EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000169813 (Gene tree)
Gene ID: 3185
Gene Symbol: HNRNPF
Alias: HNRPF
Full Name: heterogeneous nuclear ribonucleoprotein F
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 23,632 bases
Position: chr10:43,385,617-43,409,248
Accession: 5039
RBP type: canonical RBP
Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000338477	zf-RNPHF	PF08080.12	1.1e-21	1	1
ENSP00000348345	zf-RNPHF	PF08080.12	1.1e-21	1	1
ENSP00000349573	zf-RNPHF	PF08080.12	1.1e-21	1	1
ENSP00000400433	zf-RNPHF	PF08080.12	1.1e-21	1	1
ENSP00000438061	zf-RNPHF	PF08080.12	1.1e-21	1	1
ENSP00000338477	RRM_1	PF00076.22	7.2e-27	1	2
ENSP00000338477	RRM_1	PF00076.22	7.2e-27	2	2
ENSP00000348345	RRM_1	PF00076.22	7.2e-27	1	2
ENSP00000348345	RRM_1	PF00076.22	7.2e-27	2	2
ENSP00000349573	RRM_1	PF00076.22	7.2e-27	1	2
ENSP00000349573	RRM_1	PF00076.22	7.2e-27	2	2
ENSP00000400433	RRM_1	PF00076.22	7.2e-27	1	2
ENSP00000400433	RRM_1	PF00076.22	7.2e-27	2	2
ENSP00000438061	RRM_1	PF00076.22	7.2e-27	1	2
ENSP00000438061	RRM_1	PF00076.22	7.2e-27	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29366917	Functional characterization of naturally occurring genetic variations of the human guanine-rich RNA sequence binding factor 1 (GRSF1).	Biochim Biophys Acta Gen Subj	2018 Apr	Sofi S	doi: 10.1016/j.bbagen.2017.12.008
22619362	Frequent gain and loss of intronic splicing regulatory elements during the evolution of vertebrates.	Genome Biol Evol	2012	Voelker RB	doi: 10.1093/gbe/evs051
29269483	RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF.	Genes Dev	2017 Nov 15	Huang H	doi: 10.1101/gad.305862.117
8036161	GRSF-1: a poly(A)+ mRNA binding protein which interacts with a conserved G-rich element.	Nucleic Acids Res	1994 Jun 25	Qian Z	-
11725088	A Novel hnRNP Specifically Interacts with HIV-1 RRE RNA.	J Biomed Sci	1996 Apr	Xu Y	-
23275549	The high kinetic stability of a G-quadruplex limits hnRNP F qRRM3 binding to G-tract RNA.	Nucleic Acids Res	2013 Feb 1	Samatanga B	doi: 10.1093/nar/gks1289
15659559	Heterogenous nuclear ribonucleoprotein F modulates angiotensinogen gene expression in rat kidney proximal tubular cells.	J Am Soc Nephrol	2005 Mar	Wei CC	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000337970	HNRNPF-201	2186	-	ENSP00000338477	415 (aa)	-	P52597
ENST00000357065	HNRNPF-203	2617	-	ENSP00000349573	415 (aa)	-	P52597
ENST00000443950	HNRNPF-204	2755	-	ENSP00000400433	415 (aa)	-	P52597
ENST00000544000	HNRNPF-207	2676	-	ENSP00000438061	415 (aa)	-	P52597
ENST00000356053	HNRNPF-202	2670	-	ENSP00000348345	415 (aa)	-	P52597
ENST00000477108	HNRNPF-205	636	-	ENSP00000490768	98 (aa)	-	A0A1B0GW42
ENST00000498176	HNRNPF-206	715	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000169813's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169813's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000169813	HNRNPF	92	40.000	ENSG00000096746	HNRNPH3	95	57.012
