EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
  • Basic Information
  • Cancer Related Information

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000169398 (Gene tree)
Gene ID
5747
Gene Symbol
PTK2
Alias
FAK|FADK|FAK1|PPP1R71
Full Name
protein tyrosine kinase 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
344,317 bases
Position
chr8:140,657,900-141,002,216
Accession
9611
RBP type
non-canonical RBP
Summary
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
17318180The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation.EMBO J2007 Mar 21Tsai NP-
17376199Distinct signalling pathways promote phagocytosis of bacteria, latex beads and lipopolysaccharide in medfly haemocytes.Immunology2007 JulLamprou I-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000523670PTK2-247542-ENSP0000042838072 (aa)-E5RIR5
ENST00000520892PTK2-225571-ENSP00000427904121 (aa)-E5RFW9
ENST00000523675PTK2-248650--- (aa)--
ENST00000340930PTK2-2014414XM_017013664ENSP000003411891065 (aa)XP_016869153Q05397
ENST00000523679PTK2-249504-ENSP0000042902814 (aa)-E5RJN1
ENST00000523067PTK2-242488-ENSP0000042989566 (aa)-E5RG54
ENST00000521172PTK2-229507--- (aa)--
ENST00000517453PTK2-205571-ENSP00000430951117 (aa)-E5RH01
ENST00000519465PTK2-2133279-ENSP00000429170680 (aa)-E9PEI4
ENST00000524357PTK2-257535-ENSP00000429001122 (aa)-E5RJP0
ENST00000523388PTK2-243581-ENSP0000042970267 (aa)-E5RHK7
ENST00000524040PTK2-254475-ENSP0000043003751 (aa)-E5RH08
ENST00000519654PTK2-2154129-ENSP000004299291017 (aa)-H0YBP1
ENST00000430260PTK2-2031940-ENSP00000403416362 (aa)-B4DWJ1
ENST00000520917PTK2-226653--- (aa)--
ENST00000519635PTK2-214578--- (aa)--
ENST00000395218PTK2-2024415-ENSP000003786441006 (aa)-Q05397
ENST00000519899PTK2-217762--- (aa)--
ENST00000518509PTK2-209569--- (aa)--
ENST00000510126PTK2-204580--- (aa)--
ENST00000520151PTK2-220573-ENSP00000428482124 (aa)-E5RI29
ENST00000523539PTK2-2463236-ENSP00000428492724 (aa)-H0YB16
ENST00000522950PTK2-241548-ENSP0000042943767 (aa)-E5RII9
ENST00000523805PTK2-253440--- (aa)--
ENST00000519993PTK2-2184388-ENSP0000042857066 (aa)-E5RG54
ENST00000523803PTK2-252750-ENSP00000429530120 (aa)-E5RI72
ENST00000523435PTK2-244629-ENSP00000430828120 (aa)-E5RI03
ENST00000524257PTK2-256430-ENSP000004310238 (aa)-A0A1D5RMT1
ENST00000521332PTK2-231630-ENSP0000042940965 (aa)-E5RIK4
ENST00000517712PTK2-2063351-ENSP00000430916115 (aa)-E5RHD8
ENST00000520460PTK2-221572--- (aa)--
ENST00000521791PTK2-234556-ENSP0000042782566 (aa)-E5RG54
ENST00000521250PTK2-230592-ENSP0000042797272 (aa)-H0YAS0
ENST00000521029PTK2-227584-ENSP0000042995879 (aa)-E5RGP1
ENST00000521395PTK2-232540-ENSP00000429907107 (aa)-E5RH48
ENST00000520843PTK2-224438--- (aa)--
ENST00000523746PTK2-250574--- (aa)--
ENST00000518173PTK2-208441--- (aa)--
ENST00000519024PTK2-210576-ENSP00000428232168 (aa)-E5RJI4
ENST00000522684PTK2-2404955XM_017013669ENSP000004299111052 (aa)XP_016869158Q05397
ENST00000519419PTK2-2124439-ENSP000004291291096 (aa)-E7ESA6
ENST00000523474PTK2-245567--- (aa)--
ENST00000521907PTK2-235542-ENSP00000427795119 (aa)-E5RG66
ENST00000517887PTK2-2074661XM_017013653ENSP000004290821096 (aa)XP_016869142E7ESA6
ENST00000520045PTK2-219602-ENSP00000430044117 (aa)-E5RH01
ENST00000519881PTK2-216863-ENSP00000430277121 (aa)-E5RFW9
ENST00000523797PTK2-251405--- (aa)--
ENST00000521562PTK2-233678-ENSP00000431106132 (aa)-E5RJQ2
ENST00000521981PTK2-236552-ENSP00000428593128 (aa)-H0YB33
ENST00000524202PTK2-2553014-ENSP00000429023319 (aa)-H0YB99
ENST00000521059PTK2-2284405-ENSP000004294741052 (aa)-Q05397
ENST00000521985PTK2-237538--- (aa)--
ENST00000521986PTK2-2382393-ENSP00000430603753 (aa)-H0YBZ1
ENST00000520828PTK2-223574-ENSP0000042776259 (aa)-E5RG86
ENST00000520475PTK2-222570-ENSP00000428792156 (aa)-E5RGA6
ENST00000522424PTK2-239569-ENSP00000427774133 (aa)-E5RG80
ENST00000519361PTK2-211553--- (aa)--
Gene Model
Click here to download ENSG00000169398's gene model file
Pathways
Pathway IDPathway NameSource
hsa01522Endocrine resistanceKEGG
hsa04012ErbB signaling pathwayKEGG
hsa04062Chemokine signaling pathwayKEGG
hsa04151PI3K-Akt signaling pathwayKEGG
hsa04360Axon guidanceKEGG
hsa04370VEGF signaling pathwayKEGG
hsa04510Focal adhesionKEGG
hsa04670Leukocyte transendothelial migrationKEGG
hsa04810Regulation of actin cytoskeletonKEGG
hsa05100Bacterial invasion of epithelial cellsKEGG
hsa05146AmoebiasisKEGG
hsa05163Human cytomegalovirus infectionKEGG
hsa05165Human papillomavirus infectionKEGG
hsa05170Human immunodeficiency virus 1 infectionKEGG
hsa05200Pathways in cancerKEGG
hsa05202Transcriptional misregulation in cancerKEGG
hsa05205Proteoglycans in cancerKEGG
hsa05222Small cell lung cancerKEGG
hsa05418Fluid shear stress and atherosclerosisKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000169398Cardiovascular System2.6900000E-005-
ENSG00000169398Transplants4E-727595289
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000169398rs726837868140866188GMean corpuscular hemoglobin27863252[0.024-0.047] unit increase0.03577847EFO_0004527
ENSG00000169398rs100907748140816640?Acute graft versus host disease in bone marrow transplantation (recipient effect)27595289EFO_0004599
ENSG00000169398rs737147238140678939AFamilial squamous cell lung carcinoma29924316[3.65-27.08]9.94EFO_0000708|EFO_0006953
ENSG00000169398rs69947448140730769CAtrial fibrillation30061737[1.03-1.05]1.04EFO_0000275
ENSG00000169398rs117800238140982679TEducational attainment (MTAG)30038396[0.0073-0.0123] unit increase0.0098EFO_0004784
ENSG00000169398rs117800238140982679THighest math class taken30038396[0.011-0.02] unit increase0.0152EFO_0004875
ENSG00000169398rs101064068140996099CSelf-reported math ability (MTAG)30038396[0.0075-0.0145] unit increase0.011EFO_0004875
ENSG00000169398rs117800238140982679THighest math class taken (MTAG)30038396[0.0095-0.0157] unit increase0.0126EFO_0004875
ENSG00000169398rs43558228140736225AAtrial fibrillation29892015[1.03-1.07]1.05EFO_0000275
ENSG00000169398rs69932668140752560AAtrial fibrillation29892015[1.03-1.06]1.05EFO_0000275
ENSG00000169398rs101064068140996099CCognitive performance (MTAG)30038396[0.0095-0.0185] unit increase0.014EFO_0008354
