EuRBPDB

Description

Ensembl ID: ENSG00000170448 (Gene tree)
Gene ID: 152518
Gene Symbol: NFXL1
Alias: HOZFP
Full Name: nuclear transcription factor, X-box binding like 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 67,435 bases
Position: chr4:47,847,233-47,914,667
Accession: 18726
RBP type: non-canonical RBP
Summary: (Nuclear Transcription Factor, X-Box Binding Like 1) is a Protein Coding gene. Diseases associated with NFXL1 include Specific Language Impairment and Speech And Communication Disorders. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific. An important paralog of this gene is NFX1.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000329043	NFXL1-201	3723	-	ENSP00000333113	911 (aa)	-	Q6ZNB6
ENST00000464756	NFXL1-203	3865	-	ENSP00000425812	733 (aa)	-	Q6ZNB6
ENST00000508115	NFXL1-207	654	-	-	- (aa)	-	-
ENST00000507489	NFXL1-206	3833	-	ENSP00000422037	911 (aa)	-	Q6ZNB6
ENST00000381538	NFXL1-202	3728	-	ENSP00000370949	911 (aa)	-	Q6ZNB6
ENST00000502448	NFXL1-204	1760	-	-	- (aa)	-	-
ENST00000507131	NFXL1-205	2664	-	-	- (aa)	-	-
ENST00000511452	NFXL1-208	419	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000170448	Erythrocyte Count	9.4270000E-005	-
ENSG00000170448	Erythrocyte Count	9.4270000E-005	-

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000170448	NFXL1	100	88.562	ENSMUSG00000072889	Nfxl1	100	89.107	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	21873635.	IBA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	ISM	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component