EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000169635 (Gene tree)
Gene ID: 23119
Gene Symbol: HIC2
Alias: KIAA1020|HRG22|ZBTB30|ZNF907
Full Name: HIC ZBTB transcriptional repressor 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 34,060 bases
Position: chr22:21,417,404-21,451,463
Accession: 18595
RBP type: canonical RBP
Summary: HIC2 (HIC ZBTB Transcriptional Repressor 2) is a Protein Coding gene. Diseases associated with HIC2 include Digeorge Syndrome. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding. An important paralog of this gene is HIC1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000384889	zf-C2H2	PF00096.26	1.2e-23	1	4
ENSP00000384889	zf-C2H2	PF00096.26	1.2e-23	2	4
ENSP00000384889	zf-C2H2	PF00096.26	1.2e-23	3	4
ENSP00000384889	zf-C2H2	PF00096.26	1.2e-23	4	4
ENSP00000385319	zf-C2H2	PF00096.26	1.2e-23	1	4
ENSP00000385319	zf-C2H2	PF00096.26	1.2e-23	2	4
ENSP00000385319	zf-C2H2	PF00096.26	1.2e-23	3	4
ENSP00000385319	zf-C2H2	PF00096.26	1.2e-23	4	4
ENSP00000387757	zf-C2H2	PF00096.26	1.2e-23	1	4
ENSP00000387757	zf-C2H2	PF00096.26	1.2e-23	2	4
ENSP00000387757	zf-C2H2	PF00096.26	1.2e-23	3	4
ENSP00000387757	zf-C2H2	PF00096.26	1.2e-23	4	4
ENSP00000384889	zf-met	PF12874.7	1.9e-09	1	2
ENSP00000384889	zf-met	PF12874.7	1.9e-09	2	2
ENSP00000385319	zf-met	PF12874.7	1.9e-09	1	2
ENSP00000385319	zf-met	PF12874.7	1.9e-09	2	2
ENSP00000387757	zf-met	PF12874.7	1.9e-09	1	2
ENSP00000387757	zf-met	PF12874.7	1.9e-09	2	2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000407598	HIC2-202	4734	XM_011530008	ENSP00000384889	615 (aa)	XP_011528310	Q96JB3
ENST00000443632	HIC2-203	6940	-	ENSP00000387757	615 (aa)	-	Q96JB3
ENST00000407464	HIC2-201	6798	XM_011530007	ENSP00000385319	615 (aa)	XP_011528309	Q96JB3

Gene Model

Click here to download ENSG00000169635's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000169635	Autistic Disorder	4.9945000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169635's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000169635	HIC2	96	55.431	ENSAPOG00000005694	hic2	100	55.878	Acanthochromis_polyacanthus
ENSG00000169635	HIC2	96	54.781	ENSACIG00000018835	hic2	100	56.607	Amphilophus_citrinellus
ENSG00000169635	HIC2	96	55.267	ENSAOCG00000001395	hic2	100	56.373	Amphiprion_ocellaris
ENSG00000169635	HIC2	96	55.267	ENSAPEG00000016621	hic2	100	56.373	Amphiprion_percula
ENSG00000169635	HIC2	96	55.987	ENSATEG00000021233	hic2	100	55.574	Anabas_testudineus
ENSG00000169635	HIC2	96	66.063	ENSAPLG00000002158	HIC2	100	66.392	Anas_platyrhynchos
ENSG00000169635	HIC2	100	97.236	ENSANAG00000027852	HIC2	100	97.236	Aotus_nancymaae
ENSG00000169635	HIC2	96	54.400	ENSACLG00000010236	hic2	100	55.929	Astatotilapia_calliptera
