EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000170776 (Gene tree)
Gene ID: 11214
Gene Symbol: AKAP13
Alias: Ht31|BRX|AKAP-Lbc|c-lbc|PROTO-LB|HA-3|ARHGEF13|LBC
Full Name: A-kinase anchoring protein 13
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 368,788 bases
Position: chr15:85,380,571-85,749,358
Accession: 371
RBP type: non-canonical RBP
Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
1869528	A major substrate of maturation promoting factor identified as elongation factor 1 beta gamma delta in Xenopus laevis.	J Biol Chem	1991 Aug 15	Janssen GM	-
17762649	Upregulation of AT1 receptor gene on activation of protein kinase Cbeta/nicotinamide adenine dinucleotide diphosphate oxidase/ERK1/2/c-fos signaling cascade mediates long-term pressor effect of angiotensin II in rostral ventrolateral medulla.	J Hypertens	2007 Sep	Chan SH	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000560302	AKAP13-217	3765	-	ENSP00000453634	179 (aa)	-	Q12802
ENST00000560579	AKAP13-221	4290	-	ENSP00000477780	1429 (aa)	-	A0A087WTD7
ENST00000558644	AKAP13-208	1401	-	-	- (aa)	-	-
ENST00000361243	AKAP13-201	9468	-	ENSP00000354718	2817 (aa)	-	Q12802
ENST00000560571	AKAP13-220	712	-	-	- (aa)	-	-
ENST00000558092	AKAP13-206	620	-	-	- (aa)	-	-
ENST00000559486	AKAP13-213	827	-	ENSP00000453205	275 (aa)	-	H0YLH1
ENST00000559362	AKAP13-211	5459	-	ENSP00000453768	1745 (aa)	-	H0YMW2
ENST00000558166	AKAP13-207	558	-	ENSP00000452622	93 (aa)	-	H0YK18
ENST00000557852	AKAP13-204	660	-	ENSP00000480789	166 (aa)	-	A0A087WX73
ENST00000560256	AKAP13-216	322	-	ENSP00000453620	38 (aa)	-	H0YMI5
ENST00000559391	AKAP13-212	418	-	-	- (aa)	-	-
ENST00000559820	AKAP13-214	322	-	-	- (aa)	-	-
ENST00000394510	AKAP13-202	9128	-	ENSP00000378018	1434 (aa)	-	A8MYJ1
ENST00000558009	AKAP13-205	427	-	-	- (aa)	-	-
ENST00000560676	AKAP13-222	3297	-	ENSP00000481485	967 (aa)	-	A0A087WY36
ENST00000559278	AKAP13-210	441	-	-	- (aa)	-	-
ENST00000394518	AKAP13-203	13215	-	ENSP00000378026	2813 (aa)	-	Q12802
ENST00000560957	AKAP13-223	751	-	-	- (aa)	-	-
ENST00000560482	AKAP13-219	683	-	-	- (aa)	-	-
ENST00000558811	AKAP13-209	447	-	ENSP00000452698	146 (aa)	-	H0YK84
ENST00000612418	AKAP13-224	425	-	ENSP00000482058	66 (aa)	-	A0A087WYS7
ENST00000560340	AKAP13-218	553	-	ENSP00000483091	98 (aa)	-	A0A087X047
ENST00000560185	AKAP13-215	611	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000170776's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04928	Parathyroid hormone synthesis, secretion and action	KEGG
hsa05163	Human cytomegalovirus infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000170776	Parkinson Disease	8.868E-5	16252231
ENSG00000170776	Parkinson Disease	8.877E-5	16252231
ENSG00000170776	Amyotrophic Lateral Sclerosis	2.1020000E-004	18057069
ENSG00000170776	Amyotrophic Lateral Sclerosis	2.1160000E-004	18057069
ENSG00000170776	Myocardial Infarction	1.2550098E-004	-
ENSG00000170776	Myocardial Infarction	8.3104013E-004	-
ENSG00000170776	Myocardial Infarction	9.4370822E-004	-
ENSG00000170776	Body Mass Index	5.6430000E-006	-
ENSG00000170776	Potassium	9.4950000E-005	-
ENSG00000170776	Potassium	6.8680000E-005	-
ENSG00000170776	Lung Diseases, Interstitial	2E-6	23583980
ENSG00000170776	Carboplatin	9E-6	21844884
ENSG00000170776	Psoriasis	2E-6	25939698

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000170776	rs62022112	15	85466377	T	Intraocular pressure	29617998	[0.065-0.133] unit decrease	0.099	EFO_0004695
ENSG00000170776	rs62024517	15	85404905	T	Intraocular pressure	29617998	[0.062-0.128] unit decrease	0.095	EFO_0004695
ENSG00000170776	rs74346567	15	85706491	A	Mean corpuscular volume	27863252	[0.029-0.06] unit increase	0.04451132	EFO_0004526
