EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

PRI

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000170027 (Gene tree)
Gene ID: 7532
Gene Symbol: YWHAG
Alias: PPP1R170
Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 32,241 bases
Position: chr7:76,326,791-76,359,031
Accession: 12852
RBP type: non-canonical RBP
Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000307630	YWHAG-201	3750	-	ENSP00000306330	247 (aa)	-	P61981

Gene Model

Click here to download ENSG00000170027's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04110	Cell cycle	KEGG
hsa04114	Oocyte meiosis	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04390	Hippo signaling pathway	KEGG
hsa05160	Hepatitis C	KEGG
hsa05203	Viral carcinogenesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000170027	Multiple Sclerosis	6E-6	21654844
ENSG00000170027	Multiple Sclerosis	8E-6	21654844

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000170027	rs17149161	7	76348912	A	Multiple sclerosis	21654844	[NR]	1.87	EFO_0003885
ENSG00000170027	rs7779014	7	76346269	T	Multiple sclerosis	21654844	[NR] unit increase	0.48	EFO_0003885
ENSG00000170027	rs2961033	7	76335026	C	Schizophrenia	30285260	[1.05-1.12]	1.082	EFO_0000692

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000170027's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000170027	YWHAG	99	86.992	ENSG00000128245	YWHAH	100	86.992	Homo_sapiens
ENSG00000170027	YWHAG	100	63.968	ENSG00000108953	YWHAE	99	71.930	Homo_sapiens
ENSG00000170027	YWHAG	100	100.000	ENSMUSG00000051391	Ywhag	100	100.000	Mus_musculus
ENSG00000170027	YWHAG	99	86.992	ENSMUSG00000018965	Ywhah	100	86.992	Mus_musculus
ENSG00000170027	YWHAG	100	63.968	ENSMUSG00000020849	Ywhae	95	63.968	Mus_musculus
ENSG00000170027	YWHAG	94	65.385	YDR099W	BMH2	85	65.385	Saccharomyces_cerevisiae
ENSG00000170027	YWHAG	98	62.810	YER177W	BMH1	90	62.810	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005080	protein kinase C binding	10433554.	IPI	Function
GO:0005159	insulin-like growth factor receptor binding	12482592.	IPI	Function
GO:0005515	protein binding	11237865.11504882.12364343.15696159.16511560.16511572.16516142.16959763.17085597.17159145.18045992.18458160.18812399.19172738.19640509.19860830.19933256.20639859.20642453.20936779.21044950.21988832.22653443.23075850.23572552.23622247.23752268.24255178.24947832.25416956.25852190.26638075.28330616.30021884.	IPI	Function
GO:0005739	mitochondrion	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006469	negative regulation of protein kinase activity	10433554.	NAS	Process
GO:0006605	protein targeting	-	IEA	Process
GO:0008426	protein kinase C inhibitor activity	10433554.	NAS	Function
GO:0009966	regulation of signal transduction	10433554.10486217.	NAS	Process
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0019904	protein domain specific binding	-	IEA	Function
GO:0030971	receptor tyrosine kinase binding	-	IEA	Function
GO:0032869	cellular response to insulin stimulus	-	IEA	Process
GO:0042802	identical protein binding	17085597.20639859.	IPI	Function
GO:0045664	regulation of neuron differentiation	11824616.	IMP	Process
GO:0048167	regulation of synaptic plasticity	11824616.	IMP	Process
GO:0061024	membrane organization	-	TAS	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.	HDA	Component
GO:0071901	negative regulation of protein serine/threonine kinase activity	-	IEA	Process
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	Process
GO:0098793	presynapse	-	IEA	Component
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	-	TAS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22658894	Expression of 14-3-3γ in patients with breast cancer: correlation with clinicopathological features and prognosis.	Cancer Epidemiol	2012 Dec	Song Y	doi: 10.1016/j.canep.2012.05.003
27894843	MiR-509-5p suppresses the proliferation, migration, and invasion of non-small cell lung cancer by targeting YWHAG.	Biochem Biophys Res Commun	2017 Jan 22	Wang P	doi: 10.1016/j.bbrc.2016.11.136
27253419	14-3-3γ Prevents Centrosome Amplification and Neoplastic Progression.	Sci Rep	2016 Jun 2	Mukhopadhyay A	doi: 10.1038/srep26580.
27102539	miR-181b-3p promotes epithelial-mesenchymal transition in breast cancer cells through Snail stabilization by directly targeting YWHAG.	Biochim Biophys Acta	2016 Jul	Yoo JO	doi: 10.1016/j.bbamcr.2016.04.016
15057270	14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1).	EMBO J	2004 May 5	Sekimoto T	-
