EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000169714 (Gene tree)
Gene ID: 7555
Gene Symbol: CNBP
Alias: RNF163|ZCCHC22|CNBP1|DM2|ZNF9
Full Name: CCHC-type zinc finger nucleic acid binding protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 16,153 bases
Position: chr3:129,167,815-129,183,967
Accession: 13164
RBP type: canonical RBP
Summary: This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000426223	zf-CCHC	PF00098.23	4.1e-52	1	7
ENSP00000426223	zf-CCHC	PF00098.23	4.1e-52	2	7
ENSP00000426223	zf-CCHC	PF00098.23	4.1e-52	3	7
ENSP00000426223	zf-CCHC	PF00098.23	4.1e-52	4	7
ENSP00000426223	zf-CCHC	PF00098.23	4.1e-52	5	7
ENSP00000426223	zf-CCHC	PF00098.23	4.1e-52	6	7
ENSP00000426223	zf-CCHC	PF00098.23	4.1e-52	7	7
ENSP00000422110	zf-CCHC	PF00098.23	6.1e-52	1	7
ENSP00000422110	zf-CCHC	PF00098.23	6.1e-52	2	7
ENSP00000422110	zf-CCHC	PF00098.23	6.1e-52	3	7
ENSP00000422110	zf-CCHC	PF00098.23	6.1e-52	4	7
ENSP00000422110	zf-CCHC	PF00098.23	6.1e-52	5	7
ENSP00000422110	zf-CCHC	PF00098.23	6.1e-52	6	7
ENSP00000422110	zf-CCHC	PF00098.23	6.1e-52	7	7
ENSP00000421323	zf-CCHC	PF00098.23	7.3e-52	1	7
ENSP00000421323	zf-CCHC	PF00098.23	7.3e-52	2	7
ENSP00000421323	zf-CCHC	PF00098.23	7.3e-52	3	7
ENSP00000421323	zf-CCHC	PF00098.23	7.3e-52	4	7
ENSP00000421323	zf-CCHC	PF00098.23	7.3e-52	5	7
ENSP00000421323	zf-CCHC	PF00098.23	7.3e-52	6	7
ENSP00000421323	zf-CCHC	PF00098.23	7.3e-52	7	7
ENSP00000400444	zf-CCHC	PF00098.23	9.9e-52	1	7
ENSP00000400444	zf-CCHC	PF00098.23	9.9e-52	2	7
ENSP00000400444	zf-CCHC	PF00098.23	9.9e-52	3	7
ENSP00000400444	zf-CCHC	PF00098.23	9.9e-52	4	7
ENSP00000400444	zf-CCHC	PF00098.23	9.9e-52	5	7
ENSP00000400444	zf-CCHC	PF00098.23	9.9e-52	6	7
ENSP00000400444	zf-CCHC	PF00098.23	9.9e-52	7	7
ENSP00000410619	zf-CCHC	PF00098.23	1e-51	1	7
ENSP00000410619	zf-CCHC	PF00098.23	1e-51	2	7
ENSP00000410619	zf-CCHC	PF00098.23	1e-51	3	7
ENSP00000410619	zf-CCHC	PF00098.23	1e-51	4	7
ENSP00000410619	zf-CCHC	PF00098.23	1e-51	5	7
ENSP00000410619	zf-CCHC	PF00098.23	1e-51	6	7
ENSP00000410619	zf-CCHC	PF00098.23	1e-51	7	7
ENSP00000399488	zf-CCHC	PF00098.23	1.4e-51	1	7
ENSP00000399488	zf-CCHC	PF00098.23	1.4e-51	2	7
ENSP00000399488	zf-CCHC	PF00098.23	1.4e-51	3	7
ENSP00000399488	zf-CCHC	PF00098.23	1.4e-51	4	7
ENSP00000399488	zf-CCHC	PF00098.23	1.4e-51	5	7
ENSP00000399488	zf-CCHC	PF00098.23	1.4e-51	6	7
ENSP00000399488	zf-CCHC	PF00098.23	1.4e-51	7	7
ENSP00000410769	zf-CCHC	PF00098.23	1.4e-51	1	7
ENSP00000410769	zf-CCHC	PF00098.23	1.4e-51	2	7
ENSP00000410769	zf-CCHC	PF00098.23	1.4e-51	3	7
ENSP00000410769	zf-CCHC	PF00098.23	1.4e-51	4	7
ENSP00000410769	zf-CCHC	PF00098.23	1.4e-51	5	7
ENSP00000410769	zf-CCHC	PF00098.23	1.4e-51	6	7
ENSP00000410769	zf-CCHC	PF00098.23	1.4e-51	7	7
ENSP00000424787	zf-CCHC	PF00098.23	6.1e-16	1	2
ENSP00000424787	zf-CCHC	PF00098.23	6.1e-16	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21889481	RNA Foci, CUGBP1, and ZNF9 are the primary targets of the mutant CUG and CCUG repeats expanded in myotonic dystrophies type 1 and type 2.	Am J Pathol	2011 Nov	Jones K	doi: 10.1016/j.ajpath.2011.07.013
23796888	Molecular mechanisms of muscle atrophy in myotonic dystrophies.	Int J Biochem Cell Biol	2013 Oct	Timchenko L	doi: 10.1016/j.biocel.2013.06.010
31323950	Short Tandem Repeat Expansions and RNA-Mediated Pathogenesis in Myotonic Dystrophy.	Int J Mol Sci	2019 Jul 9	Sznajder LJ	doi: 10.3390/ijms20133365.