ENSG00000170776	rs12440599	15	85567625	T	Cognitive empathy	28584286	[0.069-0.17] unit decrease	0.1198	EFO_0009183
ENSG00000170776	rs35343117	15	85535884	G	Psoriasis	25939698	[NR]	1.1	EFO_0000676
ENSG00000170776	rs6496044	15	85524075	G	Interstitial lung disease	23583980	[1.15-1.36]	1.25	EFO_0004244
ENSG00000170776	rs2279168	15	85533958	?	Response to platinum-based chemotherapy (carboplatin)	21844884			GO_0097328
ENSG00000170776	rs2880765	15	85513231	A	Coronary artery disease	29212778	[0.017-0.04] unit increase	0.0284	EFO_0000378
ENSG00000170776	rs12909648	15	85681339	A	Systolic blood pressure	30578418	[0.14-0.24] mmHg increase	0.1911	EFO_0006335
ENSG00000170776	rs56241813	15	85721280	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000170776	rs338533	15	85708862	?	Red blood cell count	30595370			EFO_0004305
ENSG00000170776	rs55767890	15	85460911	?	Hair color	30595370			EFO_0007822
ENSG00000170776	rs7166269	15	85423058	T	Pulse pressure	30578418	[0.11-0.21] mmHg increase	0.1579	EFO_0005763
ENSG00000170776	rs12907384	15	85732769	?	Fat-free mass	30593698	[0.12-0.25] unit decrease	0.18655	EFO_0004995
ENSG00000170776	rs12907384	15	85732769	?	Fat-free mass	30593698	[0.1-0.19] unit decrease	0.14652	EFO_0004995

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000170776's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004691	cAMP-dependent protein kinase activity	-	IEA	Function
GO:0005078	MAP-kinase scaffold activity	21224381.	IDA	Function
GO:0005089	Rho guanyl-nucleotide exchange factor activity	11546812.25186459.	IDA	Function
GO:0005515	protein binding	9627117.16301118.21224381.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005829	cytosol	11546812.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005884	actin filament	-	IEA	Component
GO:0005938	cell cortex	11546812.	IDA	Component
GO:0006468	protein phosphorylation	-	IEA	Process
GO:0007186	G protein-coupled receptor signaling pathway	11546812.	IDA	Process
GO:0007186	G protein-coupled receptor signaling pathway	-	TAS	Process
GO:0007507	heart development	-	ISS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0017048	Rho GTPase binding	25186459.	IPI	Function
GO:0030864	cortical actin cytoskeleton	11546812.	IDA	Component
GO:0035025	positive regulation of Rho protein signal transduction	11546812.	IDA	Process
GO:0035025	positive regulation of Rho protein signal transduction	21224381.	IMP	Process
GO:0043065	positive regulation of apoptotic process	-	TAS	Process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	23090968.	IMP	Process
GO:0043406	positive regulation of MAP kinase activity	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0051018	protein kinase A binding	11546812.	IDA	Function
GO:0051056	regulation of small GTPase mediated signal transduction	-	TAS	Process
GO:0051168	nuclear export	-	IEA	Process
GO:0055007	cardiac muscle cell differentiation	-	ISS	Process
GO:0060090	molecular adaptor activity	23090968.	IDA	Function
GO:0060297	regulation of sarcomere organization	-	ISS	Process
GO:0060348	bone development	-	ISS	Process
GO:0061049	cell growth involved in cardiac muscle cell development	-	IEA	Process
GO:0071875	adrenergic receptor signaling pathway	21224381.23090968.	IMP	Process
GO:0086023	adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	-	ISS	Process
GO:1900169	regulation of glucocorticoid mediated signaling pathway	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26617690	Up-regulation of AKAP13 and MAGT1 on cytoplasmic membrane in progressive hepatocellular carcinoma: a novel target for prognosis.	Int J Clin Exp Pathol	2015 Sep 1	Molee P	-
26272591	Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13.	BMC Cancer	2015 Aug 14	Bentin Toaldo C	doi: 10.1186/s12885-015-1591-4.
