EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000169972 (Gene tree)
Gene ID: 126789
Gene Symbol: PUSL1
Alias: FLJ90811
Full Name: pseudouridine synthase like 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 3,111 bases
Position: chr1:1,308,567-1,311,677
Accession: 26914
RBP type: canonical RBP
Summary: (Pseudouridine Synthase Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding and pseudouridine synthase activity. An important paralog of this gene is PUS3.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000368318	PseudoU_synth_1	PF01416.20	1.8e-35	1	2
ENSP00000368318	PseudoU_synth_1	PF01416.20	1.8e-35	2	2
ENSP00000462968	PseudoU_synth_1	PF01416.20	3.9e-26	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000379031	PUSL1-201	1287	XM_005244720	ENSP00000368318	303 (aa)	XP_005244777	Q8N0Z8
ENST00000470520	PUSL1-204	769	-	-	- (aa)	-	-
ENST00000463758	PUSL1-202	940	-	-	- (aa)	-	-
ENST00000493657	PUSL1-205	1783	-	-	- (aa)	-	-
ENST00000467712	PUSL1-203	877	-	ENSP00000462968	125 (aa)	-	J3KTG4

Gene Model

Click here to download ENSG00000169972's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000169972	Colitis, Ulcerative	1E-9	26192919
ENSG00000169972	Inflammatory Bowel Diseases	2E-7	28067908
ENSG00000169972	Crohn Disease	6E-7	26192919
ENSG00000169972	Inflammatory Bowel Diseases	3E-11	26192919
ENSG00000169972	Inflammatory Bowel Diseases	8E-13	23128233
ENSG00000169972	Colitis, Ulcerative	3E-6	28067908

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000169972	rs11590283	1	1309988	?	Systemic lupus erythematosus	28714469	[1.10-1.22]	1.1627907	EFO_0002690

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169972's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000169972	PUSL1	97	49.593	ENSAPOG00000016290	pusl1	92	50.725	Acanthochromis_polyacanthus
ENSG00000169972	PUSL1	98	86.066	ENSAMEG00000013752	PUSL1	98	83.502	Ailuropoda_melanoleuca
ENSG00000169972	PUSL1	98	49.600	ENSACIG00000015240	pusl1	99	48.162	Amphilophus_citrinellus
ENSG00000169972	PUSL1	97	48.780	ENSAOCG00000019419	pusl1	83	50.357	Amphiprion_ocellaris
ENSG00000169972	PUSL1	97	48.780	ENSAPEG00000005452	pusl1	92	50.725	Amphiprion_percula
ENSG00000169972	PUSL1	97	47.967	ENSATEG00000024154	pusl1	92	51.087	Anabas_testudineus
ENSG00000169972	PUSL1	97	52.846	ENSAPLG00000004946	PUSL1	96	54.325	Anas_platyrhynchos
ENSG00000169972	PUSL1	100	50.394	ENSACAG00000014111	PUSL1	96	54.510	Anolis_carolinensis
ENSG00000169972	PUSL1	99	93.046	ENSANAG00000037456	PUSL1	99	93.046	Aotus_nancymaae
ENSG00000169972	PUSL1	98	48.000	ENSACLG00000008675	pusl1	95	48.221	Astatotilapia_calliptera
