EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000170248 (Gene tree)
Gene ID: 10015
Gene Symbol: PDCD6IP
Alias: Alix|AIP1|Hp95
Full Name: programmed cell death 6 interacting protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 71,356 bases
Position: chr3:33,798,352-33,869,707
Accession: 8766
RBP type: non-canonical RBP
Summary: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26935291	Role of Alix in miRNA packaging during extracellular vesicle biogenesis.	Int J Mol Med	2016 Apr	Iavello A	doi: 10.3892/ijmm.2016.2488
22896625	Identification of the HIV-1 NC binding interface in Alix Bro1 reveals a role for RNA.	J Virol	2012 Nov	Sette P	doi: 10.1128/JVI.01260-12

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000430877	PDCD6IP-204	582	-	ENSP00000398895	78 (aa)	-	F8WBR8
ENST00000435909	PDCD6IP-205	587	-	ENSP00000393777	72 (aa)	-	F8WEQ7
ENST00000498147	PDCD6IP-217	802	-	-	- (aa)	-	-
ENST00000489869	PDCD6IP-214	842	-	-	- (aa)	-	-
ENST00000473593	PDCD6IP-209	540	-	-	- (aa)	-	-
ENST00000307296	PDCD6IP-201	6161	XM_017005488	ENSP00000307387	868 (aa)	XP_016860977	Q8WUM4
ENST00000482561	PDCD6IP-211	626	-	-	- (aa)	-	-
ENST00000648706	PDCD6IP-218	6049	-	ENSP00000497537	300 (aa)	-	-
ENST00000484478	PDCD6IP-212	596	-	-	- (aa)	-	-
ENST00000412887	PDCD6IP-202	842	-	ENSP00000415150	95 (aa)	-	F8WDK9
ENST00000413073	PDCD6IP-203	566	-	ENSP00000406693	153 (aa)	-	C9IZF9
ENST00000487821	PDCD6IP-213	750	-	-	- (aa)	-	-
ENST00000477798	PDCD6IP-210	587	-	-	- (aa)	-	-
ENST00000495235	PDCD6IP-216	428	-	-	- (aa)	-	-
ENST00000457054	PDCD6IP-206	5962	XM_011533252	ENSP00000411825	873 (aa)	XP_011531554	Q8WUM4
ENST00000459659	PDCD6IP-207	662	-	-	- (aa)	-	-
ENST00000465122	PDCD6IP-208	894	-	-	- (aa)	-	-
ENST00000494810	PDCD6IP-215	619	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000170248's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04144	Endocytosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000170248	Hemoglobin A, Glycosylated	4.008E-05	19875614
ENSG00000170248	Stroke	5.7034959E-004	19369658
ENSG00000170248	Stroke	5.4640000E-004	19369658
ENSG00000170248	Stroke	4.4964743E-005	19369658
ENSG00000170248	Body Fat Distribution	8.9840000E-005	-
ENSG00000170248	Body Fat Distribution	4.9970000E-005	-
ENSG00000170248	Body Fat Distribution	9.5100000E-005	-
ENSG00000170248	Blood Pressure	8.9510000E-005	-
ENSG00000170248	Cholesterol, LDL	2.5570000E-005	-
ENSG00000170248	Child Development Disorders, Pervasive	1.8592900E-005	-
ENSG00000170248	Lactate Dehydrogenases	5.0320000E-005	-
ENSG00000170248	Conduct Disorder	9E-6	23942779
ENSG00000170248	Neuroticism	2E-8	27089181
ENSG00000170248	Cognition	3E-6	24684796
ENSG00000170248	Influenza A Virus, H1N1 Subtype	2E-8	26379185

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000170248's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000281	mitotic cytokinesis	18641129.	IDA	Process
GO:0000915	actomyosin contractile ring assembly	-	ISS	Process
GO:0001772	immunological synapse	19706535.	IDA	Component
GO:0005515	protein binding	11883939.12860994.14505570.14519844.17196169.17350572.17853893.18256029.18434552.18511562.18641129.18940611.19706535.20176808.20670214.21889351.21911577.21988832.22484091.22641034.22660413.23088713.25118280.25416956.25667979.25686249.26496610.	IPI	Function
GO:0005815	microtubule organizing center	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005923	bicellular tight junction	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006915	apoptotic process	-	IEA	Process
GO:0006997	nucleus organization	20616062.	IMP	Process
GO:0007080	mitotic metaphase plate congression	20616062.	IMP	Process
GO:0010824	regulation of centrosome duplication	20616062.	IMP	Process
GO:0015031	protein transport	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0019058	viral life cycle	-	TAS	Process
GO:0031871	proteinase activated receptor binding	22547407.	IPI	Function
GO:0036258	multivesicular body assembly	20588296.	NAS	Process
GO:0039702	viral budding via host ESCRT complex	24107264.	IGI	Process
GO:0039702	viral budding via host ESCRT complex	20588296.	NAS	Process
GO:0042470	melanosome	-	IEA	Component
GO:0042641	actomyosin	-	ISS	Component
GO:0042803	protein homodimerization activity	14505570.14519844.	IPI	Function
GO:0045199	maintenance of epithelial cell apical/basal polarity	-	ISS	Process
GO:0046755	viral budding	18641129.	IDA	Process
GO:0048306	calcium-dependent protein binding	18256029.19520058.23924735.	IPI	Function
GO:0051260	protein homooligomerization	18641129.	IDA	Process
GO:0061952	midbody abscission	20616062.	IMP	Process
GO:0070062	extracellular exosome	19056867.19199708.23533145.	HDA	Component
GO:0070062	extracellular exosome	15326289.16501490.21276792.23092844.	IDA	Component
GO:0070830	bicellular tight junction assembly	-	ISS	Process
GO:0070971	endoplasmic reticulum exit site	16957052.	IMP	Component
GO:0090543	Flemming body	18641129.	IDA	Component
GO:0090559	regulation of membrane permeability	-	ISS	Process
GO:0090611	ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway	22547407.	IMP	Process
GO:1901673	regulation of mitotic spindle assembly	20616062.	IMP	Process
GO:1903543	positive regulation of exosomal secretion	22660413.	IMP	Process
GO:1903551	regulation of extracellular exosome assembly	24105262.	IMP	Process
GO:1903553	positive regulation of extracellular exosome assembly	22660413.	IMP	Process
GO:1903561	extracellular vesicle	24769233.	HDA	Component