EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000169554 (Gene tree)
Gene ID: 9839
Gene Symbol: ZEB2
Alias: KIAA0569|SIP-1|SIP1|ZFHX1B
Full Name: zinc finger E-box binding homeobox 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 160,220 bases
Position: chr2:144,364,364-144,524,583
Accession: 14881
RBP type: canonical RBP
Summary: The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000490141	zf-C2H2	PF00096.26	1.8e-24	1	5
ENSP00000490141	zf-C2H2	PF00096.26	1.8e-24	2	5
ENSP00000490141	zf-C2H2	PF00096.26	1.8e-24	3	5
ENSP00000490141	zf-C2H2	PF00096.26	1.8e-24	4	5
ENSP00000490141	zf-C2H2	PF00096.26	1.8e-24	5	5
ENSP00000490508	zf-C2H2	PF00096.26	1.8e-24	1	5
ENSP00000490508	zf-C2H2	PF00096.26	1.8e-24	2	5
ENSP00000490508	zf-C2H2	PF00096.26	1.8e-24	3	5
ENSP00000490508	zf-C2H2	PF00096.26	1.8e-24	4	5
ENSP00000490508	zf-C2H2	PF00096.26	1.8e-24	5	5
ENSP00000490673	zf-C2H2	PF00096.26	1.8e-24	1	5
ENSP00000490673	zf-C2H2	PF00096.26	1.8e-24	2	5
ENSP00000490673	zf-C2H2	PF00096.26	1.8e-24	3	5
ENSP00000490673	zf-C2H2	PF00096.26	1.8e-24	4	5
ENSP00000490673	zf-C2H2	PF00096.26	1.8e-24	5	5
ENSP00000490723	zf-C2H2	PF00096.26	1.8e-24	1	5
ENSP00000490723	zf-C2H2	PF00096.26	1.8e-24	2	5
ENSP00000490723	zf-C2H2	PF00096.26	1.8e-24	3	5
ENSP00000490723	zf-C2H2	PF00096.26	1.8e-24	4	5
ENSP00000490723	zf-C2H2	PF00096.26	1.8e-24	5	5
ENSP00000490872	zf-C2H2	PF00096.26	1.8e-24	1	5
ENSP00000490872	zf-C2H2	PF00096.26	1.8e-24	2	5
ENSP00000490872	zf-C2H2	PF00096.26	1.8e-24	3	5
ENSP00000490872	zf-C2H2	PF00096.26	1.8e-24	4	5
ENSP00000490872	zf-C2H2	PF00096.26	1.8e-24	5	5
ENSP00000443792	zf-C2H2	PF00096.26	3.7e-24	1	5
ENSP00000443792	zf-C2H2	PF00096.26	3.7e-24	2	5
ENSP00000443792	zf-C2H2	PF00096.26	3.7e-24	3	5
ENSP00000443792	zf-C2H2	PF00096.26	3.7e-24	4	5
ENSP00000443792	zf-C2H2	PF00096.26	3.7e-24	5	5
ENSP00000490776	zf-C2H2	PF00096.26	4e-24	1	5
ENSP00000490776	zf-C2H2	PF00096.26	4e-24	2	5
ENSP00000490776	zf-C2H2	PF00096.26	4e-24	3	5
ENSP00000490776	zf-C2H2	PF00096.26	4e-24	4	5
ENSP00000490776	zf-C2H2	PF00096.26	4e-24	5	5
ENSP00000302501	zf-C2H2	PF00096.26	4.4e-24	1	5
ENSP00000302501	zf-C2H2	PF00096.26	4.4e-24	2	5
ENSP00000302501	zf-C2H2	PF00096.26	4.4e-24	3	5
ENSP00000302501	zf-C2H2	PF00096.26	4.4e-24	4	5
ENSP00000302501	zf-C2H2	PF00096.26	4.4e-24	5	5
ENSP00000386854	zf-C2H2	PF00096.26	4.4e-24	1	5
ENSP00000386854	zf-C2H2	PF00096.26	4.4e-24	2	5
ENSP00000386854	zf-C2H2	PF00096.26	4.4e-24	3	5
ENSP00000386854	zf-C2H2	PF00096.26	4.4e-24	4	5
ENSP00000386854	zf-C2H2	PF00096.26	4.4e-24	5	5
ENSP00000454157	zf-C2H2	PF00096.26	4.4e-24	1	5
ENSP00000454157	zf-C2H2	PF00096.26	4.4e-24	2	5
ENSP00000454157	zf-C2H2	PF00096.26	4.4e-24	3	5
ENSP00000454157	zf-C2H2	PF00096.26	4.4e-24	4	5
ENSP00000454157	zf-C2H2	PF00096.26	4.4e-24	5	5
ENSP00000487174	zf-C2H2	PF00096.26	4.4e-24	1	5
ENSP00000487174	zf-C2H2	PF00096.26	4.4e-24	2	5
ENSP00000487174	zf-C2H2	PF00096.26	4.4e-24	3	5
ENSP00000487174	zf-C2H2	PF00096.26	4.4e-24	4	5
ENSP00000487174	zf-C2H2	PF00096.26	4.4e-24	5	5
ENSP00000490317	zf-C2H2	PF00096.26	5.3e-24	1	5
ENSP00000490317	zf-C2H2	PF00096.26	5.3e-24	2	5
ENSP00000490317	zf-C2H2	PF00096.26	5.3e-24	3	5
ENSP00000490317	zf-C2H2	PF00096.26	5.3e-24	4	5
ENSP00000490317	zf-C2H2	PF00096.26	5.3e-24	5	5
ENSP00000475553	zf-C2H2	PF00096.26	5e-18	1	4
ENSP00000475553	zf-C2H2	PF00096.26	5e-18	2	4
ENSP00000475553	zf-C2H2	PF00096.26	5e-18	3	4
ENSP00000475553	zf-C2H2	PF00096.26	5e-18	4	4
ENSP00000490293	zf-C2H2	PF00096.26	9.6e-18	1	4
ENSP00000490293	zf-C2H2	PF00096.26	9.6e-18	2	4
ENSP00000490293	zf-C2H2	PF00096.26	9.6e-18	3	4
ENSP00000490293	zf-C2H2	PF00096.26	9.6e-18	4	4
ENSP00000376601	zf-C2H2	PF00096.26	9.8e-18	1	4
ENSP00000376601	zf-C2H2	PF00096.26	9.8e-18	2	4
ENSP00000376601	zf-C2H2	PF00096.26	9.8e-18	3	4
ENSP00000376601	zf-C2H2	PF00096.26	9.8e-18	4	4
ENSP00000395496	zf-C2H2	PF00096.26	2.5e-17	1	4
ENSP00000395496	zf-C2H2	PF00096.26	2.5e-17	2	4
ENSP00000395496	zf-C2H2	PF00096.26	2.5e-17	3	4
ENSP00000395496	zf-C2H2	PF00096.26	2.5e-17	4	4
ENSP00000490934	zf-C2H2	PF00096.26	2.7e-16	1	3
ENSP00000490934	zf-C2H2	PF00096.26	2.7e-16	2	3
ENSP00000490934	zf-C2H2	PF00096.26	2.7e-16	3	3
ENSP00000394777	zf-C2H2	PF00096.26	2.5e-15	1	3
ENSP00000394777	zf-C2H2	PF00096.26	2.5e-15	2	3
ENSP00000394777	zf-C2H2	PF00096.26	2.5e-15	3	3
ENSP00000490141	zf-met	PF12874.7	1.9e-06	1	1
ENSP00000490508	zf-met	PF12874.7	1.9e-06	1	1
ENSP00000490673	zf-met	PF12874.7	1.9e-06	1	1
ENSP00000490723	zf-met	PF12874.7	1.9e-06	1	1
ENSP00000490872	zf-met	PF12874.7	1.9e-06	1	1
ENSP00000490776	zf-met	PF12874.7	2.5e-06	1	1
ENSP00000443792	zf-met	PF12874.7	3.4e-06	1	1
ENSP00000302501	zf-met	PF12874.7	4e-06	1	1
ENSP00000386854	zf-met	PF12874.7	4.1e-06	1	1
ENSP00000454157	zf-met	PF12874.7	4.1e-06	1	1
ENSP00000487174	zf-met	PF12874.7	4.1e-06	1	1
ENSP00000490317	zf-met	PF12874.7	4.9e-06	1	1
ENSP00000475553	zf-met	PF12874.7	5.7e-06	1	2
ENSP00000475553	zf-met	PF12874.7	5.7e-06	2	2
ENSP00000490293	zf-met	PF12874.7	6.3e-06	1	2
ENSP00000490293	zf-met	PF12874.7	6.3e-06	2	2
ENSP00000376601	zf-met	PF12874.7	8.9e-06	1	2
ENSP00000376601	zf-met	PF12874.7	8.9e-06	2	2
ENSP00000395496	zf-met	PF12874.7	1.5e-05	1	2
ENSP00000395496	zf-met	PF12874.7	1.5e-05	2	2
ENSP00000490934	zf-met	PF12874.7	0.00054	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26136338	Role and prognostic significance of the epithelial-mesenchymal transition factor ZEB2 in ovarian cancer.	Oncotarget	2015 Aug 7	Prislei S	-
30824187	LBX2-AS1 is activated by ZEB1 and promotes the development of esophageal squamous cell carcinoma by interacting with HNRNPC toenhance the stability of ZEB1 and ZEB2 mRNAs.	Biochem Biophys Res Commun	2019 Apr 9	Zhang Y	doi: 10.1016/j.bbrc.2019.02.079
30635820	LncRNA ZEB2-AS1 contributes to the tumorigenesis of gastric cancer via activating the Wnt/β-catenin pathway.	Mol Cell Biochem	2019 Jun	Wang F	doi: 10.1007/s11010-018-03491-7
31128021	Long non-coding RNA ZEB2-AS1 expression is associated with disease progression and predicts outcome in gastric cancer patients.	J BUON	2019 Mar-Apr	Xu C	-
31186703	Overexpression of ZEB2-AS1 lncRNA is associated with poor clinical outcomes in acute myeloid leukemia.	Oncol Lett	2019 Jun	Shi X	doi: 10.3892/ol.2019.10149
28992472	LncRNA ZEB2-AS1 promotes bladder cancer cell proliferation and inhibits apoptosis by regulating miR-27b.	Biomed Pharmacother	2017 Dec	Wu X	doi: 10.1016/j.biopha.2017.08.060
29552161	Long non-coding RNA ZEB2-AS1 promotes proliferation and inhibits apoptosis in human lung cancer cells.	Oncol Lett	2018 Apr	Guo Y	doi: 10.3892/ol.2018.7918
30705594	The lncRNA ZEB2-AS1 is upregulated in gastric cancer and affects cell proliferation and invasion via miR-143-5p/HIF-1α axis.	Onco Targets Ther	2019 Jan 18	Wu F	doi: 10.2147/OTT.S175521
30950191	Overexpression of ZEB2-AS1 promotes epithelial-to-mesenchymal transition and metastasis by stabilizing ZEB2 mRNA in head neck squamous cell carcinoma.	J Cell Mol Med	2019 Jun	Diao P	doi: 10.1111/jcmm.14318
22234932	Rnd3/RhoE Is down-regulated in hepatocellular carcinoma and controls cellular invasion.	Hepatology	2012 Jun	Grise F	doi: 10.1002/hep.25568.