ENSG00000169398rs117800238140982679TEducational attainment (years of education)30038396[0.0058-0.0112] unit increase0.0085EFO_0004784
ENSG00000169398rs132539898140922363?Educational attainment (years of education)30595370EFO_0004784
ENSG00000169398rs726837858140866103?Red cell distribution width30595370EFO_0005192
ENSG00000169398rs132560888140844857?Systolic blood pressure30595370EFO_0006335
ENSG00000169398rs100877828140848521TDiastolic blood pressure30224653[0.092-0.151] mmHg increase0.1211EFO_0006336
ENSG00000169398rs132660668140690018TSmoking initiation (ever regular vs never regular) (MTAG)30643251[0.0049-0.0092] unit increase0.00708517EFO_0006527
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169398's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000165MAPK cascade-TASProcess
GO:0000226microtubule cytoskeleton organization-IEAProcess
GO:0001525angiogenesis21873635.IBAProcess
GO:0001525angiogenesis20552554.TASProcess
GO:0001570vasculogenesis-IEAProcess
GO:0001725stress fiber24036928.IDAComponent
GO:0001764neuron migration-IEAProcess
GO:0001890placenta development20552554.TASProcess
GO:0001932regulation of protein phosphorylation19913511.IGIProcess
GO:0001934positive regulation of protein phosphorylation15166238.IMPProcess
GO:0003007heart morphogenesis20552554.TASProcess
GO:0003779actin binding16803572.IDAFunction
GO:0004672protein kinase activity-TASFunction
GO:0004713protein tyrosine kinase activity12391143.EXPFunction
GO:0004713protein tyrosine kinase activity-TASFunction
GO:0004715non-membrane spanning protein tyrosine kinase activity21873635.IBAFunction
GO:0004715non-membrane spanning protein tyrosine kinase activity10655584.11331870.IDAFunction
GO:0005515protein binding7561682.8649368.9285683.9756887.9786953.10655584.10822899.11331870.14688263.15657067.15855171.16291744.16803572.16966330.17525734.18256281.18497331.18560762.18835089.19494199.19732724.19857493.19917054.21034468.21266176.21383007.21637765.21741599.21900206.22270917.22402981.23065768.23397142.24658140.25241761.25814554.27178753.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus15855171.IDAComponent
GO:0005737cytoplasm21637765.IDAComponent
GO:0005815microtubule organizing center-IEAComponent
GO:0005829cytosol15855171.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005856cytoskeleton10801330.TASComponent
GO:0005886plasma membrane21637765.IDAComponent
GO:0005925focal adhesion21873635.IBAComponent
GO:0005925focal adhesion10655584.15855171.IDAComponent
GO:0005938cell cortex-IEAComponent
GO:0007097nuclear migration-IEAProcess
GO:0007172signal complex assembly-IEAProcess
GO:0007173epidermal growth factor receptor signaling pathway21873635.IBAProcess
GO:0007179transforming growth factor beta receptor signaling pathway24036928.IDAProcess
GO:0007229integrin-mediated signaling pathway24036928.IDAProcess
GO:0007229integrin-mediated signaling pathway11331870.IMPProcess
GO:0007229integrin-mediated signaling pathway15725728.TASProcess
GO:0007411axon guidance15725728.TASProcess
GO:0008284positive regulation of cell proliferation-ISSProcess
GO:0008360regulation of cell shape10655584.15166238.IMPProcess
GO:0008432JUN kinase binding10925297.IDAFunction
GO:0010507negative regulation of autophagy-IEAProcess
GO:0010594regulation of endothelial cell migration20552554.TASProcess
GO:0010613positive regulation of cardiac muscle hypertrophy-IEAProcess
GO:0010632regulation of epithelial cell migration19913511.IGIProcess
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling15166238.IMPProcess
GO:0016324apical plasma membrane-IEAComponent
GO:0018108peptidyl-tyrosine phosphorylation10655584.11331870.IDAProcess
GO:0019901protein kinase binding19118217.IPIFunction
GO:0019903protein phosphatase binding28759036.IPIFunction
GO:0021955central nervous system neuron axonogenesis-IEAProcess
GO:0022408negative regulation of cell-cell adhesion21703394.IDAProcess
GO:0030010establishment of cell polarity19525103.TASProcess
GO:0030027lamellipodium-IEAComponent
GO:0030154cell differentiation21873635.IBAProcess
GO:0030155regulation of cell adhesion21873635.IBAProcess
GO:0030198extracellular matrix organization-IEAProcess
GO:0030335positive regulation of cell migration11331870.21703394.IDAProcess
GO:0033628regulation of cell adhesion mediated by integrin10655584.IDAProcess
GO:0038007netrin-activated signaling pathway15725728.TASProcess
GO:0038083peptidyl-tyrosine autophosphorylation21873635.IBAProcess
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis-TASProcess
GO:0042127regulation of cell proliferation21873635.IBAProcess
GO:0042127regulation of cell proliferation18206965.IMPProcess
GO:0042169SH2 domain binding15077193.IPIFunction
GO:0043066negative regulation of apoptotic process15166238.IMPProcess
GO:0043087regulation of GTPase activity19525103.TASProcess
GO:0043197dendritic spine21873635.IBAComponent
GO:0043542endothelial cell migration-IEAProcess
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity15725728.TASProcess
GO:0045667regulation of osteoblast differentiation16927379.IMPProcess
GO:0045860positive regulation of protein kinase activity11331870.IMPProcess
GO:0046621negative regulation of organ growth-IEAProcess
GO:0046777protein autophosphorylation10655584.11331870.IDAProcess
GO:0048010vascular endothelial growth factor receptor signaling pathway-TASProcess
GO:0048013ephrin receptor signaling pathway10655584.IDAProcess
GO:0048013ephrin receptor signaling pathway-TASProcess
GO:0048870cell motility15725728.TASProcess
GO:0050771negative regulation of axonogenesis-IEAProcess
GO:0051493regulation of cytoskeleton organization15725728.TASProcess
GO:0051893regulation of focal adhesion assembly19913511.IGIProcess
GO:0051893regulation of focal adhesion assembly16919435.19525103.TASProcess
GO:0051897positive regulation of protein kinase B signaling15166238.IMPProcess
GO:0051964negative regulation of synapse assembly-IEAProcess
GO:0060396growth hormone receptor signaling pathway10925297.IDAProcess
GO:1900024regulation of substrate adhesion-dependent cell spreading19913511.IGIProcess
GO:2000060positive regulation of ubiquitin-dependent protein catabolic process-ISSProcess
GO:2000811negative regulation of anoikis22402981.IMPProcess