16927100	Flies deficient in Muscleblind protein model features of myotonic dystrophy with altered splice forms of Z-band associated transcripts.	Hum Genet	2006 Nov	Machuca-Tzili L	-
12915312	Developmental expression of mouse muscleblind genes Mbnl1, Mbnl2 and Mbnl3.	Gene Expr Patterns	2003 Aug	Kanadia RN	-
16776586	RNA-mediated neuromuscular disorders.	Annu Rev Neurosci	2006	Ranum LP	-
12432575	Novel CNBP- and La-based translation control systems for mammalian cells.	Biotechnol Bioeng	2003 Jan 5	Schlatter S	-
20058255	The role of flexibility in the rational design of modularly assembled ligands targeting the RNAs that cause the myotonic dystrophies.	Chembiochem	2010 Feb 15	Disney MD	doi: 10.1002/cbic.200900716.
19902080	Model for alternative splicing of insulin receptor in myotonic dystrophy type 1.	Bull Exp Biol Med	2009 Jun	Tonevitsky EA	-
19864209	RNA/MBNL1-containing foci in myoblast nuclei from patients affected by myotonic dystrophy type 2: an immunocytochemical study.	Eur J Histochem	2009 Sep 23	Perdoni F	-
19605641	Reduction of the rate of protein translation in patients with myotonic dystrophy 2.	J Neurosci	2009 Jul 15	Huichalaf C	doi: 10.1523/JNEUROSCI.1983-09.2009.
21387185	RNA processing is altered in skeletal muscle nuclei of patients affected by myotonic dystrophy.	Histochem Cell Biol	2011 Apr	Malatesta M	doi: 10.1007/s00418-011-0797-z
24726729	Arginine methylation of the cellular nucleic acid binding protein does not affect its subcellular localization but impedes RNA binding.	FEBS Lett	2014 May 2	Wei HM	doi: 10.1016/j.febslet.2014.03.052
26939892	The nucleic acid-binding protein PcCNBP is transcriptionally regulated during the immune response in red swamp crayfish Procambarus clarkii.	Cell Stress Chaperones	2016 May	Nicosia A	doi: 10.1007/s12192-016-0681-9
23536431	Dysfunction of protein homeostasis in myotonic dystrophies.	Histol Histopathol	2013 Sep	Meola G	doi: 10.14670/HH-28.1089
30089646	CNBP Homologues Gis2 and Znf9 Interact with a Putative G-Quadruplex-Forming 3' Untranslated Region, Altering Polysome Association and Stress Tolerance in Cryptococcus neoformans.	mSphere	2018 Aug 8	Leipheimer J	doi: 10.1128/mSphere.00201-18.
30256871	RNA/MBNL1-containing foci in myoblast nuclei from patients affected by myotonic dystrophy type 2: an immunocytochemical study.	Eur J Histochem	2009 Sep 30	Perdoni F	doi: 10.4081/ejh.2009.e18
22444451	Effect of level of eicosapentaenoic acid on the transcriptional regulation of delta-9 desaturase using a novel in vitro bovine intramuscular adipocyte cell culture model.	Animal	2009 May	Waters SM	doi: 10.1017/S1751731109004054.
25048402	Supplementation dietary zinc levels on growth performance, carcass traits, and intramuscular fat deposition in weaned piglets.	Biol Trace Elem Res	2014 Oct	Zhang HB	doi: 10.1007/s12011-014-0078-5
23138120	Response to a long-term high-fat diet in the signature of genes involved in lipid metabolism in ApoE(-/-) mice.	Am J Med Sci	2013 Sep	Yang M	doi: 10.1097/MAJ.0b013e3182688026.
19292868	Novel genes in cell cycle control and lipid metabolism with dynamically regulated binding sites for sterol regulatory element-binding protein 1 and RNA polymerase II in HepG2 cells detected by chromatin immunoprecipitation with microarray detection.	FEBS J	2009 Apr	Motallebipour M	doi: 10.1111/j.1742-4658.2009.06914.x.
29579170	miR-122 Regulates LHR Expression in Rat Granulosa Cells by Targeting Insig1 mRNA.	Endocrinology	2018 May 1	Menon B	doi: 10.1210/en.2017-03270.
29567358	Effect of short-term liver X receptor activation on epidermal barrier features in mild to moderate atopic dermatitis: A randomized controlled trial.	Ann Allergy Asthma Immunol	2018 Jun	Czarnowicki T	doi: 10.1016/j.anai.2018.03.013
30419118	Epigenetic Hallmarks of Fetal Early Atherosclerotic Lesions in Humans.	JAMA Cardiol	2018 Nov 7	de Nigris F	doi: 10.1001/jamacardio.2018.3546
16631440	Dietary fatty acids differentially modulate messenger RNA abundance of low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and microsomal triglyceride transfer protein in Golden-Syrian hamsters.	Metabolism	2006 May	Dorfman SE	-
12891061	Expression of adipogenic transcription factors, peroxisome proliferator-activated receptor gamma co-activator 1, IL-6 and CD45 in subcutaneous adipose tissue in lipodystrophy associated with highly active antiretroviral therapy.	AIDS	2003 Aug 15	Kannisto K	-
16284533	Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudine- and zidovudine-containing regimens.	J Acquir Immune Defic Syndr	2005 Dec 15	Jones SP	-
19251398	Soybean diet modulates acetyl-coenzyme A carboxylase expression in livers of rats recovering from early-life malnutrition.	Nutrition	2009 Jul-Aug	Milanski M	doi: 10.1016/j.nut.2008.12.003
19026012	Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.	Hepatology	2008 Dec	Qiu W	doi: 10.1002/hep.22565.