25798844	miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes.	Oncogene	2016 Jan 14	Perdigao-Henriques R	doi: 10.1038/onc.2015.69

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000558170	ZEB2-225	4012	-	ENSP00000454157	1214 (aa)	-	O60315
ENST00000629520	ZEB2-229	2564	-	ENSP00000486240	58 (aa)	-	U3KQ33
ENST00000636413	ZEB2-234	8984	-	ENSP00000490508	1102 (aa)	-	A0A1B0GVV8
ENST00000638128	ZEB2-246	8932	-	ENSP00000490934	955 (aa)	-	A0A1B0GWI0
ENST00000636471	ZEB2-236	9583	-	ENSP00000490317	1239 (aa)	-	A0A1B0GV02
ENST00000440875	ZEB2-210	1809	-	ENSP00000475553	423 (aa)	-	U3KQ51
ENST00000479735	ZEB2-221	543	-	-	- (aa)	-	-
ENST00000462355	ZEB2-214	656	-	ENSP00000475400	58 (aa)	-	U3KQ33
ENST00000636732	ZEB2-237	5073	-	ENSP00000490175	122 (aa)	-	A0A1B0GUM8
ENST00000630572	ZEB2-231	468	-	ENSP00000486346	39 (aa)	-	A0A0D9SF74
ENST00000497268	ZEB2-223	674	-	-	- (aa)	-	-
ENST00000409211	ZEB2-203	587	-	ENSP00000387256	120 (aa)	-	E7EVG9
ENST00000465308	ZEB2-216	1071	-	ENSP00000487476	141 (aa)	-	A0A0D9SGG5
ENST00000419938	ZEB2-205	1755	-	ENSP00000394777	220 (aa)	-	H7C0G0
ENST00000484313	ZEB2-222	845	-	ENSP00000486341	41 (aa)	-	A0A0D9SF71
ENST00000639389	ZEB2-247	1414	-	ENSP00000492572	70 (aa)	-	A0A1W2PS25
ENST00000637304	ZEB2-241	9158	-	ENSP00000490872	1102 (aa)	-	A0A1B0GVV8
ENST00000453352	ZEB2-212	581	-	-	- (aa)	-	-
ENST00000476394	ZEB2-220	601	-	-	- (aa)	-	-
ENST00000628473	ZEB2-228	2967	-	-	- (aa)	-	-
ENST00000470879	ZEB2-217	2648	-	ENSP00000475329	87 (aa)	-	U3KPX6
ENST00000392861	ZEB2-202	1514	-	ENSP00000376601	467 (aa)	-	E7ESP8
ENST00000444559	ZEB2-211	577	-	ENSP00000399451	63 (aa)	-	C9JUQ1
ENST00000629955	ZEB2-230	1435	-	-	- (aa)	-	-
ENST00000461784	ZEB2-213	751	-	-	- (aa)	-	-
ENST00000647488	ZEB2-248	1654	-	ENSP00000494820	79 (aa)	-	A0A2R8YDQ8
ENST00000637591	ZEB2-242	101	-	-	- (aa)	-	-
ENST00000637267	ZEB2-240	2677	-	ENSP00000490293	612 (aa)	-	A0A1X7SC99
ENST00000472146	ZEB2-218	3837	-	-	- (aa)	-	-
ENST00000431672	ZEB2-207	709	-	ENSP00000475267	184 (aa)	-	U3KPV5
ENST00000435831	ZEB2-209	554	-	ENSP00000400993	91 (aa)	-	C9JU62
ENST00000475115	ZEB2-219	536	-	-	- (aa)	-	-
ENST00000627532	ZEB2-227	9541	-	ENSP00000487174	1214 (aa)	-	O60315
ENST00000636445	ZEB2-235	2947	-	ENSP00000490851	36 (aa)	-	A0A1B0GWA7
ENST00000539609	ZEB2-224	4061	-	ENSP00000443792	1190 (aa)	-	O60315
ENST00000465070	ZEB2-215	2949	-	ENSP00000475502	58 (aa)	-	U3KQ33
ENST00000637045	ZEB2-239	9091	-	ENSP00000490141	1102 (aa)	-	A0A1B0GVV8
ENST00000636026	ZEB2-232	5172	-	ENSP00000490776	1202 (aa)	-	A0A1B0GW50
ENST00000434448	ZEB2-208	583	-	ENSP00000487261	41 (aa)	-	A0A0D9SG93
ENST00000638007	ZEB2-244	9140	-	ENSP00000490723	1102 (aa)	-	A0A1B0GVV8
ENST00000625161	ZEB2-226	3061	-	-	- (aa)	-	-
ENST00000427902	ZEB2-206	2236	-	ENSP00000395496	731 (aa)	-	E7EUW9
ENST00000409487	ZEB2-204	5361	-	ENSP00000386854	1214 (aa)	-	O60315
ENST00000636179	ZEB2-233	8984	-	-	- (aa)	-	-
ENST00000636820	ZEB2-238	9115	-	-	- (aa)	-	-
ENST00000303660	ZEB2-201	3913	-	ENSP00000302501	1213 (aa)	-	A0JP08
ENST00000637873	ZEB2-243	100	-	ENSP00000489701	21 (aa)	-	A0A1B0GTH3
ENST00000638087	ZEB2-245	9339	-	ENSP00000490673	1102 (aa)	-	A0A1B0GVV8

Gene Model

Click here to download ENSG00000169554's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05206	MicroRNAs in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000169554	Myopia, Degenerative	6E-10	23933737
ENSG00000169554	Carcinoma, Renal Cell	2E-8	23184150
ENSG00000169554	Schizophrenia	1E-8	23974872
ENSG00000169554	Schizophrenia	4E-7	26198764
ENSG00000169554	Carcinoma, Renal Cell	2E-7	25826619

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000169554	rs72858496	2	144452349	T	Renal cell carcinoma	25826619	[1.32-1.60]	1.46	EFO_0000681
ENSG00000169554	rs12991836	2	144383974	C	Schizophrenia	26198764	[NR]	1.0526316	EFO_0000692
ENSG00000169554	rs12105918	2	144450626	?	Renal cell carcinoma	23184150	[1.20-1.75]	1.45	EFO_0000681
ENSG00000169554	rs13382811	2	144466053	T	Myopia (severe)	23933737	[NR]	1.26	EFO_0004207
ENSG00000169554	rs12991836	2	144383974	C	Schizophrenia	23974872	[1.05-1.11]	1.08	EFO_0000692
ENSG00000169554	rs6740731	2	144513025	A	Coronary artery disease	29212778	[0.033-0.069] unit increase	0.051	EFO_0000378
ENSG00000169554	rs10187371	2	144468803	T	Spherical equivalent or myopia (age of diagnosis)	29808027	[NR] z score decrease	6.561	EFO_0004847\|HP_0000545\|EFO_0007814
ENSG00000169554	rs1427298	2	144456854	T	Educational attainment (MTAG)	30038396	[0.0055-0.0105] unit increase	0.008	EFO_0004784
ENSG00000169554	rs10164806	2	144435759	?	Red blood cell count	29403010	[0.037-0.068] unit increase novel	0.05205	EFO_0004305
ENSG00000169554	rs10164806	2	144435759	?	Mean corpuscular volume	29403010	[0.062-0.093] unit decrease novel	0.0778	EFO_0004526
ENSG00000169554	rs10210063	2	144425390	?	Mean corpuscular hemoglobin	29403010	[0.073-0.104] unit decrease novel	0.08847	EFO_0004527
ENSG00000169554	rs10192562	2	144426749	?	Mean corpuscular hemoglobin concentration	29403010	[0.036-0.067] unit decrease novel	0.05113	EFO_0004528
ENSG00000169554	rs12105918	2	144450626	?	Renal cell carcinoma	28598434	1.16-1.34	1.25	EFO_0000681
ENSG00000169554	rs11893047	2	144463339	?	General cognitive ability	29844566	z-score increase	4.76	EFO_0004337
ENSG00000169554	rs12991836	2	144383974	?	Schizophrenia	29483656	[1.04-1.08]	1.0626993	EFO_0000692
ENSG00000169554	rs1427298	2	144456854	T	Educational attainment (years of education)	30038396	[0.0059-0.0113] unit increase	0.0086	EFO_0004784
ENSG00000169554	rs17739820	2	144472879	?	Lung function (FEV1/FVC)	30595370			EFO_0004713
ENSG00000169554	rs62169220	2	144467504	A	Corneal astigmatism	30306274	[0.01-0.026] dioptres decrease	0.018	EFO_1002040

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169554's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000169554	ZEB2	99	92.661	ENSAPOG00000016286	zeb2b	100	74.008	Acanthochromis_polyacanthus
ENSG00000169554	ZEB2	100	100.000	ENSAMEG00000009337	ZEB2	100	98.270	Ailuropoda_melanoleuca
ENSG00000169554	ZEB2	79	67.273	ENSAMEG00000010224	ZEB1	98	43.973	Ailuropoda_melanoleuca
ENSG00000169554	ZEB2	99	92.661	ENSACIG00000010911	zeb2b	100	72.540	Amphilophus_citrinellus
ENSG00000169554	ZEB2	100	84.615	ENSAOCG00000009065	zeb2b	100	73.744	Amphiprion_ocellaris
ENSG00000169554	ZEB2	99	92.661	ENSAPEG00000021041	zeb2b	100	73.888	Amphiprion_percula
ENSG00000169554	ZEB2	99	92.661	ENSATEG00000013248	zeb2b	100	71.741	Anabas_testudineus
ENSG00000169554	ZEB2	97	100.000	ENSAPLG00000007687	ZEB2	100	90.304	Anas_platyrhynchos
ENSG00000169554	ZEB2	89	69.930	ENSAPLG00000007482	ZEB1	100	44.504	Anas_platyrhynchos
ENSG00000169554	ZEB2	100	92.579	ENSACAG00000023811	ZEB2	99	92.540	Anolis_carolinensis
ENSG00000169554	ZEB2	79	67.273	ENSACAG00000007353	ZEB1	92	43.977	Anolis_carolinensis
ENSG00000169554	ZEB2	87	76.471	ENSANAG00000035865	ZEB1	93	45.830	Aotus_nancymaae
ENSG00000169554	ZEB2	100	100.000	ENSANAG00000029252	ZEB2	100	99.664	Aotus_nancymaae
ENSG00000169554	ZEB2	99	92.661	ENSACLG00000014590	zeb2b	93	73.463	Astatotilapia_calliptera
ENSG00000169554	ZEB2	99	95.413	ENSAMXG00000008022	zeb2b	100	74.535	Astyanax_mexicanus
ENSG00000169554	ZEB2	100	98.953	ENSBTAG00000012615	ZEB2	100	98.911	Bos_taurus
ENSG00000169554	ZEB2	87	76.471	ENSBTAG00000020053	ZEB1	97	43.993	Bos_taurus
ENSG00000169554	ZEB2	87	76.471	ENSCJAG00000013332	ZEB1	93	45.830	Callithrix_jacchus
ENSG00000169554	ZEB2	100	100.000	ENSCJAG00000012457	ZEB2	99	100.000	Callithrix_jacchus
ENSG00000169554	ZEB2	100	97.096	ENSCAFG00000005497	ZEB2	100	96.558	Canis_familiaris
ENSG00000169554	ZEB2	87	76.471	ENSCAFG00000004023	ZEB1	98	44.454	Canis_familiaris
ENSG00000169554	ZEB2	100	97.096	ENSCAFG00020016311	ZEB2	100	96.806	Canis_lupus_dingo
ENSG00000169554	ZEB2	87	76.471	ENSCAFG00020026358	ZEB1	98	44.444	Canis_lupus_dingo
ENSG00000169554	ZEB2	100	100.000	ENSCHIG00000020961	ZEB2	100	98.571	Capra_hircus
ENSG00000169554	ZEB2	87	76.471	ENSCHIG00000016385	ZEB1	96	43.647	Capra_hircus
ENSG00000169554	ZEB2	99	100.000	ENSTSYG00000009434	ZEB2	99	100.000	Carlito_syrichta
ENSG00000169554	ZEB2	79	67.273	ENSTSYG00000009177	ZEB1	93	44.136	Carlito_syrichta
ENSG00000169554	ZEB2	79	67.273	ENSCAPG00000012614	ZEB1	93	48.352	Cavia_aperea
ENSG00000169554	ZEB2	100	98.115	ENSCAPG00000007189	ZEB2	100	97.459	Cavia_aperea
ENSG00000169554	ZEB2	100	100.000	ENSCPOG00000004182	ZEB2	99	100.000	Cavia_porcellus
ENSG00000169554	ZEB2	87	76.471	ENSCPOG00000007682	ZEB1	98	43.453	Cavia_porcellus
ENSG00000169554	ZEB2	100	100.000	ENSCCAG00000036823	ZEB2	100	99.546	Cebus_capucinus
ENSG00000169554	ZEB2	87	76.471	ENSCCAG00000030793	ZEB1	93	45.654	Cebus_capucinus
ENSG00000169554	ZEB2	100	100.000	ENSCATG00000038567	ZEB2	100	99.832	Cercocebus_atys
ENSG00000169554	ZEB2	87	76.471	ENSCATG00000017202	ZEB1	93	45.614	Cercocebus_atys
ENSG00000169554	ZEB2	79	67.273	ENSCLAG00000007760	ZEB1	92	44.325	Chinchilla_lanigera
ENSG00000169554	ZEB2	100	99.162	ENSCLAG00000002230	ZEB2	99	100.000	Chinchilla_lanigera
ENSG00000169554	ZEB2	87	76.471	ENSCSAG00000011628	ZEB1	93	45.366	Chlorocebus_sabaeus
ENSG00000169554	ZEB2	100	100.000	ENSCSAG00000016197	ZEB2	99	99.753	Chlorocebus_sabaeus
ENSG00000169554	ZEB2	100	96.230	ENSCHOG00000001435	ZEB2	100	94.098	Choloepus_hoffmanni
ENSG00000169554	ZEB2	99	100.000	ENSCPBG00000000598	ZEB2	100	94.403	Chrysemys_picta_bellii
ENSG00000169554	ZEB2	87	79.412	ENSCPBG00000015907	ZEB1	95	45.391	Chrysemys_picta_bellii
ENSG00000169554	ZEB2	79	67.273	ENSCANG00000029417	ZEB1	93	44.781	Colobus_angolensis_palliatus
ENSG00000169554	ZEB2	100	100.000	ENSCANG00000029391	ZEB2	100	99.832	Colobus_angolensis_palliatus
ENSG00000169554	ZEB2	100	100.000	ENSCGRG00001003812	Zeb2	99	100.000	Cricetulus_griseus_chok1gshd
ENSG00000169554	ZEB2	87	73.529	ENSCGRG00001016946	Zeb1	93	44.553	Cricetulus_griseus_chok1gshd
ENSG00000169554	ZEB2	79	67.273	ENSCGRG00000005581	Zeb1	93	43.834	Cricetulus_griseus_crigri