ENSG00000169635	HIC2	65	59.908	ENSAMXG00000030914	hic1l	77	59.908	Astyanax_mexicanus
ENSG00000169635	HIC2	99	54.062	ENSAMXG00000024918	hic2	99	55.803	Astyanax_mexicanus
ENSG00000169635	HIC2	100	83.793	ENSBTAG00000005951	HIC2	100	83.955	Bos_taurus
ENSG00000169635	HIC2	100	97.398	ENSCJAG00000006497	HIC2	100	97.398	Callithrix_jacchus
ENSG00000169635	HIC2	100	93.528	ENSCAFG00000032493	HIC2	100	92.395	Canis_familiaris
ENSG00000169635	HIC2	100	93.528	ENSCAFG00020015055	HIC2	100	92.395	Canis_lupus_dingo
ENSG00000169635	HIC2	100	83.630	ENSCHIG00000007511	HIC2	100	83.306	Capra_hircus
ENSG00000169635	HIC2	100	94.797	ENSTSYG00000031032	HIC2	100	93.984	Carlito_syrichta
ENSG00000169635	HIC2	100	91.748	ENSCPOG00000001134	HIC2	100	91.748	Cavia_porcellus
ENSG00000169635	HIC2	100	97.724	ENSCCAG00000023925	HIC2	100	97.724	Cebus_capucinus
ENSG00000169635	HIC2	100	98.537	ENSCATG00000032567	HIC2	100	98.537	Cercocebus_atys
ENSG00000169635	HIC2	100	91.909	ENSCLAG00000017018	HIC2	100	91.909	Chinchilla_lanigera
ENSG00000169635	HIC2	100	98.211	ENSCSAG00000013356	HIC2	100	98.211	Chlorocebus_sabaeus
ENSG00000169635	HIC2	96	66.722	ENSCPBG00000010464	HIC2	100	67.049	Chrysemys_picta_bellii
ENSG00000169635	HIC2	100	98.211	ENSCANG00000040132	HIC2	100	98.211	Colobus_angolensis_palliatus
ENSG00000169635	HIC2	100	87.279	ENSCGRG00001021159	Hic2	100	86.035	Cricetulus_griseus_chok1gshd
ENSG00000169635	HIC2	100	87.279	ENSCGRG00000006928	Hic2	100	86.035	Cricetulus_griseus_crigri
ENSG00000169635	HIC2	96	53.686	ENSCSEG00000019899	hic2	100	54.952	Cynoglossus_semilaevis
ENSG00000169635	HIC2	96	55.122	ENSCVAG00000019191	hic2	100	55.520	Cyprinodon_variegatus
ENSG00000169635	HIC2	55	69.672	ENSDARG00000045660	hic1l	69	69.672	Danio_rerio
ENSG00000169635	HIC2	96	57.616	ENSDARG00000100497	hic2	100	56.860	Danio_rerio
ENSG00000169635	HIC2	100	90.097	ENSDNOG00000003162	HIC2	100	90.097	Dasypus_novemcinctus
ENSG00000169635	HIC2	100	90.584	ENSDORG00000028360	Hic2	100	90.584	Dipodomys_ordii
ENSG00000169635	HIC2	100	94.337	ENSEASG00005022299	HIC2	100	93.204	Equus_asinus_asinus
ENSG00000169635	HIC2	100	94.175	ENSECAG00000017997	HIC2	100	93.042	Equus_caballus
ENSG00000169635	HIC2	96	48.293	ENSELUG00000002408	hic2	100	48.293	Esox_lucius
ENSG00000169635	HIC2	96	57.532	ENSELUG00000021193	hic2	100	56.888	Esox_lucius
ENSG00000169635	HIC2	100	93.204	ENSFCAG00000023903	HIC2	100	92.071	Felis_catus
ENSG00000169635	HIC2	96	67.545	ENSFALG00000014495	HIC2	100	66.227	Ficedula_albicollis
ENSG00000169635	HIC2	100	90.129	ENSFDAG00000011245	HIC2	100	90.129	Fukomys_damarensis
ENSG00000169635	HIC2	96	54.812	ENSFHEG00000006964	hic2	100	55.285	Fundulus_heteroclitus
ENSG00000169635	HIC2	99	53.395	ENSGMOG00000011705	hic2	99	54.206	Gadus_morhua
