EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000170439 (Gene tree)
Gene ID: 196410
Gene Symbol: METTL7B
Alias: MGC17301|ALDI
Full Name: methyltransferase like 7B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 3,066 bases
Position: chr12:55,681,546-55,684,611
Accession: 28276
RBP type: canonical RBP
Summary: METTL7B (Methyltransferase Like 7B) is a Protein Coding gene. Diseases associated with METTL7B include Muscular Dystrophy, Congenital, Due To Integrin Alpha-7 Deficiency. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and S-adenosylmethionine-dependent methyltransferase activity. An important paralog of this gene is METTL7A.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000377796	Methyltransf_31	PF13847.6	4.4e-11	1	1
ENSP00000482867	Methyltransf_31	PF13847.6	5.9e-11	1	1
ENSP00000377796	Methyltransf_8	PF05148.15	0.00023	1	1
ENSP00000482867	Methyltransf_8	PF05148.15	0.00028	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000614691	METTL7B-202	1368	-	ENSP00000482867	276 (aa)	-	A0A087WZT2
ENST00000394252	METTL7B-201	1506	-	ENSP00000377796	244 (aa)	-	Q6UX53

Gene Model

Click here to download ENSG00000170439's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000170439's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000170439	METTL7B	91	84.753	ENSAMEG00000011933	METTL7B	91	84.753	Ailuropoda_melanoleuca
ENSG00000170439	METTL7B	91	91.480	ENSANAG00000036477	METTL7B	91	91.480	Aotus_nancymaae
ENSG00000170439	METTL7B	92	85.778	ENSBTAG00000012896	METTL7B	91	85.650	Bos_taurus
ENSG00000170439	METTL7B	91	89.641	ENSCJAG00000008201	METTL7B	92	89.412	Callithrix_jacchus
ENSG00000170439	METTL7B	91	87.444	ENSCAFG00000031038	METTL7B	91	87.444	Canis_familiaris
ENSG00000170439	METTL7B	91	86.937	ENSCAFG00020026120	METTL7B	91	82.917	Canis_lupus_dingo
ENSG00000170439	METTL7B	92	87.556	ENSCHIG00000027137	METTL7B	91	87.444	Capra_hircus
ENSG00000170439	METTL7B	91	91.071	ENSTSYG00000007994	METTL7B	91	91.071	Carlito_syrichta
ENSG00000170439	METTL7B	89	82.488	ENSCPOG00000014972	METTL7B	91	82.063	Cavia_porcellus
ENSG00000170439	METTL7B	91	94.170	ENSCCAG00000028514	METTL7B	91	94.170	Cebus_capucinus
ENSG00000170439	METTL7B	91	95.516	ENSCATG00000041077	METTL7B	91	95.516	Cercocebus_atys
ENSG00000170439	METTL7B	89	87.558	ENSCLAG00000016551	METTL7B	91	86.996	Chinchilla_lanigera
ENSG00000170439	METTL7B	91	95.964	ENSCSAG00000005338	METTL7B	91	95.964	Chlorocebus_sabaeus
ENSG00000170439	METTL7B	91	95.067	ENSCANG00000039775	METTL7B	91	95.067	Colobus_angolensis_palliatus
ENSG00000170439	METTL7B	90	84.091	ENSCGRG00001020267	Mettl7b	91	83.857	Cricetulus_griseus_chok1gshd
ENSG00000170439	METTL7B	90	84.091	ENSCGRG00000015365	Mettl7b	91	83.857	Cricetulus_griseus_crigri
ENSG00000170439	METTL7B	99	50.617	ENSCSEG00000003205	-	87	52.113	Cynoglossus_semilaevis
ENSG00000170439	METTL7B	91	89.686	ENSDNOG00000046100	METTL7B	100	89.344	Dasypus_novemcinctus
ENSG00000170439	METTL7B	100	81.148	ENSDORG00000014149	Mettl7b	100	81.148	Dipodomys_ordii
