EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000170325 (Gene tree)
Gene ID: 56980
Gene Symbol: PRDM10
Alias: KIAA1231|PFM7|MGC131802
Full Name: PR/SET domain 10
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 103,345 bases
Position: chr11:129,899,706-130,003,050
Accession: 13995
RBP type: canonical RBP
Summary: The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000435940	zf-C2H2	PF00096.26	1.2e-33	1	5
ENSP00000435940	zf-C2H2	PF00096.26	1.2e-33	2	5
ENSP00000435940	zf-C2H2	PF00096.26	1.2e-33	3	5
ENSP00000435940	zf-C2H2	PF00096.26	1.2e-33	4	5
ENSP00000435940	zf-C2H2	PF00096.26	1.2e-33	5	5
ENSP00000302669	zf-C2H2	PF00096.26	6.6e-33	1	5
ENSP00000302669	zf-C2H2	PF00096.26	6.6e-33	2	5
ENSP00000302669	zf-C2H2	PF00096.26	6.6e-33	3	5
ENSP00000302669	zf-C2H2	PF00096.26	6.6e-33	4	5
ENSP00000302669	zf-C2H2	PF00096.26	6.6e-33	5	5
ENSP00000398431	zf-C2H2	PF00096.26	9.9e-33	1	5
ENSP00000398431	zf-C2H2	PF00096.26	9.9e-33	2	5
ENSP00000398431	zf-C2H2	PF00096.26	9.9e-33	3	5
ENSP00000398431	zf-C2H2	PF00096.26	9.9e-33	4	5
ENSP00000398431	zf-C2H2	PF00096.26	9.9e-33	5	5
ENSP00000432237	zf-C2H2	PF00096.26	1.1e-32	1	5
ENSP00000432237	zf-C2H2	PF00096.26	1.1e-32	2	5
ENSP00000432237	zf-C2H2	PF00096.26	1.1e-32	3	5
ENSP00000432237	zf-C2H2	PF00096.26	1.1e-32	4	5
ENSP00000432237	zf-C2H2	PF00096.26	1.1e-32	5	5
ENSP00000431262	zf-C2H2	PF00096.26	1.8e-32	1	5
ENSP00000431262	zf-C2H2	PF00096.26	1.8e-32	2	5
ENSP00000431262	zf-C2H2	PF00096.26	1.8e-32	3	5
ENSP00000431262	zf-C2H2	PF00096.26	1.8e-32	4	5
ENSP00000431262	zf-C2H2	PF00096.26	1.8e-32	5	5
ENSP00000354118	zf-C2H2	PF00096.26	2.6e-32	1	5
ENSP00000354118	zf-C2H2	PF00096.26	2.6e-32	2	5
ENSP00000354118	zf-C2H2	PF00096.26	2.6e-32	3	5
ENSP00000354118	zf-C2H2	PF00096.26	2.6e-32	4	5
ENSP00000354118	zf-C2H2	PF00096.26	2.6e-32	5	5
ENSP00000351686	zf-C2H2	PF00096.26	2.8e-32	1	5
ENSP00000351686	zf-C2H2	PF00096.26	2.8e-32	2	5
ENSP00000351686	zf-C2H2	PF00096.26	2.8e-32	3	5
ENSP00000351686	zf-C2H2	PF00096.26	2.8e-32	4	5
ENSP00000351686	zf-C2H2	PF00096.26	2.8e-32	5	5
ENSP00000435940	zf-met	PF12874.7	2.1e-08	1	2
ENSP00000435940	zf-met	PF12874.7	2.1e-08	2	2
ENSP00000302669	zf-met	PF12874.7	2.3e-05	1	2
ENSP00000302669	zf-met	PF12874.7	2.3e-05	2	2
ENSP00000398431	zf-met	PF12874.7	2.6e-05	1	2
ENSP00000398431	zf-met	PF12874.7	2.6e-05	2	2
ENSP00000432237	zf-met	PF12874.7	2.7e-05	1	2
ENSP00000432237	zf-met	PF12874.7	2.7e-05	2	2
ENSP00000431262	zf-met	PF12874.7	3.1e-05	1	2
ENSP00000431262	zf-met	PF12874.7	3.1e-05	2	2
ENSP00000354118	zf-met	PF12874.7	3.5e-05	1	2
ENSP00000354118	zf-met	PF12874.7	3.5e-05	2	2
ENSP00000351686	zf-met	PF12874.7	3.5e-05	1	2
ENSP00000351686	zf-met	PF12874.7	3.5e-05	2	2
ENSP00000435940	zf-C2H2_jaz	PF12171.8	3.7e-19	1	1
ENSP00000302669	zf-C2H2_jaz	PF12171.8	7.3e-17	1	1
ENSP00000398431	zf-C2H2_jaz	PF12171.8	1.1e-16	1	1
ENSP00000432237	zf-C2H2_jaz	PF12171.8	1.2e-16	1	1
ENSP00000431262	zf-C2H2_jaz	PF12171.8	1.8e-16	1	1
ENSP00000354118	zf-C2H2_jaz	PF12171.8	2.7e-16	1	1
