EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000170348 (Gene tree)
Gene ID: 10972
Gene Symbol: TMED10
Alias: TMP21|P24(DELTA)|p24d1|p24delta1|p23
Full Name: transmembrane p24 trafficking protein 10
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 45,179 bases
Position: chr14:75,131,468-75,176,646
Accession: 16998
RBP type: non-canonical RBP
Summary: This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000303575	TMED10-201	4127	-	ENSP00000303145	219 (aa)	-	P49755
ENST00000555036	TMED10-202	888	-	-	- (aa)	-	-
ENST00000555085	TMED10-203	553	-	-	- (aa)	-	-
ENST00000622441	TMED10-207	612	-	-	- (aa)	-	-
ENST00000557670	TMED10-206	917	-	-	- (aa)	-	-
ENST00000555873	TMED10-204	1161	-	ENSP00000450726	153 (aa)	-	G3V2K7
ENST00000556969	TMED10-205	1314	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000170348's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000170348	Body Mass Index	9.8840000E-005	-
ENSG00000170348	Inflammatory Bowel Diseases	3E-9	26192919
ENSG00000170348	Inflammatory Bowel Diseases	3E-8	23128233
ENSG00000170348	Body Height	1E-7	19343178
ENSG00000170348	Crohn Disease	1E-7	28067908
ENSG00000170348	Crohn Disease	6E-11	26192919

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000170348	rs910316	14	75159339	?	Height	19343178	[0.03-0.07] s.d. increase	0.05	EFO_0004339
ENSG00000170348	rs876403	14	75136131	?	Heel bone mineral density	30048462	[0.012-0.02] unit decrease	0.0158684	EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000170348's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000170348	TMED10	95	54.976	FBgn0045866	bai	91	58.639	Drosophila_melanogaster
ENSG00000170348	TMED10	100	92.694	ENSMUSG00000021248	Tmed10	100	100.000	Mus_musculus
ENSG00000170348	TMED10	93	38.571	YML012W		84	41.899	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	TAS	Component
GO:0001822	kidney development	-	IEA	Process
GO:0005515	protein binding	10359607.12237308.16595549.16641999.18287528.20427317.	IPI	Function
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005783	endoplasmic reticulum	12237308.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	21873635.	IBA	Component
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	12237308.	IDA	Component
GO:0005794	Golgi apparatus	21873635.	IBA	Component
GO:0005794	Golgi apparatus	12237308.	IDA	Component
GO:0005801	cis-Golgi network	-	ISS	Component
GO:0005886	plasma membrane	-	ISS	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0006886	intracellular protein transport	20427317.	IDA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	20427317.	TAS	Process
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	-	ISS	Process
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	-	TAS	Process
GO:0007030	Golgi organization	21873635.	IBA	Process
GO:0012507	ER to Golgi transport vesicle membrane	-	TAS	Component
GO:0016021	integral component of membrane	-	ISS	Component
GO:0019905	syntaxin binding	21545355.	IPI	Function
GO:0030133	transport vesicle	-	TAS	Component
GO:0030134	COPII-coated ER to Golgi transport vesicle	21873635.	IBA	Component
GO:0030137	COPI-coated vesicle	21873635.	IBA	Component
GO:0030137	COPI-coated vesicle	-	ISS	Component
GO:0030140	trans-Golgi network transport vesicle	-	ISS	Component
GO:0030667	secretory granule membrane	-	ISS	Component
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	-	TAS	Component
GO:0035459	cargo loading into vesicle	20427317.	TAS	Process
GO:0035964	COPI-coated vesicle budding	10052452.	IDA	Process
GO:0042470	melanosome	-	IEA	Component
GO:0042589	zymogen granule membrane	-	ISS	Component
GO:0043279	response to alkaloid	-	IEA	Process
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0045055	regulated exocytosis	-	ISS	Process
GO:0048199	vesicle targeting, to, from or within Golgi	-	ISS	Process
GO:0048205	COPI coating of Golgi vesicle	10761932.	TAS	Process
GO:0048208	COPII vesicle coating	20427317.	TAS	Process
GO:0051259	protein complex oligomerization	-	IEA	Process
GO:0070765	gamma-secretase complex	16641999.	IDA	Component
GO:1902003	regulation of amyloid-beta formation	16641999.	IMP	Process