EuRBPDB

Ensembl ID

ENSG00000170445 (Gene tree)

Gene ID

3035

Gene Symbol

HARS

Alias

HisRS|USH3B

Full Name

histidyl-tRNA synthetase

Gene Type

protein_coding

Species

Homo_sapiens

Status

confidence

Strand

Minus strand

Length

17,959 bases

Position

chr5:140,673,904-140,691,862

Accession

4816

RBP type

canonical RBP

Summary

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]