ENSG00000169554	ZEB2	100	98.115	ENSCGRG00000003246	Zeb2	99	100.000	Cricetulus_griseus_crigri
ENSG00000169554	ZEB2	95	83.784	ENSCSEG00000006933	zeb2b	97	73.545	Cynoglossus_semilaevis
ENSG00000169554	ZEB2	92	73.913	ENSCVAG00000013156	zeb1b	88	73.913	Cyprinodon_variegatus
ENSG00000169554	ZEB2	99	92.661	ENSCVAG00000022820	zeb2b	100	73.537	Cyprinodon_variegatus
ENSG00000169554	ZEB2	84	59.701	ENSCVAG00000009111	-	61	49.084	Cyprinodon_variegatus
ENSG00000169554	ZEB2	99	94.495	ENSDARG00000078416	zeb2b	100	70.978	Danio_rerio
ENSG00000169554	ZEB2	97	49.123	ENSDARG00000016788	zeb1a	75	58.491	Danio_rerio
ENSG00000169554	ZEB2	87	76.471	ENSDNOG00000016748	ZEB1	93	44.947	Dasypus_novemcinctus
ENSG00000169554	ZEB2	100	100.000	ENSDNOG00000039558	ZEB2	100	98.549	Dasypus_novemcinctus
ENSG00000169554	ZEB2	100	100.000	ENSDORG00000023390	Zeb2	100	98.682	Dipodomys_ordii
ENSG00000169554	ZEB2	87	76.471	ENSDORG00000007230	Zeb1	99	45.021	Dipodomys_ordii
ENSG00000169554	ZEB2	88	100.000	ENSETEG00000003283	ZEB2	81	93.803	Echinops_telfairi
ENSG00000169554	ZEB2	95	68.421	ENSEBUG00000001421	-	82	41.735	Eptatretus_burgeri
ENSG00000169554	ZEB2	100	99.062	ENSEASG00005023468	ZEB2	99	98.377	Equus_asinus_asinus
ENSG00000169554	ZEB2	87	76.471	ENSEASG00005010209	ZEB1	93	45.892	Equus_asinus_asinus
ENSG00000169554	ZEB2	100	100.000	ENSECAG00000019355	ZEB2	99	98.599	Equus_caballus
ENSG00000169554	ZEB2	87	76.471	ENSECAG00000020102	ZEB1	98	48.352	Equus_caballus
ENSG00000169554	ZEB2	80	63.492	ENSEEUG00000006386	ZEB1	82	48.352	Erinaceus_europaeus
ENSG00000169554	ZEB2	99	94.495	ENSELUG00000014998	zeb2b	100	70.922	Esox_lucius
ENSG00000169554	ZEB2	88	69.231	ENSELUG00000011887	zeb1a	82	69.231	Esox_lucius
ENSG00000169554	ZEB2	100	100.000	ENSFCAG00000015532	ZEB2	99	100.000	Felis_catus
ENSG00000169554	ZEB2	87	76.471	ENSFCAG00000010440	ZEB1	93	45.351	Felis_catus
ENSG00000169554	ZEB2	97	99.083	ENSFALG00000013846	ZEB2	100	94.385	Ficedula_albicollis
ENSG00000169554	ZEB2	79	67.273	ENSFALG00000007118	ZEB1	94	43.662	Ficedula_albicollis
ENSG00000169554	ZEB2	100	99.058	ENSFDAG00000004686	ZEB2	97	97.202	Fukomys_damarensis
ENSG00000169554	ZEB2	79	67.273	ENSFDAG00000002324	ZEB1	93	43.470	Fukomys_damarensis
ENSG00000169554	ZEB2	87	76.471	ENSFHEG00000007706	zeb1b	90	42.566	Fundulus_heteroclitus
ENSG00000169554	ZEB2	99	92.661	ENSFHEG00000020874	zeb2b	100	70.897	Fundulus_heteroclitus
ENSG00000169554	ZEB2	85	85.075	ENSGMOG00000014388	zeb2b	100	70.736	Gadus_morhua
ENSG00000169554	ZEB2	99	100.000	ENSGALG00000040465	ZEB2	100	94.079	Gallus_gallus
ENSG00000169554	ZEB2	87	73.529	ENSGALG00000007260	ZEB1	95	44.646	Gallus_gallus
ENSG00000169554	ZEB2	94	92.661	ENSGAFG00000020457	zeb2b	99	72.490	Gambusia_affinis
ENSG00000169554	ZEB2	97	54.673	ENSGAFG00000012161	zeb1b	96	39.606	Gambusia_affinis
ENSG00000169554	ZEB2	85	91.045	ENSGACG00000015660	zeb2b	100	71.920	Gasterosteus_aculeatus
ENSG00000169554	ZEB2	79	67.273	ENSGAGG00000013822	ZEB1	92	45.308	Gopherus_agassizii
ENSG00000169554	ZEB2	99	100.000	ENSGAGG00000011928	ZEB2	100	94.321	Gopherus_agassizii
ENSG00000169554	ZEB2	100	100.000	ENSGGOG00000003186	ZEB2	100	99.812	Gorilla_gorilla
ENSG00000169554	ZEB2	79	67.273	ENSGGOG00000010090	ZEB1	93	44.781	Gorilla_gorilla
ENSG00000169554	ZEB2	99	92.661	ENSHBUG00000009312	zeb2b	100	71.278	Haplochromis_burtoni
ENSG00000169554	ZEB2	79	67.273	ENSHGLG00000018844	ZEB1	92	44.043	Heterocephalus_glaber_female
ENSG00000169554	ZEB2	100	98.953	ENSHGLG00000018878	ZEB2	99	100.000	Heterocephalus_glaber_female
ENSG00000169554	ZEB2	79	67.273	ENSHGLG00100000798	ZEB1	90	44.669	Heterocephalus_glaber_male
ENSG00000169554	ZEB2	100	100.000	ENSHGLG00100005619	ZEB2	99	100.000	Heterocephalus_glaber_male
ENSG00000169554	ZEB2	99	93.578	ENSHCOG00000015167	zeb2b	100	71.371	Hippocampus_comes
ENSG00000169554	ZEB2	97	52.049	ENSIPUG00000015972	zeb1a	61	64.286	Ictalurus_punctatus
ENSG00000169554	ZEB2	97	86.842	ENSIPUG00000017622	zeb2b	100	73.505	Ictalurus_punctatus
ENSG00000169554	ZEB2	87	67.647	ENSIPUG00000011262	ZEB1	94	41.254	Ictalurus_punctatus
ENSG00000169554	ZEB2	87	76.471	ENSSTOG00000016404	ZEB1	93	45.070	Ictidomys_tridecemlineatus
ENSG00000169554	ZEB2	100	100.000	ENSSTOG00000003811	ZEB2	99	100.000	Ictidomys_tridecemlineatus
ENSG00000169554	ZEB2	79	67.273	ENSJJAG00000009716	Zeb1	92	43.993	Jaculus_jaculus
ENSG00000169554	ZEB2	100	100.000	ENSJJAG00000015138	Zeb2	100	97.694	Jaculus_jaculus
ENSG00000169554	ZEB2	99	92.661	ENSKMAG00000004104	zeb2b	100	70.931	Kryptolebias_marmoratus
ENSG00000169554	ZEB2	99	91.743	ENSLBEG00000004635	zeb2b	100	71.475	Labrus_bergylta
ENSG00000169554	ZEB2	99	97.248	ENSLACG00000009946	ZEB2	100	86.513	Latimeria_chalumnae
ENSG00000169554	ZEB2	89	54.893	ENSLACG00000013253	ZEB1	96	46.023	Latimeria_chalumnae
ENSG00000169554	ZEB2	99	94.495	ENSLOCG00000001301	zeb2b	100	80.687	Lepisosteus_oculatus
ENSG00000169554	ZEB2	87	76.471	ENSLOCG00000007239	zeb1b	93	45.677	Lepisosteus_oculatus
ENSG00000169554	ZEB2	84	61.194	ENSLOCG00000005919	-	62	47.292	Lepisosteus_oculatus
ENSG00000169554	ZEB2	99	100.000	ENSLAFG00000008960	ZEB2	100	98.353	Loxodonta_africana
ENSG00000169554	ZEB2	79	67.273	ENSLAFG00000009663	ZEB1	100	43.830	Loxodonta_africana
ENSG00000169554	ZEB2	87	76.471	ENSMFAG00000042570	ZEB1	93	45.614	Macaca_fascicularis
ENSG00000169554	ZEB2	100	100.000	ENSMFAG00000030381	ZEB2	100	99.832	Macaca_fascicularis
ENSG00000169554	ZEB2	100	100.000	ENSMMUG00000016845	ZEB2	100	100.000	Macaca_mulatta
ENSG00000169554	ZEB2	88	79.330	ENSMMUG00000015453	ZEB1	100	71.220	Macaca_mulatta
ENSG00000169554	ZEB2	87	76.471	ENSMNEG00000034471	ZEB1	91	58.298	Macaca_nemestrina
ENSG00000169554	ZEB2	100	100.000	ENSMNEG00000039161	ZEB2	100	99.748	Macaca_nemestrina
ENSG00000169554	ZEB2	100	100.000	ENSMLEG00000003652	ZEB2	100	99.748	Mandrillus_leucophaeus
ENSG00000169554	ZEB2	79	67.273	ENSMLEG00000041117	ZEB1	93	44.781	Mandrillus_leucophaeus
ENSG00000169554	ZEB2	100	84.615	ENSMAMG00000022475	zeb2b	100	74.463	Mastacembelus_armatus
ENSG00000169554	ZEB2	99	92.661	ENSMZEG00005015857	zeb2b	100	73.463	Maylandia_zebra
ENSG00000169554	ZEB2	79	67.273	ENSMGAG00000006355	ZEB1	94	43.810	Meleagris_gallopavo
ENSG00000169554	ZEB2	100	94.746	ENSMGAG00000012628	ZEB2	100	94.044	Meleagris_gallopavo
ENSG00000169554	ZEB2	100	100.000	ENSMAUG00000015393	Zeb2	99	100.000	Mesocricetus_auratus
ENSG00000169554	ZEB2	79	67.273	ENSMAUG00000000582	Zeb1	91	44.593	Mesocricetus_auratus
ENSG00000169554	ZEB2	100	100.000	ENSMICG00000017462	ZEB2	100	99.545	Microcebus_murinus
ENSG00000169554	ZEB2	87	76.471	ENSMICG00000006165	ZEB1	94	44.921	Microcebus_murinus
ENSG00000169554	ZEB2	100	100.000	ENSMOCG00000016943	Zeb2	100	97.364	Microtus_ochrogaster
ENSG00000169554	ZEB2	87	73.529	ENSMOCG00000013432	Zeb1	93	44.474	Microtus_ochrogaster
ENSG00000169554	ZEB2	100	82.051	ENSMMOG00000019667	zeb2b	100	72.690	Mola_mola
ENSG00000169554	ZEB2	87	79.412	ENSMODG00000007847	ZEB1	99	44.830	Monodelphis_domestica
ENSG00000169554	ZEB2	100	96.451	ENSMODG00000003112	ZEB2	100	96.147	Monodelphis_domestica
ENSG00000169554	ZEB2	99	100.000	MGP_CAROLIEiJ_G0023541	Zeb2	99	100.000	Mus_caroli
ENSG00000169554	ZEB2	87	73.529	MGP_CAROLIEiJ_G0021973	Zeb1	99	57.143	Mus_caroli
ENSG00000169554	ZEB2	99	100.000	ENSMUSG00000026872	Zeb2	99	100.000	Mus_musculus
ENSG00000169554	ZEB2	87	73.529	ENSMUSG00000024238	Zeb1	99	57.143	Mus_musculus
ENSG00000169554	ZEB2	86	77.778	MGP_PahariEiJ_G0018711	Zeb1	99	68.900	Mus_pahari
ENSG00000169554	ZEB2	99	100.000	MGP_PahariEiJ_G0024992	Zeb2	99	100.000	Mus_pahari
ENSG00000169554	ZEB2	99	100.000	MGP_SPRETEiJ_G0024461	Zeb2	99	100.000	Mus_spretus
ENSG00000169554	ZEB2	87	73.529	MGP_SPRETEiJ_G0022889	Zeb1	99	57.143	Mus_spretus
ENSG00000169554	ZEB2	79	67.273	ENSMPUG00000013033	ZEB1	99	43.223	Mustela_putorius_furo
ENSG00000169554	ZEB2	100	100.000	ENSMPUG00000003620	ZEB2	99	98.435	Mustela_putorius_furo
ENSG00000169554	ZEB2	79	67.273	ENSMLUG00000010631	ZEB1	97	41.895	Myotis_lucifugus
ENSG00000169554	ZEB2	100	98.848	ENSMLUG00000002019	ZEB2	100	97.815	Myotis_lucifugus
ENSG00000169554	ZEB2	95	52.016	ENSNGAG00000016254	Zeb1	92	44.094	Nannospalax_galili
ENSG00000169554	ZEB2	100	100.000	ENSNGAG00000016618	Zeb2	100	97.858	Nannospalax_galili
ENSG00000169554	ZEB2	99	92.661	ENSNBRG00000014957	zeb2b	100	73.382	Neolamprologus_brichardi
ENSG00000169554	ZEB2	100	100.000	ENSNLEG00000009020	ZEB2	100	99.748	Nomascus_leucogenys
ENSG00000169554	ZEB2	79	67.273	ENSNLEG00000018130	ZEB1	97	44.010	Nomascus_leucogenys
ENSG00000169554	ZEB2	88	100.000	ENSMEUG00000008997	ZEB2	87	97.590	Notamacropus_eugenii
ENSG00000169554	ZEB2	79	67.273	ENSMEUG00000008117	-	53	56.846	Notamacropus_eugenii
ENSG00000169554	ZEB2	100	99.058	ENSOPRG00000006205	ZEB2	95	98.640	Ochotona_princeps
ENSG00000169554	ZEB2	87	76.471	ENSOPRG00000007291	ZEB1	80	64.286	Ochotona_princeps
ENSG00000169554	ZEB2	79	67.273	ENSODEG00000002458	ZEB1	92	44.337	Octodon_degus
ENSG00000169554	ZEB2	100	99.058	ENSODEG00000006916	ZEB2	100	98.270	Octodon_degus
ENSG00000169554	ZEB2	88	92.661	ENSONIG00000012271	zeb2b	100	72.915	Oreochromis_niloticus
ENSG00000169554	ZEB2	58	90.476	ENSOANG00000006051	ZEB1	94	43.723	Ornithorhynchus_anatinus
ENSG00000169554	ZEB2	98	90.121	ENSOANG00000011947	ZEB2	100	90.450	Ornithorhynchus_anatinus
ENSG00000169554	ZEB2	96	98.639	ENSOCUG00000027880	ZEB2	99	97.082	Oryctolagus_cuniculus
ENSG00000169554	ZEB2	81	62.500	ENSOCUG00000006516	ZEB1	96	48.352	Oryctolagus_cuniculus
ENSG00000169554	ZEB2	100	84.615	ENSORLG00000000098	zeb2b	100	73.140	Oryzias_latipes
ENSG00000169554	ZEB2	99	92.661	ENSORLG00020012327	zeb2b	100	72.853	Oryzias_latipes_hni
ENSG00000169554	ZEB2	100	84.615	ENSORLG00015014555	zeb2b	100	73.223	Oryzias_latipes_hsok
ENSG00000169554	ZEB2	99	91.743	ENSOMEG00000020511	zeb2b	100	73.015	Oryzias_melastigma
ENSG00000169554	ZEB2	87	76.471	ENSOGAG00000008365	ZEB1	93	45.326	Otolemur_garnettii