18167199	Mechanisms of dysregulation of low-density lipoprotein receptor expression in HepG2 cells induced by inflammatory cytokines.	Chin Med J (Engl)	2007 Dec 20	Chen YX	-
17474309	Pathogenesis of lipodystrophy and lipid abnormalities in patients taking antiretroviral therapy.	AIDS Rev	2007 Jan-Mar	Mallon PW	-
17484888	Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma.	Gastroenterology	2007 May	Kim KH	-
22469867	Therapeutic effects of angiotensin II type 1 receptor blocker, irbesartan, on non-alcoholic steatohepatitis using FLS-ob/ob male mice.	Int J Mol Med	2012 Jul	Kato J	doi: 10.3892/ijmm.2012.958
20889723	Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development.	Cancer Res	2010 Nov 15	Willemarck N	doi: 10.1158/0008-5472.CAN-10-2324
20580384	The role of JAZF1 on lipid metabolism and related genes in vitro.	Metabolism	2011 Apr	Li L	doi: 10.1016/j.metabol.2010.04.021
20360843	The role of nuclear receptor NHR-64 in fat storage regulation in Caenorhabditis elegans.	PLoS One	2010 Mar 25	Liang B	doi: 10.1371/journal.pone.0009869.
25733650	High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.	Am J Clin Nutr	2015 Mar	Christensen KE	doi: 10.3945/ajcn.114.086603
24297394	Difference in LDL receptor feedback regulation in macrophages and vascular smooth muscle cells: foam cell transformation under inflammatory stress.	Inflammation	2014 Apr	Ye Q	doi: 10.1007/s10753-013-9769-x.
26409000	Biocompatible polymeric nanocomplexes as an intracellular stimuli-sensitive prodrug for type-2 diabetes combination therapy.	Biomaterials	2015 Dec	Wang FZ	doi: 10.1016/j.biomaterials.2015.09.013
27763516	Transcriptome Profile Reveals that Pu-Erh Tea Represses the Expression of Vitellogenin Family to Reduce Fat Accumulation in Caenorhabditis elegans.	Molecules	2016 Oct 17	Xiao RY	-
28794002	Kruppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility.	Circulation	2017 Oct 3	Li Z	doi: 10.1161/CIRCULATIONAHA.117.027462
31297058	Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.	Front Pharmacol	2019 Jun 25	Yang N	doi: 10.3389/fphar.2019.00709
1718676	Localized and inducible expression of Xenopus-posterior (Xpo), a novel gene active in early frog embryos, encoding a protein with a 'CCHC' finger domain.	Development	1991 Jul	Sato SM	-
19348464	Rational and modular design of potent ligands targeting the RNA that causes myotonic dystrophy 2.	ACS Chem Biol	2009 May 15	Lee MM	doi: 10.1021/cb900025w.
18703071	Dissecting CNBP, a zinc-finger protein required for neural crest development, in its structural and functional domains.	J Mol Biol	2008 Oct 17	Armas P	doi: 10.1016/j.jmb.2008.07.079
20960530	CNBP: a multifunctional nucleic acid chaperone involved in cell death and proliferation control.	IUBMB Life	2010 Oct	Calcaterra NB	doi: 10.1002/iub.379.
28329689	The Human CCHC-type Zinc Finger Nucleic Acid-Binding Protein Binds G-Rich Elements in Target mRNA Coding Sequences and Promotes Translation.	Cell Rep	2017 Mar 21	Benhalevy D	doi: 10.1016/j.celrep.2017.02.080.
29789616	rbFOX1/MBNL1 competition for CCUG RNA repeats bindingcontributes to myotonic dystrophy type1/type2 differences.	Nat Commun	2018 May 22	Sellier C	doi: 10.1038/s41467-018-04370-x.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000507573	CNBP-209	641	-	-	- (aa)	-	-
ENST00000446936	CNBP-203	1623	-	ENSP00000400444	172 (aa)	-	P62633
ENST00000502976	CNBP-207	1626	-	ENSP00000421323	170 (aa)	-	P62633
ENST00000422453	CNBP-201	1664	-	ENSP00000410619	177 (aa)	-	P62633
ENST00000504813	CNBP-208	1549	-	ENSP00000422110	167 (aa)	-	P62633
ENST00000500450	CNBP-205	1516	-	ENSP00000426223	160 (aa)	-	P62633
ENST00000451728	CNBP-204	1641	-	ENSP00000399488	178 (aa)	-	P62633
ENST00000441626	CNBP-202	1040	-	ENSP00000410769	179 (aa)	-	P62633
ENST00000512338	CNBP-210	502	-	ENSP00000424787	113 (aa)	-	D6RAT4