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23232649Sphingosine kinase 1 promotes tumor progression and confers malignancy phenotypes of colon cancer by regulating the focal adhesion kinase pathway and adhesion molecules.Int J Oncol2013 FebLiu SQdoi: 10.3892/ijo.2012.1733
25918719Emerging roles of focal adhesion kinase in cancer.Biomed Res Int2015Tai YLdoi: 10.1155/2015/690690
14699482Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling.Gastroenterology2004 JanThamilselvan V-
25391374Insulin-like growth factor-1 receptor signaling increases the invasive potential of human epidermal growth factor receptor 2-overexpressing breast cancer cells via Src-focal adhesion kinase and forkhead box protein M1.Mol Pharmacol2015 FebSanabria-Figueroa Edoi: 10.1124/mol.114.095380
20389021Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis.J Clin Invest2010 MaySood AKdoi: 10.1172/JCI40802
24675423Melittin suppresses EGF-induced cell motility and invasion by inhibiting PI3K/Akt/mTOR signaling pathway in breast cancer cells.Food Chem Toxicol2014 JunJeong YJdoi: 10.1016/j.fct.2014.03.022
27832972CXCL1 from tumor-associated lymphatic endothelial cells drives gastric cancer cell into lymphatic system via activating integrin β1/FAK/AKT signaling.Cancer Lett2017 Jan 28Wang Zdoi: 10.1016/j.canlet.2016.10.043
28692661The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma.PLoS One2017 Jul 10Begum Adoi: 10.1371/journal.pone.0180181
27061113Association of the upregulated expression of focal adhesion kinase with poor prognosis and tumor dissemination in hypopharyngeal cancer.Head Neck2016 AugOmura Gdoi: 10.1002/hed.24176
27064283FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal.J Clin Invest2016 May 2Haemmerle Mdoi: 10.1172/JCI85086
25684663Restoration of TRAIL-induced apoptosis in resistant human pancreatic cancer cells by a novel FAK inhibitor, PH11.Cancer Lett2015 Apr 28Dao Pdoi: 10.1016/j.canlet.2015.02.016
12169389Inhibition of migration of human glioblastoma cells by cerivastatin in association with focal adhesion kinase (FAK).Cancer Lett2002 Nov 28Obara S-
19147981Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling.J Clin Invest2009 FebPylayeva Ydoi: 10.1172/JCI37160
21667138A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt.Angiogenesis2011 SepMehta RRdoi: 10.1007/s10456-011-9220-6
20160475Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma.Cell Cycle2010 Mar 1Beierle EA-
23920124Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling.Cancer Lett2013 Dec 1Macha MAdoi: 10.1016/j.canlet.2013.07.037
22894899Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth.Cell Cycle2012 Sep 1Ucar DAdoi: 10.4161/cc.21611
20515733Focal adhesion kinase and p53 signal transduction pathways in cancer.Front Biosci (Landmark Ed)2010 Jun 1Golubovskaya VM-
26962872Focal Adhesion Kinase Inhibitors in Combination with Erlotinib Demonstrate Enhanced Anti-Tumor Activity in Non-Small Cell Lung Cancer.PLoS One2016 Mar 10Howe GAdoi: 10.1371/journal.pone.0150567
15532706Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines.Mol Cell Biochem2004 JulZhang L-
23536552High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma.Cancer Res2013 May 1Crompton BDdoi: 10.1158/0008-5472.CAN-12-1944
24284889Activated hepatic stellate cells promote hepatocellular carcinoma cell migration and invasion via the activation of FAK-MMP9 signaling.Oncol Rep2014 FebHan Sdoi: 10.3892/or.2013.2872
23588386Contribution of the PI3K/MMPs/Ln-5γ2 and EphA2/FAK/Paxillin signaling pathways to tumor growth and vasculogenic mimicry of gallbladder carcinomas.Int J Oncol2013 JunLu XSdoi: 10.3892/ijo.2013.1897
24657306Inhibition of both focal adhesion kinase and fibroblast growth factor receptor 2 pathways induces anti-tumor and anti-angiogenic activities.Cancer Lett2014 Jun 28Dao Pdoi: 10.1016/j.canlet.2014.03.007
16251422In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation.Am J Pathol2005 NovRiemenschneider MJ-
19695682Involvement of focal adhesion kinase in the progression and prognosis of gastrointestinal stromal tumors.Hum Pathol2009 NovKamo Ndoi: 10.1016/j.humpath.2009.05.004
16920698Gastrin-releasing peptide mediates its morphogenic properties in human colon cancer by upregulating intracellular adhesion protein-1 (ICAM-1) via focal adhesion kinase.Am J Physiol Gastrointest Liver Physiol2007 JanTaglia L-
27769864HMGB1 induces human non-small cell lung cancer cell motility by activating integrin αvβ3/FAK through TLR4/NF-??B signaling pathway.Biochem Biophys Res Commun2016 Nov 25Zhu Jdoi: 10.1016/j.bbrc.2016.10.052
27226554The Interaction between Cancer Stem Cell Marker CD133 and Src Protein Promotes Focal Adhesion Kinase (FAK) Phosphorylation and Cell Migration.J Biol Chem2016 Jul 22Liu Cdoi: 10.1074/jbc.M115.712976
28007596Soft matrices downregulate FAK activity to promote growth of tumor-repopulating cells.Biochem Biophys Res Commun2017 Jan 29Tan Ydoi: 10.1016/j.bbrc.2016.12.122
28757207Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.Mol Cell2017 Aug 3Yoon SOdoi: 10.1016/j.molcel.2017.06.033
27259715FAK Expression, Not Kinase Activity, Is a Key Mediator of Thyroid Tumorigenesis and Protumorigenic Processes.Mol Cancer Res2016 SepKessler BEdoi: 10.1158/1541-7786.MCR-16-0007
27708220Myocardin-related transcription factor A (MRTF-A) activity-dependent cell adhesion is correlated to focal adhesion kinase (FAK) activity.Oncotarget2016 Nov 1Kishi Tdoi: 10.18632/oncotarget.12350.
28286026Clonorchis sinensis excretory-secretory products promote the migration and invasion of cholangiocarcinoma cells by activating the integrin β4-FAK/Src signaling pathway.Mol Biochem Parasitol2017 JunPak JHdoi: 10.1016/j.molbiopara.2017.03.002
29133485Pyk2 and FAK differentially regulate invadopodia formation and function in breast cancer cells.J Cell Biol2018 Jan 2Genna Adoi: 10.1083/jcb.201702184
28652618Intracellular targeting of annexin A2 inhibits tumor cell adhesion, migration, and in vivo grafting.Sci Rep2017 Jun 26Staquicini DIdoi: 10.1038/s41598-017-03470-w.
30261900Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-β-induced epithelial-mesenchymal transition and metastasis by controlling TIF1γ in non-small cell lung cancer.Mol Cancer2018 Sep 27Wang Ldoi: 10.1186/s12943-018-0889-7.
21209368Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis.Am J Physiol Cell Physiol2011 MarWang Sdoi: 10.1152/ajpcell.00377.2010