ENSG00000169554	ZEB2	100	99.162	ENSOGAG00000010020	ZEB2	100	98.266	Otolemur_garnettii
ENSG00000169554	ZEB2	90	62.500	ENSOARG00000013971	ZEB1	98	48.352	Ovis_aries
ENSG00000169554	ZEB2	100	96.014	ENSOARG00000009880	ZEB2	100	95.641	Ovis_aries
ENSG00000169554	ZEB2	79	67.273	ENSPPAG00000035575	ZEB1	93	44.781	Pan_paniscus
ENSG00000169554	ZEB2	100	100.000	ENSPPAG00000025839	ZEB2	100	100.000	Pan_paniscus
ENSG00000169554	ZEB2	87	76.471	ENSPPRG00000024896	ZEB1	93	45.223	Panthera_pardus
ENSG00000169554	ZEB2	100	100.000	ENSPPRG00000023971	ZEB2	99	100.000	Panthera_pardus
ENSG00000169554	ZEB2	100	98.820	ENSPTIG00000015892	ZEB2	100	98.820	Panthera_tigris_altaica
ENSG00000169554	ZEB2	79	67.273	ENSPTIG00000006311	ZEB1	92	44.296	Panthera_tigris_altaica
ENSG00000169554	ZEB2	87	76.471	ENSPTRG00000002404	ZEB1	93	45.614	Pan_troglodytes
ENSG00000169554	ZEB2	100	100.000	ENSPTRG00000012513	ZEB2	100	100.000	Pan_troglodytes
ENSG00000169554	ZEB2	87	76.471	ENSPANG00000022899	ZEB1	93	45.614	Papio_anubis
ENSG00000169554	ZEB2	100	99.895	ENSPANG00000008399	ZEB2	100	100.000	Papio_anubis
ENSG00000169554	ZEB2	87	73.529	ENSPKIG00000016747	ZEB1	94	40.281	Paramormyrops_kingsleyae
ENSG00000169554	ZEB2	85	94.030	ENSPKIG00000003462	ZEB2	99	73.724	Paramormyrops_kingsleyae
ENSG00000169554	ZEB2	99	90.517	ENSPKIG00000011898	ZEB2	99	74.204	Paramormyrops_kingsleyae
ENSG00000169554	ZEB2	87	79.412	ENSPSIG00000009469	ZEB1	95	45.079	Pelodiscus_sinensis
ENSG00000169554	ZEB2	100	95.652	ENSPSIG00000016788	ZEB2	100	93.965	Pelodiscus_sinensis
ENSG00000169554	ZEB2	85	88.060	ENSPMGG00000023546	zeb2b	100	70.564	Periophthalmus_magnuspinnatus
ENSG00000169554	ZEB2	71	74.000	ENSPMGG00000018696	zeb1b	99	38.203	Periophthalmus_magnuspinnatus
ENSG00000169554	ZEB2	100	100.000	ENSPEMG00000004029	Zeb2	99	100.000	Peromyscus_maniculatus_bairdii
ENSG00000169554	ZEB2	79	67.273	ENSPEMG00000019404	Zeb1	91	45.109	Peromyscus_maniculatus_bairdii
ENSG00000169554	ZEB2	76	66.667	ENSPMAG00000005091	-	62	82.243	Petromyzon_marinus
ENSG00000169554	ZEB2	84	65.152	ENSPMAG00000003720	-	99	48.750	Petromyzon_marinus
ENSG00000169554	ZEB2	99	100.000	ENSPCIG00000011418	ZEB2	100	96.059	Phascolarctos_cinereus
ENSG00000169554	ZEB2	79	67.273	ENSPCIG00000011050	ZEB1	93	44.654	Phascolarctos_cinereus
ENSG00000169554	ZEB2	87	76.471	ENSPFOG00000013823	zeb1b	94	40.478	Poecilia_formosa
ENSG00000169554	ZEB2	99	92.661	ENSPFOG00000004757	zeb2b	100	73.344	Poecilia_formosa
ENSG00000169554	ZEB2	99	92.661	ENSPLAG00000012661	zeb2b	100	71.244	Poecilia_latipinna
ENSG00000169554	ZEB2	87	76.471	ENSPLAG00000006361	zeb1b	99	40.720	Poecilia_latipinna
ENSG00000169554	ZEB2	99	92.661	ENSPMEG00000018295	zeb2b	100	71.244	Poecilia_mexicana
ENSG00000169554	ZEB2	87	76.471	ENSPMEG00000003006	zeb1b	92	73.913	Poecilia_mexicana
ENSG00000169554	ZEB2	99	77.982	ENSPREG00000022031	-	100	76.423	Poecilia_reticulata
ENSG00000169554	ZEB2	87	76.471	ENSPREG00000012707	zeb1b	95	40.333	Poecilia_reticulata
ENSG00000169554	ZEB2	87	76.471	ENSPPYG00000002189	ZEB1	93	45.614	Pongo_abelii
ENSG00000169554	ZEB2	100	99.895	ENSPPYG00000012831	ZEB2	100	99.748	Pongo_abelii
ENSG00000169554	ZEB2	87	61.765	ENSPCAG00000004425	ZEB1	93	41.104	Procavia_capensis
ENSG00000169554	ZEB2	100	97.436	ENSPCAG00000014674	ZEB2	100	94.069	Procavia_capensis
ENSG00000169554	ZEB2	53	94.737	ENSPCOG00000021709	ZEB1	90	44.849	Propithecus_coquereli
ENSG00000169554	ZEB2	100	100.000	ENSPCOG00000022388	ZEB2	100	100.000	Propithecus_coquereli
ENSG00000169554	ZEB2	99	100.000	ENSPVAG00000015557	ZEB2	80	98.381	Pteropus_vampyrus
ENSG00000169554	ZEB2	92	55.349	ENSPVAG00000010088	ZEB1	92	45.181	Pteropus_vampyrus
ENSG00000169554	ZEB2	99	92.661	ENSPNYG00000022218	zeb2b	100	73.382	Pundamilia_nyererei
ENSG00000169554	ZEB2	99	93.396	ENSPNAG00000023882	zeb2b	100	74.113	Pygocentrus_nattereri
ENSG00000169554	ZEB2	89	52.814	ENSRNOG00000017863	Zeb1	84	76.596	Rattus_norvegicus
ENSG00000169554	ZEB2	99	100.000	ENSRNOG00000004677	Zeb2	99	97.117	Rattus_norvegicus
ENSG00000169554	ZEB2	100	100.000	ENSRBIG00000032824	ZEB2	100	100.000	Rhinopithecus_bieti
ENSG00000169554	ZEB2	79	67.273	ENSRBIG00000031956	ZEB1	93	44.702	Rhinopithecus_bieti
ENSG00000169554	ZEB2	100	100.000	ENSRROG00000036815	ZEB2	100	99.832	Rhinopithecus_roxellana
ENSG00000169554	ZEB2	79	67.273	ENSRROG00000042035	ZEB1	93	44.692	Rhinopithecus_roxellana
ENSG00000169554	ZEB2	100	100.000	ENSSBOG00000026124	ZEB2	100	99.580	Saimiri_boliviensis_boliviensis
ENSG00000169554	ZEB2	89	60.099	ENSSBOG00000032906	ZEB1	93	44.800	Saimiri_boliviensis_boliviensis
ENSG00000169554	ZEB2	79	67.273	ENSSHAG00000005352	ZEB1	92	44.435	Sarcophilus_harrisii
ENSG00000169554	ZEB2	97	100.000	ENSSHAG00000016692	ZEB2	100	95.720	Sarcophilus_harrisii
ENSG00000169554	ZEB2	85	63.636	ENSSFOG00015016850	ZEB1	71	64.286	Scleropages_formosus
ENSG00000169554	ZEB2	100	89.744	ENSSFOG00015006557	ZEB2	100	75.980	Scleropages_formosus
ENSG00000169554	ZEB2	99	95.833	ENSSMAG00000002657	zeb2b	94	95.833	Scophthalmus_maximus
ENSG00000169554	ZEB2	99	92.661	ENSSDUG00000013274	zeb2b	100	74.170	Seriola_dumerili
ENSG00000169554	ZEB2	99	92.661	ENSSLDG00000010668	zeb2b	100	71.984	Seriola_lalandi_dorsalis
ENSG00000169554	ZEB2	79	67.273	ENSSARG00000010985	ZEB1	93	44.524	Sorex_araneus
ENSG00000169554	ZEB2	96	96.252	ENSSARG00000006858	ZEB2	94	96.746	Sorex_araneus
ENSG00000169554	ZEB2	99	99.083	ENSSPUG00000007767	-	99	99.083	Sphenodon_punctatus
ENSG00000169554	ZEB2	87	79.412	ENSSPUG00000004934	ZEB1	93	45.221	Sphenodon_punctatus
ENSG00000169554	ZEB2	99	92.661	ENSSPAG00000016513	zeb2b	100	74.413	Stegastes_partitus
ENSG00000169554	ZEB2	95	51.600	ENSSSCG00000011025	ZEB1	92	43.774	Sus_scrofa
ENSG00000169554	ZEB2	100	100.000	ENSSSCG00000021343	ZEB2	100	99.002	Sus_scrofa
ENSG00000169554	ZEB2	74	71.154	ENSTGUG00000001020	ZEB1	98	43.364	Taeniopygia_guttata
ENSG00000169554	ZEB2	100	95.018	ENSTGUG00000011904	ZEB2	100	94.295	Taeniopygia_guttata
ENSG00000169554	ZEB2	99	92.661	ENSTRUG00000005095	zeb2b	100	70.908	Takifugu_rubripes
ENSG00000169554	ZEB2	100	100.000	ENSTTRG00000006478	ZEB2	100	98.189	Tursiops_truncatus
ENSG00000169554	ZEB2	90	86.538	ENSTTRG00000011798	ZEB1	79	49.474	Tursiops_truncatus
ENSG00000169554	ZEB2	90	67.308	ENSUAMG00000002001	ZEB1	81	64.286	Ursus_americanus
ENSG00000169554	ZEB2	100	100.000	ENSUAMG00000026838	ZEB2	100	98.487	Ursus_americanus
ENSG00000169554	ZEB2	90	67.308	ENSUMAG00000015956	ZEB1	76	64.286	Ursus_maritimus
ENSG00000169554	ZEB2	100	98.848	ENSUMAG00000006420	ZEB2	99	98.820	Ursus_maritimus
ENSG00000169554	ZEB2	96	97.274	ENSVPAG00000002128	ZEB2	88	100.000	Vicugna_pacos
ENSG00000169554	ZEB2	80	63.492	ENSVPAG00000001316	ZEB1	72	47.398	Vicugna_pacos
ENSG00000169554	ZEB2	87	76.471	ENSVVUG00000004560	ZEB1	93	45.462	Vulpes_vulpes
ENSG00000169554	ZEB2	100	100.000	ENSVVUG00000010869	ZEB2	100	96.723	Vulpes_vulpes
ENSG00000169554	ZEB2	79	67.273	ENSXETG00000011655	zeb1	97	43.482	Xenopus_tropicalis
ENSG00000169554	ZEB2	89	99.083	ENSXETG00000000237	zeb2	100	86.516	Xenopus_tropicalis
ENSG00000169554	ZEB2	77	72.222	ENSXCOG00000003605	zeb1b	94	39.255	Xiphophorus_couchianus
ENSG00000169554	ZEB2	99	92.661	ENSXMAG00000010581	zeb2b	92	70.736	Xiphophorus_maculatus
ENSG00000169554	ZEB2	77	72.222	ENSXMAG00000005475	zeb1b	93	39.494	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	12837246.20516212.	IDA	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	24769727.	IMP	Process
GO:0000790	nuclear chromatin	20516212.	IDA	Component
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	ISM	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	NAS	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	20516212.	IDA	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	-	IEA	Function
GO:0001755	neural crest cell migration	-	IEA	Process
GO:0001756	somitogenesis	-	IEA	Process
GO:0001843	neural tube closure	-	IEA	Process
GO:0005515	protein binding	26028330.	IPI	Function
GO:0005634	nucleus	24769727.	IDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0007399	nervous system development	11279515.	NAS	Process
GO:0019208	phosphatase regulator activity	11477103.	NAS	Function
GO:0021540	corpus callosum morphogenesis	-	IEA	Process
GO:0021766	hippocampus development	-	IEA	Process
GO:0021846	cell proliferation in forebrain	-	IEA	Process
GO:0021957	corticospinal tract morphogenesis	-	IEA	Process
GO:0030177	positive regulation of Wnt signaling pathway	-	IEA	Process
GO:0043507	positive regulation of JUN kinase activity	-	IEA	Process
GO:0043565	sequence-specific DNA binding	20516212.	IDA	Function
GO:0045636	positive regulation of melanocyte differentiation	24769727.	ISS	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	24769727.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048023	positive regulation of melanin biosynthetic process	24769727.	IC	Process
GO:0048066	developmental pigmentation	24769727.	ISS	Process
GO:0048668	collateral sprouting	-	IEA	Process
GO:0050772	positive regulation of axonogenesis	-	IEA	Process
GO:0061373	mammillary axonal complex development	-	IEA	Process
GO:0070412	R-SMAD binding	-	IEA	Function
GO:0097324	melanocyte migration	24769727.	ISS	Process
GO:1902748	positive regulation of lens fiber cell differentiation	-	IEA	Process
GO:1903056	regulation of melanosome organization	24769727.	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
16568083	Regulation of vimentin by SIP1 in human epithelial breast tumor cells.	Oncogene	2006 Aug 17	Bindels S	-
26503460	miR-154 targeting ZEB2 in hepatocellular carcinoma functions as a potential tumor suppressor.	Oncol Rep	2015 Dec	Pang X	-
25975736	MicroRNA-141 inhibits migration of gastric cancer by targeting zinc finger E-box-binding homeobox 2.	Mol Med Rep	2015 Sep	Du Y	doi: 10.3892/mmr.2015.3789
21426561	MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells.	J Transl Med	2011 Mar 22	Matsushima K	doi: 10.1186/1479-5876-9-30.