ENST00000502372	CNBP-206	1026	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000169714's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000169714	rs73212431	3	129176671	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169714's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000169714	CNBP	86	67.808	ENSG00000187969	ZCCHC13	88	67.808

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000169714	CNBP	100	70.732	ENSAPOG00000010571	cnbpa	99	70.732	Acanthochromis_polyacanthus
ENSG00000169714	CNBP	100	100.000	ENSAMEG00000015334	CNBP	100	100.000	Ailuropoda_melanoleuca
ENSG00000169714	CNBP	100	71.341	ENSACIG00000003540	cnbpa	99	71.341	Amphilophus_citrinellus
ENSG00000169714	CNBP	100	74.534	ENSACIG00000014747	-	100	74.534	Amphilophus_citrinellus
ENSG00000169714	CNBP	97	70.886	ENSAOCG00000007087	cnbpa	97	70.988	Amphiprion_ocellaris
ENSG00000169714	CNBP	97	70.886	ENSAPEG00000014455	cnbpa	97	70.988	Amphiprion_percula
ENSG00000169714	CNBP	100	74.534	ENSATEG00000009504	cnbpb	95	74.534	Anabas_testudineus
ENSG00000169714	CNBP	100	71.341	ENSATEG00000015473	cnbpa	99	71.341	Anabas_testudineus
ENSG00000169714	CNBP	100	97.688	ENSAPLG00000014227	-	100	97.688	Anas_platyrhynchos
ENSG00000169714	CNBP	100	100.000	ENSANAG00000030514	-	100	100.000	Aotus_nancymaae
ENSG00000169714	CNBP	100	84.795	ENSANAG00000018980	-	100	82.486	Aotus_nancymaae
ENSG00000169714	CNBP	97	67.808	ENSANAG00000019917	ZCCHC13	98	67.808	Aotus_nancymaae
ENSG00000169714	CNBP	96	35.821	ENSACLG00000011307	-	78	38.406	Astatotilapia_calliptera
ENSG00000169714	CNBP	100	62.500	ENSACLG00000006926	cnbpa	81	62.500	Astatotilapia_calliptera
ENSG00000169714	CNBP	97	39.716	ENSACLG00000015919	-	76	40.141	Astatotilapia_calliptera
ENSG00000169714	CNBP	100	75.155	ENSACLG00000014402	cnbpb	99	75.625	Astatotilapia_calliptera
ENSG00000169714	CNBP	100	69.412	ENSAMXG00000032363	cnbpa	99	69.412	Astyanax_mexicanus
ENSG00000169714	CNBP	100	75.155	ENSAMXG00000005433	cnbpb	100	75.155	Astyanax_mexicanus
ENSG00000169714	CNBP	100	100.000	ENSBTAG00000012159	CNBP	100	100.000	Bos_taurus
ENSG00000169714	CNBP	100	73.099	ENSBTAG00000032003	ZCCHC13	100	69.591	Bos_taurus
ENSG00000169714	CNBP	99	32.877	WBGene00019537	K08D12.3	100	33.742	Caenorhabditis_elegans
ENSG00000169714	CNBP	100	100.000	ENSCJAG00000017430	-	100	100.000	Callithrix_jacchus
ENSG00000169714	CNBP	100	100.000	ENSCAFG00000004320	CNBP	100	100.000	Canis_familiaris
ENSG00000169714	CNBP	97	75.342	ENSCAFG00000032517	ZCCHC13	100	75.342	Canis_familiaris
ENSG00000169714	CNBP	100	100.000	ENSCAFG00020004863	-	100	100.000	Canis_lupus_dingo
ENSG00000169714	CNBP	100	78.363	ENSCAFG00020024539	ZCCHC13	100	78.363	Canis_lupus_dingo
ENSG00000169714	CNBP	97	73.973	ENSCHIG00000019132	ZCCHC13	100	73.973	Capra_hircus
ENSG00000169714	CNBP	100	88.623	ENSCHIG00000023083	CNBP	100	88.623	Capra_hircus
ENSG00000169714	CNBP	100	100.000	ENSTSYG00000004344	-	100	100.000	Carlito_syrichta
ENSG00000169714	CNBP	100	100.000	ENSCAPG00000015285	CNBP	100	100.000	Cavia_aperea
ENSG00000169714	CNBP	100	100.000	ENSCPOG00000032294	-	100	100.000	Cavia_porcellus
ENSG00000169714	CNBP	97	65.909	ENSCCAG00000028785	ZCCHC13	89	65.909	Cebus_capucinus
ENSG00000169714	CNBP	100	100.000	ENSCCAG00000034056	-	100	100.000	Cebus_capucinus
ENSG00000169714	CNBP	100	100.000	ENSCATG00000020089	-	100	100.000	Cercocebus_atys
ENSG00000169714	CNBP	100	100.000	ENSCLAG00000009193	-	100	100.000	Chinchilla_lanigera
ENSG00000169714	CNBP	100	100.000	ENSCSAG00000008817	-	100	100.000	Chlorocebus_sabaeus
ENSG00000169714	CNBP	100	70.588	ENSCSAG00000000095	ZCCHC13	100	70.588	Chlorocebus_sabaeus
ENSG00000169714	CNBP	100	85.294	ENSCHOG00000003279	-	100	85.294	Choloepus_hoffmanni
ENSG00000169714	CNBP	97	96.154	ENSCHOG00000000883	-	100	98.519	Choloepus_hoffmanni
ENSG00000169714	CNBP	100	97.674	ENSCPBG00000026349	-	100	97.674	Chrysemys_picta_bellii
ENSG00000169714	CNBP	96	49.682	ENSCING00000021342	-	94	49.045	Ciona_intestinalis
ENSG00000169714	CNBP	99	44.512	ENSCSAVG00000001395	-	86	44.512	Ciona_savignyi