ENSG00000170439	METTL7B	80	81.959	ENSETEG00000009099	METTL7B	100	81.959	Echinops_telfairi
ENSG00000170439	METTL7B	91	85.973	ENSEASG00005001861	METTL7B	90	83.475	Equus_asinus_asinus
ENSG00000170439	METTL7B	91	86.099	ENSECAG00000011720	METTL7B	91	86.099	Equus_caballus
ENSG00000170439	METTL7B	91	88.341	ENSFCAG00000039385	METTL7B	91	88.341	Felis_catus
ENSG00000170439	METTL7B	89	84.332	ENSFDAG00000014366	METTL7B	91	83.857	Fukomys_damarensis
ENSG00000170439	METTL7B	100	51.639	ENSGMOG00000002697	-	88	53.738	Gadus_morhua
ENSG00000170439	METTL7B	100	100.000	ENSGGOG00000008581	METTL7B	100	100.000	Gorilla_gorilla
ENSG00000170439	METTL7B	89	81.567	ENSHGLG00000006754	METTL7B	91	81.166	Heterocephalus_glaber_female
ENSG00000170439	METTL7B	89	81.567	ENSHGLG00100016921	METTL7B	91	81.166	Heterocephalus_glaber_male
ENSG00000170439	METTL7B	90	87.215	ENSJJAG00000015629	Mettl7b	100	86.885	Jaculus_jaculus
ENSG00000170439	METTL7B	91	86.937	ENSLAFG00000032588	METTL7B	91	86.547	Loxodonta_africana
ENSG00000170439	METTL7B	91	95.516	ENSMFAG00000041138	METTL7B	91	95.516	Macaca_fascicularis
ENSG00000170439	METTL7B	91	95.516	ENSMMUG00000013225	METTL7B	91	95.516	Macaca_mulatta
ENSG00000170439	METTL7B	91	95.516	ENSMNEG00000030037	METTL7B	91	95.516	Macaca_nemestrina
ENSG00000170439	METTL7B	91	94.619	ENSMLEG00000033453	METTL7B	91	94.619	Mandrillus_leucophaeus
ENSG00000170439	METTL7B	100	84.426	ENSMAUG00000015292	Mettl7b	91	84.753	Mesocricetus_auratus
ENSG00000170439	METTL7B	100	80.738	ENSMOCG00000008376	Mettl7b	91	80.269	Microtus_ochrogaster
ENSG00000170439	METTL7B	100	77.459	ENSMODG00000001722	METTL7B	91	78.475	Monodelphis_domestica
ENSG00000170439	METTL7B	90	83.562	MGP_CAROLIEiJ_G0015964	Mettl7b	91	83.408	Mus_caroli
ENSG00000170439	METTL7B	90	83.562	ENSMUSG00000025347	Mettl7b	91	83.408	Mus_musculus
ENSG00000170439	METTL7B	90	82.648	MGP_PahariEiJ_G0031120	Mettl7b	91	82.511	Mus_pahari
ENSG00000170439	METTL7B	90	84.018	MGP_SPRETEiJ_G0016789	Mettl7b	91	83.857	Mus_spretus
ENSG00000170439	METTL7B	90	85.845	ENSMPUG00000000852	METTL7B	91	85.650	Mustela_putorius_furo
ENSG00000170439	METTL7B	90	87.671	ENSNGAG00000018609	Mettl7b	91	87.444	Nannospalax_galili
ENSG00000170439	METTL7B	100	98.770	ENSNLEG00000017612	METTL7B	100	98.770	Nomascus_leucogenys
ENSG00000170439	METTL7B	100	79.098	ENSMEUG00000000400	METTL7B	91	80.717	Notamacropus_eugenii
ENSG00000170439	METTL7B	89	87.097	ENSODEG00000004695	METTL7B	91	86.547	Octodon_degus
ENSG00000170439	METTL7B	91	86.996	ENSOCUG00000023347	METTL7B	91	86.996	Oryctolagus_cuniculus
ENSG00000170439	METTL7B	92	92.444	ENSOGAG00000010513	METTL7B	91	92.377	Otolemur_garnettii
ENSG00000170439	METTL7B	90	88.128	ENSOARG00000011505	METTL7B	93	87.892	Ovis_aries
ENSG00000170439	METTL7B	100	100.000	ENSPPAG00000029723	METTL7B	100	100.000	Pan_paniscus
ENSG00000170439	METTL7B	91	88.789	ENSPPRG00000023193	METTL7B	91	88.789	Panthera_pardus
ENSG00000170439	METTL7B	91	88.341	ENSPTIG00000012796	METTL7B	91	88.341	Panthera_tigris_altaica
ENSG00000170439	METTL7B	100	100.000	ENSPTRG00000005058	METTL7B	100	100.000	Pan_troglodytes