23381389	Downregulated microRNA-200a promotes EMT and tumor growth through the wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma.	Oncol Rep	2013 Apr	Cong N	doi: 10.3892/or.2013.2267
25008569	MiR-141 targets ZEB2 to suppress HCC progression.	Tumour Biol	2014 Oct	Wu SM	doi: 10.1007/s13277-014-2299-9
25894377	Akt2/ZEB2 may be a biomarker for exfoliant cells in ascitic fluid in advanced grades of serous ovarian carcinoma.	Tumour Biol	2015 Sep	Liu C	doi: 10.1007/s13277-015-3437-8
25427583	miRNA-205 is a candidate tumor suppressor that targets ZEB2 in renal cell carcinoma.	Oncol Res Treat	2014	Chen Z	doi: 10.1159/000368792
27589832	A directly negative interaction of miR-203 and ZEB2 modulates tumor stemness and chemotherapy resistance in nasopharyngeal carcinoma.	Oncotarget	2016 Oct 11	Jiang Q	doi: 10.18632/oncotarget.11691.
22350782	ZEB2 promotes the metastasis of gastric cancer and modulates epithelial mesenchymal transition of gastric cancer cells.	Dig Dis Sci	2012 May	Dai YH	doi: 10.1007/s10620-012-2042-6
25954928	MicroRNA-153 functions as a tumor suppressor by targeting SET7 and ZEB2 in ovarian cancer cells.	Oncol Rep	2015 Jul	Zhou J	doi: 10.3892/or.2015.3952
28192397	Downregulation of miR-218 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer by targeting Slug/ZEB2 signaling.	Oncogene	2017 May 4	Shi ZM	doi: 10.1038/onc.2016.414
30592286	miR498 inhibits the growth and metastasis of liver cancer by targeting ZEB2.	Oncol Rep	2019 Mar	Zhang X	doi: 10.3892/or.2018.6948
25296715	Double-negative feedback loop between ZEB2 and miR-145 regulates epithelial-mesenchymal transition and stem cell properties in prostate cancer cells.	Cell Tissue Res	2014 Dec	Ren D	doi: 10.1007/s00441-014-2001-y
23184150	Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer.	Hum Mol Genet	2013 Feb 15	Henrion M	doi: 10.1093/hmg/dds489
24885194	Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells.	Mol Cancer	2014 Jun 2	Li H	doi: 10.1186/1476-4598-13-136.
26823172	The potential role of regulator of G-protein signaling 16 in cell motility mediated by δEF1 family proteins.	FEBS Lett	2016 Jan	Hoshi Y	doi: 10.1002/1873-3468.12042
23376074	Interplay between KLF4 and ZEB2/SIP1 in the regulation of E-cadherin expression.	Biochem Biophys Res Commun	2013 Feb 22	Koopmansch B	doi: 10.1016/j.bbrc.2013.01.070
25913622	Expression of SIP1 is strongly correlated with LDHA and shows a significantly poor outcome in gastric cancer.	Tumour Biol	2015 Sep	Sun X	doi: 10.1007/s13277-015-3470-7
22311119	MicroRNA-200b regulates cell proliferation, invasion, and migration by directly targeting ZEB2 in gastric carcinoma.	Ann Surg Oncol	2012 Jul	Kurashige J	doi: 10.1245/s10434-012-2217-6
22042972	Overexpression of ZEB2 at the invasion front of colorectal cancer is an independent prognostic marker and regulates tumor invasion in vitro.	Clin Cancer Res	2011 Dec 15	Kahlert C	doi: 10.1158/1078-0432.CCR-10-2816
24829139	MicroRNA-335 inhibits invasion and metastasis of colorectal cancer by targeting ZEB2.	Med Oncol	2014 Jun	Sun Z	doi: 10.1007/s12032-014-0982-8
22213144	Epithelial-mesenchymal transition and mesenchymal-epithelial transition via regulation of ZEB-1 and ZEB-2 expression in pancreatic cancer.	J Surg Oncol	2012 Jun 1	Kurahara H	doi: 10.1002/jso.23020
26136338	Role and prognostic significance of the epithelial-mesenchymal transition factor ZEB2 in ovarian cancer.	Oncotarget	2015 Aug 7	Prislei S	-
24968735	Down-regulation of miR-144 promotes thyroid cancer cell invasion by targeting ZEB1 and ZEB2.	Endocrine	2015 Mar	Guan H	doi: 10.1007/s12020-014-0326-7
24130169	ZEB2-Sp1 cooperation induces invasion by upregulating cadherin-11 and integrin α5 expression.	Carcinogenesis	2014 Feb	Nam EH	doi: 10.1093/carcin/bgt340
23143680	Smad interacting protein 1 (SIP1) is associated with peritoneal carcinomatosis in intestinal type gastric cancer.	Clin Exp Metastasis	2013 Apr	Okugawa Y	doi: 10.1007/s10585-012-9547-4
15026811	Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells.	Br J Cancer	2004 Mar 22	Miyoshi A	-
25779673	FOXA2 attenuates the epithelial to mesenchymal transition by regulating the transcription of E-cadherin and ZEB2 in human breast cancer.	Cancer Lett	2015 Jun 1	Zhang Z	doi: 10.1016/j.canlet.2015.03.008
24812058	Androgen receptor as a regulator of ZEB2 expression and its implications in epithelial-to-mesenchymal transition in prostate cancer.	Endocr Relat Cancer	2014 May 8	Jacob S	doi: 10.1530/ERC-13-0514
27761656	HOXB8 promotes tumor metastasis and the epithelial-mesenchymal transition via ZEB2 targets in gastric cancer.	J Cancer Res Clin Oncol	2017 Mar	Ding WJ	doi: 10.1007/s00432-016-2283-4
25412653	SIP1 predicts progression and poor prognosis in pharyngeal squamous cell carcinoma.	Histol Histopathol	2015 May	Jouppila-Matto A	doi: 10.14670/HH-30.569
25052237	miR-200c modulates ovarian cancer cell metastasis potential by targeting zinc finger E-box-binding homeobox 2 (ZEB2) expression.	Med Oncol	2014 Aug	Lu YM	doi: 10.1007/s12032-014-0134-1
24914372	miR-132 inhibits colorectal cancer invasion and metastasis via directly targeting ZEB2.	World J Gastroenterol	2014 Jun 7	Zheng YB	doi: 10.3748/wjg.v20.i21.6515.
18411277	The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2.	J Biol Chem	2008 May 30	Korpal M	doi: 10.1074/jbc.C800074200
24769353	Zinc finger E-box-binding homeobox 2 (ZEB2) regulated by miR-200b contributes to multi-drug resistance of small cell lung cancer.	Exp Mol Pathol	2014 Jun	Fang S	doi: 10.1016/j.yexmp.2014.04.008
24810210	Honokiol suppresses renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition and cancer stem cell properties through modulating miR-141/ZEB2 signaling.	Mol Cells	2014 May	Li W	doi: 10.14348/molcells.2014.0009
27933466	microRNA-145 modulates epithelial-mesenchymal transition and suppresses proliferation, migration and invasion by targeting SIP1 in human cervical cancer cells.	Cell Oncol (Dordr)	2017 Apr	Sathyanarayanan A	doi: 10.1007/s13402-016-0307-3
28675122	MiR-204/ZEB2 axis functions as key mediator for MALAT1-induced epithelial-mesenchymal transition in breast cancer.	Tumour Biol	2017 Jul	Wang Y	doi: 10.1177/1010428317690998.
28135249	The Cdc42/Rac1 regulator CdGAP is a novel E-cadherin transcriptional co-repressor with Zeb2 in breast cancer.	Oncogene	2017 Jun 15	He Y	doi: 10.1038/onc.2016.492
28739727	miR-141 Inhibits Proliferation and Migration of Colorectal Cancer SW480 Cells.	Anticancer Res	2017 Aug	Long ZH	-
28133913	The role of epithelial-mesenchymal transition drivers ZEB1 and ZEB2 in mediating docetaxel-resistant prostate cancer.	Mol Oncol	2017 Mar	Hanrahan K	doi: 10.1002/1878-0261.12030
28783176	Short stretches of rare codons regulate translation of the transcription factor ZEB2 in cancer cells.	Oncogene	2017 Nov 23	Wan Makhtar WR	doi: 10.1038/onc.2017.273
28534959	MicroRNA-200c regulates cisplatin resistance by targeting ZEB2 in human gastric cancer cells.	Oncol Rep	2017 Jul	Jiang T	doi: 10.3892/or.2017.5659
28416756	Prognostic significance of ZEB1 and ZEB2 in digestive cancers: a cohort-based analysis and secondary analysis.	Oncotarget	2017 May 9	Chen H	doi: 10.18632/oncotarget.15634.
29115924	Transcription factor E2F1 promotes EMT by regulating ZEB2 in small cell lung cancer.	BMC Cancer	2017 Nov 7	Wang T	doi: 10.1186/s12885-017-3701-y.
29052277	Src promotes EGF-induced epithelial-to-mesenchymal transition and migration in gastric cancer cells by upregulating ZEB1 and ZEB2 through AKT.	Cell Biol Int	2018 Mar	Zhao L	doi: 10.1002/cbin.10894
28833449	microRNA-145 downregulates SIP1-expression but differentially regulates proliferation, migration, invasion and Wnt signaling in SW480 and SW620 cells.	J Cell Biochem	2018 Feb	Sathyanarayanan A	doi: 10.1002/jcb.26365
29516288	Genome-wide analysis of endogenously expressed ZEB2 binding sites reveals inverse correlations between ZEB2 and GalNAc-transferase GALNT3 in human tumors.	Cell Oncol (Dordr)	2018 Aug	Balcik-Ercin P	doi: 10.1007/s13402-018-0375-7
30119219	Long non-coding RNA NORAD upregulate SIP1 expression to promote cell proliferation and invasion in cervical cancer.	Biomed Pharmacother	2018 Oct	Huo H	doi: 10.1016/j.biopha.2018.07.101
29523224	MicroRNA-377 Targets Zinc Finger E-box-Binding Homeobox 2 to Inhibit Cell Proliferation and Invasion of Cervical Cancer.	Oncol Res	2019 Feb 5	Ye C	doi: 10.3727/096504018X15201124340860
29302045	miR-200c inhibits TGF-β-induced-EMT to restore trastuzumab sensitivity by targeting ZEB1 and ZEB2 in gastric cancer.	Cancer Gene Ther	2018 May	Zhou X	doi: 10.1038/s41417-017-0005-y
30361097	FAT10 promotes the invasion and migration of breast cancer cell through stabilization of ZEB2.	Biochem Biophys Res Commun	2018 Nov 30	Zou Y	doi: 10.1016/j.bbrc.2018.10.109
30415780	CircNUP214 sponges miR-145 to promote the expression of ZEB2 in thyroid cancer cells.	Biochem Biophys Res Commun	2018 Dec 9	Li X	doi: 10.1016/j.bbrc.2018.10.200

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr2	144396421	Nonsense_Mutation	novel	E1020*	0.29
ACC	chr2	144429991	Nonsense_Mutation	novel	E37*	0.13
BLCA	chr2	144399792	Missense_Mutation	novel	Q465H	0.57
BLCA	chr2	144398704	Missense_Mutation	novel	K828R	0.28
BLCA	chr2	144389949	Silent	NA	H1049H	0.15
BLCA	chr2	144429844	Frame_Shift_Ins	novel	*D86Rfs2**	0.51
BLCA	chr2	144399925	Missense_Mutation	NA	G421E	0.15
BLCA	chr2	144398405	Missense_Mutation	novel	Q928K	0.22
BLCA	chr2	144389816	Missense_Mutation	novel	E1094Q	0.22
BLCA	chr2	144396506	Missense_Mutation	NA	I991M	0.37
BLCA	chr2	144399551	Missense_Mutation	novel	D546H	0.37
BLCA	chr2	144400191	Silent	novel	K332K	0.4