ENSP00000351686	zf-C2H2_jaz	PF12171.8	2.8e-16	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000527581	PRDM10-206	620	-	ENSP00000432093	139 (aa)	-	E9PS52
ENST00000531431	PRDM10-208	528	-	ENSP00000436681	115 (aa)	-	E9PIB4
ENST00000304538	PRDM10-201	5817	-	ENSP00000302669	1023 (aa)	-	Q9NQV6
ENST00000533431	PRDM10-209	2643	-	ENSP00000435940	865 (aa)	-	E9PRS0
ENST00000526082	PRDM10-205	3308	-	ENSP00000432237	1074 (aa)	-	Q9NQV6
ENST00000360871	PRDM10-203	6301	XM_011542912	ENSP00000354118	1156 (aa)	XP_011541214	Q9NQV6
ENST00000528746	PRDM10-207	6182	-	ENSP00000431262	1117 (aa)	-	E9PLV1
ENST00000358825	PRDM10-202	6322	-	ENSP00000351686	1160 (aa)	-	Q9NQV6
ENST00000423662	PRDM10-204	5998	XM_017018023	ENSP00000398431	1061 (aa)	XP_016873512	Q9NQV6

Gene Model

Click here to download ENSG00000170325's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000170325	C-Reactive Protein	9.42253851003642E-5	17903293
ENSG00000170325	Platelet Function Tests	1.3302200E-005	-
ENSG00000170325	Ferritins	7.9500000E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000170325	rs145658364	11	129988672	?	DNA methylation variation (age effect)	30348214			GO_0006306
ENSG00000170325	rs111703287	11	129982285	T	Carotid intima media thickness in rheumatoid arthritis	30251476	[0.074-0.164] unit increase	0.119	EFO_0000685\|EFO_0007117

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000170325's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000170325	PRDM10	100	94.104	ENSAMEG00000002425	PRDM10	100	91.402	Ailuropoda_melanoleuca
ENSG00000170325	PRDM10	99	86.207	ENSAPLG00000004858	PRDM10	100	85.026	Anas_platyrhynchos
ENSG00000170325	PRDM10	100	89.515	ENSANAG00000022064	PRDM10	100	83.491	Aotus_nancymaae
ENSG00000170325	PRDM10	100	93.534	ENSBTAG00000019001	PRDM10	100	94.118	Bos_taurus
ENSG00000170325	PRDM10	100	98.497	ENSCJAG00000009235	PRDM10	100	98.190	Callithrix_jacchus
ENSG00000170325	PRDM10	100	93.873	ENSCAFG00000010164	PRDM10	100	93.253	Canis_familiaris
ENSG00000170325	PRDM10	100	94.718	ENSCAFG00020010152	PRDM10	100	94.718	Canis_lupus_dingo
ENSG00000170325	PRDM10	100	93.858	ENSCHIG00000026530	PRDM10	100	93.253	Capra_hircus
ENSG00000170325	PRDM10	100	98.103	ENSTSYG00000000544	PRDM10	100	98.139	Carlito_syrichta
ENSG00000170325	PRDM10	100	85.458	ENSCAPG00000017296	PRDM10	98	87.638	Cavia_aperea
ENSG00000170325	PRDM10	99	81.504	ENSCPOG00000000389	PRDM10	98	86.040	Cavia_porcellus
ENSG00000170325	PRDM10	100	98.382	ENSCCAG00000024567	PRDM10	100	98.190	Cebus_capucinus
ENSG00000170325	PRDM10	100	98.844	ENSCATG00000040031	PRDM10	100	98.789	Cercocebus_atys
ENSG00000170325	PRDM10	100	93.037	ENSCLAG00000014605	PRDM10	99	97.403	Chinchilla_lanigera
ENSG00000170325	PRDM10	100	98.875	ENSCSAG00000002202	PRDM10	100	98.875	Chlorocebus_sabaeus
ENSG00000170325	PRDM10	99	85.977	ENSCPBG00000026880	PRDM10	99	82.255	Chrysemys_picta_bellii
ENSG00000170325	PRDM10	100	99.075	ENSCANG00000032669	PRDM10	100	98.879	Colobus_angolensis_palliatus
