EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000170627 (Gene tree)
Gene ID: 121355
Gene Symbol: GTSF1
Alias: FLJ32942|Cue110|FAM112B
Full Name: gametocyte specific factor 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 17,653 bases
Position: chr12:54,455,950-54,473,602
Accession: 26565
RBP type: canonical RBP
Summary: GTSF1 (Gametocyte Specific Factor 1) is a Protein Coding gene. An important paralog of this gene is GTSF1L.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000304185	zf-U11-48K	PF05253.12	1.7e-19	1	2
ENSP00000304185	zf-U11-48K	PF05253.12	1.7e-19	2	2
ENSP00000446485	zf-U11-48K	PF05253.12	1.7e-19	1	2
ENSP00000446485	zf-U11-48K	PF05253.12	1.7e-19	2	2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000549083	GTSF1-206	575	-	-	- (aa)	-	-
ENST00000546575	GTSF1-202	458	-	-	- (aa)	-	-
ENST00000546931	GTSF1-204	902	-	ENSP00000446918	176 (aa)	-	G3V1V4
ENST00000552397	GTSF1-209	1621	XM_024448834	ENSP00000446485	167 (aa)	XP_024304602	Q8WW33
ENST00000305879	GTSF1-201	804	XM_017018800	ENSP00000304185	167 (aa)	XP_016874289	Q8WW33
ENST00000552395	GTSF1-208	671	-	-	- (aa)	-	-
ENST00000548538	GTSF1-205	594	-	-	- (aa)	-	-
ENST00000552336	GTSF1-207	520	-	-	- (aa)	-	-
ENST00000546739	GTSF1-203	567	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000170627's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000170627's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000170627	GTSF1	88	47.619	ENSAPOG00000022724	-	95	47.619	Acanthochromis_polyacanthus
ENSG00000170627	GTSF1	98	92.121	ENSAMEG00000000939	GTSF1	98	92.121	Ailuropoda_melanoleuca
ENSG00000170627	GTSF1	88	46.939	ENSAOCG00000022214	-	72	45.806	Amphiprion_ocellaris
ENSG00000170627	GTSF1	75	60.317	ENSAPLG00000004814	GTSF1	93	60.317	Anas_platyrhynchos
ENSG00000170627	GTSF1	97	62.963	ENSACAG00000014260	-	94	63.354	Anolis_carolinensis
ENSG00000170627	GTSF1	69	47.414	ENSACAG00000029590	-	95	47.414	Anolis_carolinensis
ENSG00000170627	GTSF1	100	95.808	ENSANAG00000024529	GTSF1	100	95.808	Aotus_nancymaae
ENSG00000170627	GTSF1	100	92.216	ENSBTAG00000018085	GTSF1	100	92.216	Bos_taurus
ENSG00000170627	GTSF1	100	92.216	ENSCJAG00000039915	-	88	92.216	Callithrix_jacchus
ENSG00000170627	GTSF1	100	97.605	ENSCJAG00000018968	-	100	97.605	Callithrix_jacchus
ENSG00000170627	GTSF1	100	92.814	ENSCAFG00000006465	-	100	92.814	Canis_familiaris
ENSG00000170627	GTSF1	100	92.814	ENSCAFG00020020373	-	100	91.477	Canis_lupus_dingo
ENSG00000170627	GTSF1	98	91.411	ENSCHIG00000012215	-	95	91.411	Capra_hircus
ENSG00000170627	GTSF1	99	90.361	ENSTSYG00000004679	-	100	90.361	Carlito_syrichta
ENSG00000170627	GTSF1	100	73.054	ENSTSYG00000035266	-	100	73.054	Carlito_syrichta
ENSG00000170627	GTSF1	100	91.018	ENSCPOG00000008743	GTSF1	100	91.018	Cavia_porcellus
ENSG00000170627	GTSF1	97	71.345	ENSCCAG00000032808	GTSF1	100	71.345	Cebus_capucinus