BLCA	chr2	144517336	Silent	novel	I5I	0.44
BLCA	chr2	144403940	Silent	NA	V261V	0.09
BLCA	chr2	144399185	Missense_Mutation	novel	E668Q	0.16
BLCA	chr2	144398703	Missense_Mutation	novel	K828N	0.17
BLCA	chr2	144389930	Nonsense_Mutation	novel	Q1056*	0.26
BLCA	chr2	144389544	Silent	novel	E1184E	0.1
BLCA	chr2	144389366	3'UTR	novel		0.09
BLCA	chr2	144396496	Missense_Mutation	novel	E995K	0.54
BLCA	chr2	144389816	Missense_Mutation	NA	E1094K	0.23
BLCA	chr2	144389816	Missense_Mutation	NA	E1094K	0.18
BLCA	chr2	144389522	Missense_Mutation	novel	D1192N	0.49
BLCA	chr2	144401259	Missense_Mutation	novel	E286Q	0.28
BLCA	chr2	144389816	Missense_Mutation	novel	E1094Q	0.17
BRCA	chr2	144430007	Silent	novel	V31V	0.22
BRCA	chr2	144398526	Missense_Mutation	novel	N887K	0.05
BRCA	chr2	144389807	Missense_Mutation	NA	E1097K	0.42
BRCA	chr2	144389682	In_Frame_Del	NA	K1138del	0.27
BRCA	chr2	144520226	5'Flank	novel		0.39
BRCA	chr2	144517317	Missense_Mutation	novel	C12G	0.22
BRCA	chr2	144389890	Missense_Mutation	novel	S1069L	0.16
BRCA	chr2	144399360	Missense_Mutation	novel	E609D	0.24
BRCA	chr2	144429830	Missense_Mutation	novel	E90D	0.13
BRCA	chr2	144389549	Missense_Mutation	NA	E1183K	0.19
BRCA	chr2	144429912	Frame_Shift_Del	novel	*Q58Lfs12**	0.19	zf-C2H2
BRCA	chr2	144398534	In_Frame_Ins	novel	S885_M886insFLHS	0.08
BRCA	chr2	144401210	Missense_Mutation	rs730881174	R302Q	0.28
BRCA	chr2	144399425	Missense_Mutation	novel	E588Q	0.07
BRCA	chr2	144398518	Missense_Mutation	novel	S890N	0.42
BRCA	chr2	144389515	Missense_Mutation	rs766682838	S1194L	0.09
BRCA	chr2	144389816	Missense_Mutation	NA	E1094K	0.14
BRCA	chr2	144399983	Missense_Mutation	NA	V402L	0.28
BRCA	chr2	144404021	In_Frame_Del	novel	I230_H234del	0.11
CESC	chr2	144404942	Silent	novel	S162S	0.16
CESC	chr2	144399654	Silent	rs587780994	V511V	0.1
CESC	chr2	144389693	Missense_Mutation	NA	E1135K	0.2
CESC	chr2	144389669	Nonsense_Mutation	NA	E1143*	0.28
CESC	chr2	144389355	3'UTR	novel		0.18
CESC	chr2	144388397	3'UTR	novel		0.22
CESC	chr2	144388927	3'UTR	novel		0.31
CESC	chr2	144389816	Missense_Mutation	NA	E1094K	0.11
CESC	chr2	144400138	Missense_Mutation	NA	T350K	0.3
CESC	chr2	144400226	Missense_Mutation	novel	H321Y	0.24
CESC	chr2	144400143	Frame_Shift_Del	novel	*K349Rfs21**	0.42
CESC	chr2	144398995	Missense_Mutation	novel	S731Y	0.3
CESC	chr2	144399789	Silent	novel	I466I	0.48
CESC	chr2	144400159	Missense_Mutation	rs746958005	R343Q	0.38
CESC	chr2	144424838	Missense_Mutation	novel	G121R	0.06
CESC	chr2	144517723	5'UTR	novel		0.36
CESC	chr2	144398486	Missense_Mutation	NA	Q901E	0.49
CESC	chr2	144520102	5'Flank	novel		0.49
CESC	chr2	144399460	Missense_Mutation	rs748955225	N576S	0.27
CESC	chr2	144398316	Silent	novel	R957R	0.09
COAD	chr2	144398596	Missense_Mutation	NA	F864C	0.38
COAD	chr2	144401218	Missense_Mutation	NA	E299D	0.35
COAD	chr2	144404885	Missense_Mutation	NA	E181D	0.43
COAD	chr2	144399905	Missense_Mutation	rs761671566	V428I	0.26
COAD	chr2	144401210	Missense_Mutation	rs730881174	R302Q	0.28
COAD	chr2	144403965	Missense_Mutation	NA	R253H	0.18
COAD	chr2	144517304	Missense_Mutation	novel	K16R	0.14
COAD	chr2	144517324	Silent	novel	G9G	0.41
COAD	chr2	144403917	Missense_Mutation	novel	Q269P	0.13
COAD	chr2	144399772	Missense_Mutation	NA	S472Y	0.27
COAD	chr2	144400065	Missense_Mutation	novel	E374D	0.08
COAD	chr2	144388883	3'UTR	novel		0.3
COAD	chr2	144389225	3'UTR	novel		0.33
COAD	chr2	144389664	Silent	rs768007761	G1144G	0.33
COAD	chr2	144404070	Missense_Mutation	NA	R218Q	0.17
COAD	chr2	144403953	Missense_Mutation	novel	E257V	0.2
COAD	chr2	144404961	Missense_Mutation	novel	R156H	0.36
COAD	chr2	144389923	Missense_Mutation	novel	D1058A	0.33
COAD	chr2	144399561	Silent	NA	S542S	0.37
COAD	chr2	144399452	Missense_Mutation	novel	T579S	0.31
COAD	chr2	144389809	Missense_Mutation	novel	R1096H	0.1
COAD	chr2	144400171	Missense_Mutation	novel	S339Y	0.33
COAD	chr2	144399351	Silent	rs754916469	A612A	0.28
COAD	chr2	144399311	Missense_Mutation	rs727504224	G626R	0.28
COAD	chr2	144388900	3'UTR	novel		0.32
COAD	chr2	144399929	Missense_Mutation	NA	L420F	0.15
COAD	chr2	144404020	Missense_Mutation	novel	E235K	0.15
COAD	chr2	144429713	Intron	novel		0.14
COAD	chr2	144399528	Silent	NA	N553N	0.29
COAD	chr2	144399737	Missense_Mutation	NA	S484A	0.45
COAD	chr2	144400108	Missense_Mutation	novel	S360Y	0.3
COAD	chr2	144398825	Missense_Mutation	NA	L788I	0.33
COAD	chr2	144399687	Silent	NA	E500E	0.21
COAD	chr2	144429765	Splice_Region	novel		0.3
COAD	chr2	144398477	Frame_Shift_Ins	novel	*F904Ifs47**	0.04
COAD	chr2	144389803	Missense_Mutation	NA	K1098T	0.39
COAD	chr2	144398352	Silent	novel	T945T	0.27
COAD	chr2	144389827	Missense_Mutation	novel	A1090V	0.33
COAD	chr2	144399635	Missense_Mutation	novel	H518Y	0.14
ESCA	chr2	144424815	Silent	rs573552493	T128T	0.27
ESCA	chr2	144398900	Missense_Mutation	novel	P763S	0.43
ESCA	chr2	144398442	Silent	novel	T915T	0.11
ESCA	chr2	144388369	3'UTR	novel		0.3
ESCA	chr2	144388156	3'UTR	novel		0.54
ESCA	chr2	144389546	Missense_Mutation	novel	E1184Q	0.14
ESCA	chr2	144424825	Missense_Mutation	rs727504227	T125M	0.09
ESCA	chr2	144400216	Missense_Mutation	NA	S324F	0.66
ESCA	chr2	144388518	3'UTR	rs529571252		0.3
ESCA	chr2	144388519	3'UTR	rs541011980		0.45
ESCA	chr2	144517690	5'UTR	novel		0.09
ESCA	chr2	144399146	Missense_Mutation	novel	V681L	0.55
GBM	chr2	144399474	Frame_Shift_Ins	novel	*M571Ifs3**	0.1
GBM	chr2	144389577	Silent	novel	D1173D	0.06
GBM	chr2	144398913	Silent	novel	L758L	0.08
GBM	chr2	144399848	Frame_Shift_Ins	novel	*L448Tfs8**	0.19
GBM	chr2	144401263	Silent	rs769481151	C284C	0.07
GBM	chr2	144389543	Missense_Mutation	novel	T1185S	0.05
GBM	chr2	144429689	Intron	novel		0.19
GBM	chr2	144389562	Silent	NA	T1178T	0.26
GBM	chr2	144398959	Missense_Mutation	novel	S743Y	0.3
GBM	chr2	144400271	Splice_Site	novel	X306_splice	0.18
GBM	chr2	144399838	Missense_Mutation	novel	F450Y	0.06
GBM	chr2	144517332	Missense_Mutation	novel	A7P	0.35
HNSC	chr2	144517405	5'UTR	novel		0.27
HNSC	chr2	144389832	Silent	rs774763773	R1088R	0.11
HNSC	chr2	144399081	Silent	NA	N702N	0.24
HNSC	chr2	144429800	Silent	rs768338735	N100N	0.16
HNSC	chr2	144398393	Missense_Mutation	novel	L932V	0.33
HNSC	chr2	144399946	Missense_Mutation	novel	P414H	0.04
HNSC	chr2	144389824	Missense_Mutation	novel	A1091E	0.15
HNSC	chr2	144398510	Missense_Mutation	NA	P893S	0.06
HNSC	chr2	144398798	Missense_Mutation	NA	H797N	0.12
HNSC	chr2	144398799	Silent	novel	S796S	0.13
HNSC	chr2	144429949	Missense_Mutation	rs749173524	G51S	0.14	zf-C2H2
HNSC	chr2	144389855	Missense_Mutation	novel	C1081R	0.4
HNSC	chr2	144389947	Missense_Mutation	novel	S1050W	0.07
HNSC	chr2	144400160	Nonsense_Mutation	rs786204815	R343*	0.39
HNSC	chr2	144399475	Missense_Mutation	novel	M571T	0.22
KIRC	chr2	144399875	Missense_Mutation	NA	H438Y	0.26
KIRC	chr2	144517280	Missense_Mutation	novel	N24T	0.25
KIRC	chr2	144399783	Missense_Mutation	NA	D468E	0.37
KIRC	chr2	144389654	Missense_Mutation	novel	Y1148N	0.53
KIRC	chr2	144396591	Missense_Mutation	novel	G963E	0.12
KIRC	chr2	144400006	Missense_Mutation	NA	P394L	0.06
KIRC	chr2	144399905	Missense_Mutation	NA	V428L	0.27
KIRP	chr2	144399823	Missense_Mutation	NA	S455N	0.14
KIRP	chr2	144398460	Silent	NA	F909F	0.35
LAML	chr2	144398780	Missense_Mutation	novel	P803S	0.05
LAML	chr2	144398817	Silent	novel	S790S	0.12
LGG	chr2	144389650	Missense_Mutation	novel	G1149A	0.1
LGG	chr2	144389352	3'UTR	novel		0.25
LGG	chr2	144398790	Silent	novel	S799S	0.13
LGG	chr2	144401211	Nonsense_Mutation	rs587784571	R302*	0.34
LGG	chr2	144400163	Missense_Mutation	NA	G342R	0.17
LGG	chr2	144389802	Silent	NA	K1098K	0.29
LGG	chr2	144430020	Frame_Shift_Del	novel	*N27Lfs2**	0.31
LIHC	chr2	144388728	3'UTR	novel		0.22
LIHC	chr2	144399072	Silent	novel	S705S	0.33
LIHC	chr2	144399790	Missense_Mutation	novel	I466T	0.49
LIHC	chr2	144424831	Missense_Mutation	novel	E123V	0.28
LIHC	chr2	144424832	Nonsense_Mutation	novel	E123*	0.28
LIHC	chr2	144398441	Missense_Mutation	novel	S916C	0.24
LIHC	chr2	144388811	3'UTR	novel		0.4
LIHC	chr2	144389709	Missense_Mutation	novel	S1129R	0.23
LIHC	chr2	144398419	Missense_Mutation	NA	Y923F	0.3
LUAD	chr2	144398509	Frame_Shift_Del	novel	*P893Lfs37**	0.21
LUAD	chr2	144399033	Missense_Mutation	NA	N718K	0.06
LUAD	chr2	144399620	Missense_Mutation	NA	K523E	0.14
LUAD	chr2	144429956	Missense_Mutation	NA	E48D	0.16
LUAD	chr2	144389604	Missense_Mutation	NA	E1164D	0.22
LUAD	chr2	144396464	Missense_Mutation	novel	D1005E	0.13
LUAD	chr2	144399620	Nonsense_Mutation	NA	K523*	0.25
LUAD	chr2	144403929	Frame_Shift_Del	novel	*Q255Rfs14**	0.06
LUAD	chr2	144429692	Intron	novel		0.32
LUAD	chr2	144517308	Missense_Mutation	NA	R15S	0.54
LUAD	chr2	144400040	Nonsense_Mutation	novel	E383*	0.16
LUAD	chr2	144398701	Missense_Mutation	novel	S829I	0.38
LUAD	chr2	144398526	Silent	novel	N887N	0.05
LUAD	chr2	144404874	Missense_Mutation	NA	R185H	0.21
LUAD	chr2	144389944	Missense_Mutation	novel	G1051V	0.17
LUAD	chr2	144398487	Silent	novel	P900P	0.05
LUAD	chr2	144517339	Silent	NA	P4P	0.36
LUAD	chr2	144398729	Missense_Mutation	NA	L820V	0.45
LUAD	chr2	144398562	Silent	NA	L875L	0.38
LUAD	chr2	144400029	Silent	novel	G386G	0.49
LUAD	chr2	144399893	Missense_Mutation	NA	A432S	0.18
LUAD	chr2	144399502	Frame_Shift_Del	novel	L562*	0.13
LUAD	chr2	144389783	Missense_Mutation	rs769219699	E1105K	0.13
LUAD	chr2	144398619	Silent	novel	S856S	0.31
LUAD	chr2	144403935	Missense_Mutation	NA	H263R	0.54
LUAD	chr2	144399509	Missense_Mutation	novel	R560G	0.08
LUAD	chr2	144389851	Missense_Mutation	novel	K1082M	0.33
LUAD	chr2	144424844	Missense_Mutation	novel	T119S	0.27
LUAD	chr2	144400092	Silent	novel	A365A	0.3
LUAD	chr2	144429931	Missense_Mutation	novel	D57H	0.17	zf-C2H2
LUAD	chr2	144399834	Frame_Shift_Del	novel	*T452Pfs2**	0.18
LUAD	chr2	144399185	Nonsense_Mutation	novel	E668*	0.17
