EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000169397 (Gene tree)
Gene ID: 6037
Gene Symbol: RNASE3
Alias: ECP|RAF1|RNS3
Full Name: ribonuclease A family member 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 950 bases
Position: chr14:20,891,399-20,892,348
Accession: 10046
RBP type: canonical RBP
Summary: The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000302324	RnaseA	PF00074.20	7e-33	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000304639	RNASE3-201	720	-	ENSP00000302324	160 (aa)	-	P12724

Gene Model

Click here to download ENSG00000169397's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05310	Asthma	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000169397	Nose	3E-8	27560520

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169397's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000169397	RNASE3	85	43.382	ENSG00000169413	RNASE6	87	43.382
ENSG00000169397	RNASE3	100	68.944	ENSG00000169385	RNASE2	100	68.944
ENSG00000169397	RNASE3	88	37.143	ENSG00000165799	RNASE7	87	37.143
ENSG00000169397	RNASE3	88	37.143	ENSG00000173431	RNASE8	87	37.143
ENSG00000169397	RNASE3	69	31.532	ENSG00000129538	RNASE1	85	31.532

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000169397	RNASE3	100	70.000	ENSANAG00000014479	-	100	70.000	Aotus_nancymaae
ENSG00000169397	RNASE3	86	53.285	ENSBTAG00000025664	-	86	52.500	Bos_taurus
ENSG00000169397	RNASE3	100	50.000	ENSBTAG00000049914	-	86	50.000	Bos_taurus
ENSG00000169397	RNASE3	100	68.750	ENSCJAG00000009638	-	100	68.750	Callithrix_jacchus
ENSG00000169397	RNASE3	86	47.445	ENSCHIG00000006998	-	100	48.125	Capra_hircus
ENSG00000169397	RNASE3	100	67.500	ENSCCAG00000008336	-	100	67.500	Cebus_capucinus
ENSG00000169397	RNASE3	100	78.750	ENSCATG00000021993	RNASE3	100	78.750	Cercocebus_atys
ENSG00000169397	RNASE3	100	68.323	ENSCSAG00000000344	RNASE2	100	68.323	Chlorocebus_sabaeus
ENSG00000169397	RNASE3	98	61.392	ENSCANG00000041784	RNASE2	98	61.392	Colobus_angolensis_palliatus
ENSG00000169397	RNASE3	98	44.937	ENSCGRG00001015041	Ear10	98	44.937	Cricetulus_griseus_chok1gshd
ENSG00000169397	RNASE3	81	48.462	ENSCGRG00001015465	Ear11	98	47.468	Cricetulus_griseus_chok1gshd
ENSG00000169397	RNASE3	54	44.828	ENSCGRG00001009946	-	70	43.966	Cricetulus_griseus_chok1gshd
ENSG00000169397	RNASE3	81	50.769	ENSCGRG00001015384	Ear7	98	49.367	Cricetulus_griseus_chok1gshd
ENSG00000169397	RNASE3	81	50.769	ENSCGRG00000006180	Ear7	98	49.367	Cricetulus_griseus_crigri
ENSG00000169397	RNASE3	81	46.154	ENSCGRG00000013443	Ear10	98	45.570	Cricetulus_griseus_crigri
ENSG00000169397	RNASE3	54	44.828	ENSCGRG00000013872	-	70	43.966	Cricetulus_griseus_crigri
ENSG00000169397	RNASE3	81	48.462	ENSCGRG00000003290	Ear11	98	47.468	Cricetulus_griseus_crigri
ENSG00000169397	RNASE3	98	46.154	ENSDNOG00000043774	-	97	46.154	Dasypus_novemcinctus
ENSG00000169397	RNASE3	86	50.725	ENSDNOG00000033465	-	99	49.057	Dasypus_novemcinctus
ENSG00000169397	RNASE3	86	45.985	ENSDORG00000028426	-	88	45.775	Dipodomys_ordii
ENSG00000169397	RNASE3	84	47.407	ENSEASG00005010211	-	84	48.344	Equus_asinus_asinus
ENSG00000169397	RNASE3	98	48.101	ENSECAG00000002332	-	98	48.101	Equus_caballus
ENSG00000169397	RNASE3	100	97.500	ENSGGOG00000037139	RNASE3	100	97.500	Gorilla_gorilla
ENSG00000169397	RNASE3	100	69.565	ENSGGOG00000043975	RNASE2	100	69.565	Gorilla_gorilla
ENSG00000169397	RNASE3	98	52.229	ENSSTOG00000020133	-	98	52.229	Ictidomys_tridecemlineatus
ENSG00000169397	RNASE3	99	47.170	ENSSTOG00000024645	-	99	47.170	Ictidomys_tridecemlineatus
ENSG00000169397	RNASE3	89	45.455	ENSSTOG00000030965	-	88	44.025	Ictidomys_tridecemlineatus
ENSG00000169397	RNASE3	100	88.750	ENSMFAG00000014172	-	100	88.750	Macaca_fascicularis
ENSG00000169397	RNASE3	100	78.125	ENSMFAG00000014110	-	100	78.125	Macaca_fascicularis
ENSG00000169397	RNASE3	100	76.875	ENSMMUG00000040314	-	100	76.875	Macaca_mulatta
ENSG00000169397	RNASE3	100	66.460	ENSMMUG00000046252	RNASE2	100	66.460	Macaca_mulatta
ENSG00000169397	RNASE3	100	88.125	ENSMMUG00000037666	-	100	88.125	Macaca_mulatta