ENSG00000169972	PUSL1	98	44.715	ENSAMXG00000044007	pusl1	96	47.518	Astyanax_mexicanus
ENSG00000169972	PUSL1	98	85.366	ENSBTAG00000007619	PUSL1	99	84.669	Bos_taurus
ENSG00000169972	PUSL1	99	93.046	ENSCJAG00000010972	PUSL1	99	93.046	Callithrix_jacchus
ENSG00000169972	PUSL1	98	82.114	ENSCAFG00000019291	PUSL1	98	81.271	Canis_familiaris
ENSG00000169972	PUSL1	99	81.667	ENSCAFG00020011568	PUSL1	98	81.667	Canis_lupus_dingo
ENSG00000169972	PUSL1	98	86.992	ENSCHIG00000012615	PUSL1	98	86.170	Capra_hircus
ENSG00000169972	PUSL1	98	81.967	ENSCAPG00000011911	-	92	82.258	Cavia_aperea
ENSG00000169972	PUSL1	75	30.263	ENSCAPG00000006421	PUS1	63	30.263	Cavia_aperea
ENSG00000169972	PUSL1	100	80.800	ENSCPOG00000005149	PUSL1	97	80.268	Cavia_porcellus
ENSG00000169972	PUSL1	100	93.600	ENSCCAG00000027475	PUSL1	99	93.709	Cebus_capucinus
ENSG00000169972	PUSL1	100	94.400	ENSCATG00000018260	PUSL1	99	94.040	Cercocebus_atys
ENSG00000169972	PUSL1	100	81.600	ENSCLAG00000005232	PUSL1	99	82.724	Chinchilla_lanigera
ENSG00000169972	PUSL1	100	95.200	ENSCSAG00000000680	PUSL1	99	95.033	Chlorocebus_sabaeus
ENSG00000169972	PUSL1	98	55.200	ENSCPBG00000022621	PUSL1	96	54.643	Chrysemys_picta_bellii
ENSG00000169972	PUSL1	100	95.200	ENSCANG00000034373	PUSL1	99	94.040	Colobus_angolensis_palliatus
ENSG00000169972	PUSL1	100	78.400	ENSCGRG00001012429	Pusl1	100	76.976	Cricetulus_griseus_chok1gshd
ENSG00000169972	PUSL1	100	78.400	ENSCGRG00000006466	Pusl1	100	77.320	Cricetulus_griseus_crigri
ENSG00000169972	PUSL1	97	49.593	ENSCSEG00000005159	pusl1	92	49.638	Cynoglossus_semilaevis
ENSG00000169972	PUSL1	79	45.378	ENSCVAG00000012923	pusl1	91	45.378	Cyprinodon_variegatus
ENSG00000169972	PUSL1	98	47.200	ENSDARG00000074565	pusl1	97	48.746	Danio_rerio
ENSG00000169972	PUSL1	96	30.000	FBgn0083976	CG34140	98	32.143	Drosophila_melanogaster
ENSG00000169972	PUSL1	100	84.000	ENSECAG00000006248	PUSL1	95	83.333	Equus_caballus
ENSG00000169972	PUSL1	100	76.800	ENSEEUG00000000837	PUSL1	98	76.289	Erinaceus_europaeus
ENSG00000169972	PUSL1	97	49.593	ENSELUG00000015945	pusl1	94	50.360	Esox_lucius
ENSG00000169972	PUSL1	98	85.366	ENSFCAG00000007617	PUSL1	99	83.893	Felis_catus
ENSG00000169972	PUSL1	98	81.967	ENSFDAG00000010007	-	95	82.258	Fukomys_damarensis
ENSG00000169972	PUSL1	97	54.472	ENSFHEG00000006370	pusl1	92	52.899	Fundulus_heteroclitus
ENSG00000169972	PUSL1	98	50.000	ENSGMOG00000019388	pusl1	98	51.971	Gadus_morhua
ENSG00000169972	PUSL1	98	52.419	ENSGALG00000001714	PUSL1	98	52.265	Gallus_gallus
ENSG00000169972	PUSL1	96	52.459	ENSGAFG00000007546	pusl1	95	51.071	Gambusia_affinis
