	ENSMAUG00000016887	-	83	55.970	Mesocricetus_auratus
ENSG00000169385	RNASE2	80	49.231	ENSMUSG00000059606	Rnase2b	82	49.231	Mus_musculus
ENSG00000169385	RNASE2	77	53.600	ENSMUSG00000050766	Ear14	80	53.175	Mus_musculus
ENSG00000169385	RNASE2	81	49.618	ENSMUSG00000047222	Rnase2a	83	49.618	Mus_musculus
ENSG00000169385	RNASE2	98	47.799	ENSMUSG00000090166	Ear10	98	47.799	Mus_musculus
ENSG00000169385	RNASE2	78	51.969	ENSMUSG00000062148	Ear6	98	51.572	Mus_musculus
ENSG00000169385	RNASE2	78	48.819	ENSMUSG00000072596	Ear2	98	47.799	Mus_musculus
ENSG00000169385	RNASE2	78	49.606	ENSMUSG00000072601	Ear1	98	48.428	Mus_musculus
ENSG00000169385	RNASE2	65	51.429	MGP_PahariEiJ_G0030246	-	97	51.429	Mus_pahari
ENSG00000169385	RNASE2	87	51.429	ENSMLUG00000023348	-	100	51.429	Myotis_lucifugus
ENSG00000169385	RNASE2	100	48.193	ENSMLUG00000030121	-	100	48.193	Myotis_lucifugus
ENSG00000169385	RNASE2	86	51.449	ENSOCUG00000007497	-	99	49.682	Oryctolagus_cuniculus
ENSG00000169385	RNASE2	100	44.172	ENSOCUG00000015951	-	100	44.172	Oryctolagus_cuniculus
ENSG00000169385	RNASE2	99	61.250	ENSOGAG00000013322	-	100	61.250	Otolemur_garnettii
ENSG00000169385	RNASE2	100	54.658	ENSOGAG00000032016	-	100	54.658	Otolemur_garnettii
ENSG00000169385	RNASE2	100	59.006	ENSOGAG00000027626	-	100	59.006	Otolemur_garnettii
ENSG00000169385	RNASE2	100	53.416	ENSOARG00000019719	-	100	53.416	Ovis_aries
ENSG00000169385	RNASE2	100	98.758	ENSPPAG00000033117	RNASE2	100	98.758	Pan_paniscus
ENSG00000169385	RNASE2	100	99.379	ENSPTRG00000006106	RNASE2	100	99.379	Pan_troglodytes
ENSG00000169385	RNASE2	100	68.323	ENSPANG00000005471	-	100	68.323	Papio_anubis
ENSG00000169385	RNASE2	89	52.448	ENSPEMG00000023630	-	100	54.037	Peromyscus_maniculatus_bairdii
ENSG00000169385	RNASE2	100	77.019	ENSPPYG00000005579	-	100	77.019	Pongo_abelii
ENSG00000169385	RNASE2	100	93.168	ENSPPYG00000005580	RNASE2	100	93.168	Pongo_abelii
ENSG00000169385	RNASE2	83	51.111	ENSRNOG00000031445	LOC100361866	100	50.000	Rattus_norvegicus
ENSG00000169385	RNASE2	80	52.308	ENSRNOG00000032133	Rnase2	81	52.344	Rattus_norvegicus
ENSG00000169385	RNASE2	80	53.846	ENSRNOG00000025515	Ear1	100	49.383	Rattus_norvegicus
ENSG00000169385	RNASE2	83	51.111	ENSRNOG00000050295	Rnase17	100	50.617	Rattus_norvegicus
ENSG00000169385	RNASE2	83	51.111	ENSRNOG00000053457	Rnase3	100	50.000	Rattus_norvegicus
ENSG00000169385	RNASE2	100	65.217	ENSRBIG00000010077	RNASE3	100	65.217	Rhinopithecus_bieti
ENSG00000169385	RNASE2	100	73.913	ENSSBOG00000007632	-	100	73.913	Saimiri_boliviensis_boliviensis
ENSG00000169385	RNASE2	86	52.899	ENSSSCG00000035377	-	89	52.113	Sus_scrofa

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001530	lipopolysaccharide binding	23992292.	IMP	Function
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0004522	ribonuclease A activity	-	IEA	Function