ENSG00000170627	GTSF1	100	100.000	ENSCATG00000036328	GTSF1	100	100.000	Cercocebus_atys
ENSG00000170627	GTSF1	100	90.419	ENSCLAG00000012811	GTSF1	100	90.419	Chinchilla_lanigera
ENSG00000170627	GTSF1	95	98.734	ENSCSAG00000005394	GTSF1	100	98.734	Chlorocebus_sabaeus
ENSG00000170627	GTSF1	100	91.018	ENSCHOG00000001659	GTSF1	100	91.018	Choloepus_hoffmanni
ENSG00000170627	GTSF1	95	58.125	ENSCPBG00000024905	-	86	58.125	Chrysemys_picta_bellii
ENSG00000170627	GTSF1	99	68.675	ENSCPBG00000005134	-	72	69.277	Chrysemys_picta_bellii
ENSG00000170627	GTSF1	100	93.413	ENSCANG00000031776	-	100	93.413	Colobus_angolensis_palliatus
ENSG00000170627	GTSF1	100	98.802	ENSCANG00000033118	GTSF1	100	98.802	Colobus_angolensis_palliatus
ENSG00000170627	GTSF1	100	91.617	ENSCGRG00001013814	Gtsf1	100	91.617	Cricetulus_griseus_chok1gshd
ENSG00000170627	GTSF1	100	91.617	ENSCGRG00000007733	Gtsf1	100	91.617	Cricetulus_griseus_crigri
ENSG00000170627	GTSF1	94	90.446	ENSDNOG00000001438	-	90	90.446	Dasypus_novemcinctus
ENSG00000170627	GTSF1	100	92.216	ENSDORG00000003228	Gtsf1	100	92.216	Dipodomys_ordii
ENSG00000170627	GTSF1	100	89.820	ENSETEG00000009310	GTSF1	100	89.820	Echinops_telfairi
ENSG00000170627	GTSF1	100	92.814	ENSEASG00005010260	GTSF1	90	92.814	Equus_asinus_asinus
ENSG00000170627	GTSF1	100	92.814	ENSECAG00000013618	GTSF1	100	92.814	Equus_caballus
ENSG00000170627	GTSF1	100	92.814	ENSEEUG00000005185	GTSF1	100	92.814	Erinaceus_europaeus
ENSG00000170627	GTSF1	100	92.814	ENSFCAG00000010156	-	100	92.814	Felis_catus
ENSG00000170627	GTSF1	100	66.467	ENSFCAG00000023672	-	96	63.429	Felis_catus
ENSG00000170627	GTSF1	75	54.762	ENSFALG00000007613	-	100	54.762	Ficedula_albicollis
ENSG00000170627	GTSF1	100	87.425	ENSFDAG00000009383	GTSF1	100	87.425	Fukomys_damarensis
ENSG00000170627	GTSF1	96	54.658	ENSGALG00000001109	GTSF1	99	54.658	Gallus_gallus
ENSG00000170627	GTSF1	88	51.701	ENSGACG00000010783	-	80	51.701	Gasterosteus_aculeatus
ENSG00000170627	GTSF1	100	61.582	ENSGAGG00000011062	GTSF1	91	61.582	Gopherus_agassizii
ENSG00000170627	GTSF1	66	45.045	ENSGAGG00000018216	-	89	45.045	Gopherus_agassizii
ENSG00000170627	GTSF1	62	51.887	ENSGAGG00000016342	-	99	51.887	Gopherus_agassizii
ENSG00000170627	GTSF1	100	100.000	ENSGGOG00000016063	GTSF1	100	100.000	Gorilla_gorilla
ENSG00000170627	GTSF1	100	89.222	ENSHGLG00000002436	GTSF1	100	89.222	Heterocephalus_glaber_female
ENSG00000170627	GTSF1	100	89.222	ENSHGLG00100017301	GTSF1	100	89.222	Heterocephalus_glaber_male
ENSG00000170627	GTSF1	96	48.780	ENSIPUG00000002483	-	84	49.068	Ictalurus_punctatus
ENSG00000170627	GTSF1	100	92.216	ENSSTOG00000025170	GTSF1	100	92.216	Ictidomys_tridecemlineatus
ENSG00000170627	GTSF1	100	83.234	ENSJJAG00000017442	-	100	83.234	Jaculus_jaculus
ENSG00000170627	GTSF1	100	89.222	ENSJJAG00000003323	-	100	89.222	Jaculus_jaculus
ENSG00000170627	GTSF1	88	52.381	ENSKMAG00000006038	-	80	52.381	Kryptolebias_marmoratus