LUAD	chr2	144389416	3'UTR	novel		0.2
LUAD	chr2	144399398	Frame_Shift_Ins	novel	*H597Sfs4**	0.05
LUAD	chr2	144399399	Missense_Mutation	novel	L596F	0.06
LUAD	chr2	144429828	Frame_Shift_Del	novel	*G91Vfs17**	0.16
LUAD	chr2	144398795	Missense_Mutation	NA	S798C	0.35
LUAD	chr2	144429688	Intron	novel		0.1
LUAD	chr2	144389959	Nonsense_Mutation	rs797046121	S1046*	0.23
LUAD	chr2	144398743	Missense_Mutation	novel	P815H	0.33
LUAD	chr2	144398744	Missense_Mutation	novel	P815T	0.34
LUAD	chr2	144400111	Missense_Mutation	NA	S359C	0.22
LUAD	chr2	144403995	Missense_Mutation	NA	C243F	0.37
LUAD	chr2	144399749	Missense_Mutation	rs143854197	A480S	0.11
LUAD	chr2	144429898	Missense_Mutation	novel	H68N	0.61	zf-C2H2
LUAD	chr2	144399280	Nonsense_Mutation	NA	L636*	0.08
LUAD	chr2	144399652	Missense_Mutation	novel	G512V	0.44
LUAD	chr2	144399426	Missense_Mutation	NA	K587N	0.37
LUAD	chr2	144429889	Missense_Mutation	NA	S71P	0.2	zf-C2H2
LUAD	chr2	144399312	Silent	rs752759296	A625A	0.39
LUAD	chr2	144398464	Missense_Mutation	novel	T908N	0.49
LUAD	chr2	144389505	Silent	NA	G1197G	0.18
LUAD	chr2	144401250	Nonsense_Mutation	NA	K289*	0.21
LUAD	chr2	144389513	Nonsense_Mutation	novel	E1195*	0.12
LUAD	chr2	144404090	Silent	novel	L211L	0.1
LUAD	chr2	144424837	Missense_Mutation	novel	G121V	0.17
LUAD	chr2	144403988	Silent	NA	L245L	0.32
LUAD	chr2	144517330	Silent	NA	A7A	0.14
LUSC	chr2	144399403	Missense_Mutation	novel	P595R	0.15
LUSC	chr2	144399511	Missense_Mutation	novel	L559P	0.19
LUSC	chr2	144399408	Silent	novel	P593P	0.3
LUSC	chr2	144405016	Missense_Mutation	novel	A138T	0.1
LUSC	chr2	144398890	Missense_Mutation	novel	F766Y	0.49
LUSC	chr2	144404841	Missense_Mutation	novel	E196V	0.15
LUSC	chr2	144404011	Nonsense_Mutation	NA	E238*	0.2
LUSC	chr2	144429797	Silent	novel	E101E	0.2
LUSC	chr2	144399416	Missense_Mutation	NA	P591S	0.25
LUSC	chr2	144400228	Missense_Mutation	novel	S320F	0.38
LUSC	chr2	144399778	Missense_Mutation	NA	T470N	0.15
LUSC	chr2	144401264	Missense_Mutation	NA	C284F	0.31
LUSC	chr2	144401253	Missense_Mutation	novel	G288C	0.22
LUSC	chr2	144389819	Missense_Mutation	novel	R1093S	0.24
LUSC	chr2	144389988	Missense_Mutation	novel	F1036L	0.18
LUSC	chr2	144399450	Silent	novel	T579T	0.32
LUSC	chr2	144398701	Frame_Shift_Del	novel	*S829Ifs3**	0.16
LUSC	chr2	144399460	Missense_Mutation	rs748955225	N576S	0.46
LUSC	chr2	144399758	Missense_Mutation	NA	D477Y	0.52
LUSC	chr2	144424820	Missense_Mutation	novel	Q127K	0.26
LUSC	chr2	144399797	Missense_Mutation	novel	L464I	0.17
LUSC	chr2	144400197	Missense_Mutation	novel	S330R	0.64
LUSC	chr2	144400120	Missense_Mutation	novel	S356Y	0.08
LUSC	chr2	144398721	Silent	novel	K822K	0.35
LUSC	chr2	144398947	Missense_Mutation	NA	L747H	0.41
LUSC	chr2	144399878	Missense_Mutation	rs760437173	Q437K	0.4
LUSC	chr2	144399781	Missense_Mutation	NA	N469I	0.39
LUSC	chr2	144429952	Missense_Mutation	novel	D50N	0.25
LUSC	chr2	144399125	Missense_Mutation	novel	V688L	0.25
LUSC	chr2	144399704	Missense_Mutation	novel	C495R	0.47
LUSC	chr2	144389486	Missense_Mutation	novel	D1204Y	0.13
LUSC	chr2	144396569	Silent	novel	Q970Q	0.13
LUSC	chr2	144398656	Missense_Mutation	novel	L844S	0.33
LUSC	chr2	144399571	Missense_Mutation	NA	C539F	0.31
LUSC	chr2	144398442	Silent	novel	T915T	0.21
LUSC	chr2	144404906	Silent	novel	I174I	0.32
LUSC	chr2	144399725	Missense_Mutation	NA	G488S	0.53
LUSC	chr2	144396572	Silent	novel	A969A	0.18
LUSC	chr2	144398318	Silent	novel	R957R	0.24
LUSC	chr2	144399584	Missense_Mutation	NA	E535K	0.22
LUSC	chr2	144398853	Silent	NA	S778S	0.31
LUSC	chr2	144404048	Silent	novel	S225S	0.59
LUSC	chr2	144399996	Missense_Mutation	novel	F397L	0.26
LUSC	chr2	144429690	Intron	novel		0.24
LUSC	chr2	144399031	Missense_Mutation	novel	S719T	0.17
LUSC	chr2	144400227	Silent	novel	S320S	0.21
LUSC	chr2	144398978	Missense_Mutation	novel	D737Y	0.52
LUSC	chr2	144399913	Missense_Mutation	novel	P425H	0.18
LUSC	chr2	144399700	Missense_Mutation	novel	S496F	0.31
LUSC	chr2	144429955	Missense_Mutation	novel	D49H	0.27
OV	chr2	144429635	Intron	novel		0.33
OV	chr2	144389461	Missense_Mutation	rs753328374	D1212G	0.06
OV	chr2	144429620	Intron	novel		0.42
OV	chr2	144429669	Intron	novel		0.57
OV	chr2	144429843	Missense_Mutation	rs770528613	D86G	0.62
OV	chr2	144404856	Missense_Mutation	NA	A191G	0.14
OV	chr2	144398631	Silent	novel	S852S	0.26
OV	chr2	144429863	Silent	novel	L79L	0.2
OV	chr2	144404046	Missense_Mutation	NA	L226P	0.23
OV	chr2	144398945	Missense_Mutation	novel	H748N	0.07
OV	chr2	144429698	Intron	novel		0.09
OV	chr2	144389736	Silent	NA	G1120G	0.27
OV	chr2	144398636	Missense_Mutation	novel	S851P	0.07
OV	chr2	144389953	Missense_Mutation	novel	L1048R	0.1
OV	chr2	144429608	Intron	novel		0.48
OV	chr2	144404009	Frame_Shift_Del	novel	*E239Rfs23**	0.06
PAAD	chr2	144389572	Missense_Mutation	novel	D1175G	0.08
PAAD	chr2	144398426	Nonsense_Mutation	rs587784566	R921*	0.09
PAAD	chr2	144399344	Nonsense_Mutation	NA	Q615*	0.33
PAAD	chr2	144404000	Silent	novel	F241F	0.11
PAAD	chr2	144429750	Intron	novel		0.09
PAAD	chr2	144429973	Missense_Mutation	novel	K43E	0.29
PAAD	chr2	144517401	5'UTR	novel		0.28
PAAD	chr2	144404923	Missense_Mutation	rs769433211	R169C	0.18
PAAD	chr2	144389889	Silent	NA	S1069S	0.11
PAAD	chr2	144399352	Missense_Mutation	NA	A612V	0.09
PCPG	chr2	144399557	Missense_Mutation	novel	T544A	0.17
PRAD	chr2	144398864	Silent	NA	L775L	0.22
PRAD	chr2	144389872	Missense_Mutation	novel	N1075S	0.45
PRAD	chr2	144404958	Missense_Mutation	rs761041545	D157G	0.19
PRAD	chr2	144389318	3'UTR	novel		0.75
PRAD	chr2	144389934	Silent	novel	P1054P	0.41
PRAD	chr2	144517324	Silent	novel	G9G	0.33
READ	chr2	144399008	Missense_Mutation	NA	L727V	0.29
READ	chr2	144400161	Silent	NA	G342G	0.33
READ	chr2	144401220	Missense_Mutation	NA	E299K	0.19
READ	chr2	144429734	Intron	novel		0.37
READ	chr2	144517308	Missense_Mutation	NA	R15C	0.17
READ	chr2	144404938	Missense_Mutation	rs771155056	E164K	0.33
READ	chr2	144400159	Missense_Mutation	rs746958005	R343Q	0.44
READ	chr2	144399352	Missense_Mutation	NA	A612V	0.38
READ	chr2	144399724	Missense_Mutation	novel	G488D	0.11
READ	chr2	144398921	Missense_Mutation	NA	P756S	0.36
READ	chr2	144398308	Missense_Mutation	novel	G960E	0.38
READ	chr2	144398318	Missense_Mutation	NA	R957W	0.32
READ	chr2	144389383	3'UTR	novel		0.25
READ	chr2	144398329	Missense_Mutation	NA	R953I	0.64
READ	chr2	144400001	Missense_Mutation	NA	D396N	0.18
READ	chr2	144400207	Missense_Mutation	novel	S327L	0.25
READ	chr2	144404842	Nonsense_Mutation	NA	E196*	0.66
READ	chr2	144404982	Missense_Mutation	NA	A149V	0.25
READ	chr2	144429971	Missense_Mutation	novel	K43N	0.2
SARC	chr2	144400147	Frame_Shift_Del	novel	*N347Yfs8**	0.23
SARC	chr2	144399321	Silent	novel	P622P	0.08
SARC	chr2	144519948	5'Flank	novel		0.38
SKCM	chr2	144389801	Missense_Mutation	NA	G1099R	0.34
SKCM	chr2	144389870	Missense_Mutation	NA	H1076D	0.08
SKCM	chr2	144399560	Missense_Mutation	NA	L543V	0.25
SKCM	chr2	144398597	Missense_Mutation	novel	F864I	0.21
SKCM	chr2	144399113	Missense_Mutation	novel	F692I	0.3
SKCM	chr2	144517291	Silent	novel	P20P	0.26
SKCM	chr2	144517292	Missense_Mutation	rs730881206	P20L	0.27
SKCM	chr2	144400216	Missense_Mutation	NA	S324F	0.31
SKCM	chr2	144398746	Missense_Mutation	novel	E814G	0.18
SKCM	chr2	144399566	Nonsense_Mutation	NA	Q541*	0.31
SKCM	chr2	144398948	Missense_Mutation	novel	L747V	0.28
SKCM	chr2	144398447	Nonsense_Mutation	novel	Q914*	0.29
SKCM	chr2	144389616	Silent	NA	F1160F	0.06
SKCM	chr2	144398896	Missense_Mutation	NA	S764F	0.11
SKCM	chr2	144389534	Missense_Mutation	NA	H1188Y	0.43
SKCM	chr2	144401245	Silent	NA	A290A	0.46
SKCM	chr2	144389936	Missense_Mutation	NA	P1054S	0.43
SKCM	chr2	144399448	Missense_Mutation	NA	P580L	0.71
SKCM	chr2	144396427	Missense_Mutation	NA	K1018E	0.38
SKCM	chr2	144401269	Silent	NA	F282F	0.41
SKCM	chr2	144398875	Missense_Mutation	novel	P771L	0.5
SKCM	chr2	144399432	Silent	novel	F585F	0.31
SKCM	chr2	144401205	Missense_Mutation	novel	H304Y	0.39
SKCM	chr2	144401259	Missense_Mutation	NA	E286K	0.37
STAD	chr2	144517377	5'UTR	novel		0.07
STAD	chr2	144399923	Missense_Mutation	rs141793065	A422T	0.24
STAD	chr2	144429746	Intron	novel		0.17
STAD	chr2	144400240	Missense_Mutation	novel	K316R	0.08
STAD	chr2	144399733	Missense_Mutation	NA	K485T	0.11
STAD	chr2	144399755	Missense_Mutation	NA	C478G	0.38
STAD	chr2	144399069	Silent	NA	P706P	0.5
STAD	chr2	144396584	Missense_Mutation	novel	L965F	0.17
STAD	chr2	144398481	Silent	rs754727621	S902S	0.31
STAD	chr2	144399118	Missense_Mutation	NA	E690G	0.29
STAD	chr2	144399538	Missense_Mutation	NA	Q550R	0.21
STAD	chr2	144398675	Missense_Mutation	novel	K838Q	0.17
STAD	chr2	144389535	Silent	NA	D1187D	0.32
STAD	chr2	144399994	Missense_Mutation	NA	N398S	0.21
STAD	chr2	144396516	Missense_Mutation	rs776367143	R988H	0.22
STAD	chr2	144399189	Silent	NA	N666N	0.23
STAD	chr2	144399646	Missense_Mutation	NA	P514L	0.27
STAD	chr2	144398647	Missense_Mutation	NA	N847T	0.08
STAD	chr2	144424814	Missense_Mutation	rs730881187	A129T	0.32
STAD	chr2	144404021	Silent	rs140169964	H234H	0.12
STAD	chr2	144429715	Intron	novel		0.2
STAD	chr2	144398638	Missense_Mutation	rs529220318	S850F	0.23
STAD	chr2	144396419	Silent	NA	E1020E	0.33
STAD	chr2	144399154	Missense_Mutation	NA	S678F	0.21
STAD	chr2	144404874	Missense_Mutation	NA	R185H	0.37
STAD	chr2	144517417	Splice_Region	novel		0.38
STAD	chr2	144399509	Missense_Mutation	rs730881194	R560C	0.12
STAD	chr2	144404909	Silent	novel	A173A	0.3
STAD	chr2	144398584	Missense_Mutation	novel	E868V	0.18
STAD	chr2	144398585	Nonsense_Mutation	novel	E868*	0.19
STAD	chr2	144429769	Nonsense_Mutation	NA	E111*	0.2
STAD	chr2	144517320	Frame_Shift_Del	NA	*R11Gfs16**	0.1
STAD	chr2	144398637	Silent	NA	S850S	0.04
STAD	chr2	144404863	Missense_Mutation	NA	P189S	0.22