GO:0004540	ribonuclease activity	21873635.	IBA	Function
GO:0004540	ribonuclease activity	9826755.	IDA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0006401	RNA catabolic process	2734298.	TAS	Process
GO:0006935	chemotaxis	12855582.	IDA	Process
GO:0035578	azurophil granule lumen	-	TAS	Component
GO:0043152	induction of bacterial agglutination	23992292.	IMP	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0050829	defense response to Gram-negative bacterium	23992292.	IMP	Process
GO:0050830	defense response to Gram-positive bacterium	23992292.	IMP	Process
GO:0051607	defense response to virus	9826755.	IDA	Process
GO:0070062	extracellular exosome	23533145.	HDA	Component
GO:0090501	RNA phosphodiester bond hydrolysis	9826755.	IDA	Process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
16428483	Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine.	Clin Cancer Res	2006 Jan 15	Ye B	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr14	20956341	3'UTR	novel		0.46
BRCA	chr14	20955916	Missense_Mutation	novel	Q49K	0.09	RnaseA
CESC	chr14	20955935	Frame_Shift_Ins	novel	*Q55Hfs4**	0.14	RnaseA
COAD	chr14	20956083	Missense_Mutation	NA	Q104H	0.32	RnaseA
DLBC	chr14	20956396	3'UTR	novel		0.05
ESCA	chr14	20955998	Missense_Mutation	novel	A76D	0.42	RnaseA
ESCA	chr14	20956054	Missense_Mutation	novel	R95C	0.38	RnaseA
GBM	chr14	20956263	3'UTR	novel		0.07
GBM	chr14	20955955	Missense_Mutation	rs769149096	R62W	0.21	RnaseA
GBM	chr14	20956407	3'UTR	novel		0.14
GBM	chr14	20956292	3'UTR	novel		0.07
HNSC	chr14	20956389	3'UTR	novel		0.23
HNSC	chr14	20956095	Missense_Mutation	novel	I108M	0.2	RnaseA
HNSC	chr14	20956096	Missense_Mutation	novel	H109Y	0.21	RnaseA
HNSC	chr14	20955856	Missense_Mutation	novel	P29S	0.13
HNSC	chr14	20956148	Missense_Mutation	rs199746668	A126V	0.35	RnaseA
LAML	chr14	20955932	Missense_Mutation	novel	M54K	0.04	RnaseA
LIHC	chr14	20955799	Missense_Mutation	NA	I10V	0.24
LUAD	chr14	20955838	Missense_Mutation	NA	G23C	0.26
LUAD	chr14	20955861	Silent	novel	P30P	0.09
LUAD	chr14	20956142	Missense_Mutation	NA	R124T	0.24	RnaseA
LUAD	chr14	20955814	Silent	novel	L15L	0.28
LUAD	chr14	20955838	Missense_Mutation	NA	G23C	0.21
LUAD	chr14	20955899	Frame_Shift_Del	novel	*I43Tfs3**	0.06	RnaseA
LUAD	chr14	20955902	Missense_Mutation	NA	N44I	0.15	RnaseA
LUAD	chr14	20956095	Silent	NA	I108I	0.13
LUAD	chr14	20955855	Missense_Mutation	NA	K28N	0.08
LUAD	chr14	20956128	Silent	novel	N119N	0.21
LUAD	chr14	20955886	Missense_Mutation	NA	E39Q	0.23	RnaseA
LUSC	chr14	20956149	Silent	rs147476821	A126A	0.11
LUSC	chr14	20956411	3'UTR	novel		0.41
LUSC	chr14	20956251	Missense_Mutation	NA	I160M	0.24
LUSC	chr14	20956173	Nonsense_Mutation	novel	Y134*	0.24	RnaseA
LUSC	chr14	20956148	Missense_Mutation	NA	A126E	0.75	RnaseA
LUSC	chr14	20955939	Silent	rs200694912	V56V	0.63