ENSG00000169397	RNASE3	100	76.250	ENSMNEG00000038266	-	100	76.250	Macaca_nemestrina
ENSG00000169397	RNASE3	100	88.750	ENSMNEG00000001455	-	100	88.750	Macaca_nemestrina
ENSG00000169397	RNASE3	100	76.250	ENSMLEG00000002481	RNASE3	100	76.250	Mandrillus_leucophaeus
ENSG00000169397	RNASE3	81	49.231	ENSMAUG00000016887	-	81	49.231	Mesocricetus_auratus
ENSG00000169397	RNASE3	79	47.244	ENSMUSG00000050766	Ear14	99	46.203	Mus_musculus
ENSG00000169397	RNASE3	80	50.388	ENSMUSG00000072601	Ear1	100	49.068	Mus_musculus
ENSG00000169397	RNASE3	100	47.826	ENSMUSG00000090166	Ear10	100	47.826	Mus_musculus
ENSG00000169397	RNASE3	80	48.062	ENSMUSG00000072596	Ear2	100	47.205	Mus_musculus
ENSG00000169397	RNASE3	78	46.825	ENSMUSG00000059606	Rnase2b	98	45.000	Mus_musculus
ENSG00000169397	RNASE3	79	52.756	ENSMUSG00000047222	Rnase2a	81	52.756	Mus_musculus
ENSG00000169397	RNASE3	80	47.287	ENSMUSG00000062148	Ear6	100	47.205	Mus_musculus
ENSG00000169397	RNASE3	67	45.794	MGP_PahariEiJ_G0030246	-	100	45.794	Mus_pahari
ENSG00000169397	RNASE3	100	44.242	ENSMLUG00000030121	-	100	44.242	Myotis_lucifugus
ENSG00000169397	RNASE3	88	50.714	ENSMLUG00000023348	-	100	50.714	Myotis_lucifugus
ENSG00000169397	RNASE3	88	50.355	ENSOCUG00000007497	-	99	49.359	Oryctolagus_cuniculus
ENSG00000169397	RNASE3	86	45.070	ENSOCUG00000015951	-	100	46.061	Oryctolagus_cuniculus
ENSG00000169397	RNASE3	100	54.375	ENSOGAG00000027626	-	100	54.375	Otolemur_garnettii
ENSG00000169397	RNASE3	100	55.000	ENSOGAG00000032016	-	100	55.000	Otolemur_garnettii
ENSG00000169397	RNASE3	98	55.063	ENSOGAG00000013322	-	99	55.063	Otolemur_garnettii
ENSG00000169397	RNASE3	100	48.125	ENSOARG00000019719	-	100	48.125	Ovis_aries
ENSG00000169397	RNASE3	100	69.565	ENSPPAG00000033117	RNASE2	100	69.565	Pan_paniscus
ENSG00000169397	RNASE3	100	68.944	ENSPTRG00000006106	RNASE2	100	68.944	Pan_troglodytes
ENSG00000169397	RNASE3	100	88.125	ENSPANG00000005471	-	100	88.125	Papio_anubis
ENSG00000169397	RNASE3	81	52.713	ENSPEMG00000023630	-	98	52.866	Peromyscus_maniculatus_bairdii
ENSG00000169397	RNASE3	100	68.944	ENSPPYG00000005580	RNASE2	100	68.944	Pongo_abelii
ENSG00000169397	RNASE3	100	76.875	ENSPPYG00000005579	-	100	76.875	Pongo_abelii
ENSG00000169397	RNASE3	78	53.175	ENSRNOG00000050295	Rnase17	98	51.899	Rattus_norvegicus
ENSG00000169397	RNASE3	81	54.198	ENSRNOG00000053457	Rnase3	98	52.532	Rattus_norvegicus
ENSG00000169397	RNASE3	78	50.000	ENSRNOG00000032133	Rnase2	80	50.000	Rattus_norvegicus
ENSG00000169397	RNASE3	78	50.794	ENSRNOG00000025515	Ear1	98	49.367	Rattus_norvegicus
ENSG00000169397	RNASE3	81	54.198	ENSRNOG00000031445	LOC100361866	98	52.532	Rattus_norvegicus
ENSG00000169397	RNASE3	100	76.875	ENSRBIG00000010077	RNASE3	100	76.875	Rhinopithecus_bieti
ENSG00000169397	RNASE3	100	71.250	ENSSBOG00000007632	-	100	71.250	Saimiri_boliviensis_boliviensis
ENSG00000169397	RNASE3	86	49.635	ENSSSCG00000035377	-	90	49.296	Sus_scrofa

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001530	lipopolysaccharide binding	23992292.	IDA	Function
GO:0002227	innate immune response in mucosa	12860195.	IDA	Process
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0004519	endonuclease activity	-	IEA	Function
GO:0004540	ribonuclease activity	21873635.	IBA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005615	extracellular space	12860195.	IDA	Component
GO:0006401	RNA catabolic process	2745977.	TAS	Process
GO:0019730	antimicrobial humoral response	-	TAS	Process
GO:0019731	antibacterial humoral response	12860195.	IDA	Process
GO:0035578	azurophil granule lumen	-	TAS	Component
GO:0043152	induction of bacterial agglutination	23992292.	IDA	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045087	innate immune response	23992292.	IDA	Process
GO:0050829	defense response to Gram-negative bacterium	23992292.	IDA	Process
GO:0050830	defense response to Gram-positive bacterium	12860195.23992292.	IDA	Process
GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	12860195.	IDA	Process
GO:0090501	RNA phosphodiester bond hydrolysis	-	IEA	Process