ENSG00000170325	PRDM10	100	94.335	ENSCGRG00001021647	Prdm10	98	92.494	Cricetulus_griseus_chok1gshd
ENSG00000170325	PRDM10	100	94.335	ENSCGRG00000006562	Prdm10	98	92.494	Cricetulus_griseus_crigri
ENSG00000170325	PRDM10	86	91.348	ENSDNOG00000001366	PRDM10	95	94.292	Dasypus_novemcinctus
ENSG00000170325	PRDM10	100	94.798	ENSDORG00000014292	Prdm10	100	93.945	Dipodomys_ordii
ENSG00000170325	PRDM10	100	95.242	ENSEASG00005022914	PRDM10	100	95.242	Equus_asinus_asinus
ENSG00000170325	PRDM10	100	95.329	ENSECAG00000011499	PRDM10	100	95.156	Equus_caballus
ENSG00000170325	PRDM10	100	94.220	ENSFCAG00000004111	PRDM10	96	94.709	Felis_catus
ENSG00000170325	PRDM10	99	85.813	ENSFALG00000004873	PRDM10	100	80.667	Ficedula_albicollis
ENSG00000170325	PRDM10	100	93.799	ENSFDAG00000017311	PRDM10	100	91.794	Fukomys_damarensis
ENSG00000170325	PRDM10	99	86.552	ENSGALG00000033660	PRDM10	99	85.586	Gallus_gallus
ENSG00000170325	PRDM10	98	63.877	ENSGACG00000012293	prdm10	99	67.901	Gasterosteus_aculeatus
ENSG00000170325	PRDM10	100	83.805	ENSGAGG00000012523	PRDM10	99	83.719	Gopherus_agassizii
ENSG00000170325	PRDM10	100	100.000	ENSGGOG00000015359	PRDM10	100	99.397	Gorilla_gorilla
ENSG00000170325	PRDM10	100	93.658	ENSHGLG00000001106	PRDM10	100	92.249	Heterocephalus_glaber_female
ENSG00000170325	PRDM10	100	94.211	ENSHGLG00100002350	PRDM10	100	92.577	Heterocephalus_glaber_male
ENSG00000170325	PRDM10	100	96.416	ENSSTOG00000002015	PRDM10	100	96.021	Ictidomys_tridecemlineatus
ENSG00000170325	PRDM10	93	93.433	ENSJJAG00000021493	Prdm10	100	83.275	Jaculus_jaculus
ENSG00000170325	PRDM10	100	92.775	ENSLAFG00000031867	PRDM10	100	91.402	Loxodonta_africana
ENSG00000170325	PRDM10	100	99.281	ENSMFAG00000031008	PRDM10	100	98.966	Macaca_fascicularis
ENSG00000170325	PRDM10	100	99.281	ENSMMUG00000017555	PRDM10	100	98.966	Macaca_mulatta
ENSG00000170325	PRDM10	100	99.281	ENSMNEG00000036493	PRDM10	100	98.879	Macaca_nemestrina
ENSG00000170325	PRDM10	94	98.824	ENSMLEG00000042028	PRDM10	100	98.824	Mandrillus_leucophaeus
ENSG00000170325	PRDM10	99	86.851	ENSMGAG00000001112	PRDM10	100	82.235	Meleagris_gallopavo
ENSG00000170325	PRDM10	100	96.810	ENSMICG00000013888	PRDM10	100	96.810	Microcebus_murinus
ENSG00000170325	PRDM10	100	92.971	ENSMOCG00000021853	Prdm10	100	90.878	Microtus_ochrogaster
ENSG00000170325	PRDM10	100	87.115	ENSMODG00000004979	PRDM10	99	87.443	Monodelphis_domestica
ENSG00000170325	PRDM10	100	94.335	ENSMUSG00000042496	Prdm10	100	93.834	Mus_musculus
ENSG00000170325	PRDM10	99	94.240	MGP_SPRETEiJ_G0033061	-	100	92.599	Mus_spretus
ENSG00000170325	PRDM10	100	94.896	ENSMPUG00000008711	PRDM10	99	94.896	Mustela_putorius_furo
ENSG00000170325	PRDM10	100	93.362	ENSMLUG00000013051	PRDM10	100	93.362	Myotis_lucifugus
ENSG00000170325	PRDM10	99	96.647	ENSNGAG00000000580	Prdm10	100	95.156	Nannospalax_galili
ENSG00000170325	PRDM10	100	99.281	ENSNLEG00000007488	PRDM10	100	98.707	Nomascus_leucogenys
ENSG00000170325	PRDM10	100	90.508	ENSODEG00000005309	PRDM10	99	94.805	Octodon_degus