ENSG00000169714	CNBP	100	100.000	ENSCANG00000042967	-	100	100.000	Colobus_angolensis_palliatus
ENSG00000169714	CNBP	100	77.059	ENSCGRG00001009786	Zcchc13	100	77.059	Cricetulus_griseus_chok1gshd
ENSG00000169714	CNBP	100	100.000	ENSCGRG00001000923	-	100	100.000	Cricetulus_griseus_chok1gshd
ENSG00000169714	CNBP	100	91.860	ENSCGRG00001014784	-	100	91.860	Cricetulus_griseus_chok1gshd
ENSG00000169714	CNBP	100	77.059	ENSCGRG00000019302	Zcchc13	100	77.059	Cricetulus_griseus_crigri
ENSG00000169714	CNBP	100	100.000	ENSCGRG00000011470	-	100	100.000	Cricetulus_griseus_crigri
ENSG00000169714	CNBP	100	91.860	ENSCGRG00000019849	-	100	91.860	Cricetulus_griseus_crigri
ENSG00000169714	CNBP	99	68.553	ENSCSEG00000021428	cnbpa	98	68.553	Cynoglossus_semilaevis
ENSG00000169714	CNBP	100	67.901	ENSCSEG00000020388	cnbpb	100	67.901	Cynoglossus_semilaevis
ENSG00000169714	CNBP	100	70.732	ENSCVAG00000012825	cnbpa	99	70.732	Cyprinodon_variegatus
ENSG00000169714	CNBP	100	74.534	ENSDARG00000070922	cnbpb	100	74.534	Danio_rerio
ENSG00000169714	CNBP	100	71.429	ENSDARG00000045776	cnbpa	99	71.429	Danio_rerio
ENSG00000169714	CNBP	100	100.000	ENSDNOG00000032573	-	100	100.000	Dasypus_novemcinctus
ENSG00000169714	CNBP	100	79.532	ENSDNOG00000048874	ZCCHC13	100	80.117	Dasypus_novemcinctus
ENSG00000169714	CNBP	100	65.882	ENSDORG00000028312	Zcchc13	99	66.272	Dipodomys_ordii
ENSG00000169714	CNBP	100	100.000	ENSDORG00000002919	-	100	100.000	Dipodomys_ordii
ENSG00000169714	CNBP	95	39.181	FBgn0034802	CNBP	96	39.655	Drosophila_melanogaster
ENSG00000169714	CNBP	100	81.356	ENSETEG00000001978	-	99	81.921	Echinops_telfairi
ENSG00000169714	CNBP	100	100.000	ENSETEG00000008408	-	100	100.000	Echinops_telfairi
ENSG00000169714	CNBP	100	74.850	ENSEBUG00000002192	cnbpb	93	74.850	Eptatretus_burgeri
ENSG00000169714	CNBP	100	77.647	ENSEASG00005003120	ZCCHC13	100	77.647	Equus_asinus_asinus
ENSG00000169714	CNBP	100	100.000	ENSEASG00005015811	-	100	100.000	Equus_asinus_asinus
ENSG00000169714	CNBP	100	100.000	ENSECAG00000009512	CNBP	100	100.000	Equus_caballus
ENSG00000169714	CNBP	87	76.351	ENSECAG00000019315	ZCCHC13	93	76.351	Equus_caballus
ENSG00000169714	CNBP	100	72.840	ENSELUG00000017627	cnbpa	99	72.840	Esox_lucius
ENSG00000169714	CNBP	100	75.155	ENSELUG00000013402	cnbpb	100	75.155	Esox_lucius
ENSG00000169714	CNBP	100	100.000	ENSFCAG00000042197	-	100	100.000	Felis_catus
ENSG00000169714	CNBP	100	98.235	ENSFALG00000000020	-	100	98.235	Ficedula_albicollis
ENSG00000169714	CNBP	100	99.438	ENSFDAG00000019770	CNBP	100	99.438	Fukomys_damarensis
ENSG00000169714	CNBP	100	70.732	ENSFHEG00000002985	cnbpa	99	70.732	Fundulus_heteroclitus
ENSG00000169714	CNBP	99	63.905	ENSGMOG00000017012	cnbpa	100	63.158	Gadus_morhua
ENSG00000169714	CNBP	96	65.854	ENSGMOG00000007798	-	100	65.854	Gadus_morhua
ENSG00000169714	CNBP	100	98.235	ENSGALG00000005001	ZCCHC13	100	98.235	Gallus_gallus
ENSG00000169714	CNBP	100	65.476	ENSGAFG00000015332	cnbpa	99	65.476	Gambusia_affinis
ENSG00000169714	CNBP	99	64.458	ENSGACG00000000061	cnbpa	99	63.855	Gasterosteus_aculeatus
ENSG00000169714	CNBP	100	97.674	ENSGAGG00000010888	-	100	97.674	Gopherus_agassizii
ENSG00000169714	CNBP	100	100.000	ENSGGOG00000010085	CNBP	100	100.000	Gorilla_gorilla
ENSG00000169714	CNBP	96	63.699	ENSGGOG00000008056	ZCCHC13	88	66.438	Gorilla_gorilla
ENSG00000169714	CNBP	100	71.341	ENSHBUG00000021569	cnbpa	99	71.341	Haplochromis_burtoni
ENSG00000169714	CNBP	100	75.155	ENSHBUG00000019302	-	99	75.625	Haplochromis_burtoni
ENSG00000169714	CNBP	100	100.000	ENSHGLG00000002069	Cnbp	100	100.000	Heterocephalus_glaber_female
ENSG00000169714	CNBP	100	100.000	ENSHGLG00100005610	-	100	100.000	Heterocephalus_glaber_male
ENSG00000169714	CNBP	99	68.098	ENSHCOG00000003457	cnbpa	97	69.325	Hippocampus_comes
ENSG00000169714	CNBP	100	62.346	ENSHCOG00000014737	-	100	61.111	Hippocampus_comes