STAD	chr2	144398603	Missense_Mutation	NA	L862V	0.23
STAD	chr2	144398603	Silent	NA	L862L	0.23
STAD	chr2	144517365	5'UTR	novel		0.23
STAD	chr2	144389630	Missense_Mutation	rs776351453	G1156C	0.33
STAD	chr2	144398984	Missense_Mutation	rs144154908	P735S	0.19
STAD	chr2	144399009	Silent	novel	S726S	0.23
THCA	chr2	144398513	In_Frame_Ins	novel	A891_K892insE	0.03
THCA	chr2	144398514	Silent	novel	A891A	0.03
THCA	chr2	144399188	Nonsense_Mutation	novel	*M667Yfs4**	0.06
THCA	chr2	144403977	Missense_Mutation	novel	T249M	0.4
THCA	chr2	144429704	Intron	novel		0.08
THYM	chr2	144388511	3'UTR	novel		0.33
THYM	chr2	144388937	3'UTR	novel		0.73
UCEC	chr2	144404006	Missense_Mutation	NA	E239D	0.37
UCEC	chr2	144430007	Silent	novel	V31V	0.07
UCEC	chr2	144389979	Missense_Mutation	NA	K1039N	0.28
UCEC	chr2	144399689	Missense_Mutation	NA	E500K	0.25
UCEC	chr2	144388297	3'UTR	novel		0.33
UCEC	chr2	144388793	3'UTR	novel		0.5
UCEC	chr2	144388965	3'UTR	novel		0.29
UCEC	chr2	144398360	Missense_Mutation	novel	A943T	0.55
UCEC	chr2	144389852	Missense_Mutation	novel	K1082E	0.4
UCEC	chr2	144399512	Silent	NA	L559L	0.28
UCEC	chr2	144429799	Missense_Mutation	NA	E101K	0.39
UCEC	chr2	144398393	Missense_Mutation	novel	L932I	0.34
UCEC	chr2	144398711	Nonsense_Mutation	novel	E826*	0.36
UCEC	chr2	144399971	Missense_Mutation	novel	T406A	0.22
UCEC	chr2	144389676	Silent	novel	H1140H	0.31
UCEC	chr2	144390023	Missense_Mutation	novel	R1025G	0.67
UCEC	chr2	144520154	5'Flank	novel		0.4
UCEC	chr2	144399497	Missense_Mutation	NA	D564Y	0.43
UCEC	chr2	144430007	Silent	novel	V31V	0.12
UCEC	chr2	144430009	In_Frame_Ins	novel	N30_V31insL	0.12
UCEC	chr2	144399402	Silent	novel	P595P	0.38
UCEC	chr2	144401204	Missense_Mutation	novel	H304R	0.15
UCEC	chr2	144399516	Missense_Mutation	novel	E557D	0.47
UCEC	chr2	144389675	Missense_Mutation	NA	E1141K	0.36
UCEC	chr2	144398910	Silent	novel	R759R	0.4
UCEC	chr2	144400137	Silent	rs532720008	T350T	0.39
UCEC	chr2	144404100	Missense_Mutation	novel	A208V	0.48
UCEC	chr2	144429942	Missense_Mutation	novel	A53V	0.38	zf-C2H2
UCEC	chr2	144388686	3'UTR	novel		0.12
UCEC	chr2	144388945	3'UTR	novel		0.28
UCEC	chr2	144388164	3'UTR	novel		0.13
UCEC	chr2	144396503	Missense_Mutation	novel	K992N	0.19
UCEC	chr2	144401210	Missense_Mutation	novel	R302L	0.26
UCEC	chr2	144513691	Intron	novel		0.27
UCEC	chr2	144519948	5'Flank	novel		0.5
UCEC	chr2	144401248	Silent	NA	K289K	0.12
UCEC	chr2	144398534	Frame_Shift_Ins	novel	*S885Ffs4**	0.03
UCEC	chr2	144430006	Frame_Shift_Ins	novel	*V32Ffs8**	0.08
UCEC	chr2	144389562	Silent	NA	T1178T	0.3
UCEC	chr2	144389889	Silent	NA	S1069S	0.25
UCEC	chr2	144398534	Frame_Shift_Ins	novel	*S885Ffs4**	0.03
UCEC	chr2	144424814	Missense_Mutation	rs730881187	A129T	0.22
UCEC	chr2	144399904	Missense_Mutation	rs730881192	V428A	0.2
UCEC	chr2	144389051	3'UTR	novel		0.16
UCEC	chr2	144400137	Silent	rs532720008	T350T	0.44
UCEC	chr2	144405020	Missense_Mutation	NA	K136N	0.44
UCEC	chr2	144424811	Missense_Mutation	NA	I130V	0.48
UCEC	chr2	144424865	Missense_Mutation	NA	E112K	0.39
UCEC	chr2	144398633	Nonsense_Mutation	novel	*S851_S852insIVLAHRFVHVKANSSVSS*	0.02
UCEC	chr2	144399325	Missense_Mutation	NA	V621A	0.31
UCEC	chr2	144399660	Silent	rs759999662	P509P	0.23
UCEC	chr2	144388059	3'UTR	novel		0.45
UCEC	chr2	144388351	3'UTR	novel		0.17
UCEC	chr2	144399985	Missense_Mutation	novel	K401T	0.42
UCEC	chr2	144400230	Silent	novel	F319F	0.46
UCEC	chr2	144401210	Missense_Mutation	rs730881174	R302Q	0.33
UCEC	chr2	144404006	Missense_Mutation	NA	E239D	0.43
UCEC	chr2	144389023	3'UTR	novel		0.4
UCEC	chr2	144389169	3'UTR	novel		0.34
UCEC	chr2	144389515	Missense_Mutation	rs766682838	S1194L	0.4
UCEC	chr2	144398564	Missense_Mutation	novel	L875M	0.27
UCEC	chr2	144398812	Missense_Mutation	novel	S792Y	0.42
UCEC	chr2	144400207	Missense_Mutation	novel	S327L	0.18
UCEC	chr2	144403917	Missense_Mutation	novel	Q269P	0.21
UCEC	chr2	144404960	Silent	NA	R156R	0.34
UCEC	chr2	144429753	Intron	novel		0.48
UCEC	chr2	144389318	3'UTR	novel		0.19
UCEC	chr2	144520231	5'Flank	novel		0.24
UCEC	chr2	144398419	Missense_Mutation	novel	Y923C	0.16
UCEC	chr2	144389816	Missense_Mutation	NA	E1094K	0.54
UCEC	chr2	144389206	3'UTR	novel		0.38
UCEC	chr2	144400138	Missense_Mutation	NA	T350M	0.24
UCEC	chr2	144389817	Silent	novel	R1093R	0.13
UCEC	chr2	144399337	Missense_Mutation	NA	H617R	0.49
UCEC	chr2	144388220	3'UTR	rs550711574		0.32
UCEC	chr2	144396509	Missense_Mutation	novel	K990N	0.38
UCEC	chr2	144388238	3'UTR	novel		0.25
UCEC	chr2	144396533	Silent	rs769095107	S982S	0.35
UCEC	chr2	144388511	3'UTR	novel		0.41
UCEC	chr2	144404875	Missense_Mutation	rs755598619	R185C	0.14
UCEC	chr2	144400235	Missense_Mutation	novel	R318C	0.1
UCEC	chr2	144404910	Missense_Mutation	novel	A173V	0.15
UCEC	chr2	144388518	3'UTR	rs529571252		0.54
UCEC	chr2	144398480	Missense_Mutation	NA	A903T	0.46
UCEC	chr2	144399892	Missense_Mutation	novel	A432D	0.55
UCEC	chr2	144520209	5'Flank	novel		0.55
UCEC	chr2	144388797	3'UTR	novel		0.56
UCEC	chr2	144401210	Missense_Mutation	rs730881174	R302Q	0.42
UCEC	chr2	144429687	Intron	novel		0.1
UCEC	chr2	144429688	Intron	novel		0.1
UCEC	chr2	144389501	Frame_Shift_Del	novel	*M1199Wfs42**	0.48
UCEC	chr2	144401210	Missense_Mutation	rs730881174	R302Q	0.2
UCEC	chr2	144403965	Missense_Mutation	NA	R253H	0.4
UCEC	chr2	144388717	3'UTR	novel		0.39
UCEC	chr2	144388125	3'UTR	novel		0.28
UCEC	chr2	144388307	3'UTR	novel		0.16
UCEC	chr2	144389675	Missense_Mutation	NA	E1141K	0.27
UCEC	chr2	144388544	3'UTR	novel		0.41
UCEC	chr2	144389149	3'UTR	novel		0.08
UCEC	chr2	144398930	Missense_Mutation	novel	N753D	0.36
UCEC	chr2	144400225	Missense_Mutation	NA	H321R	0.28
UCEC	chr2	144430007	Silent	novel	V31V	0.27
UCEC	chr2	144430009	In_Frame_Ins	novel	N30_V31insYL	0.25
UCEC	chr2	144398534	Frame_Shift_Ins	novel	*S885Ffs4**	0.05
UCEC	chr2	144399368	Missense_Mutation	novel	N607D	0.07
UCEC	chr2	144388220	3'UTR	rs550711574		0.26
UCEC	chr2	144388987	3'UTR	novel		0.25
UCEC	chr2	144399497	Missense_Mutation	NA	D564Y	0.13
UCEC	chr2	144404074	Missense_Mutation	rs755199698	D217N	0.29
UCEC	chr2	144400207	Missense_Mutation	novel	S327L	0.35
UCEC	chr2	144388937	3'UTR	novel		0.64
UCEC	chr2	144398602	Frame_Shift_Ins	novel	*L862Sfs17**	0.05
UCEC	chr2	144404131	Splice_Site	novel	X198_splice	0.23
UCEC	chr2	144399966	Silent	rs144613207	H407H	0.38
UCEC	chr2	144513684	Intron	novel		0.49
UCEC	chr2	144429770	Splice_Region	novel	P110P	0.53
UCEC	chr2	144400207	Missense_Mutation	novel	S327L	0.48
UCEC	chr2	144401277	Missense_Mutation	rs773002262	R280C	0.37
UCEC	chr2	144398313	Missense_Mutation	novel	K958N	0.48
UCEC	chr2	144399285	Silent	novel	L634L	0.31
UCEC	chr2	144400191	Missense_Mutation	novel	K332N	0.35
UCEC	chr2	144401210	Missense_Mutation	rs730881174	R302Q	0.34
UCEC	chr2	144520316	5'Flank	novel		0.55
UCEC	chr2	144389567	Missense_Mutation	NA	E1177K	0.28
UCEC	chr2	144398769	Missense_Mutation	NA	F806L	0.2
UCEC	chr2	144399082	Missense_Mutation	novel	N702T	0.17
UCEC	chr2	144404006	Missense_Mutation	NA	E239D	0.18
UCEC	chr2	144398481	Silent	rs754727621	S902S	0.08
UCEC	chr2	144389119	3'UTR	novel		0.25
UCEC	chr2	144389563	Missense_Mutation	novel	T1178M	0.32
UCEC	chr2	144398969	Missense_Mutation	novel	T740A	0.2
UCEC	chr2	144399501	Silent	novel	L562L	0.3
UCEC	chr2	144399730	Missense_Mutation	novel	L486W	0.15
UCEC	chr2	144429667	Intron	novel		0.31
UCEC	chr2	144513670	Intron	novel		0.25
UCEC	chr2	144388511	3'UTR	novel		0.48
UCEC	chr2	144424816	Missense_Mutation	NA	T128I	0.27
UCEC	chr2	144388660	3'UTR	novel		0.24
UCEC	chr2	144388511	3'UTR	novel		0.41
UCEC	chr2	144399477	Silent	novel	K570K	0.48
UCEC	chr2	144403951	Missense_Mutation	NA	R258W	0.25
UCEC	chr2	144400076	Missense_Mutation	NA	N371D	0.39
UCEC	chr2	144401269	Missense_Mutation	novel	F282L	0.07
UCEC	chr2	144517339	Silent	NA	P4P	0.44
UCEC	chr2	144401210	Missense_Mutation	rs730881174	R302Q	0.38
UCEC	chr2	144399284	Missense_Mutation	NA	L635I	0.49
UCEC	chr2	144396421	Missense_Mutation	NA	E1020K	0.25
UCEC	chr2	144396589	Nonsense_Mutation	NA	E964*	0.44
UCEC	chr2	144398599	Missense_Mutation	novel	T863S	0.04
UCEC	chr2	144398820	Silent	NA	S789S	0.35
UCEC	chr2	144389557	Missense_Mutation	novel	R1180Q	0.22
UCEC	chr2	144399885	Silent	novel	S434S	0.44
UCEC	chr2	144399293	Missense_Mutation	novel	K632E	0.45
UCEC	chr2	144398900	Missense_Mutation	novel	P763S	0.43
UCEC	chr2	144513698	Intron	novel		0.32
UCEC	chr2	144389883	Silent	NA	S1071S	0.25
UCEC	chr2	144398426	Nonsense_Mutation	rs587784566	R921*	0.28
UCEC	chr2	144404960	Silent	NA	R156R	0.23
UCEC	chr2	144388937	3'UTR	novel		0.48
UCEC	chr2	144388039	3'UTR	novel		0.42
UCEC	chr2	144388856	3'UTR	novel		0.23
UCEC	chr2	144396589	Missense_Mutation	novel	E964K	0.45
UCEC	chr2	144400132	Missense_Mutation	novel	S352Y	0.38
UCEC	chr2	144404058	Missense_Mutation	novel	R222H	0.38
UCEC	chr2	144513731	Intron	novel		0.49
UCEC	chr2	144430007	Silent	novel	V31V	0.11
UCEC	chr2	144430009	Nonsense_Mutation	novel	V31*	0.11
UCEC	chr2	144388645	3'UTR	novel		0.3
UCEC	chr2	144388847	3'UTR	novel		0.41
UCEC	chr2	144429907	Missense_Mutation	novel	V65M	0.17	zf-C2H2
UCEC	chr2	144388937	3'UTR	novel		0.56

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
COAD	DEL	0.031	0.13394
DLBC	DEL	0.1458	0.01124
PAAD	DEL	0.0489	0.2014

Survival Analysis

Cancer	P-value	Q-value
THYM	0.043	Kaplan-Meier Survival Analysis
STAD	0.026	Kaplan-Meier Survival Analysis
SARC	0.0089	Kaplan-Meier Survival Analysis
MESO	0.0096	Kaplan-Meier Survival Analysis
LUSC	0.0059	Kaplan-Meier Survival Analysis
TGCT	0.046	Kaplan-Meier Survival Analysis
BLCA	0.025	Kaplan-Meier Survival Analysis
LGG	0.017	Kaplan-Meier Survival Analysis
CHOL	0.029	Kaplan-Meier Survival Analysis
LUAD	0.00032	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742