21867493	P53 suppresses expression of the 14-3-3 gamma oncogene.	BMC Cancer	2011 Aug 25	Radhakrishnan VM	doi: 10.1186/1471-2407-11-378.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr7	76329707	Missense_Mutation	novel	I205T	0.21
BLCA	chr7	76329717	Missense_Mutation	NA	D202N	0.11
BLCA	chr7	76329955	Missense_Mutation	novel	F122L	0.16
BLCA	chr7	76330148	Missense_Mutation	novel	S58C	0.43
BRCA	chr7	76330069	Silent	rs569904540	A84A	0.55
BRCA	chr7	76330184	Missense_Mutation	NA	S46C	0.23
CESC	chr7	76358930	5'UTR	novel		0.57
CESC	chr7	76358870	5'UTR	novel		0.08
CESC	chr7	76358909	5'UTR	novel		0.57
COAD	chr7	76330109	Missense_Mutation	novel	S71Y	0.35
COAD	chr7	76329991	Missense_Mutation	NA	K110N	0.25
COAD	chr7	76330168	Silent	rs751763117	N51N	0.34
COAD	chr7	76329781	Silent	rs368289861	S180S	0.46
ESCA	chr7	76329702	Missense_Mutation	NA	E207K	0.1
ESCA	chr7	76329732	Missense_Mutation	novel	A197S	0.32
ESCA	chr7	76327669	3'UTR	novel		0.18
HNSC	chr7	76358767	Silent	novel	A14A	0.26
HNSC	chr7	76330135	Silent	novel	V62V	0.16
KIRP	chr7	76329793	Silent	novel	A176A	0.13
LGG	chr7	76329592	Silent	rs780581872	G243G	0.67
LGG	chr7	76330058	Missense_Mutation	novel	K88R	0.38
LIHC	chr7	76330207	Silent	NA	S38S	0.5
LUAD	chr7	76358766	Nonsense_Mutation	novel	E15*	0.11
LUAD	chr7	76358917	5'UTR	novel		0.57
LUAD	chr7	76358878	5'UTR	novel		0.5
LUAD	chr7	76329800	Missense_Mutation	novel	G174V	0.17
LUAD	chr7	76329836	Missense_Mutation	NA	K162I	0.18
LUSC	chr7	76358926	5'UTR	novel		0.29
LUSC	chr7	76358742	Missense_Mutation	novel	M23V	0.27
OV	chr7	76329992	Frame_Shift_Ins	novel	*K110Sfs23**	0.04
OV	chr7	76330032	Missense_Mutation	novel	C97S	0.1
OV	chr7	76330033	Silent	novel	V96V	0.1
OV	chr7	76358816	5'UTR	novel		0.23
OV	chr7	76358817	5'UTR	novel		0.22
OV	chr7	76330152	Missense_Mutation	NA	R57C	0.25
PAAD	chr7	76330207	Silent	rs749090391	S38S	0.2
SARC	chr7	76328932	3'UTR	novel		0.12
SARC	chr7	76329613	Silent	novel	D236D	0.52
SARC	chr7	76330030	Nonsense_Mutation	novel	C97*	0.08
SARC	chr7	76327337	3'UTR	novel		0.48
SKCM	chr7	76330091	Missense_Mutation	NA	K77R	0.03
SKCM	chr7	76329973	Silent	NA	Q116Q	0.4
SKCM	chr7	76329706	Silent	NA	I205I	0.34
SKCM	chr7	76329889	Silent	NA	A144A	0.36
SKCM	chr7	76329572	3'UTR	novel		0.15
STAD	chr7	76330167	Missense_Mutation	rs780366000	V52I	0.1
STAD	chr7	76329819	Missense_Mutation	novel	T168A	0.39
STAD	chr7	76358846	5'UTR	novel		0.09
STAD	chr7	76330120	Silent	NA	E67E	0.1
UCEC	chr7	76329578	Silent	novel	*248*	0.34
UCEC	chr7	76329118	3'UTR	novel		0.29
UCEC	chr7	76329702	Missense_Mutation	NA	E207K	0.3
UCEC	chr7	76329621	Missense_Mutation	novel	T234A	0.44
UCEC	chr7	76328906	3'UTR	novel		0.33
UCEC	chr7	76330114	Missense_Mutation	novel	K69N	0.04
UCEC	chr7	76330101	Missense_Mutation	novel	G74S	0.37
UCEC	chr7	76329362	3'UTR	novel		0.36
UCEC	chr7	76329840	Missense_Mutation	novel	S161G	0.19
UCEC	chr7	76326834	3'UTR	novel		0.35
UCEC	chr7	76329661	Silent	rs563125209	T220T	0.31
UCEC	chr7	76329832	Missense_Mutation	novel	E163D	0.54
UCEC	chr7	76329981	Missense_Mutation	NA	E114K	0.34
UCEC	chr7	76329714	Missense_Mutation	NA	D203N	0.42
UCEC	chr7	76329444	3'UTR	novel		0.44
UCEC	chr7	76358921	5'UTR	novel		0.41
UCEC	chr7	76329525	3'UTR	NA		0.32
UCEC	chr7	76329724	Silent	NA	T199T	0.35
UCEC	chr7	76329628	Silent	rs150625762	T231T	0.46
UCEC	chr7	76327673	3'UTR	novel		0.37
UCEC	chr7	76330151	Missense_Mutation	NA	R57H	0.48
UCEC	chr7	76326966	3'UTR	novel		0.23
UCEC	chr7	76329856	Silent	rs111385409	S155S	0.24
UCEC	chr7	76329520	3'UTR	novel		0.36
UCEC	chr7	76329570	3'UTR	rs745551920		0.35
UCEC	chr7	76330101	Missense_Mutation	novel	G74S	0.37
UCEC	chr7	76328994	3'UTR	novel		0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.2708	0.13215
TGCT	AMP	0.6933	0.035574
THCA	DEL	0.002	0.27619

Survival Analysis

Cancer	P-value	Q-value
MESO	0.0014	Kaplan-Meier Survival Analysis
HNSC	0.0014	Kaplan-Meier Survival Analysis
PRAD	0.05	Kaplan-Meier Survival Analysis
BRCA	0.021	Kaplan-Meier Survival Analysis
KIRP	0.0033	Kaplan-Meier Survival Analysis
COAD	0.016	Kaplan-Meier Survival Analysis
PAAD	0.0028	Kaplan-Meier Survival Analysis
CESC	0.0029	Kaplan-Meier Survival Analysis
LAML	0.04	Kaplan-Meier Survival Analysis
KICH	0.00019	Kaplan-Meier Survival Analysis
UCEC	0.019	Kaplan-Meier Survival Analysis
GBM	0.0073	Kaplan-Meier Survival Analysis
LIHC	0.0016	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.0039	Kaplan-Meier Survival Analysis