18832579Focal adhesion kinase-related proline-rich tyrosine kinase 2 and focal adhesion kinase are co-overexpressed in early-stage and invasive ErbB-2-positive breast cancer and cooperate for breast cancer cell tumorigenesis and invasiveness.Am J Pathol2008 NovBehmoaram Edoi: 10.2353/ajpath.2008.080292
21042764Growth and differentiation factor-9 promotes adhesive and motile capacity of prostate cancer cells by up-regulating FAK and Paxillin via Smad dependent pathway.Oncol Rep2010 DecBokobza SM-
20127254Focal adhesion kinase serves as a marker of cervical lymph node metastasis and is a potential therapeutic target in tongue cancer.J Cancer Res Clin Oncol2010 SepJiang Hdoi: 10.1007/s00432-010-0780-4
20869748Focal adhesion kinase (FAK) gene amplification and its clinical implications in gastric cancer.Hum Pathol2010 DecPark JHdoi: 10.1016/j.humpath.2010.06.004
27542844Prolactin-induced PAK1 tyrosyl phosphorylation promotes FAK dephosphorylation, breast cancer cell motility, invasion and metastasis.BMC Cell Biol2016 Aug 20Hammer Adoi: 10.1186/s12860-016-0109-5.
28820394The C-terminal region of the focal adhesion kinase F1 domain binds Akt1 and inhibits pressure-induced cell adhesion.J Physiol Pharmacol2017 JunBasson MD-
29048635Novel focal adhesion kinase 1 inhibitor sensitizes lung cancer cells to radiation in a p53-independent manner.Int J Oncol2017 NovJung SYdoi: 10.3892/ijo.2017.4141
29515233Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway.Oncogene2018 MayCheng Ydoi: 10.1038/s41388-018-0177-4
19089993A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling.J Cell Physiol2009 AprSawhney RSdoi: 10.1002/jcp.21662.
22817694Vascular endothelial growth factor C enhances cervical cancer migration and invasion via activation of focal adhesion kinase.Gynecol Endocrinol2013 JanChen Hdoi: 10.3109/09513590.2012.705387
24655477Ambivalent role of pFAK-Y397 in serous ovarian cancer--a study of the OVCAD consortium.Mol Cancer2014 Mar 21Aust Sdoi: 10.1186/1476-4598-13-67.
20725143ECE-1 influences prostate cancer cell invasion via ET-1-mediated FAK phosphorylation and ET-1-independent mechanisms.Can J Physiol Pharmacol2010 AugWhyteside ARdoi: 10.1139/Y10-054.
24114522Somatic copy number alterations by whole-exome sequencing implicates YWHAZ and PTK2 in castration-resistant prostate cancer.J Pathol2013 DecMenon Rdoi: 10.1002/path.4274.
16136050Specific induction of pp125 focal adhesion kinase in human breast cancer.Br J Cancer2005 Sep 19Watermann DO-
25041835Association of CD98, integrin β1, integrin β3 and Fak with the progression and liver metastases of colorectal cancer.Pathol Res Pract2014 OctSun Cdoi: 10.1016/j.prp.2014.06.016
17028776Cancer/testis antigen cancer-associated gene (CAGE) promotes motility of cancer cells through activation of focal adhesion kinase (FAK).Biotechnol Lett2006 DecShim H-
20201928Ethanol enhances the interaction of breast cancer cells over-expressing ErbB2 with fibronectin.Alcohol Clin Exp Res2010 MayXu Mdoi: 10.1111/j.1530-0277.2010.01147.x
25277212Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.Nat Commun2014 Oct 3Leung CSdoi: 10.1038/ncomms6092.
17515959Phosphorylation of FAK, PI-3K, and impaired actin organization in CK-positive micrometastatic breast cancer cells.Mol Med2007 Jan-FebKallergi G-
20400979Ovarian cancer ascites protects from TRAIL-induced cell death through alphavbeta5 integrin-mediated focal adhesion kinase and Akt activation.Oncogene2010 Jun 17Lane Ddoi: 10.1038/onc.2010.107
12884911FAK regulates biological processes important for the pathogenesis of cancer.Cancer Metastasis Rev2003 DecGabarra-Niecko V-
22733437FAK, CD44v6, c-Met and EGFR in colorectal cancer parameters: tumour progression, metastasis, patient survival and receptor crosstalk.Int J Colorectal Dis2013 JanGarouniatis Adoi: 10.1007/s00384-012-1520-9
23143646Overexpression of focal adhesion kinase correlates with increased lymph node metastasis and poor prognosis in non-small-cell lung cancer.J Cancer Res Clin Oncol2013 MarJi HFdoi: 10.1007/s00432-012-1342-8
21338601Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo.Exp Cell Res2011 May 1Kurio Ndoi: 10.1016/j.yexcr.2011.02.008
25925610Filamin B Enhances the Invasiveness of Cancer Cells into 3D Collagen Matrices.Cell Struct Funct2015Iguchi Ydoi: 10.1247/csf.15001
22488171FAK and Src expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival.J Cancer Res Clin Oncol2012 AugTheocharis Sdoi: 10.1007/s00432-012-1215-1
18184462[Effect of gastrin on tyrosine phosphorylation of focal adhesion kinase in human gastric cancer cell line SGC7901].Ai Zheng2008 JanLi D-
16638855Weak expression of focal adhesion kinase (pp125FAK) in patients with cervical cancer is associated with poor disease outcome.Clin Cancer Res2006 Apr 15Gabriel B-
26386190HPW-RX40 restores anoikis sensitivity of human breast cancer cells by inhibiting integrin/FAK signaling.Toxicol Appl Pharmacol2015 Dec 1Chen IHdoi: 10.1016/j.taap.2015.09.011
20145126Activation of the integrin effector kinase focal adhesion kinase in cancer cells is regulated by crosstalk between protein kinase Calpha and the PDZ adapter protein mda-9/Syntenin.Cancer Res2010 Feb 15Hwangbo Cdoi: 10.1158/0008-5472.CAN-09-2447
22473839Effects of lysophosphatidic acid on calpain-mediated proteolysis of focal adhesion kinase in human prostate cancer cells.Prostate2012 NovPark JJdoi: 10.1002/pros.22513
21637765Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src.PLoS One2011Fu Mdoi: 10.1371/journal.pone.0019945
16912186Role of focal adhesion kinase and phosphatidylinositol 3'-kinase in integrin fibronectin receptor-mediated, matrix metalloproteinase-1-dependent invasion by metastatic prostate cancer cells.Cancer Res2006 Aug 15Zeng ZZ-
19364917FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion.J Cell Biol2009 Apr 20Chan KTdoi: 10.1083/jcb.200809110
18632638Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer.Cancer Res2008 Jul 15Aponte Mdoi: 10.1158/0008-5472.CAN-07-5771.
20140743Suppression of human MDA-MB-435S tumor by U6 promoter-driven short hairpin RNAs targeting focal adhesion kinase.J Cancer Res Clin Oncol2010 AugHuang ALdoi: 10.1007/s00432-010-0773-3
26506240Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer.Oncotarget2015 Dec 29Tseng RCdoi: 10.18632/oncotarget.6229.
24194567Phosphoproteomic profiling identifies focal adhesion kinase as a mediator of docetaxel resistance in castrate-resistant prostate cancer.Mol Cancer Ther2014 JanLee BYdoi: 10.1158/1535-7163.MCT-13-0225-T
20880986Estrogen receptor-alpha promotes breast cancer cell motility and invasion via focal adhesion kinase and N-WASP.Mol Endocrinol2010 NovSanchez AMdoi: 10.1210/me.2010-0252