ENSG00000169972	PUSL1	97	49.194	ENSGACG00000007848	pusl1	97	47.475	Gasterosteus_aculeatus
ENSG00000169972	PUSL1	98	54.400	ENSGAGG00000004730	PUSL1	96	54.804	Gopherus_agassizii
ENSG00000169972	PUSL1	100	96.800	ENSGGOG00000005364	PUSL1	100	98.062	Gorilla_gorilla
ENSG00000169972	PUSL1	98	48.000	ENSHBUG00000001264	pusl1	91	49.638	Haplochromis_burtoni
ENSG00000169972	PUSL1	100	81.746	ENSHGLG00000017570	PUSL1	97	80.201	Heterocephalus_glaber_female
ENSG00000169972	PUSL1	100	81.746	ENSHGLG00100007641	PUSL1	88	81.955	Heterocephalus_glaber_male
ENSG00000169972	PUSL1	98	50.400	ENSHCOG00000010077	pusl1	99	50.730	Hippocampus_comes
ENSG00000169972	PUSL1	98	43.200	ENSIPUG00000023921	pusl1	96	48.571	Ictalurus_punctatus
ENSG00000169972	PUSL1	98	83.607	ENSSTOG00000001783	PUSL1	87	85.305	Ictidomys_tridecemlineatus
ENSG00000169972	PUSL1	100	79.200	ENSJJAG00000020471	Pusl1	97	81.533	Jaculus_jaculus
ENSG00000169972	PUSL1	97	46.341	ENSKMAG00000005154	pusl1	88	50.000	Kryptolebias_marmoratus
ENSG00000169972	PUSL1	97	49.593	ENSLBEG00000013469	pusl1	94	52.000	Labrus_bergylta
ENSG00000169972	PUSL1	63	55.102	ENSLACG00000018795	PUSL1	95	55.102	Latimeria_chalumnae
ENSG00000169972	PUSL1	77	30.672	ENSLACG00000016044	-	63	30.672	Latimeria_chalumnae
ENSG00000169972	PUSL1	98	46.400	ENSLOCG00000002210	pusl1	97	46.758	Lepisosteus_oculatus
ENSG00000169972	PUSL1	98	82.927	ENSLAFG00000013685	PUSL1	99	82.510	Loxodonta_africana
ENSG00000169972	PUSL1	100	96.000	ENSMFAG00000046288	PUSL1	99	95.033	Macaca_fascicularis
ENSG00000169972	PUSL1	100	95.200	ENSMMUG00000016279	PUSL1	99	83.444	Macaca_mulatta
ENSG00000169972	PUSL1	100	94.400	ENSMNEG00000037989	PUSL1	99	94.371	Macaca_nemestrina
ENSG00000169972	PUSL1	94	97.436	ENSMLEG00000039224	-	89	97.436	Mandrillus_leucophaeus
ENSG00000169972	PUSL1	98	47.200	ENSMAMG00000016538	pusl1	97	47.635	Mastacembelus_armatus
ENSG00000169972	PUSL1	98	48.000	ENSMZEG00005026990	pusl1	98	45.105	Maylandia_zebra
ENSG00000169972	PUSL1	98	52.419	ENSMGAG00000003037	PUSL1	96	52.837	Meleagris_gallopavo
ENSG00000169972	PUSL1	100	78.400	ENSMAUG00000019924	Pusl1	100	77.320	Mesocricetus_auratus
ENSG00000169972	PUSL1	97	85.124	ENSMICG00000014171	PUSL1	98	84.028	Microcebus_murinus
ENSG00000169972	PUSL1	100	80.800	ENSMOCG00000005602	Pusl1	100	78.351	Microtus_ochrogaster
ENSG00000169972	PUSL1	97	48.780	ENSMMOG00000003269	pusl1	99	48.921	Mola_mola
ENSG00000169972	PUSL1	97	45.528	ENSMALG00000021686	pusl1	93	47.931	Monopterus_albus
ENSG00000169972	PUSL1	98	84.553	MGP_CAROLIEiJ_G0026911	Pusl1	100	79.381	Mus_caroli