ENSG00000169714	CNBP	100	73.913	ENSIPUG00000018873	cnbpa	100	73.913	Ictalurus_punctatus
ENSG00000169714	CNBP	100	73.913	ENSIPUG00000011418	cnbpb	100	73.913	Ictalurus_punctatus
ENSG00000169714	CNBP	100	80.588	ENSSTOG00000011570	ZCCHC13	100	80.588	Ictidomys_tridecemlineatus
ENSG00000169714	CNBP	100	100.000	ENSSTOG00000000173	-	100	100.000	Ictidomys_tridecemlineatus
ENSG00000169714	CNBP	100	77.246	ENSJJAG00000017592	-	100	77.246	Jaculus_jaculus
ENSG00000169714	CNBP	100	88.889	ENSJJAG00000001509	-	70	87.719	Jaculus_jaculus
ENSG00000169714	CNBP	100	99.412	ENSJJAG00000010709	-	100	99.412	Jaculus_jaculus
ENSG00000169714	CNBP	100	70.732	ENSKMAG00000013742	cnbpa	99	70.732	Kryptolebias_marmoratus
ENSG00000169714	CNBP	100	86.335	ENSLACG00000005327	cnbpb	99	86.957	Latimeria_chalumnae
ENSG00000169714	CNBP	100	88.136	ENSLOCG00000013985	cnbpb	100	88.136	Lepisosteus_oculatus
ENSG00000169714	CNBP	100	100.000	ENSLAFG00000002502	-	100	100.000	Loxodonta_africana
ENSG00000169714	CNBP	100	71.930	ENSLAFG00000029278	ZCCHC13	100	71.930	Loxodonta_africana
ENSG00000169714	CNBP	100	100.000	ENSMFAG00000030262	CNBP	100	100.000	Macaca_fascicularis
ENSG00000169714	CNBP	100	100.000	ENSMMUG00000011585	CNBP	100	100.000	Macaca_mulatta
ENSG00000169714	CNBP	100	100.000	ENSMNEG00000028473	-	100	100.000	Macaca_nemestrina
ENSG00000169714	CNBP	100	100.000	ENSMLEG00000041892	CNBP	100	100.000	Mandrillus_leucophaeus
ENSG00000169714	CNBP	100	73.913	ENSMAMG00000009547	cnbpb	98	73.913	Mastacembelus_armatus
ENSG00000169714	CNBP	100	71.341	ENSMAMG00000024106	cnbpa	99	71.341	Mastacembelus_armatus
ENSG00000169714	CNBP	100	71.341	ENSMZEG00005025913	cnbpa	99	71.341	Maylandia_zebra
ENSG00000169714	CNBP	100	75.155	ENSMZEG00005012030	cnbpb	99	75.625	Maylandia_zebra
ENSG00000169714	CNBP	100	87.429	ENSMGAG00000005152	-	100	84.916	Meleagris_gallopavo
ENSG00000169714	CNBP	100	91.620	ENSMAUG00000016631	-	100	91.620	Mesocricetus_auratus
ENSG00000169714	CNBP	100	100.000	ENSMAUG00000011845	-	100	100.000	Mesocricetus_auratus
ENSG00000169714	CNBP	100	100.000	ENSMICG00000045988	-	100	100.000	Microcebus_murinus
ENSG00000169714	CNBP	100	82.353	ENSMICG00000002990	ZCCHC13	100	82.353	Microcebus_murinus
ENSG00000169714	CNBP	100	100.000	ENSMOCG00000002044	-	100	100.000	Microtus_ochrogaster
ENSG00000169714	CNBP	100	72.050	ENSMMOG00000017816	cnbpb	95	72.050	Mola_mola
ENSG00000169714	CNBP	99	65.217	ENSMMOG00000017210	cnbpa	99	65.839	Mola_mola
ENSG00000169714	CNBP	78	74.242	ENSMODG00000024488	-	100	74.242	Monodelphis_domestica
ENSG00000169714	CNBP	98	76.786	ENSMODG00000012714	-	98	76.786	Monodelphis_domestica
ENSG00000169714	CNBP	100	99.435	ENSMODG00000008362	-	100	99.435	Monodelphis_domestica
ENSG00000169714	CNBP	100	73.913	ENSMALG00000020638	cnbpb	100	73.913	Monopterus_albus
ENSG00000169714	CNBP	100	70.732	ENSMALG00000021932	cnbpa	99	70.732	Monopterus_albus
ENSG00000169714	CNBP	100	74.706	MGP_CAROLIEiJ_G0033311	Zcchc13	100	74.706	Mus_caroli
ENSG00000169714	CNBP	100	99.438	MGP_CAROLIEiJ_G0028620	Cnbp	100	99.438	Mus_caroli
ENSG00000169714	CNBP	100	75.294	ENSMUSG00000031330	Zcchc13	100	75.294	Mus_musculus
ENSG00000169714	CNBP	100	100.000	ENSMUSG00000030057	Cnbp	100	100.000	Mus_musculus
ENSG00000169714	CNBP	100	76.471	MGP_PahariEiJ_G0031848	Zcchc13	100	76.471	Mus_pahari
ENSG00000169714	CNBP	100	100.000	MGP_PahariEiJ_G0022358	-	100	100.000	Mus_pahari
ENSG00000169714	CNBP	100	75.294	MGP_SPRETEiJ_G0034475	Zcchc13	100	75.294	Mus_spretus
ENSG00000169714	CNBP	100	100.000	MGP_SPRETEiJ_G0029632	-	100	100.000	Mus_spretus
ENSG00000169714	CNBP	100	100.000	ENSMPUG00000017315	-	100	100.000	Mustela_putorius_furo
ENSG00000169714	CNBP	100	98.352	ENSMLUG00000012554	CNBP	100	98.352	Myotis_lucifugus
ENSG00000169714	CNBP	100	70.760	ENSMLUG00000002814	ZCCHC13	100	67.251	Myotis_lucifugus
ENSG00000169714	CNBP	100	100.000	ENSNGAG00000005084	-	100	100.000	Nannospalax_galili
ENSG00000169714	CNBP	100	71.341	ENSNBRG00000022113	cnbpa	99	71.341	Neolamprologus_brichardi