ENSG00000169813	HNRNPF	100	77.551	ENSG00000169045	HNRNPH1	100	86.000
ENSG00000169813	HNRNPF	100	72.449	ENSG00000126945	HNRNPH2	97	71.954
ENSG00000169813	HNRNPF	90	46.591	ENSG00000132463	GRSF1	98	41.520
ENSG00000169813	HNRNPF	96	34.783	ENSG00000183808	RBM12B	94	36.250

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000169813	HNRNPF	100	98.980	ENSAMEG00000018983	HNRNPF	100	97.831	Ailuropoda_melanoleuca
ENSG00000169813	HNRNPF	100	98.980	ENSANAG00000033285	-	100	96.867	Aotus_nancymaae
ENSG00000169813	HNRNPF	100	92.857	ENSANAG00000033452	-	89	83.514	Aotus_nancymaae
ENSG00000169813	HNRNPF	100	96.939	ENSBTAG00000008853	HNRNPF	100	96.867	Bos_taurus
ENSG00000169813	HNRNPF	100	79.952	ENSBTAG00000020513	-	100	79.952	Bos_taurus
ENSG00000169813	HNRNPF	100	99.518	ENSCJAG00000008291	HNRNPF	100	99.518	Callithrix_jacchus
ENSG00000169813	HNRNPF	100	98.980	ENSCAFG00000007044	HNRNPF	100	97.831	Canis_familiaris
ENSG00000169813	HNRNPF	100	96.939	ENSCHIG00000006714	HNRNPF	100	96.867	Capra_hircus
ENSG00000169813	HNRNPF	100	70.408	ENSCHIG00000022971	-	99	72.616	Capra_hircus
ENSG00000169813	HNRNPF	100	86.869	ENSTSYG00000002112	-	100	83.654	Carlito_syrichta
ENSG00000169813	HNRNPF	100	98.313	ENSTSYG00000030439	-	100	98.313	Carlito_syrichta
ENSG00000169813	HNRNPF	99	97.826	ENSCAPG00000011521	HNRNPF	99	97.826	Cavia_aperea
ENSG00000169813	HNRNPF	99	97.826	ENSCPOG00000003678	HNRNPF	99	97.826	Cavia_porcellus
ENSG00000169813	HNRNPF	100	93.878	ENSCCAG00000028687	-	100	80.482	Cebus_capucinus
ENSG00000169813	HNRNPF	100	99.277	ENSCCAG00000031457	-	100	99.277	Cebus_capucinus
ENSG00000169813	HNRNPF	99	97.826	ENSCLAG00000005161	HNRNPF	99	97.826	Chinchilla_lanigera
ENSG00000169813	HNRNPF	100	100.000	ENSCANG00000003086	-	100	98.554	Colobus_angolensis_palliatus
ENSG00000169813	HNRNPF	94	73.333	ENSCGRG00001016206	-	88	73.333	Cricetulus_griseus_chok1gshd
ENSG00000169813	HNRNPF	100	98.072	ENSCGRG00001016276	Hnrnpf	100	98.072	Cricetulus_griseus_chok1gshd
ENSG00000169813	HNRNPF	100	92.857	ENSDNOG00000030849	-	100	92.771	Dasypus_novemcinctus
ENSG00000169813	HNRNPF	100	96.627	ENSDORG00000024298	-	100	96.627	Dipodomys_ordii
ENSG00000169813	HNRNPF	100	88.193	ENSDORG00000005431	-	100	88.193	Dipodomys_ordii
ENSG00000169813	HNRNPF	100	93.735	ENSDORG00000024936	-	100	93.735	Dipodomys_ordii
ENSG00000169813	HNRNPF	100	90.120	ENSDORG00000008260	-	100	90.120	Dipodomys_ordii
ENSG00000169813	HNRNPF	100	97.590	ENSEASG00005006903	HNRNPF	100	97.590	Equus_asinus_asinus
ENSG00000169813	HNRNPF	100	96.939	ENSECAG00000003229	HNRNPF	100	93.735	Equus_caballus
ENSG00000169813	HNRNPF	100	98.980	ENSFCAG00000028219	-	100	97.831	Felis_catus
ENSG00000169813	HNRNPF	99	93.814	ENSFDAG00000007858	-	98	88.295	Fukomys_damarensis
ENSG00000169813	HNRNPF	99	86.598	ENSFDAG00000015308	-	99	80.435	Fukomys_damarensis
ENSG00000169813	HNRNPF	99	97.826	ENSFDAG00000011431	-	99	97.826	Fukomys_damarensis
