EuRBPDB

Ensembl ID

ENSG00000170748 (Gene tree)

Gene ID

27288

Gene Symbol

RBMXL2

Alias

HNRNPG-T|HNRPGT

Full Name

RBMX like 2

Gene Type

protein_coding

Species

Homo_sapiens

Status

confidence

Strand

Plus strand

Length

2,215 bases

Position

chr11:7,088,934-7,091,148

Accession

17886

RBP type

canonical RBP

Summary

This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon. However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility. [provided by RefSeq, Jul 2008]