ENSG00000169714	CNBP	100	72.353	ENSNBRG00000006996	cnbpb	99	72.781	Neolamprologus_brichardi
ENSG00000169714	CNBP	100	100.000	ENSNLEG00000035879	CNBP	100	100.000	Nomascus_leucogenys
ENSG00000169714	CNBP	100	99.435	ENSMEUG00000011699	-	100	99.435	Notamacropus_eugenii
ENSG00000169714	CNBP	100	100.000	ENSOPRG00000005487	-	100	100.000	Ochotona_princeps
ENSG00000169714	CNBP	100	100.000	ENSODEG00000001984	-	100	100.000	Octodon_degus
ENSG00000169714	CNBP	100	70.930	ENSODEG00000013916	-	100	70.930	Octodon_degus
ENSG00000169714	CNBP	100	69.325	ENSODEG00000002073	-	100	69.375	Octodon_degus
ENSG00000169714	CNBP	100	72.050	ENSONIG00000000269	cnbpb	92	72.050	Oreochromis_niloticus
ENSG00000169714	CNBP	100	97.605	ENSOANG00000000585	-	100	97.605	Ornithorhynchus_anatinus
ENSG00000169714	CNBP	100	100.000	ENSOCUG00000008696	CNBP	100	100.000	Oryctolagus_cuniculus
ENSG00000169714	CNBP	100	71.176	ENSOCUG00000008008	ZCCHC13	100	71.176	Oryctolagus_cuniculus
ENSG00000169714	CNBP	100	70.732	ENSORLG00000011453	cnbpa	99	70.732	Oryzias_latipes
ENSG00000169714	CNBP	100	70.732	ENSORLG00020018904	cnbp	99	70.732	Oryzias_latipes_hni
ENSG00000169714	CNBP	100	70.732	ENSORLG00015014097	cnbp	99	70.732	Oryzias_latipes_hsok
ENSG00000169714	CNBP	97	87.770	ENSOGAG00000013898	-	100	100.000	Otolemur_garnettii
ENSG00000169714	CNBP	100	100.000	ENSOGAG00000031673	-	100	100.000	Otolemur_garnettii
ENSG00000169714	CNBP	100	82.941	ENSOGAG00000007579	ZCCHC13	100	82.941	Otolemur_garnettii
ENSG00000169714	CNBP	100	80.000	ENSOARG00000005961	ZCCHC13	100	80.000	Ovis_aries
ENSG00000169714	CNBP	100	94.382	ENSOARG00000003577	CNBP	100	94.382	Ovis_aries
ENSG00000169714	CNBP	100	100.000	ENSPPAG00000028059	-	100	96.089	Pan_paniscus
ENSG00000169714	CNBP	100	100.000	ENSPPRG00000003431	-	100	100.000	Panthera_pardus
ENSG00000169714	CNBP	100	100.000	ENSPTIG00000017929	-	100	100.000	Panthera_tigris_altaica
ENSG00000169714	CNBP	100	100.000	ENSPTRG00000015369	CNBP	100	100.000	Pan_troglodytes
ENSG00000169714	CNBP	100	100.000	ENSPANG00000007815	-	100	100.000	Papio_anubis
ENSG00000169714	CNBP	100	76.398	ENSPKIG00000024603	cnbpb	100	76.398	Paramormyrops_kingsleyae
ENSG00000169714	CNBP	99	73.750	ENSPKIG00000017562	cnbpa	99	73.750	Paramormyrops_kingsleyae
ENSG00000169714	CNBP	100	97.674	ENSPSIG00000009556	-	100	97.674	Pelodiscus_sinensis
ENSG00000169714	CNBP	58	91.667	ENSPEMG00000024256	-	80	97.333	Peromyscus_maniculatus_bairdii
ENSG00000169714	CNBP	87	51.000	ENSPMAG00000009411	-	96	51.000	Petromyzon_marinus
ENSG00000169714	CNBP	97	55.725	ENSPMAG00000003418	-	100	55.725	Petromyzon_marinus
ENSG00000169714	CNBP	100	99.435	ENSPCIG00000000448	-	100	99.435	Phascolarctos_cinereus
ENSG00000169714	CNBP	100	70.732	ENSPFOG00000015951	cnbpa	99	70.732	Poecilia_formosa
ENSG00000169714	CNBP	100	70.732	ENSPLAG00000019977	cnbpa	99	70.732	Poecilia_latipinna
ENSG00000169714	CNBP	100	70.732	ENSPMEG00000012771	cnbpa	99	70.732	Poecilia_mexicana
ENSG00000169714	CNBP	100	70.732	ENSPREG00000008229	cnbpa	99	70.732	Poecilia_reticulata
ENSG00000169714	CNBP	100	100.000	ENSPPYG00000013423	CNBP	100	100.000	Pongo_abelii
ENSG00000169714	CNBP	100	100.000	ENSPCAG00000011572	-	100	100.000	Procavia_capensis
ENSG00000169714	CNBP	100	98.876	ENSPVAG00000015070	-	100	98.876	Pteropus_vampyrus
ENSG00000169714	CNBP	100	71.341	ENSPNYG00000005020	cnbpa	99	71.341	Pundamilia_nyererei
ENSG00000169714	CNBP	100	75.155	ENSPNYG00000014889	-	99	75.625	Pundamilia_nyererei
ENSG00000169714	CNBP	100	73.913	ENSPNAG00000022431	cnbpa	99	73.913	Pygocentrus_nattereri
ENSG00000169714	CNBP	100	74.534	ENSPNAG00000008143	cnbpb	100	74.534	Pygocentrus_nattereri
ENSG00000169714	CNBP	100	76.471	ENSRNOG00000002923	Zcchc13	100	76.471	Rattus_norvegicus
ENSG00000169714	CNBP	100	100.000	ENSRNOG00000010239	Cnbp	100	100.000	Rattus_norvegicus
ENSG00000169714	CNBP	100	100.000	ENSRBIG00000030361	-	100	100.000	Rhinopithecus_bieti