15161045Focal adhesion kinase interacts with the transcriptional coactivator FHL2 and both are overexpressed in epithelial ovarian cancer.Anticancer Res2004 Mar-AprGabriel B-
19479902Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1.J Cell Biochem2009 Jul 1Demers MJdoi: 10.1002/jcb.22131.
18073135Phosphorylation of focal adhesion kinase promotes extravasation of breast cancer cells.Biochem Biophys Res Commun2008 Feb 8Earley S-
24370784Dysregulation of microRNA-34a expression in colorectal cancer inhibits the phosphorylation of FAK via VEGF.Dig Dis Sci2014 MayZhang Ddoi: 10.1007/s10620-013-2983-4
26786295KLF5 promotes cell migration by up-regulating FYN in bladder cancer cells.FEBS Lett2016 FebDu Cdoi: 10.1002/1873-3468.12069
16998832Enhanced expression of cholecystokinin-2 receptor promotes the progression of colon cancer through activation of focal adhesion kinase.Int J Cancer2006 Dec 15Yu HG-
21483099Tyrosine phosphatases in the HER2-directed motility of ovarian cancer cells: Involvement of PTPN12, ERK5 and FAK.Anal Cell Pathol (Amst)2011Villa-Moruzzi Edoi: 10.3233/ACP-2011-0008.
24693876Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer.BMC Cancer2014 Apr 2Alexopoulou ANdoi: 10.1186/1471-2407-14-237.
19029090The lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cells.J Biol Chem2009 Jan 16Zhao Ydoi: 10.1074/jbc.M802612200
24885567Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway.Mol Cancer2014 May 4Du Tdoi: 10.1186/1476-4598-13-100.
26443539Overexpression of Rab5a promotes hepatocellular carcinoma cell proliferation and invasion via FAK signaling pathway.Tumour Biol2016 MarGeng Ddoi: 10.1007/s13277-015-4124-5
18449907Genetic upregulation of matriptase-2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation.J Cell Physiol2008 SepSanders AJdoi: 10.1002/jcp.21460.
24858039Vimentin regulates lung cancer cell adhesion through a VAV2-Rac1 pathway to control focal adhesion kinase activity.Oncogene2015 Apr 9Havel LSdoi: 10.1038/onc.2014.123
20233709Progesterone receptor enhances breast cancer cell motility and invasion via extranuclear activation of focal adhesion kinase.Endocr Relat Cancer2010 Apr 21Fu XDdoi: 10.1677/ERC-09-0258
20811717P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910.Int J Oncol2010 OctLi LH-
23328701RNA interference targeting human FAK and EGFR suppresses human non-small-cell lung cancer xenograft growth in nude mice.Cancer Gene Ther2013 FebLi Cdoi: 10.1038/cgt.2012.91
23387972Focal adhesion kinase regulates expression of thioredoxin-interacting protein (TXNIP) in cancer cells.Anticancer Agents Med Chem2014 JanHo B-
26579576Akt1 binds focal adhesion kinase via the Akt1 kinase domain independently of the pleckstrin homology domain.J Physiol Pharmacol2015 OctBasson MD-
26758421Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin α2/β5/FAK signaling pathway.Oncotarget2016 Feb 23Liu Fdoi: 10.18632/oncotarget.6840.
19671193The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis.BMC Cancer2009 Aug 12Golubovskaya VMdoi: 10.1186/1471-2407-9-280.
19020730TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells.Oncol Rep2008 DecWang ZG-
24533083Down-regulation of Gli transcription factor leads to the inhibition of migration and invasion of ovarian cancer cells via integrin β4-mediated FAK signaling.PLoS One2014 Feb 12Chen Qdoi: 10.1371/journal.pone.0088386
25070659USP22 promotes epithelial-mesenchymal transition via the FAK pathway in pancreatic cancer cells.Oncol Rep2014 OctNing Zdoi: 10.3892/or.2014.3354
25703140CEACAM6 promotes tumor angiogenesis and vasculogenic mimicry in gastric cancer via FAK signaling.Biochim Biophys Acta2015 MayZang Mdoi: 10.1016/j.bbadis.2015.02.005
22481092Paxillin phosphorylation and complexing with Erk and FAK are regulated by PLD activity in MDA-MB-231 cells.Cell Signal2012 AugPribic Jdoi: 10.1016/j.cellsig.2012.03.015
22760257Effect of small interfering RNA transfection on FAK and DLC1 mRNA expression in OVCAR-3.Mol Biol Rep2012 OctShi Hdoi: 10.1007/s11033-012-1724-7
18353772Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells.J Biol Chem2008 May 16Wang Xdoi: 10.1074/jbc.M709300200
25625869Focal adhesion kinase regulates the phosphorylation protein tyrosine phosphatase-α at Tyr789 in breast cancer cells.Mol Med Rep2015 JunFang XQdoi: 10.3892/mmr.2015.3262
25839165Down-regulation of ARNT promotes cancer metastasis by activating the fibronectin/integrin β1/FAK axis.Oncotarget2015 May 10Huang CR-
26984508FAK tyrosine 407 organized with integrin αVβ5 in Hs578Ts(i)8 advanced triple-negative breast cancer cells.Int J Oncol2016 MayPayan Idoi: 10.3892/ijo.2016.3422
22934708The role of focal adhesion kinase in lung cancer.Anticancer Agents Med Chem2013 MayDy GK-
25726913Lewis y enhances CAM-DR in ovarian cancer cells by activating the FAK signaling pathway and upregulating Bcl-2/Bcl-XL expression.Biochimie2015 JunYan Ldoi: 10.1016/j.biochi.2015.01.013
24742605The Polycomb group protein RING1B is overexpressed in ductal breast carcinoma and is required to sustain FAK steady state levels in breast cancer epithelial cells.Oncotarget2014 Apr 30Bosch A-
23812425KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer.Oncogene2014 May 29Lu Hdoi: 10.1038/onc.2013.247
21875461[FAK/c-Src signaling pathway mediates the expression of cell surface HSP90 in cultured human prostate cancer cells and its association with their invasive capability].Zhonghua Zhong Liu Za Zhi2011 MayLiu XG-
21281808Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells.Am J Pathol2011 FebNagaharu Kdoi: 10.1016/j.ajpath.2010.10.015.
12216109Functional involvement of src and focal adhesion kinase in a CD99 splice variant-induced motility of human breast cancer cells.Exp Mol Med2002 Jul 31Lee HJ-
26648422MicroRNA7 suppresses human colon cancer invasion and proliferation by targeting the expression of focal adhesion kinase.Mol Med Rep2016 FebZeng CYdoi: 10.3892/mmr.2015.4643
17982280Activation of FAK/PI3K/Rac1 signaling controls actin reorganization and inhibits cell motility in human cancer cells.Cell Physiol Biochem2007Kallergi G-
21646305Cortactin and focal adhesion kinase as predictors of cancer risk in patients with laryngeal premalignancy.Cancer Prev Res (Phila)2011 AugRodrigo JPdoi: 10.1158/1940-6207.CAPR-10-0338
24223781RTK/ERK pathway under natural selection associated with prostate cancer.PLoS One2013 Nov 4Chen Ydoi: 10.1371/journal.pone.0078254
12847914Inhibition of focal adhesion kinase by antisense oligonucleotides enhances the sensitivity of breast cancer cells to camptothecins.Biocell2003 AprSatoh TH-