ENSG00000170325	PRDM10	100	82.200	ENSOANG00000000577	-	100	79.745	Ornithorhynchus_anatinus
ENSG00000170325	PRDM10	100	93.772	ENSOCUG00000003736	PRDM10	100	93.685	Oryctolagus_cuniculus
ENSG00000170325	PRDM10	100	95.000	ENSOGAG00000010723	PRDM10	100	94.655	Otolemur_garnettii
ENSG00000170325	PRDM10	100	93.772	ENSOARG00000014507	PRDM10	100	93.166	Ovis_aries
ENSG00000170325	PRDM10	100	99.307	ENSPPAG00000042881	PRDM10	100	99.225	Pan_paniscus
ENSG00000170325	PRDM10	100	94.569	ENSPPRG00000007002	PRDM10	100	94.569	Panthera_pardus
ENSG00000170325	PRDM10	100	94.655	ENSPTIG00000013331	PRDM10	100	94.655	Panthera_tigris_altaica
ENSG00000170325	PRDM10	100	100.000	ENSPTRG00000004477	PRDM10	100	99.225	Pan_troglodytes
ENSG00000170325	PRDM10	100	99.281	ENSPANG00000017470	PRDM10	100	98.793	Papio_anubis
ENSG00000170325	PRDM10	100	92.873	ENSPEMG00000014985	Prdm10	100	91.249	Peromyscus_maniculatus_bairdii
ENSG00000170325	PRDM10	100	99.422	ENSPPYG00000004061	PRDM10	100	99.394	Pongo_abelii
ENSG00000170325	PRDM10	93	87.035	ENSPCAG00000014514	PRDM10	99	85.888	Procavia_capensis
ENSG00000170325	PRDM10	100	82.631	ENSPCOG00000023406	PRDM10	100	82.631	Propithecus_coquereli
ENSG00000170325	PRDM10	100	94.914	ENSPVAG00000012764	PRDM10	100	95.000	Pteropus_vampyrus
ENSG00000170325	PRDM10	99	94.792	ENSRNOG00000007853	Prdm10	100	92.919	Rattus_norvegicus
ENSG00000170325	PRDM10	100	99.281	ENSRBIG00000030924	PRDM10	100	99.052	Rhinopithecus_bieti
ENSG00000170325	PRDM10	100	99.075	ENSRROG00000034334	PRDM10	100	99.052	Rhinopithecus_roxellana
ENSG00000170325	PRDM10	100	98.497	ENSSBOG00000008773	PRDM10	100	98.190	Saimiri_boliviensis_boliviensis
ENSG00000170325	PRDM10	100	87.743	ENSSHAG00000004503	PRDM10	99	87.360	Sarcophilus_harrisii
ENSG00000170325	PRDM10	74	100.000	ENSSARG00000013953	-	68	100.000	Sorex_araneus
ENSG00000170325	PRDM10	100	85.763	ENSSPUG00000001178	PRDM10	99	83.673	Sphenodon_punctatus
ENSG00000170325	PRDM10	100	93.064	ENSSSCG00000015243	PRDM10	100	93.287	Sus_scrofa
ENSG00000170325	PRDM10	99	85.747	ENSTGUG00000000530	PRDM10	100	83.691	Taeniopygia_guttata
ENSG00000170325	PRDM10	93	98.204	ENSTBEG00000007221	PRDM10	94	95.133	Tupaia_belangeri
ENSG00000170325	PRDM10	100	92.175	ENSTTRG00000009189	PRDM10	100	90.690	Tursiops_truncatus
ENSG00000170325	PRDM10	91	96.256	ENSUAMG00000018832	PRDM10	95	96.256	Ursus_americanus
ENSG00000170325	PRDM10	100	94.451	ENSUMAG00000003167	PRDM10	99	94.995	Ursus_maritimus
ENSG00000170325	PRDM10	100	94.291	ENSVVUG00000019878	PRDM10	100	94.291	Vulpes_vulpes
ENSG00000170325	PRDM10	99	72.269	ENSXETG00000032173	PRDM10	100	69.417	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	21873635.	IBA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0008168	methyltransferase activity	-	IEA	Function
GO:0010468	regulation of gene expression	21873635.	IBA	Process
GO:0032259	methylation	-	IEA	Process
GO:0035097	histone methyltransferase complex	21873635.	IBA	Component
GO:0046872	metal ion binding	-	IEA	Function