ENSG00000169714	CNBP	100	100.000	ENSRROG00000045469	CNBP	100	100.000	Rhinopithecus_roxellana
ENSG00000169714	CNBP	98	42.308	YNL255C	-	100	46.988	Saccharomyces_cerevisiae
ENSG00000169714	CNBP	100	100.000	ENSSBOG00000023735	-	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000169714	CNBP	97	68.831	ENSSBOG00000029912	ZCCHC13	99	68.831	Saimiri_boliviensis_boliviensis
ENSG00000169714	CNBP	100	99.435	ENSSHAG00000017132	-	100	99.435	Sarcophilus_harrisii
ENSG00000169714	CNBP	99	74.375	ENSSFOG00015014361	cnbpa	98	74.375	Scleropages_formosus
ENSG00000169714	CNBP	100	75.776	ENSSFOG00015001140	cnbpb	100	75.776	Scleropages_formosus
ENSG00000169714	CNBP	100	71.429	ENSSMAG00000006593	cnbpb	100	71.429	Scophthalmus_maximus
ENSG00000169714	CNBP	99	61.798	ENSSMAG00000012994	cnbpa	98	61.798	Scophthalmus_maximus
ENSG00000169714	CNBP	100	73.913	ENSSDUG00000018275	cnbpb	100	73.913	Seriola_dumerili
ENSG00000169714	CNBP	100	72.222	ENSSDUG00000000383	cnbpa	99	72.222	Seriola_dumerili
ENSG00000169714	CNBP	100	73.913	ENSSLDG00000022237	cnbpb	100	73.913	Seriola_lalandi_dorsalis
ENSG00000169714	CNBP	100	72.222	ENSSLDG00000011731	cnbpa	99	72.222	Seriola_lalandi_dorsalis
ENSG00000169714	CNBP	100	100.000	ENSSARG00000011874	-	100	100.000	Sorex_araneus
ENSG00000169714	CNBP	100	97.647	ENSSPUG00000018059	-	100	97.647	Sphenodon_punctatus
ENSG00000169714	CNBP	99	73.913	ENSSPAG00000021850	cnbpb	95	73.913	Stegastes_partitus
ENSG00000169714	CNBP	100	71.166	ENSSPAG00000019754	cnbpa	99	71.166	Stegastes_partitus
ENSG00000169714	CNBP	100	75.439	ENSSSCG00000035737	ZCCHC13	100	75.439	Sus_scrofa
ENSG00000169714	CNBP	100	100.000	ENSSSCG00000040879	-	100	100.000	Sus_scrofa
ENSG00000169714	CNBP	100	98.235	ENSTGUG00000004001	-	100	98.235	Taeniopygia_guttata
ENSG00000169714	CNBP	99	66.049	ENSTRUG00000025415	cnbpa	99	66.049	Takifugu_rubripes
ENSG00000169714	CNBP	99	61.111	ENSTNIG00000017940	cnbpa	97	61.111	Tetraodon_nigroviridis
ENSG00000169714	CNBP	100	96.045	ENSTBEG00000012620	-	100	96.045	Tupaia_belangeri
ENSG00000169714	CNBP	100	100.000	ENSTTRG00000015266	CNBP	100	100.000	Tursiops_truncatus
ENSG00000169714	CNBP	100	76.023	ENSUAMG00000005999	ZCCHC13	100	76.023	Ursus_americanus
ENSG00000169714	CNBP	100	100.000	ENSUAMG00000018978	CNBP	100	100.000	Ursus_americanus
ENSG00000169714	CNBP	100	100.000	ENSUMAG00000015120	CNBP	100	100.000	Ursus_maritimus
ENSG00000169714	CNBP	88	66.019	ENSUMAG00000022910	-	79	75.510	Ursus_maritimus
ENSG00000169714	CNBP	100	76.023	ENSUMAG00000021847	ZCCHC13	100	76.023	Ursus_maritimus
ENSG00000169714	CNBP	100	98.870	ENSVPAG00000007138	CNBP	100	98.870	Vicugna_pacos
ENSG00000169714	CNBP	100	78.363	ENSVVUG00000015754	ZCCHC13	100	78.363	Vulpes_vulpes
ENSG00000169714	CNBP	100	100.000	ENSVVUG00000018264	-	100	100.000	Vulpes_vulpes
ENSG00000169714	CNBP	95	88.757	ENSVVUG00000003294	-	94	88.757	Vulpes_vulpes
ENSG00000169714	CNBP	100	93.889	ENSXETG00000025147	cnbp	100	93.889	Xenopus_tropicalis
ENSG00000169714	CNBP	100	70.732	ENSXCOG00000011191	cnbpa	99	70.732	Xiphophorus_couchianus
ENSG00000169714	CNBP	100	70.732	ENSXMAG00000024938	cnbpa	99	70.732	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	23774591.	IDA	Process
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	23774591.	IDA	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	23774591.	IDA	Function
GO:0003700	DNA-binding transcription factor activity	2562787.	TAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	24726729.	IPI	Function
GO:0005634	nucleus	-	ISS	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005783	endoplasmic reticulum	-	ISS	Component
GO:0005829	cytosol	-	ISS	Component
GO:0006355	regulation of transcription, DNA-templated	2562787.	TAS	Process
GO:0006695	cholesterol biosynthetic process	2562787.	TAS	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0008284	positive regulation of cell proliferation	-	ISS	Process
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	Process