15657578RET signals through focal adhesion kinase in medullary thyroid cancer cells.Surgery2004 DecPanta GR-
18922979Focal adhesion kinase controls aggressive phenotype of androgen-independent prostate cancer.Mol Cancer Res2008 OctJohnson TRdoi: 10.1158/1541-7786.MCR-08-0052.
21868344[Expression of deleted in liver cancer 1 and phosphorelated focal adhesion kinase in breast cancer].Nan Fang Yi Ke Da Xue Xue Bao2011 AugFeng Y-
12939401Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines.Mol Cancer Res2003 AugGolubovskaya VM-
17317726FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway.FASEB J2007 JunThamilselvan V-
18562041Focal adhesion kinase is not required for Src-induced formation of invadopodia in KM12C colon cancer cells and can interfere with their assembly.Eur J Cell Biol2008 SepVitale Sdoi: 10.1016/j.ejcb.2008.04.002
24360952Somatic mutational analysis of FAK in breast cancer: a novel gain-of-function mutation due to deletion of exon 33.Biochem Biophys Res Commun2014 Jan 10Fang XQdoi: 10.1016/j.bbrc.2013.11.134
23275034Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression.Clin Exp Metastasis2013 JunWard KKdoi: 10.1007/s10585-012-9562-5
16842883Up-regulation of focal adhesion kinase in non-small cell lung cancer.Lung Cancer2006 SepCarelli S-
25749031FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells.Oncotarget2015 Mar 10Taliaferro-Smith L-
27175819Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-??B signaling pathways.Oncol Rep2016 JulJiang Qdoi: 10.3892/or.2016.4798
22934707FAK and Nanog cross talk with p53 in cancer stem cells.Anticancer Agents Med Chem2013 MayGolubovskaya VM-
27278554Effects of combining erlotinib and RNA-interfered downregulation of focal adhesion kinase expression on gastric cancer.J Int Med Res2016 AugFeng Rdoi: 10.1177/0300060516647550
27178753Activation of focal adhesion kinase through an interaction with β4 integrin contributes to tumorigenicity of colon cancer.FEBS Lett2016 JunTai YLdoi: 10.1002/1873-3468.12215
27400161Tyrosine Phosphorylation of Focal Adhesion Anchoring Proteins Enhances Human Pancreatic Cancer Cell Invasion.Pancreas2016 AugOkamoto Hdoi: 10.1097/MPA.0000000000000629.
27834811Focal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell Dissociation.Int J Mol Sci2016 Nov 8B??raud-Dufour S-
28459212Focal adhesion kinase inhibitor PF573228 and death receptor 5 agonist lexatumumab synergistically induce apoptosis in pancreatic carcinoma.Tumour Biol2017 MayZhao Xdoi: 10.1177/1010428317699120.
27171907Focal adhesion kinase: predictor of tumour response and risk factor for recurrence after neoadjuvant chemoradiation in rectal cancer.J Cell Mol Med2016 SepG??mez Del Pulgar Tdoi: 10.1111/jcmm.12879
28050799Thyroid Hormone Controls Breast Cancer Cell Movement via Integrin αV/β3/SRC/FAK/PI3-Kinases.Horm Cancer2017 FebFlamini MIdoi: 10.1007/s12672-016-0280-3
27495308SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway.Breast Cancer Res2016 Aug 5Sethuraman Adoi: 10.1186/s13058-016-0738-9.
27698189miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3.Cancer Res2016 Oct 1Zhou Y-
27637100Prognostic Value of Focal Adhesion Kinase (FAK) in Human Solid Carcinomas: A Meta-Analysis.PLoS One2016 Sep 16Zeng XQdoi: 10.1371/journal.pone.0162666
26751774MUC5AC interactions with integrin β4 enhances the migration of lung cancer cells through FAK signaling.Oncogene2016 Aug 4Lakshmanan Idoi: 10.1038/onc.2015.478
28145580sp2 -Iminosugar α-glucosidase inhibitor 1-C-octyl-2-oxa-3-oxocastanospermine specifically affected breast cancer cell migration through Stim1, β1-integrin, and FAK signaling pathways.J Cell Physiol2017 DecGueder Ndoi: 10.1002/jcp.25832
28398603Kctd20 promotes the development of non-small cell lung cancer through activating Fak/AKT pathway and predicts poor overall survival of patients.Mol Carcinog2017 SepZhang Xdoi: 10.1002/mc.22660
27130522Retinoic acid induces nuclear FAK translocation and reduces breast cancer cell adhesion through Moesin, FAK, and Paxillin.Mol Cell Endocrinol2016 Jul 15Sanchez AMdoi: 10.1016/j.mce.2016.04.021
27095481Paxillin, a novel controller in the signaling of estrogen to FAK/N-WASP/Arp2/3 complex in breast cancer cells.Mol Cell Endocrinol2016 Jul 15Shortrede JEdoi: 10.1016/j.mce.2016.04.007
27185392Bile acids-mediated overexpression of MUC4 via FAK-dependent c-Jun activation in pancreatic cancer.Mol Oncol2016 AugJoshi Sdoi: 10.1016/j.molonc.2016.04.007
28103122PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment.Autophagy2017 Mar 4Ma Kdoi: 10.1080/15548627.2016.1272742
28933561CKAP2 Promotes Ovarian Cancer Proliferation and Tumorigenesis Through the FAK-ERK Pathway.DNA Cell Biol2017 NovZhang Mdoi: 10.1089/dna.2017.3876
27733373A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors.Ann Oncol2016 DecSoria JCdoi: 10.1093/annonc/mdw427
27233075BKCa promotes growth and metastasis of prostate cancer through facilitating the coupling between αvβ3 integrin and FAK.Oncotarget2016 Jun 28Du Cdoi: 10.18632/oncotarget.9559.
27286256HER2 reduces breast cancer radiosensitivity by activating focal adhesion kinase in vitro and in vivo.Oncotarget2016 Jul 19Hou Jdoi: 10.18632/oncotarget.9870.
28338656Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2.Cell Death Differ2017 MayGnani Ddoi: 10.1038/cdd.2017.34
26993780Kr??ppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis.Oncotarget2016 Apr 26Mukherjee Ddoi: 10.18632/oncotarget.8083.
28361350FOXM1 transcriptionally regulates expression of integrin β1 in triple-negative breast cancer.Breast Cancer Res Treat2017 JunHamurcu Zdoi: 10.1007/s10549-017-4207-7
28713929MicroRNA-379 inhibits metastasis and epithelial-mesenchymal transition via targeting FAK/AKT signaling in gastric cancer.Int J Oncol2017 SepXu Mdoi: 10.3892/ijo.2017.4072
28498494A Mercaptoacetamide-Based Class II Histone Deacetylase Inhibitor Suppresses Cell Migration and Invasion in Monomorphic Malignant Human Glioma Cells by Inhibiting FAK/STAT3 Signaling.J Cell Biochem2017 DecNam JHdoi: 10.1002/jcb.26133
29777904Axed MUC4 (MUC4/X) aggravates pancreatic malignant phenotype by activating integrin-β1/FAK/ERK pathway.Biochim Biophys Acta Mol Basis Dis2018 AugJahan Rdoi: 10.1016/j.bbadis.2018.05.008
29358562Hypoxia stimulates invasion and migration of human cervical cancer cell lines HeLa/SiHa through the Rab11 trafficking of integrin αvβ3/FAK/PI3K pathway-mediated Rac1 activation.J Biosci2017 SepXu H-
29174800ETS1 induction by the microenvironment promotes ovarian cancer metastasis through focal adhesion kinase.Cancer Lett2018 Feb 1Tomar Sdoi: 10.1016/j.canlet.2017.11.012