ENSG00000170439	METTL7B	91	95.516	ENSPANG00000015541	METTL7B	91	95.516	Papio_anubis
ENSG00000170439	METTL7B	90	83.562	ENSPEMG00000001761	Mettl7b	91	83.408	Peromyscus_maniculatus_bairdii
ENSG00000170439	METTL7B	100	79.098	ENSPCIG00000024669	METTL7B	91	80.717	Phascolarctos_cinereus
ENSG00000170439	METTL7B	100	97.131	ENSPPYG00000004625	METTL7B	100	97.131	Pongo_abelii
ENSG00000170439	METTL7B	91	84.234	ENSPCAG00000008996	METTL7B	91	83.857	Procavia_capensis
ENSG00000170439	METTL7B	84	76.699	ENSPCOG00000021279	METTL7B	91	76.699	Propithecus_coquereli
ENSG00000170439	METTL7B	90	80.543	ENSPVAG00000017745	METTL7B	91	80.889	Pteropus_vampyrus
ENSG00000170439	METTL7B	90	82.648	ENSRNOG00000007927	Mettl7b	91	82.511	Rattus_norvegicus
ENSG00000170439	METTL7B	91	94.170	ENSRBIG00000028549	METTL7B	91	94.170	Rhinopithecus_bieti
ENSG00000170439	METTL7B	91	94.170	ENSRROG00000043640	METTL7B	91	94.170	Rhinopithecus_roxellana
ENSG00000170439	METTL7B	91	93.722	ENSSBOG00000013267	METTL7B	91	93.722	Saimiri_boliviensis_boliviensis
ENSG00000170439	METTL7B	91	83.857	ENSSSCG00000036547	METTL7B	91	83.857	Sus_scrofa
ENSG00000170439	METTL7B	80	92.268	ENSTBEG00000015579	METTL7B	100	92.268	Tupaia_belangeri
ENSG00000170439	METTL7B	92	88.444	ENSTTRG00000009630	METTL7B	91	88.341	Tursiops_truncatus
ENSG00000170439	METTL7B	91	84.753	ENSUAMG00000015092	METTL7B	91	84.753	Ursus_americanus
ENSG00000170439	METTL7B	91	84.753	ENSUMAG00000015411	METTL7B	91	84.753	Ursus_maritimus
ENSG00000170439	METTL7B	92	89.778	ENSVPAG00000009509	METTL7B	91	90.135	Vicugna_pacos
ENSG00000170439	METTL7B	91	86.996	ENSVVUG00000023831	METTL7B	91	86.996	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0008168	methyltransferase activity	-	IEA	Function
GO:0032259	methylation	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr12	55681802	Silent	novel	T16T	0.08
ACC	chr12	55682119	Missense_Mutation	novel	F122Y	0.12
BLCA	chr12	55683824	Silent	novel	L170L	0.62
BLCA	chr12	55683968	Silent	NA	S218S	0.28
BRCA	chr12	55682251	Missense_Mutation	NA	P166Q	0.41	Methyltransf_31
BRCA	chr12	55681999	Missense_Mutation	rs769045151	G82E	0.19
CESC	chr12	55684244	3'UTR	novel		0.45
CESC	chr12	55681714	5'UTR	novel		0.35
COAD	chr12	55683969	Missense_Mutation	rs776219569	E219K	0.09
COAD	chr12	55683990	Missense_Mutation	NA	P226T	0.4
COAD	chr12	55681962	Missense_Mutation	NA	G70R	0.39
COAD	chr12	55683969	Missense_Mutation	rs776219569	E219K	0.18
COAD	chr12	55681875	Missense_Mutation	novel	A41T	0.11
HNSC	chr12	55681991	Silent	rs751128037	C79C	0.2
HNSC	chr12	55683813	Missense_Mutation	novel	G167R	0.12	Methyltransf_31
HNSC	chr12	55683814	Missense_Mutation	NA	G167E	0.11	Methyltransf_31
KIRC	chr12	55682252	Splice_Region	rs144071589	P166P	0.38
LUAD	chr12	55682166	Missense_Mutation	novel	M138V	0.15	Methyltransf_31
LUAD	chr12	55683909	Missense_Mutation	novel	G199R	0.1
LUAD	chr12	55682064	Missense_Mutation	NA	E104Q	0.43
LUSC	chr12	55681851	Nonsense_Mutation	novel	K33*	0.2
LUSC	chr12	55682138	Silent	novel	E128E	0.21