ENSG00000169635	HIC2	96	66.227	ENSGALG00000033416	HIC2	100	65.082	Gallus_gallus
ENSG00000169635	HIC2	96	54.327	ENSGAFG00000018031	hic2	100	55.089	Gambusia_affinis
ENSG00000169635	HIC2	99	53.125	ENSGACG00000004268	hic2	99	54.646	Gasterosteus_aculeatus
ENSG00000169635	HIC2	96	66.722	ENSGAGG00000016023	HIC2	100	67.051	Gopherus_agassizii
ENSG00000169635	HIC2	100	99.675	ENSGGOG00000037763	HIC2	100	99.675	Gorilla_gorilla
ENSG00000169635	HIC2	96	54.943	ENSHBUG00000012959	hic2	100	56.494	Haplochromis_burtoni
ENSG00000169635	HIC2	100	90.453	ENSHGLG00000008541	HIC2	100	90.453	Heterocephalus_glaber_female
ENSG00000169635	HIC2	100	81.230	ENSHGLG00100007585	-	100	81.877	Heterocephalus_glaber_male
ENSG00000169635	HIC2	100	88.511	ENSHGLG00100000200	-	100	89.159	Heterocephalus_glaber_male
ENSG00000169635	HIC2	96	56.515	ENSIPUG00000013986	hic2	100	55.738	Ictalurus_punctatus
ENSG00000169635	HIC2	53	65.000	ENSIPUG00000003207	hic2	67	65.000	Ictalurus_punctatus
ENSG00000169635	HIC2	100	91.424	ENSSTOG00000006360	HIC2	100	91.909	Ictidomys_tridecemlineatus
ENSG00000169635	HIC2	99	89.303	ENSJJAG00000009939	Hic2	100	89.465	Jaculus_jaculus
ENSG00000169635	HIC2	82	46.692	ENSKMAG00000004641	hic2	91	48.381	Kryptolebias_marmoratus
ENSG00000169635	HIC2	96	54.045	ENSLBEG00000024306	hic2	100	56.026	Labrus_bergylta
ENSG00000169635	HIC2	63	52.968	ENSLBEG00000010933	-	72	59.322	Labrus_bergylta
ENSG00000169635	HIC2	52	67.797	ENSLBEG00000013821	hic2	72	67.797	Labrus_bergylta
ENSG00000169635	HIC2	87	53.721	ENSLACG00000011864	HIC2	95	52.973	Latimeria_chalumnae
ENSG00000169635	HIC2	97	61.827	ENSLOCG00000002169	hic2	96	60.522	Lepisosteus_oculatus
ENSG00000169635	HIC2	100	98.537	ENSMFAG00000004992	HIC2	100	98.537	Macaca_fascicularis
ENSG00000169635	HIC2	99	98.361	ENSMMUG00000031089	HIC2	99	98.361	Macaca_mulatta
ENSG00000169635	HIC2	100	98.211	ENSMNEG00000003509	HIC2	100	98.211	Macaca_nemestrina
ENSG00000169635	HIC2	100	98.537	ENSMLEG00000031489	HIC2	100	98.537	Mandrillus_leucophaeus
ENSG00000169635	HIC2	96	55.016	ENSMAMG00000013476	hic2	100	56.189	Mastacembelus_armatus
ENSG00000169635	HIC2	99	54.259	ENSMZEG00005010459	hic2	99	55.854	Maylandia_zebra
ENSG00000169635	HIC2	97	66.447	ENSMGAG00000000949	HIC2	100	65.303	Meleagris_gallopavo
ENSG00000169635	HIC2	100	87.923	ENSMAUG00000019790	Hic2	100	85.875	Mesocricetus_auratus
ENSG00000169635	HIC2	100	92.683	ENSMICG00000044556	HIC2	100	92.683	Microcebus_murinus
ENSG00000169635	HIC2	100	88.548	ENSMOCG00000021488	Hic2	100	88.548	Microtus_ochrogaster
ENSG00000169635	HIC2	97	72.330	ENSMODG00000017662	HIC2	98	72.123	Monodelphis_domestica
ENSG00000169635	HIC2	96	56.149	ENSMALG00000021292	hic2	100	56.230	Monopterus_albus
ENSG00000169635	HIC2	100	86.774	MGP_CAROLIEiJ_G0020510	Hic2	100	87.097	Mus_caroli