30106432Netrin1 induces the proliferation of gastric cancer cells via the ERK/MAPK signaling pathway and FAK activation.Oncol Rep2018 OctYin Kdoi: 10.3892/or.2018.6614
30272334MicroRNA433 inhibits cell growth and induces apoptosis in human cervical cancer through PI3K/AKT signaling by targeting FAK.Oncol Rep2018 DecXu Jdoi: 10.3892/or.2018.6718
29087503Somatic Mutations and Splicing Variants of Focal Adhesion Kinase in Non-Small Cell Lung Cancer.J Natl Cancer Inst2018 Feb 1Zhou Bdoi: 10.1093/jnci/djx157.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr8140739031Silentrs370124116D604D0.69
BLCAchr8140702611Missense_MutationNAH776D0.13
BLCAchr8140735411Missense_MutationnovelQ624E0.08
BLCAchr8140668374Silentrs370475701S920S0.41
BLCAchr8140744682Missense_MutationNAA535V0.22
BLCAchr8140746802Missense_MutationnovelE492D0.4
BLCAchr8140701000Missense_MutationnovelR797L0.13
BLCAchr8140732569Intronnovel0.16
BLCAchr8140764320Intronnovel0.15
BLCAchr8140675482Missense_MutationnovelI860M0.47
BLCAchr8140764261Missense_MutationnovelE403K0.16
BLCAchr8140800565SilentNAV329V0.07
BLCAchr8140659584In_Frame_DelnovelQ1006_Q1014del0.22
BLCAchr8140764349Intronnovel0.17
BLCAchr8140864362Missense_MutationnovelL134V0.44
BLCAchr8140764308Intronnovel0.09
BRCAchr8140743317Missense_MutationNAR550W0.35
BRCAchr8140890598Missense_Mutationrs374554975S47N0.47
BRCAchr8140739053Missense_MutationNAR597L0.3
BRCAchr8140743277Missense_MutationNAG563V0.18
BRCAchr8140746822Missense_MutationNAL486V0.13
BRCAchr8140830487Missense_MutationnovelL211F0.07
BRCAchr8140818909Frame_Shift_InsnovelD254*0.05
BRCAchr8140735258Nonsense_MutationNAQ675*0.24
BRCAchr8140735313Silentrs776101894T656T0.07
BRCAchr8140674341Missense_Mutationrs542542126A889V0.11
BRCAchr8140800574Splice_RegionnovelP326P0.06
BRCAchr8140818914Missense_MutationNAR252I0.26
BRCAchr8140789485Missense_MutationnovelV389A0.28
BRCAchr8140735447Missense_MutationnovelM612V0.1
BRCAchr8140890617Missense_MutationNAH41Y0.19
CESCchr8140864347Missense_MutationNAE139K0.11
CESCchr8140803593Missense_MutationNAD309Y0.33
CESCchr8140732642Intronnovel0.23
CESCchr8140732594Intronnovel0.15
CESCchr8140879577Missense_MutationNAR86C0.32
CESCchr8140890704Missense_MutationnovelH12Y0.66
CHOLchr8140659528Missense_MutationnovelN1033H0.43
COADchr8140879631Missense_MutationNAI68V0.4
COADchr8140879523Missense_Mutationrs200017517V104I0.4
COADchr8140800487Silentrs146407650S355S0.18
COADchr8140668399Frame_Shift_DelNAP912Lfs*170.38
COADchr8140735384Missense_Mutationrs371607821G633S0.19
COADchr8140702673Missense_MutationnovelA755V0.05
COADchr8140668404SilentnovelS910S0.38
COADchr8140706128Missense_MutationNAN740K0.35
COADchr8140706130Missense_MutationNAN740D0.32
COADchr8140761221Nonsense_MutationnovelR426*0.34
COADchr8140668399Frame_Shift_DelNAP912Lfs*170.48
COADchr8140659479Missense_Mutationrs746222859T1049M0.26
COADchr8140700919Missense_Mutationrs200596356R824H0.28
COADchr8140732583Intronnovel0.43
COADchr81406594493'UTRrs7488790630.26
COADchr8140735284Missense_MutationNAR666Q0.36
COADchr8140700918SilentNAR824R0.19
COADchr8140700945SilentnovelQ815Q0.16
COADchr8140830519Missense_MutationnovelV201I0.51
COADchr81408907525'UTRNA0.26
COADchr8140700992Missense_MutationnovelG800W0.07
COADchr8140818887Missense_MutationNAA261V0.43
COADchr8140864383Missense_MutationNAR127C0.06
COADchr8140864312Missense_MutationNAQ150H0.16
COADchr8140700959Missense_MutationnovelR811C0.32
COADchr8140890734Missense_Mutationrs775490424A2T0.44
COADchr8140686695Splice_SitenovelX834_splice0.16
COADchr8140717679SilentNAQ687Q0.21
ESCAchr8140789523Silentrs748726361L376L0.14
ESCAchr8140800507Missense_MutationnovelR349W0.08
ESCAchr8140735381Nonsense_MutationNAR634*0.28
GBMchr81406594313'UTRnovel0.26
GBMchr8140746790Nonsense_MutationnovelW496*0.17
GBMchr8140735380Missense_MutationnovelR634Q0.4
GBMchr8140764285Missense_MutationnovelD395Y0.21
GBMchr8140675483Missense_MutationnovelI860R0.16
GBMchr8140803554Missense_MutationnovelG322C0.08
HNSCchr8140890546SilentnovelV64V0.15
HNSCchr8140879522Missense_MutationnovelV104A0.25
HNSCchr8140864347Missense_MutationNAE139K0.32
HNSCchr8140675444Intronnovel0.14
HNSCchr8140717623Missense_MutationnovelG706V0.11
HNSCchr8140890572Missense_MutationnovelI56V0.21
HNSCchr8140700964Nonsense_MutationnovelE809delinsARRTGDEA*EIL*0.15
HNSCchr8140890647Missense_MutationnovelG31C0.25
HNSCchr8140818304Missense_MutationnovelI280M0.26
HNSCchr8140864317Nonsense_MutationnovelQ149*0.08
HNSCchr8140668272SilentnovelV954V0.19
KIRCchr8140717652Missense_MutationNAR696S0.42
KIRCchr8140818339Missense_MutationnovelS269A0.22
KIRCchr8140803618Frame_Shift_InsnovelQ300Hfs*160.02
KIRCchr8140702678SilentNAI753I0.17
KIRPchr8140675460Missense_MutationnovelD868N0.37
KIRPchr8140735283SilentNAR666R0.52
KIRPchr8140659657SilentnovelL990L0.36
LAMLchr8140675487Missense_MutationnovelH859Y0.1
LGGchr8140700924SilentnovelD822D0.33
LGGchr8140879471Missense_MutationnovelK121I0.38
LIHCchr8140879529Missense_Mutationrs747807231M102V0.43
LIHCchr8140706167SilentnovelE727E0.17
LIHCchr8140668324Missense_MutationnovelE937A0.3
LIHCchr8140746788Missense_MutationNAI497T0.12
LIHCchr8140674317Missense_MutationnovelS897N0.38
LIHCchr8140735395Missense_MutationnovelN629S0.71
LIHCchr8140864357Missense_MutationNAN135K0.35
LUADchr8140764257Missense_MutationnovelE404G0.08
LUADchr8140700931Missense_MutationnovelE820V0.22
LUADchr8140686661Missense_MutationnovelD845Y0.45
LUADchr8140752307Missense_MutationnovelA448T0.11
LUADchr8140744736Missense_MutationNAS517I0.2
LUADchr8140659664SilentnovelQ987Q0.49
LUADchr8140735333Missense_MutationNAT650A0.5
LUADchr8140743293Missense_MutationNAD558N0.2
LUADchr8140702647Nonsense_MutationNAQ764*0.12
LUSCchr8140664919Missense_MutationNAE982K0.42
LUSCchr8140879598Missense_Mutationrs749253117H79Y0.17
LUSCchr8140879599SilentNAK78K0.18
LUSCchr8140702638Missense_MutationNAL767F0.4
LUSCchr8140668302SilentnovelP944P0.33
LUSCchr8140818879Splice_SitenovelX263_splice0.23
LUSCchr8140789502SilentNAG383G0.22
LUSCchr8140668381Missense_MutationNAD918G0.17
LUSCchr8140761191Missense_MutationnovelV436I0.71
LUSCchr8140879633Missense_MutationnovelI67T0.05
LUSCchr8140706173SilentNAS725S0.49
LUSCchr8140751984Intronnovel0.16
LUSCchr8140818892Missense_MutationNAK259N0.16
LUSCchr8140735339Missense_MutationNAP648S0.21
OVchr8140674320Missense_MutationnovelD896A0.23
OVchr81406593623'UTRnovel0.14
OVchr8140751986Intronnovel0.1
OVchr8140717686Missense_MutationnovelA685D0.13
OVchr8140890722Missense_MutationnovelL6V0.08
OVchr8140761221Nonsense_MutationnovelR426*0.28