ENSG00000170627	GTSF1	96	60.625	ENSLACG00000008870	GTSF1	83	60.625	Latimeria_chalumnae
ENSG00000170627	GTSF1	97	93.210	ENSLAFG00000016318	GTSF1	97	93.210	Loxodonta_africana
ENSG00000170627	GTSF1	100	100.000	ENSMFAG00000041178	GTSF1	100	100.000	Macaca_fascicularis
ENSG00000170627	GTSF1	100	100.000	ENSMMUG00000003758	GTSF1	100	100.000	Macaca_mulatta
ENSG00000170627	GTSF1	100	100.000	ENSMNEG00000036779	GTSF1	100	100.000	Macaca_nemestrina
ENSG00000170627	GTSF1	100	99.401	ENSMLEG00000028375	GTSF1	100	99.401	Mandrillus_leucophaeus
ENSG00000170627	GTSF1	80	57.463	ENSMGAG00000000685	GTSF1	95	57.463	Meleagris_gallopavo
ENSG00000170627	GTSF1	100	68.263	ENSMAUG00000018746	Gtsf1	99	68.263	Mesocricetus_auratus
ENSG00000170627	GTSF1	100	92.814	ENSMICG00000008444	-	100	92.814	Microcebus_murinus
ENSG00000170627	GTSF1	100	91.617	ENSMOCG00000018889	Gtsf1	100	91.617	Microtus_ochrogaster
ENSG00000170627	GTSF1	100	84.431	ENSMODG00000019422	GTSF1	100	84.431	Monodelphis_domestica
ENSG00000170627	GTSF1	100	91.617	MGP_CAROLIEiJ_G0020379	Gtsf1	99	92.857	Mus_caroli
ENSG00000170627	GTSF1	100	91.617	ENSMUSG00000022487	Gtsf1	99	92.857	Mus_musculus
ENSG00000170627	GTSF1	100	91.018	MGP_PahariEiJ_G0020378	Gtsf1	99	92.063	Mus_pahari
ENSG00000170627	GTSF1	100	91.617	MGP_SPRETEiJ_G0021272	Gtsf1	99	92.857	Mus_spretus
ENSG00000170627	GTSF1	100	84.431	ENSMPUG00000019140	-	100	84.431	Mustela_putorius_furo
ENSG00000170627	GTSF1	98	93.293	ENSMPUG00000005669	-	98	93.293	Mustela_putorius_furo
ENSG00000170627	GTSF1	100	92.216	ENSMPUG00000019323	-	100	92.216	Mustela_putorius_furo
ENSG00000170627	GTSF1	100	91.018	ENSMLUG00000012961	-	100	91.018	Myotis_lucifugus
ENSG00000170627	GTSF1	100	88.024	ENSMLUG00000026557	-	100	88.024	Myotis_lucifugus
ENSG00000170627	GTSF1	100	92.216	ENSNGAG00000014213	Gtsf1	100	92.216	Nannospalax_galili
ENSG00000170627	GTSF1	100	99.401	ENSNLEG00000017635	GTSF1	100	99.401	Nomascus_leucogenys
ENSG00000170627	GTSF1	100	73.653	ENSMEUG00000016206	GTSF1	100	73.653	Notamacropus_eugenii
ENSG00000170627	GTSF1	100	67.066	ENSOPRG00000017277	GTSF1	100	67.066	Ochotona_princeps
ENSG00000170627	GTSF1	100	90.419	ENSODEG00000014220	GTSF1	100	90.419	Octodon_degus
ENSG00000170627	GTSF1	98	66.061	ENSOANG00000011386	GTSF1	99	66.061	Ornithorhynchus_anatinus
ENSG00000170627	GTSF1	100	91.018	ENSOCUG00000024495	GTSF1	100	91.018	Oryctolagus_cuniculus
ENSG00000170627	GTSF1	72	47.107	ENSORLG00015005017	-	71	50.877	Oryzias_latipes_hsok
ENSG00000170627	GTSF1	97	88.824	ENSOGAG00000017227	GTSF1	100	88.824	Otolemur_garnettii
ENSG00000170627	GTSF1	100	92.814	ENSOARG00000016162	GTSF1	100	92.814	Ovis_aries
ENSG00000170627	GTSF1	100	100.000	ENSPPAG00000028506	GTSF1	100	100.000	Pan_paniscus
ENSG00000170627	GTSF1	100	92.814	ENSPPRG00000004344	-	100	92.814	Panthera_pardus
ENSG00000170627	GTSF1	100	83.832	ENSPPRG00000017612	-	95	80.000	Panthera_pardus
ENSG00000170627	GTSF1	100	92.814	ENSPTIG00000020415	-	100	92.814	Panthera_tigris_altaica