ENSG00000169635	HIC2	100	88.065	ENSMUSG00000050240	Hic2	100	87.742	Mus_musculus
ENSG00000169635	HIC2	100	87.581	MGP_PahariEiJ_G0016215	Hic2	100	87.258	Mus_pahari
ENSG00000169635	HIC2	100	87.903	MGP_SPRETEiJ_G0021405	Hic2	100	87.581	Mus_spretus
ENSG00000169635	HIC2	100	92.880	ENSMPUG00000003198	HIC2	100	92.233	Mustela_putorius_furo
ENSG00000169635	HIC2	100	92.880	ENSMLUG00000009669	HIC2	100	91.748	Myotis_lucifugus
ENSG00000169635	HIC2	100	90.177	ENSNGAG00000000850	Hic2	100	89.855	Nannospalax_galili
ENSG00000169635	HIC2	96	55.267	ENSNBRG00000020589	hic2	100	56.818	Neolamprologus_brichardi
ENSG00000169635	HIC2	99	88.746	ENSNLEG00000000203	HIC2	99	88.746	Nomascus_leucogenys
ENSG00000169635	HIC2	100	90.777	ENSODEG00000016054	HIC2	100	88.871	Octodon_degus
ENSG00000169635	HIC2	97	55.646	ENSONIG00000014335	hic2	100	57.050	Oreochromis_niloticus
ENSG00000169635	HIC2	99	90.244	ENSOCUG00000010516	HIC2	92	90.732	Oryctolagus_cuniculus
ENSG00000169635	HIC2	96	54.708	ENSORLG00000002131	hic2	100	55.829	Oryzias_latipes
ENSG00000169635	HIC2	96	54.708	ENSORLG00020006527	hic2	100	55.829	Oryzias_latipes_hni
ENSG00000169635	HIC2	96	54.870	ENSORLG00015016278	hic2	100	56.158	Oryzias_latipes_hsok
ENSG00000169635	HIC2	96	54.457	ENSOMEG00000018752	hic2	100	55.501	Oryzias_melastigma
ENSG00000169635	HIC2	100	93.496	ENSOGAG00000030274	HIC2	100	93.496	Otolemur_garnettii
ENSG00000169635	HIC2	100	99.512	ENSPPAG00000037732	HIC2	100	99.512	Pan_paniscus
ENSG00000169635	HIC2	100	92.419	ENSPPRG00000021035	-	100	91.290	Panthera_pardus
ENSG00000169635	HIC2	99	99.180	ENSPTRG00000046730	HIC2	99	99.180	Pan_troglodytes
ENSG00000169635	HIC2	100	98.374	ENSPANG00000024301	HIC2	100	98.374	Papio_anubis
ENSG00000169635	HIC2	96	55.853	ENSPKIG00000017929	-	100	55.241	Paramormyrops_kingsleyae
ENSG00000169635	HIC2	96	61.184	ENSPKIG00000002187	hic2	100	60.992	Paramormyrops_kingsleyae
ENSG00000169635	HIC2	96	66.557	ENSPSIG00000000839	-	100	66.557	Pelodiscus_sinensis
ENSG00000169635	HIC2	96	66.227	ENSPSIG00000000992	-	100	66.227	Pelodiscus_sinensis
ENSG00000169635	HIC2	96	55.645	ENSPMGG00000013191	hic2	100	55.700	Periophthalmus_magnuspinnatus
ENSG00000169635	HIC2	96	75.753	ENSPCIG00000026758	HIC2	100	75.585	Phascolarctos_cinereus
ENSG00000169635	HIC2	97	54.560	ENSPFOG00000020465	hic2	100	55.323	Poecilia_formosa
ENSG00000169635	HIC2	96	54.647	ENSPLAG00000014754	hic2	100	55.412	Poecilia_latipinna
ENSG00000169635	HIC2	96	54.647	ENSPMEG00000020119	hic2	100	55.412	Poecilia_mexicana
ENSG00000169635	HIC2	96	55.538	ENSPREG00000010443	hic2	100	55.829	Poecilia_reticulata
ENSG00000169635	HIC2	100	98.862	ENSPPYG00000012022	HIC2	100	98.862	Pongo_abelii
ENSG00000169635	HIC2	100	90.081	ENSPCAG00000015907	HIC2	100	89.431	Procavia_capensis