ENSG00000169972	PUSL1	100	85.600	ENSMUSG00000051557	Pusl1	100	80.412	Mus_musculus
ENSG00000169972	PUSL1	100	84.000	MGP_PahariEiJ_G0029260	Pusl1	100	79.725	Mus_pahari
ENSG00000169972	PUSL1	100	84.000	MGP_SPRETEiJ_G0027906	Pusl1	100	80.412	Mus_spretus
ENSG00000169972	PUSL1	98	81.208	ENSMPUG00000014313	PUSL1	98	81.208	Mustela_putorius_furo
ENSG00000169972	PUSL1	98	80.488	ENSNGAG00000004647	Pusl1	87	77.855	Nannospalax_galili
ENSG00000169972	PUSL1	97	50.407	ENSNBRG00000014762	pusl1	94	47.876	Neolamprologus_brichardi
ENSG00000169972	PUSL1	100	95.200	ENSNLEG00000000051	PUSL1	100	95.307	Nomascus_leucogenys
ENSG00000169972	PUSL1	98	56.452	ENSMEUG00000005176	-	99	53.091	Notamacropus_eugenii
ENSG00000169972	PUSL1	98	62.097	ENSMEUG00000011649	-	99	65.371	Notamacropus_eugenii
ENSG00000169972	PUSL1	100	78.400	ENSODEG00000008247	PUSL1	93	80.069	Octodon_degus
ENSG00000169972	PUSL1	63	30.570	ENSODEG00000008248	PUS1	53	30.570	Octodon_degus
ENSG00000169972	PUSL1	97	53.226	ENSONIG00000019361	pusl1	94	51.064	Oreochromis_niloticus
ENSG00000169972	PUSL1	97	47.967	ENSORLG00000016228	pusl1	97	48.789	Oryzias_latipes
ENSG00000169972	PUSL1	97	47.154	ENSORLG00020013710	pusl1	97	49.481	Oryzias_latipes_hni
ENSG00000169972	PUSL1	97	47.154	ENSORLG00015008715	pusl1	98	49.286	Oryzias_latipes_hsok
ENSG00000169972	PUSL1	97	47.154	ENSOMEG00000018897	pusl1	94	50.362	Oryzias_melastigma
ENSG00000169972	PUSL1	98	85.366	ENSOGAG00000031692	PUSL1	100	84.321	Otolemur_garnettii
ENSG00000169972	PUSL1	98	86.992	ENSOARG00000004905	PUSL1	100	84.586	Ovis_aries
ENSG00000169972	PUSL1	100	99.010	ENSPPAG00000029283	PUSL1	100	99.010	Pan_paniscus
ENSG00000169972	PUSL1	98	84.553	ENSPPRG00000023329	PUSL1	99	82.550	Panthera_pardus
ENSG00000169972	PUSL1	98	84.553	ENSPTIG00000018532	PUSL1	97	84.733	Panthera_tigris_altaica
ENSG00000169972	PUSL1	100	99.010	ENSPTRG00000000021	PUSL1	100	99.010	Pan_troglodytes
ENSG00000169972	PUSL1	100	95.200	ENSPANG00000000591	PUSL1	99	93.709	Papio_anubis
ENSG00000169972	PUSL1	97	44.000	ENSPKIG00000002447	pusl1	96	47.857	Paramormyrops_kingsleyae
ENSG00000169972	PUSL1	98	54.400	ENSPSIG00000002781	PUSL1	94	57.087	Pelodiscus_sinensis
ENSG00000169972	PUSL1	98	46.400	ENSPMGG00000011051	pusl1	99	47.273	Periophthalmus_magnuspinnatus
ENSG00000169972	PUSL1	100	80.000	ENSPEMG00000013541	Pusl1	100	80.412	Peromyscus_maniculatus_bairdii
ENSG00000169972	PUSL1	98	63.710	ENSPCIG00000007816	-	65	65.018	Phascolarctos_cinereus
ENSG00000169972	PUSL1	97	52.846	ENSPFOG00000015448	pusl1	91	53.623	Poecilia_formosa
ENSG00000169972	PUSL1	97	52.846	ENSPLAG00000004348	pusl1	92	53.623	Poecilia_latipinna