ENSG00000169813	HNRNPF	100	100.000	ENSGGOG00000010867	HNRNPF	93	100.000	Gorilla_gorilla
ENSG00000169813	HNRNPF	100	95.918	ENSHGLG00000010276	-	100	93.735	Heterocephalus_glaber_female
ENSG00000169813	HNRNPF	99	97.585	ENSHGLG00000000147	-	99	97.585	Heterocephalus_glaber_female
ENSG00000169813	HNRNPF	99	92.784	ENSHGLG00000014139	-	97	92.819	Heterocephalus_glaber_female
ENSG00000169813	HNRNPF	99	91.753	ENSHGLG00000017607	-	100	87.440	Heterocephalus_glaber_female
ENSG00000169813	HNRNPF	99	94.845	ENSHGLG00100019558	-	100	92.995	Heterocephalus_glaber_male
ENSG00000169813	HNRNPF	99	92.784	ENSHGLG00100010905	-	97	85.904	Heterocephalus_glaber_male
ENSG00000169813	HNRNPF	99	96.535	ENSHGLG00100020825	-	100	96.535	Heterocephalus_glaber_male
ENSG00000169813	HNRNPF	99	91.753	ENSHGLG00100019910	-	100	89.646	Heterocephalus_glaber_male
ENSG00000169813	HNRNPF	99	94.845	ENSHGLG00100019572	-	99	93.478	Heterocephalus_glaber_male
ENSG00000169813	HNRNPF	100	82.734	ENSSTOG00000023820	-	100	82.734	Ictidomys_tridecemlineatus
ENSG00000169813	HNRNPF	100	91.837	ENSSTOG00000022853	-	100	87.740	Ictidomys_tridecemlineatus
ENSG00000169813	HNRNPF	100	98.313	ENSSTOG00000025560	-	100	98.313	Ictidomys_tridecemlineatus
ENSG00000169813	HNRNPF	100	93.878	ENSJJAG00000017385	-	100	88.193	Jaculus_jaculus
ENSG00000169813	HNRNPF	100	83.673	ENSJJAG00000000554	-	100	73.445	Jaculus_jaculus
ENSG00000169813	HNRNPF	100	91.837	ENSJJAG00000022288	-	100	81.446	Jaculus_jaculus
ENSG00000169813	HNRNPF	98	94.086	ENSJJAG00000014334	-	99	94.086	Jaculus_jaculus
ENSG00000169813	HNRNPF	100	63.855	ENSJJAG00000014424	-	100	63.855	Jaculus_jaculus
ENSG00000169813	HNRNPF	99	95.422	ENSLAFG00000000424	HNRNPF	99	95.422	Loxodonta_africana
ENSG00000169813	HNRNPF	100	100.000	ENSMFAG00000021184	HNRNPF	100	100.000	Macaca_fascicularis
ENSG00000169813	HNRNPF	100	100.000	ENSMMUG00000020982	HNRNPF	100	100.000	Macaca_mulatta
ENSG00000169813	HNRNPF	100	100.000	ENSMLEG00000023515	HNRNPF	100	100.000	Mandrillus_leucophaeus
ENSG00000169813	HNRNPF	100	98.072	ENSMAUG00000007892	Hnrnpf	100	98.072	Mesocricetus_auratus
ENSG00000169813	HNRNPF	100	86.735	ENSMICG00000043739	-	99	80.435	Microcebus_murinus
ENSG00000169813	HNRNPF	100	87.755	ENSMICG00000044171	-	99	80.285	Microcebus_murinus
ENSG00000169813	HNRNPF	100	97.349	ENSMOCG00000014915	Hnrnpf	100	97.349	Microtus_ochrogaster
ENSG00000169813	HNRNPF	100	98.072	ENSMUSG00000042079	Hnrnpf	100	98.072	Mus_musculus
ENSG00000169813	HNRNPF	100	96.867	MGP_PahariEiJ_G0026903	-	100	96.867	Mus_pahari
ENSG00000169813	HNRNPF	100	98.980	ENSMPUG00000017283	HNRNPF	99	97.995	Mustela_putorius_furo
ENSG00000169813	HNRNPF	100	94.712	ENSMLUG00000007261	HNRNPF	100	94.712	Myotis_lucifugus
ENSG00000169813	HNRNPF	100	79.759	ENSNGAG00000014079	-	100	79.759	Nannospalax_galili
ENSG00000169813	HNRNPF	100	97.590	ENSNGAG00000010409	-	100	97.590	Nannospalax_galili
ENSG00000169813	HNRNPF	100	69.880	ENSNGAG00000009482	-	100	69.880	Nannospalax_galili