OV	chr14	20955880	Missense_Mutation	NA	W37R	0.2	RnaseA
OV	chr14	20956316	3'UTR	novel		0.05
OV	chr14	20956318	3'UTR	novel		0.01
OV	chr14	20956277	3'UTR	novel		0.1
OV	chr14	20956279	3'UTR	novel		0.07
READ	chr14	20955939	Silent	rs200694912	V56V	0.37
READ	chr14	20956204	Nonsense_Mutation	NA	R145*	0.07	RnaseA
READ	chr14	20955808	Missense_Mutation	NA	L13F	0.39
READ	chr14	20956301	3'UTR	novel		0.39
SARC	chr14	20956205	Missense_Mutation	rs757362424	R145Q	0.5	RnaseA
SKCM	chr14	20956205	Missense_Mutation	rs757362424	R145Q	0.7	RnaseA
SKCM	chr14	20956406	3'UTR	novel		0.33
SKCM	chr14	20956330	3'UTR	novel		0.42
SKCM	chr14	20956198	Nonsense_Mutation	NA	Q143*	0.38	RnaseA
SKCM	chr14	20956155	Silent	NA	T128T	0.38
STAD	chr14	20955773	Translation_Start_Site	NA	M1?	0.29
STAD	chr14	20956204	Nonsense_Mutation	NA	R145*	0.62	RnaseA
STAD	chr14	20956148	Missense_Mutation	rs199746668	A126V	0.31	RnaseA
STAD	chr14	20956201	Nonsense_Mutation	rs755835358	R144*	0.4	RnaseA
STAD	chr14	20956204	Nonsense_Mutation	NA	R145*	0.4	RnaseA
STAD	chr14	20956258	3'UTR	novel		0.35
STAD	chr14	20955791	Missense_Mutation	novel	T7S	0.25
UCEC	chr14	20955977	Missense_Mutation	novel	T69N	0.05	RnaseA
UCEC	chr14	20956431	3'UTR	novel		0.46
UCEC	chr14	20955958	Nonsense_Mutation	rs141786181	R63*	0.51	RnaseA
UCEC	chr14	20956148	Missense_Mutation	rs199746668	A126V	0.29	RnaseA
UCEC	chr14	20955776	Missense_Mutation	novel	V2G	0.4
UCEC	chr14	20955927	Missense_Mutation	novel	N52K	0.34	RnaseA
UCEC	chr14	20956170	Missense_Mutation	novel	F133L	0.43	RnaseA
UCEC	chr14	20955931	Missense_Mutation	NA	M54V	0.42	RnaseA
UCEC	chr14	20955958	Nonsense_Mutation	rs141786181	R63*	0.38	RnaseA
UCEC	chr14	20955830	Missense_Mutation	NA	A20V	0.28
UCEC	chr14	20956193	Missense_Mutation	novel	R141I	0.22	RnaseA
UCEC	chr14	20956195	Missense_Mutation	novel	D142Y	0.19	RnaseA
UCEC	chr14	20956327	3'UTR	novel		0.37
UCEC	chr14	20956247	Missense_Mutation	novel	R159I	0.51
UCEC	chr14	20956374	3'UTR	novel		0.23
UCEC	chr14	20956149	Silent	rs147476821	A126A	0.49
UCEC	chr14	20955779	Missense_Mutation	NA	P3Q	0.44
UCEC	chr14	20955526	5'UTR	novel		0.3
UCEC	chr14	20956223	Missense_Mutation	novel	P151L	0.42	RnaseA
UCS	chr14	20955814	Silent	novel	L15L	0.25

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.2778	0.056464
ACC	DEL	0.1444	0.19769
CHOL	DEL	0.3611	0.00040262
HNSC	DEL	0.1092	0.0025503
KIRP	DEL	0.1667	0.085174
LUSC	DEL	0.2635	0.0082553
OV	AMP	0.2107	4.811e-06
PAAD	DEL	0.0924	0.11332
READ	DEL	0.3697	0.0043084

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
STAD	0.045	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.017	Kaplan-Meier Survival Analysis
PCPG	0.021	Kaplan-Meier Survival Analysis
GBM	0.025	Kaplan-Meier Survival Analysis
LIHC	0.0048	Kaplan-Meier Survival Analysis
LGG	0.00013	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742