ENSG00000169972	PUSL1	97	52.846	ENSPMEG00000000931	pusl1	92	53.623	Poecilia_mexicana
ENSG00000169972	PUSL1	97	52.893	ENSPREG00000002324	pusl1	92	53.285	Poecilia_reticulata
ENSG00000169972	PUSL1	100	96.800	ENSPPYG00000002014	PUSL1	94	95.802	Pongo_abelii
ENSG00000169972	PUSL1	98	59.350	ENSPCAG00000002272	PUSL1	99	72.016	Procavia_capensis
ENSG00000169972	PUSL1	96	82.500	ENSPCOG00000024685	-	88	80.645	Propithecus_coquereli
ENSG00000169972	PUSL1	100	80.800	ENSPVAG00000001016	PUSL1	74	86.585	Pteropus_vampyrus
ENSG00000169972	PUSL1	78	49.160	ENSPNYG00000006588	pusl1	98	49.160	Pundamilia_nyererei
ENSG00000169972	PUSL1	98	46.400	ENSPNAG00000024441	pusl1	96	50.179	Pygocentrus_nattereri
ENSG00000169972	PUSL1	100	85.600	ENSRNOG00000022354	Pusl1	98	86.290	Rattus_norvegicus
ENSG00000169972	PUSL1	99	95.161	ENSRBIG00000036842	PUSL1	99	94.040	Rhinopithecus_bieti
ENSG00000169972	PUSL1	99	94.355	ENSRROG00000030704	PUSL1	99	93.709	Rhinopithecus_roxellana
ENSG00000169972	PUSL1	100	91.200	ENSSBOG00000032249	PUSL1	99	92.029	Saimiri_boliviensis_boliviensis
ENSG00000169972	PUSL1	50	66.667	ENSSHAG00000004840	-	85	61.585	Sarcophilus_harrisii
ENSG00000169972	PUSL1	97	46.341	ENSSFOG00015008281	pusl1	95	48.780	Scleropages_formosus
ENSG00000169972	PUSL1	98	46.400	ENSSMAG00000007187	pusl1	91	48.913	Scophthalmus_maximus
ENSG00000169972	PUSL1	98	48.800	ENSSDUG00000000287	pusl1	93	47.312	Seriola_dumerili
ENSG00000169972	PUSL1	98	48.000	ENSSLDG00000009605	pusl1	88	50.360	Seriola_lalandi_dorsalis
ENSG00000169972	PUSL1	62	79.787	ENSSARG00000005323	-	100	79.787	Sorex_araneus
ENSG00000169972	PUSL1	97	41.463	ENSSPAG00000002528	pusl1	99	45.788	Stegastes_partitus
ENSG00000169972	PUSL1	100	84.800	ENSSSCG00000003338	PUSL1	99	82.450	Sus_scrofa
ENSG00000169972	PUSL1	98	49.600	ENSTGUG00000003214	PUSL1	99	53.546	Taeniopygia_guttata
ENSG00000169972	PUSL1	98	46.400	ENSTRUG00000010102	pusl1	93	49.640	Takifugu_rubripes
ENSG00000169972	PUSL1	97	47.154	ENSTNIG00000005789	pusl1	81	45.604	Tetraodon_nigroviridis
ENSG00000169972	PUSL1	97	81.818	ENSTBEG00000005001	PUSL1	99	59.603	Tupaia_belangeri
ENSG00000169972	PUSL1	98	75.920	ENSTTRG00000017030	PUSL1	98	75.920	Tursiops_truncatus
ENSG00000169972	PUSL1	98	86.066	ENSUAMG00000012801	PUSL1	83	82.470	Ursus_americanus
ENSG00000169972	PUSL1	98	85.246	ENSUMAG00000002084	PUSL1	83	82.072	Ursus_maritimus
ENSG00000169972	PUSL1	98	83.740	ENSVVUG00000004320	PUSL1	98	72.861	Vulpes_vulpes
ENSG00000169972	PUSL1	75	52.193	ENSXETG00000011145	pusl1	99	52.193	Xenopus_tropicalis
ENSG00000169972	PUSL1	97	53.659	ENSXCOG00000017748	pusl1	98	49.821	Xiphophorus_couchianus
