EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000169925 (Gene tree)
Gene ID: 8019
Gene Symbol: BRD3
Alias: RING3L|ORFX|KIAA0043
Full Name: bromodomain containing 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 38,231 bases
Position: chr9:134,030,305-134,068,535
Accession: 1104
RBP type: non-canonical RBP
Summary: This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25713319	CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET.	Am J Physiol Lung Cell Mol Physiol	2015 May 1	Clifford RL	doi: 10.1152/ajplung.00021.2015
31311960	Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production.	Sci Rep	2019 Jul 16	Gibbons HR	doi: 10.1038/s41598-019-46516-x.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000494743	BRD3-206	507	-	-	- (aa)	-	-
ENST00000473349	BRD3-205	761	-	-	- (aa)	-	-
ENST00000433041	BRD3-204	599	-	ENSP00000406749	20 (aa)	-	A9J575
ENST00000303407	BRD3-201	5652	XM_006717291	ENSP00000305918	726 (aa)	XP_006717354	Q15059
ENST00000371842	BRD3-203	574	-	ENSP00000360908	74 (aa)	-	A9J571
ENST00000371834	BRD3-202	2529	-	ENSP00000360900	556 (aa)	-	Q15059

Gene Model

Click here to download ENSG00000169925's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000169925	Platelet Function Tests	6.0896476E-006	-
ENSG00000169925	Platelet Count	2E-10	22139419

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000169925	rs11795079	9	134065012	T	Intraocular pressure	29617998	[0.12-0.19] unit decrease	0.153	EFO_0004695
ENSG00000169925	rs72766630	9	134061669	G	Intraocular pressure	29617998	[0.11-0.19] unit decrease	0.15	EFO_0004695
ENSG00000169925	rs2157770	9	134056342	G	Mean platelet volume	27863252	[0.037-0.052] unit decrease	0.04436646	EFO_0004584
ENSG00000169925	rs11789898	9	134060541	T	Platelet count	22139419	[2.08-3.95] 10^9/l increase	3.014	EFO_0004309
ENSG00000169925	rs55924785	9	134064464	C	Self-reported math ability	30038396	[0.014-0.024] unit increase	0.0188	EFO_0004875
ENSG00000169925	rs75318400	9	134068323	T	Highest math class taken	30038396	[0.012-0.021] unit increase	0.0163	EFO_0004875
ENSG00000169925	rs72766638	9	134066656	A	Self-reported math ability (MTAG)	30038396	[0.014-0.023] unit decrease	0.0186	EFO_0004875
ENSG00000169925	rs7027509	9	134062754	T	Highest math class taken (MTAG)	30038396	[0.01-0.0166] unit decrease	0.0133	EFO_0004875
ENSG00000169925	rs3180509	9	134032856	T	Granulocyte percentage of myeloid white cells	27863252	[0.016-0.033] unit increase	0.02445947	EFO_0007997
ENSG00000169925	rs456205	9	134046024	A	Neutrophil percentage of white cells	27863252	[0.018-0.034] unit increase	0.02581637	EFO_0007990
ENSG00000169925	rs2810491	9	134058209	C	Platelet count	27863252	[0.032-0.048] unit increase	0.03988658	EFO_0004309
ENSG00000169925	rs459571	9	134047504	T	Platelet distribution width	27863252	[0.022-0.038] unit decrease	0.02986666	EFO_0007984
ENSG00000169925	rs72766638	9	134066656	C	Mosquito bite size	28199695	[0.021-0.048] unit increase	0.0345953	EFO_0008378
ENSG00000169925	rs140578741	9	134042697	C	Neutrophil count	27863252	[0.017-0.033] unit increase	0.0246063	EFO_0004833
ENSG00000169925	rs392134	9	134043886	A	Neutrophil percentage of granulocytes	27863252	[0.026-0.042] unit increase	0.03358099	EFO_0007994
ENSG00000169925	rs392134	9	134043886	A	Eosinophil percentage of granulocytes	27863252	[0.025-0.041] unit decrease	0.03266084	EFO_0007996
ENSG00000169925	rs532553681	9	134037708	AT	Sum eosinophil basophil counts	27863252	[0.017-0.033] unit increase	0.02532776	EFO_0005090\|EFO_0004842
ENSG00000169925	rs140578741	9	134042697	C	Sum basophil neutrophil counts	27863252	[0.016-0.032] unit increase	0.02406677	EFO_0004833\|EFO_0005090
ENSG00000169925	rs532553681	9	134037708	AT	Eosinophil percentage of white cells	27863252	[0.023-0.039] unit increase	0.03129194	EFO_0007991
ENSG00000169925	rs532553681	9	134037708	AT	Eosinophil counts	27863252	[0.018-0.034] unit increase	0.0257505	EFO_0004842
ENSG00000169925	rs2810489	9	134057578	A	Cognitive performance (MTAG)	30038396	[0.0095-0.0197] unit decrease	0.0146	EFO_0008354
ENSG00000169925	rs2157770	9	134056342	G	Red cell distribution width	28957414	[0.023-0.041] unit decrease	0.0321037	EFO_0005192
ENSG00000169925	rs4744546	9	134059622	?	Body fat percentage	30593698	[0.08-0.164] unit decrease	0.12188	EFO_0007800
ENSG00000169925	rs4744546	9	134059622	?	Body fat percentage	30593698	[0.081-0.185] unit decrease	0.13299	EFO_0007800
ENSG00000169925	rs2520099	9	134053017	T	Alcohol consumption (drinks per week)	30643258	[0.0095-0.0193] unit decrease	0.01438478	EFO_0007878
ENSG00000169925	rs2157770	9	134056342	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000169925	rs72766630	9	134061669	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000169925	rs11789898	9	134060541	?	Red blood cell count	30595370			EFO_0004305
ENSG00000169925	rs72766630	9	134061669	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169925's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000169925	BRD3	82	80.620	ENSG00000204256	BRD2	88	66.116	Homo_sapiens
ENSG00000169925	BRD3	100	93.243	ENSMUSG00000026918	Brd3	100	94.505	Mus_musculus
ENSG00000169925	BRD3	88	74.242	ENSMUSG00000024335	Brd2	95	81.967	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003682	chromatin binding	18406326.	IDA	Function
GO:0005515	protein binding	20195357.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0006325	chromatin organization	-	IEA	Process
GO:0006357	regulation of transcription by RNA polymerase II	18406326.	IDA	Process
GO:0070577	lysine-acetylated histone binding	22464331.27105114.	IDA	Function