ENSG00000170627	GTSF1	100	84.431	ENSPTIG00000010868	-	95	80.571	Panthera_tigris_altaica
ENSG00000170627	GTSF1	100	100.000	ENSPTRG00000005041	GTSF1	100	100.000	Pan_troglodytes
ENSG00000170627	GTSF1	100	100.000	ENSPANG00000020579	GTSF1	100	100.000	Papio_anubis
ENSG00000170627	GTSF1	98	66.667	ENSPSIG00000009968	GTSF1	81	66.667	Pelodiscus_sinensis
ENSG00000170627	GTSF1	69	49.573	ENSPSIG00000009839	-	73	49.573	Pelodiscus_sinensis
ENSG00000170627	GTSF1	100	91.617	ENSPEMG00000009595	Gtsf1	100	91.617	Peromyscus_maniculatus_bairdii
ENSG00000170627	GTSF1	100	80.838	ENSPCIG00000006731	GTSF1	100	80.838	Phascolarctos_cinereus
ENSG00000170627	GTSF1	100	100.000	ENSPPYG00000004605	GTSF1	100	100.000	Pongo_abelii
ENSG00000170627	GTSF1	100	92.216	ENSPCOG00000016907	-	100	92.216	Propithecus_coquereli
ENSG00000170627	GTSF1	99	79.290	ENSPCOG00000015201	-	99	79.290	Propithecus_coquereli
ENSG00000170627	GTSF1	100	92.814	ENSPVAG00000000333	GTSF1	100	92.814	Pteropus_vampyrus
ENSG00000170627	GTSF1	90	51.316	ENSPNAG00000005737	-	82	51.316	Pygocentrus_nattereri
ENSG00000170627	GTSF1	100	91.617	ENSRNOG00000036831	Gtsf1	88	91.617	Rattus_norvegicus
ENSG00000170627	GTSF1	100	99.401	ENSRBIG00000043438	-	100	99.401	Rhinopithecus_bieti
ENSG00000170627	GTSF1	100	91.018	ENSRBIG00000039916	-	89	91.018	Rhinopithecus_bieti
ENSG00000170627	GTSF1	100	100.000	ENSRROG00000008137	GTSF1	100	100.000	Rhinopithecus_roxellana
ENSG00000170627	GTSF1	100	98.204	ENSSBOG00000029460	GTSF1	100	98.204	Saimiri_boliviensis_boliviensis
ENSG00000170627	GTSF1	100	84.431	ENSSHAG00000011633	GTSF1	100	84.431	Sarcophilus_harrisii
ENSG00000170627	GTSF1	78	92.308	ENSSARG00000004928	GTSF1	78	92.308	Sorex_araneus
ENSG00000170627	GTSF1	98	50.303	ENSSPUG00000010064	GTSF1	93	72.727	Sphenodon_punctatus
ENSG00000170627	GTSF1	100	92.216	ENSSSCG00000026333	GTSF1	100	92.216	Sus_scrofa
ENSG00000170627	GTSF1	76	57.031	ENSTGUG00000002008	-	100	57.031	Taeniopygia_guttata
ENSG00000170627	GTSF1	96	90.683	ENSTBEG00000006154	GTSF1	100	90.683	Tupaia_belangeri
ENSG00000170627	GTSF1	100	89.820	ENSTTRG00000004470	GTSF1	100	89.820	Tursiops_truncatus
ENSG00000170627	GTSF1	100	93.413	ENSUAMG00000021669	GTSF1	100	92.045	Ursus_americanus
ENSG00000170627	GTSF1	100	93.413	ENSUMAG00000011279	GTSF1	100	93.413	Ursus_maritimus
ENSG00000170627	GTSF1	100	91.018	ENSVPAG00000007016	GTSF1	100	91.018	Vicugna_pacos
ENSG00000170627	GTSF1	100	92.814	ENSVVUG00000023687	-	84	92.814	Vulpes_vulpes
ENSG00000170627	GTSF1	96	63.354	ENSXETG00000033546	gtsf1	71	63.354	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005737	cytoplasm	-	IEA	Component
GO:0007283	spermatogenesis	-	IEA	Process
GO:0030154	cell differentiation	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr12	54463290	Missense_Mutation	rs767605251	P42H	0.52
ACC	chr12	54460399	Silent	novel	P155P	0.2
BLCA	chr12	54460464	Missense_Mutation	NA	S134G	0.39