ENSG00000169972	PUSL1	97	52.846	ENSXMAG00000018846	pusl1	92	52.899	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	-	IEA	Function
GO:0009982	pseudouridine synthase activity	21873635.	IBA	Function
GO:0031119	tRNA pseudouridine synthesis	21873635.	IBA	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr1	1309271	Splice_Region	novel	I107I	0.17
BLCA	chr1	1310646	Silent	novel	F219F	0.08
BLCA	chr1	1310728	Intron	novel		0.39
BLCA	chr1	1309717	Silent	novel	Q170Q	0.35
BLCA	chr1	1310977	Silent	rs747362903	T256T	0.39
BLCA	chr1	1309461	Missense_Mutation	NA	R111W	0.55	PseudoU_synth_1
BRCA	chr1	1310552	Intron	novel		0.12
CESC	chr1	1311046	Silent	NA	L279L	0.27
CESC	chr1	1310860	Intron	novel		0.3
COAD	chr1	1309836	Frame_Shift_Del	rs764750132	*E212Rfs26**	0.16
ESCA	chr1	1310825	Intron	novel		0.24
GBM	chr1	1309515	Missense_Mutation	novel	T129A	0.63
LUAD	chr1	1311057	Missense_Mutation	rs766185058	L283P	0.24
LUSC	chr1	1308944	Missense_Mutation	NA	R36L	0.3	PseudoU_synth_1
LUSC	chr1	1309757	Missense_Mutation	NA	A184T	0.2
LUSC	chr1	1310676	Silent	novel	F229F	0.17
PAAD	chr1	1309548	Missense_Mutation	novel	R140W	0.13
PAAD	chr1	1310694	Splice_Region	novel		0.22
SKCM	chr1	1309571	Missense_Mutation	NA	F147L	0.27
STAD	chr1	1309629	Intron	novel		0.38
STAD	chr1	1309529	Silent	NA	R133R	0.24
UCEC	chr1	1310667	Silent	novel	S226S	0.19
UCEC	chr1	1310585	Intron	novel		0.13
UCEC	chr1	1310638	Missense_Mutation	novel	L217M	0.15
UCEC	chr1	1311035	Missense_Mutation	rs201132832	G276S	0.22
UCEC	chr1	1310607	Intron	novel		0.45
UCEC	chr1	1309734	In_Frame_Del	rs776346419	D177del	0.75
UCEC	chr1	1310912	Missense_Mutation	rs748869074	R235W	0.42
UCEC	chr1	1310977	Silent	rs747362903	T256T	0.34
UCEC	chr1	1311347	Missense_Mutation	novel	L294M	0.19

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.1153	0.00029523
DLBC	DEL	0.1875	0.011841
HNSC	DEL	0.1418	7.0766e-07
KIRC	DEL	0.1439	2.3538e-09
KIRP	DEL	0.184	1.462e-09
LIHC	DEL	0.4027	1.1606e-33
LUAD	DEL	0.1357	0.0024765
LUSC	DEL	0.3473	2.5882e-07
MESO	DEL	0.3448	2.434e-07
SARC	DEL	0.2412	8.425e-11
SKCM	DEL	0.1689	5.1876e-09
TGCT	DEL	0.1867	0.00046313
UCS	DEL	0.3036	0.0051125

Survival Analysis

Cancer	P-value	Q-value
SARC	0.048	Kaplan-Meier Survival Analysis
MESO	0.015	Kaplan-Meier Survival Analysis
ACC	0.05	Kaplan-Meier Survival Analysis
SKCM	0.0029	Kaplan-Meier Survival Analysis
LAML	0.00023	Kaplan-Meier Survival Analysis
LIHC	0.00015	Kaplan-Meier Survival Analysis
DLBC	0.042	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
UVM	0.00044	Kaplan-Meier Survival Analysis