OVchr8140668410SilentnovelE908E0.07
PAADchr8140764308Intronnovel0.05
PAADchr8140789497Missense_MutationnovelR385Q0.18
PAADchr8140789515Missense_MutationnovelS379N0.18
PAADchr8140846599Missense_MutationnovelR177Q0.14
PRADchr8140717672Missense_Mutationrs756149985R690C0.21
PRADchr8140735336Missense_MutationNAP649S0.29
PRADchr8140744713SilentnovelL525L0.4
PRADchr8140769575Intronnovel0.38
PRADchr8140846670Silentrs759884429S153S0.23
READchr8140761189SilentNAV436V0.15
READchr8140818940Missense_MutationnovelF243L0.31
READchr8140864388Missense_MutationNAR125K0.26
READchr8140846306In_Frame_InsnovelE182_M183insP0.04
READchr8140879561Missense_MutationNAR91Q0.09
SARCchr8140818934Missense_MutationnovelE245D0.39
SARCchr8140890698Missense_Mutationrs191376716P14T0.2
SARCchr8140803615SilentnovelT301T0.27
SARCchr8140735370Missense_MutationnovelN637K0.13
SKCMchr81408907485'UTRnovel0.37
SKCMchr8140864383Missense_MutationNAR127C0.2
SKCMchr81406594363'UTRnovel0.21
SKCMchr81406594373'UTRnovel0.21
SKCMchr8140664941SilentNAL974L0.33
SKCMchr8140789494Missense_MutationNAT386I0.5
SKCMchr8140789514Silentrs773136444S379S0.05
SKCMchr8140664945Missense_Mutationrs182400745P973L0.19
SKCMchr8140864383Missense_MutationNAR127C0.12
SKCMchr8140751915Intronnovel0.2
SKCMchr8140746859Missense_MutationnovelL473F0.53
SKCMchr8140864362SilentNAL134L0.67
SKCMchr8140864344Missense_MutationNAD140N0.23
SKCMchr8140735258Nonsense_MutationNAQ675*0.35
SKCMchr8140732612Intronnovel0.25
SKCMchr8140764409Intronnovel0.5
SKCMchr8140702638Missense_MutationNAL767F0.12
STADchr8140735326Missense_MutationnovelY652C0.27
STADchr8140879577Missense_MutationNAR86C0.24
STADchr8140743260Nonsense_MutationNAR569*0.22
STADchr8140739054Nonsense_MutationNAR597*0.27
STADchr8140717703SilentnovelI679I0.31
STADchr8140735313Silentrs776101894T656T0.09
STADchr8140735392Missense_MutationNAD630G0.05
STADchr8140761163Splice_SitenovelX444_splice0.24
STADchr8140752300Missense_Mutationrs778100779A450V0.3
STADchr8140668326Silentrs141828978I936I0.16
STADchr8140717604Silentrs759165150P712P0.17
STADchr8140735248Splice_Regionnovel0.15
STADchr8140702687SilentNAS750S0.05
STADchr8140803560Frame_Shift_DelnovelI320*0.08
STADchr8140818321Missense_MutationNAG275C0.1
STADchr8140735266Missense_MutationNAL672P0.15
STADchr8140793374SilentNAR368R0.16
STADchr8140890608Frame_Shift_InsnovelE44*0.08
STADchr8140700920Missense_Mutationrs150410292R824C0.16
THCAchr8140800528Frame_Shift_InsnovelD342Sfs*60.06
UCECchr8140659641Missense_MutationnovelG995V0.17
UCECchr8140890690Silentrs780485175S16S0.25
UCECchr8140846303Missense_MutationnovelR184W0.12
UCECchr81406588743'UTRnovel0.38
UCECchr8140879561Missense_MutationNAR91Q0.35
UCECchr8140846321Nonsense_MutationnovelR178*0.07
UCECchr8140735381Nonsense_MutationNAR634*0.44
UCECchr8140732643Intronnovel0.42
UCECchr8140890691Missense_MutationNAS16L0.26
UCECchr8140706146SilentNAQ734Q0.2
UCECchr8140752306Missense_MutationNAA448D0.26
UCECchr8140686672Missense_Mutationrs767144547R841Q0.32
UCECchr8140702673Missense_MutationnovelA755V0.35
UCECchr8140659568Missense_MutationNAQ1019H0.47
UCECchr8140675463Missense_MutationnovelP867S0.2
UCECchr8140846627Missense_MutationnovelA168T0.18
UCECchr8140664977Missense_MutationNAR962S0.15
UCECchr8140746852Missense_Mutationrs753953419R476C0.8
UCECchr8140752296SilentNAV451V0.44
UCECchr8140764408Intronnovel0.14
UCECchr81406590393'UTRnovel0.64
UCECchr8140675432Intronnovel0.24
UCECchr8140800487Silentrs146407650S355S0.37
UCECchr81406585623'UTRnovel0.38
UCECchr81406584103'UTRnovel0.29
UCECchr8140664966Missense_MutationnovelA966V0.43
UCECchr8140890691Missense_MutationNAS16L0.41
UCECchr8140735384Missense_Mutationrs371607821G633S0.43
UCECchr8140761204SilentnovelG431G0.48
UCECchr81406590133'UTRnovel0.7
UCECchr8140830479Missense_MutationnovelS214Y0.24
UCECchr8140846616Missense_MutationnovelL171F0.47
UCECchr8140879623Missense_MutationnovelK70N0.35
UCECchr81406590343'UTRnovel0.42
UCECchr8140764232Splice_SitenovelX412_splice0.44
UCECchr8140762379Intronnovel0.38
UCECchr8140700936Missense_MutationnovelE818D0.18
UCECchr8140890691Missense_MutationNAS16L0.14
UCECchr8140744721Missense_MutationnovelS522Y0.33
UCECchr8140701000Missense_Mutationrs370847963R797Q0.41
UCECchr8140732655Intronnovel0.3
UCECchr8140818953Missense_MutationnovelS239I0.58
UCECchr8140752266Silentrs750297999S461S0.16
UCECchr81406590343'UTRnovel0.33
UCECchr8140890624Missense_MutationnovelK38N0.49
UCECchr8140668326Silentrs141828978I936I0.1
UCECchr8140890723Nonsense_MutationNAY5*0.41
UCECchr8140664957Missense_MutationNAD969G0.33
UCECchr8140746857Missense_MutationNAT474I0.13
UCECchr81406587553'UTRnovel0.39
UCECchr8140793375Missense_Mutationrs771095551R368Q0.21
UCECchr8140818900Missense_MutationnovelC257R0.21
UCECchr8140846657Missense_MutationnovelE158K0.14
UCECchr8140706174Missense_MutationnovelS725F0.24
UCECchr8140879577Missense_MutationNAR86C0.13
UCECchr8140739066Missense_MutationnovelS593P0.68
UCECchr81406587413'UTRnovel0.45
UCECchr81406593813'UTRnovel0.43
UCECchr8140890590Missense_MutationnovelT50S0.42
UCECchr8140675486Missense_MutationNAH859R0.22
UCECchr8140706129Missense_Mutationrs143253214N740S0.39
UCECchr8140717598Missense_MutationnovelK714N0.5
UCECchr8140864378SilentnovelY128Y0.27
UCECchr81406588983'UTRnovel0.34
UCECchr8140739085Missense_MutationnovelI586M0.09
UCECchr8140744749Nonsense_MutationnovelV513*0.07
UCECchr8140744751Missense_MutationnovelQ512L0.05
UCECchr8140830506Missense_Mutationrs770081426R205Q0.3
UCECchr8140735385Silentrs764973361I632I0.34
UCECchr8140818957Nonsense_MutationnovelE238*0.43
UCECchr8140800561Missense_Mutationrs373258896A331T0.45
UCECchr8140764337Intronnovel0.33
UCECchr81406594013'UTRnovel0.24
UCECchr8140701001Nonsense_MutationnovelR797*0.46
UCECchr8140664963Missense_MutationnovelT967N0.27
UCECchr8140702584Nonsense_MutationnovelQ785*0.33
UCECchr8140818991Missense_MutationnovelQ226H0.3

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCAMP0.250.018626
KIRCAMP0.12120.15559
SARCAMP0.26070.18425
SKCMAMP0.4552.8957e-05
TGCTAMP0.55330.13696
UVMAMP0.73758.8879e-13

Survival Analysis
CancerP-value Q-value
THYM0.0097

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

SARC0.0082

Kaplan-Meier Survival Analysis

UCS0.022

Kaplan-Meier Survival Analysis

BRCA0.00041

Kaplan-Meier Survival Analysis

KIRP0.0011

Kaplan-Meier Survival Analysis

PAAD0.023

Kaplan-Meier Survival Analysis

BLCA0.041

Kaplan-Meier Survival Analysis

KICH0.0082

Kaplan-Meier Survival Analysis

UCEC0.0039

Kaplan-Meier Survival Analysis

LIHC0.032

Kaplan-Meier Survival Analysis

UVM0.0023

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us