BLCA	chr12	54463298	Splice_Site	novel	X40_splice	0.19
CESC	chr12	54462646	Missense_Mutation	novel	D108E	0.19
COAD	chr12	54471237	Silent	novel	T4T	0.35
COAD	chr12	54465118	Frame_Shift_Ins	NA	*N22Kfs22**	0.27
COAD	chr12	54462712	Missense_Mutation	NA	R86S	0.25
GBM	chr12	54460466	Missense_Mutation	rs186804345	A133V	0.2
HNSC	chr12	54463259	Silent	novel	P52P	0.14
HNSC	chr12	54463260	Missense_Mutation	novel	P52L	0.13	zf-U11-48K
KIRC	chr12	54463202	Silent	NA	C71C	0.21
KIRC	chr12	54463171	In_Frame_Del	novel	V82del	0.23
KIRP	chr12	54463286	Silent	NA	D43D	0.29
LGG	chr12	54462684	Nonsense_Mutation	novel	*E95_S96insFFKAIF**	0.08
LGG	chr12	54459100	3'UTR	novel		0.28
LGG	chr12	54465084	Missense_Mutation	novel	L34I	0.44
LUAD	chr12	54460400	Frame_Shift_Del	novel	*P155Rfs15**	0.28
LUAD	chr12	54463284	Missense_Mutation	novel	V44D	0.46
LUAD	chr12	54465067	Missense_Mutation	NA	K39N	0.41
LUSC	chr12	54462715	Silent	novel	T85T	0.24
LUSC	chr12	54462660	Missense_Mutation	novel	D104H	0.14
MESO	chr12	54462174	Splice_Site	novel	X110_splice	0.07
READ	chr12	54463256	Missense_Mutation	NA	F53L	0.27	zf-U11-48K
READ	chr12	54463235	Frame_Shift_Del	NA	*F53Sfs3**	0.22	zf-U11-48K
SKCM	chr12	54460404	Silent	NA	L154L	0.53
SKCM	chr12	54462648	Missense_Mutation	NA	D108N	0.83
SKCM	chr12	54462165	Nonsense_Mutation	NA	W112*	0.28
SKCM	chr12	54465093	Missense_Mutation	NA	P31S	0.44
SKCM	chr12	54462666	Missense_Mutation	rs753855929	P102S	0.34
SKCM	chr12	54471236	Missense_Mutation	NA	Y5H	0.26
UCEC	chr12	54456123	3'UTR	novel		0.49
UCEC	chr12	54456150	3'UTR	novel		0.29
UCEC	chr12	54463175	Silent	novel	D80D	0.32
UCEC	chr12	54459096	3'UTR	novel		0.22
UCEC	chr12	54462142	Missense_Mutation	novel	V120G	0.1
UCEC	chr12	54460466	Missense_Mutation	rs186804345	A133V	0.43
UCEC	chr12	54463269	Missense_Mutation	novel	A49V	0.4	zf-U11-48K
UCEC	chr12	54462670	Silent	novel	C100C	0.11
UCEC	chr12	54456150	3'UTR	novel		0.39
UCEC	chr12	54460466	Missense_Mutation	rs186804345	A133V	0.16
UCEC	chr12	54456067	3'UTR	novel		0.22
UCEC	chr12	54460419	Nonsense_Mutation	NA	R149*	0.14
UCEC	chr12	54465144	Missense_Mutation	novel	L14I	0.45
UCEC	chr12	54456025	3'UTR	novel		0.35
UCEC	chr12	54462139	Missense_Mutation	novel	W121S	0.17
UCEC	chr12	54460406	Missense_Mutation	rs768603113	S153Y	0.1
UCEC	chr12	54462159	Silent	rs766370506	Q114Q	0.17
UCEC	chr12	54463251	Missense_Mutation	NA	A55D	0.35	zf-U11-48K

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.1875	0.085003
READ	DEL	0.0727	0.064633

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.013	Kaplan-Meier Survival Analysis
STAD	0.016	Kaplan-Meier Survival Analysis
HNSC	0.011	Kaplan-Meier Survival Analysis
SKCM	0.00023	Kaplan-Meier Survival Analysis
CESC	0.015	Kaplan-Meier Survival Analysis
GBM	0.05	Kaplan-Meier Survival Analysis
LGG	0.0031	Kaplan-Meier Survival Analysis
LUAD	0.019	Kaplan-Meier Survival Analysis
UVM	0.049	Kaplan-Meier Survival Analysis