ENSG00000169813	HNRNPF	100	99.518	ENSNLEG00000019098	HNRNPF	100	99.518	Nomascus_leucogenys
ENSG00000169813	HNRNPF	99	92.784	ENSODEG00000002359	-	99	90.777	Octodon_degus
ENSG00000169813	HNRNPF	99	97.826	ENSODEG00000019266	-	99	97.826	Octodon_degus
ENSG00000169813	HNRNPF	100	93.253	ENSOCUG00000024604	-	100	93.253	Oryctolagus_cuniculus
ENSG00000169813	HNRNPF	100	98.795	ENSOCUG00000024719	-	100	98.795	Oryctolagus_cuniculus
ENSG00000169813	HNRNPF	99	94.845	ENSOGAG00000013734	-	99	91.807	Otolemur_garnettii
ENSG00000169813	HNRNPF	100	93.494	ENSOGAG00000030480	-	100	93.494	Otolemur_garnettii
ENSG00000169813	HNRNPF	100	96.939	ENSOARG00000003995	HNRNPF	92	97.820	Ovis_aries
ENSG00000169813	HNRNPF	100	84.694	ENSOARG00000016658	-	100	80.000	Ovis_aries
ENSG00000169813	HNRNPF	100	98.980	ENSPPRG00000021222	HNRNPF	100	97.831	Panthera_pardus
ENSG00000169813	HNRNPF	100	98.980	ENSPTIG00000009644	HNRNPF	100	97.831	Panthera_tigris_altaica
ENSG00000169813	HNRNPF	100	100.000	ENSPTRG00000002446	HNRNPF	100	100.000	Pan_troglodytes
ENSG00000169813	HNRNPF	100	100.000	ENSPANG00000002212	HNRNPF	100	99.759	Papio_anubis
ENSG00000169813	HNRNPF	100	100.000	ENSPPYG00000002212	HNRNPF	100	100.000	Pongo_abelii
ENSG00000169813	HNRNPF	100	94.712	ENSPCAG00000013169	HNRNPF	100	94.712	Procavia_capensis
ENSG00000169813	HNRNPF	100	96.627	ENSPVAG00000011646	HNRNPF	100	96.627	Pteropus_vampyrus
ENSG00000169813	HNRNPF	100	98.072	ENSRNOG00000014562	Hnrnpf	100	98.072	Rattus_norvegicus
ENSG00000169813	HNRNPF	100	100.000	ENSRROG00000001235	HNRNPF	100	100.000	Rhinopithecus_roxellana
ENSG00000169813	HNRNPF	100	99.518	ENSSBOG00000018361	HNRNPF	100	99.518	Saimiri_boliviensis_boliviensis
ENSG00000169813	HNRNPF	100	97.108	ENSSARG00000010059	HNRNPF	100	97.108	Sorex_araneus
ENSG00000169813	HNRNPF	100	97.959	ENSSSCG00000010203	-	100	97.108	Sus_scrofa
ENSG00000169813	HNRNPF	100	71.429	ENSSSCG00000024956	-	96	58.373	Sus_scrofa
ENSG00000169813	HNRNPF	100	75.510	ENSTBEG00000016094	HNRNPF	100	71.852	Tupaia_belangeri
ENSG00000169813	HNRNPF	100	98.980	ENSUAMG00000000455	HNRNPF	100	97.831	Ursus_americanus
ENSG00000169813	HNRNPF	100	98.980	ENSUMAG00000016485	HNRNPF	100	97.831	Ursus_maritimus
ENSG00000169813	HNRNPF	100	98.980	ENSVVUG00000021261	HNRNPF	100	97.831	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003727	single-stranded RNA binding	20526337.	IDA	Function
GO:0005515	protein binding	9111328.17932509.22365833.25416956.	IPI	Function
GO:0005634	nucleus	7499401.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006396	RNA processing	7499401.	TAS	Process
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016070	RNA metabolic process	-	TAS	Process
GO:0017025	TBP-class protein binding	-	IEA	Function
GO:0035722	interleukin-12-mediated signaling pathway	-	TAS	Process
GO:0043484	regulation of RNA splicing	20526337.	IDA	Process
GO:0043484	regulation of RNA splicing	9111328.	IMP	Process
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component