ENSG00000169635	HIC2	100	92.683	ENSPCOG00000013219	HIC2	100	92.683	Propithecus_coquereli
ENSG00000169635	HIC2	84	98.113	ENSPVAG00000000111	HIC2	84	98.113	Pteropus_vampyrus
ENSG00000169635	HIC2	96	54.400	ENSPNYG00000007402	hic2	100	55.929	Pundamilia_nyererei
ENSG00000169635	HIC2	97	43.311	ENSPNAG00000022553	hic1l	95	42.454	Pygocentrus_nattereri
ENSG00000169635	HIC2	97	52.013	ENSPNAG00000002230	hic2	99	54.992	Pygocentrus_nattereri
ENSG00000169635	HIC2	100	86.838	ENSRNOG00000051458	Hic2	100	88.283	Rattus_norvegicus
ENSG00000169635	HIC2	100	94.805	ENSRBIG00000031113	HIC2	100	94.805	Rhinopithecus_bieti
ENSG00000169635	HIC2	100	98.374	ENSRROG00000035179	HIC2	100	98.374	Rhinopithecus_roxellana
ENSG00000169635	HIC2	100	97.561	ENSSBOG00000026991	HIC2	100	97.561	Saimiri_boliviensis_boliviensis
ENSG00000169635	HIC2	96	53.691	ENSSFOG00015016070	-	100	54.027	Scleropages_formosus
ENSG00000169635	HIC2	96	60.231	ENSSFOG00015015304	hic2	100	59.344	Scleropages_formosus
ENSG00000169635	HIC2	96	55.139	ENSSMAG00000007076	hic2	100	56.129	Scophthalmus_maximus
ENSG00000169635	HIC2	96	54.649	ENSSDUG00000022819	hic2	100	55.754	Seriola_dumerili
ENSG00000169635	HIC2	96	54.397	ENSSLDG00000003123	hic2	100	55.502	Seriola_lalandi_dorsalis
ENSG00000169635	HIC2	96	54.386	ENSSPAG00000008074	hic2	100	55.466	Stegastes_partitus
ENSG00000169635	HIC2	100	86.688	ENSSSCG00000036472	HIC2	100	86.201	Sus_scrofa
ENSG00000169635	HIC2	97	67.270	ENSTGUG00000008699	HIC2	100	65.954	Taeniopygia_guttata
ENSG00000169635	HIC2	96	54.032	ENSTRUG00000013139	hic2	100	55.161	Takifugu_rubripes
ENSG00000169635	HIC2	96	49.259	ENSTNIG00000001094	hic2	86	67.647	Tetraodon_nigroviridis
ENSG00000169635	HIC2	100	93.042	ENSUAMG00000010428	HIC2	100	92.395	Ursus_americanus
ENSG00000169635	HIC2	78	98.519	ENSUMAG00000003594	HIC2	86	98.519	Ursus_maritimus
ENSG00000169635	HIC2	100	93.204	ENSVVUG00000020688	HIC2	100	92.557	Vulpes_vulpes
ENSG00000169635	HIC2	99	62.237	ENSXETG00000022419	hic2	97	61.912	Xenopus_tropicalis
ENSG00000169635	HIC2	96	54.487	ENSXCOG00000001544	hic2	100	55.250	Xiphophorus_couchianus
ENSG00000169635	HIC2	96	54.487	ENSXMAG00000020311	hic2	100	55.250	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	21873635.	IBA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	NAS	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	21873635.	IBA	Function
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003677	DNA binding	11554746.	NAS	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11554746.	IDA	Component
GO:0008022	protein C-terminus binding	12052894.	IPI	Function
GO:0045892	negative regulation of transcription, DNA-templated	11554746.	NAS	Process
GO:0046872	metal ion binding	-	IEA	Function