LUSC	chr12	55684041	Missense_Mutation	NA	V243F	0.23
LUSC	chr12	55684124	3'UTR	novel		0.28
PAAD	chr12	55681983	Missense_Mutation	novel	L77M	0.2
READ	chr12	55682051	Silent	novel	P99P	0.18
READ	chr12	55684045	Missense_Mutation	NA	K244T	0.42
SKCM	chr12	55683969	Missense_Mutation	rs776219569	E219K	0.36
SKCM	chr12	55682231	Silent	novel	E159E	0.26
SKCM	chr12	55681944	Missense_Mutation	NA	G64R	0.24
SKCM	chr12	55683814	Missense_Mutation	NA	G167E	0.27	Methyltransf_31
SKCM	chr12	55683944	Silent	novel	K210K	0.21
SKCM	chr12	55681862	Silent	novel	F36F	0.3
SKCM	chr12	55682055	Missense_Mutation	NA	P101S	0.25
SKCM	chr12	55681971	Missense_Mutation	novel	A73T	0.24
SKCM	chr12	55681999	Missense_Mutation	rs769045151	G82E	0.55
SKCM	chr12	55683941	Nonsense_Mutation	NA	W209*	0.22
SKCM	chr12	55682169	Missense_Mutation	NA	D139N	0.22	Methyltransf_31
SKCM	chr12	55683945	Missense_Mutation	NA	D211N	0.07
SKCM	chr12	55681998	Missense_Mutation	rs749574114	G82R	0.39
SKCM	chr12	55683856	Missense_Mutation	NA	G181E	0.39
SKCM	chr12	55683849	Missense_Mutation	NA	P179S	0.38
SKCM	chr12	55681998	Missense_Mutation	rs749574114	G82R	0.29
SKCM	chr12	55683855	Missense_Mutation	NA	G181R	0.21
SKCM	chr12	55682072	Silent	novel	F106F	0.45
SKCM	chr12	55682055	Missense_Mutation	NA	P101S	0.22
STAD	chr12	55682102	Silent	NA	H116H	0.18
STAD	chr12	55682205	Nonsense_Mutation	NA	Q151*	0.39	Methyltransf_31
UCEC	chr12	55684333	3'UTR	rs191835929		0.25
UCEC	chr12	55682035	Missense_Mutation	novel	V94A	0.55
UCEC	chr12	55683888	Missense_Mutation	rs140429701	E192K	0.12
UCEC	chr12	55684012	Missense_Mutation	novel	P233L	0.18
UCEC	chr12	55684237	3'UTR	novel		0.33
UCEC	chr12	55684052	3'UTR	novel		0.31
UCEC	chr12	55684054	3'UTR	novel		0.8
UCEC	chr12	55682238	Missense_Mutation	novel	R162G	0.36	Methyltransf_31
UCEC	chr12	55681667	5'UTR	novel		0.27
UCEC	chr12	55683888	Missense_Mutation	rs140429701	E192K	0.41
UCEC	chr12	55681797	Missense_Mutation	novel	L15I	0.44
UCEC	chr12	55682235	Missense_Mutation	rs139209159	R161W	0.43	Methyltransf_31
UCEC	chr12	55682162	Silent	novel	G136G	0.1
UCEC	chr12	55681997	Silent	novel	T81T	0.27
UCEC	chr12	55684237	3'UTR	novel		0.34
UCEC	chr12	55683968	Silent	NA	S218S	0.33
UCEC	chr12	55682236	Missense_Mutation	novel	R161Q	0.35	Methyltransf_31
UCEC	chr12	55684097	3'UTR	novel		0.53
UCEC	chr12	55684382	3'UTR	novel		0.23

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.2083	0.085003
PCPG	AMP	0.0802	0.028953
READ	DEL	0.0727	0.064633

Survival Analysis

Cancer	P-value	Q-value
THYM	0.05	Kaplan-Meier Survival Analysis
STAD	0.019	Kaplan-Meier Survival Analysis
SARC	0.024	Kaplan-Meier Survival Analysis
HNSC	0.0015	Kaplan-Meier Survival Analysis
SKCM	0.00037	Kaplan-Meier Survival Analysis
LUSC	0.0095	Kaplan-Meier Survival Analysis
PAAD	0.034	Kaplan-Meier Survival Analysis
LAML	0.0001	Kaplan-Meier Survival Analysis
UCEC	0.0028	Kaplan-Meier Survival Analysis
GBM	0.02	Kaplan-Meier Survival Analysis
THCA	0.0018	Kaplan-Meier Survival Analysis
UVM	0.0055	Kaplan-Meier Survival Analysis