16234258	Association of genetic variants in the Rho guanine nucleotide exchange factor AKAP13 with familial breast cancer.	Carcinogenesis	2006 Mar	Wirtenberger M	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr15	85743666	Missense_Mutation	novel	H2745N	0.4
ACC	chr15	85581612	Missense_Mutation	novel	E1182K	0.16
BLCA	chr15	85533618	Silent	novel	L72L	0.29
BLCA	chr15	85533823	Missense_Mutation	rs767360299	R141G	0.24
BLCA	chr15	85664757	Splice_Site	novel	X1664_splice	0.3
BLCA	chr15	85741352	Missense_Mutation	novel	E2639K	0.31
BLCA	chr15	85543950	Silent	rs751735705	L219L	0.51
BLCA	chr15	85735613	Missense_Mutation	novel	D2499N	0.17
BLCA	chr15	85579149	Missense_Mutation	NA	E361K	0.15
BLCA	chr15	85543930	Missense_Mutation	NA	H213Y	0.23
BLCA	chr15	85658569	Missense_Mutation	novel	R1593K	0.16
BLCA	chr15	85580756	Silent	novel	S896S	0.53
BLCA	chr15	85581232	Missense_Mutation	novel	D1055G	0.14
BLCA	chr15	85710630	Missense_Mutation	novel	I1862F	0.63
BLCA	chr15	85718141	Silent	novel	R1995R	0.12
BLCA	chr15	85581491	Silent	novel	V1141V	0.18
BLCA	chr15	85730667	Silent	NA	A2414A	0.2
BLCA	chr15	85580410	Missense_Mutation	rs530733643	S781L	0.46
BLCA	chr15	85543770	Splice_Site	novel	X160_splice	0.39
BLCA	chr15	85580469	Missense_Mutation	rs751149430	A801T	0.21
BLCA	chr15	85662405	Intron	rs763908818		0.35
BLCA	chr15	85521544	Silent	NA	V50V	0.15
BLCA	chr15	85575154	Missense_Mutation	novel	S229C	0.05
BLCA	chr15	85645851	Missense_Mutation	novel	R1424K	0.17
BLCA	chr15	85744682	3'UTR	rs771624671		0.1
BLCA	chr15	85579171	Missense_Mutation	rs144259676	S368F	0.19
BLCA	chr15	85580175	Missense_Mutation	rs537413224	P703S	0.11
BLCA	chr15	85581770	Silent	novel	V1234V	0.31
BLCA	chr15	85723295	Silent	novel	L2240L	0.2
BLCA	chr15	85579593	Missense_Mutation	novel	E509Q	0.06
BLCA	chr15	85717396	Missense_Mutation	novel	D1948N	0.52
BLCA	chr15	85684794	Missense_Mutation	novel	S1737F	0.16
BLCA	chr15	85580528	Silent	NA	T820T	0.28
BLCA	chr15	85533703	Missense_Mutation	NA	Q101E	0.25
BLCA	chr15	85543922	Missense_Mutation	NA	R210Q	0.15
BLCA	chr15	85741421	Missense_Mutation	NA	E2662Q	0.37
BLCA	chr15	85693348	Silent	novel	K1787K	0.29
BRCA	chr15	85684779	Missense_Mutation	novel	P1732L	0.07
BRCA	chr15	85723166	Silent	novel	K2197K	0.5
BRCA	chr15	85579772	Silent	rs755297450	T568T	0.11
BRCA	chr15	85741418	Missense_Mutation	NA	L2661F	0.28
BRCA	chr15	85579295	Silent	novel	V409V	0.05
BRCA	chr15	85579296	Missense_Mutation	novel	K410Q	0.05
BRCA	chr15	85579288	Missense_Mutation	rs768166553	C407Y	0.22
BRCA	chr15	85719201	Missense_Mutation	NA	D2043H	0.31
BRCA	chr15	85579812	Missense_Mutation	novel	V582I	0.22
BRCA	chr15	85655597	Missense_Mutation	NA	E1519K	0.27
BRCA	chr15	85580547	Missense_Mutation	novel	G827C	0.1
BRCA	chr15	85579146	Missense_Mutation	NA	V360I	0.24
BRCA	chr15	85743496	Missense_Mutation	novel	S2688C	0.33
BRCA	chr15	85743666	Missense_Mutation	novel	H2745Y	0.19
BRCA	chr15	85580301	Missense_Mutation	rs747774362	D745Y	0.13
BRCA	chr15	85581386	Missense_Mutation	novel	E1106D	0.42
BRCA	chr15	85533868	Nonsense_Mutation	NA	Q156*	0.33
BRCA	chr15	85664703	Nonsense_Mutation	NA	S1647*	0.27
BRCA	chr15	85693330	Silent	novel	D1781D	0.27
BRCA	chr15	85580580	Missense_Mutation	rs748198504	R838W	0.22
BRCA	chr15	85741363	Missense_Mutation	NA	Q2642H	0.13
BRCA	chr15	85726451	Nonsense_Mutation	novel	Q2263*	0.09
BRCA	chr15	85721988	Splice_Region	novel		0.29
BRCA	chr15	85521575	Missense_Mutation	novel	G61R	0.18
CESC	chr15	85747877	3'UTR	novel		0.09
CESC	chr15	85684831	Silent	NA	F1749F	0.39
CESC	chr15	85743742	Missense_Mutation	novel	S2770F	0.26
CESC	chr15	85533703	Missense_Mutation	NA	Q101E	0.18
CESC	chr15	85580136	Missense_Mutation	NA	S690P	0.35
CESC	chr15	85585734	Missense_Mutation	NA	D1358H	0.48
CESC	chr15	85580663	Silent	NA	L865L	0.12
CESC	chr15	85533773	In_Frame_Ins	novel	P124_P125insKGN	0.08
CESC	chr15	85579213	Frame_Shift_Ins	novel	*V383Tfs15**	0.07
CESC	chr15	85543878	Missense_Mutation	NA	I195M	0.2
CESC	chr15	85743603	Missense_Mutation	NA	E2724K	0.23
CESC	chr15	85744685	3'UTR	novel		0.56
CESC	chr15	85658534	Splice_Region	novel		0.31
CESC	chr15	85645909	Silent	NA	L1443L	0.16
CESC	chr15	85730547	Silent	novel	L2374L	0.26
CESC	chr15	85579002	Nonsense_Mutation	novel	E312*	0.4
CESC	chr15	85579595	Missense_Mutation	novel	E509D	0.5
CESC	chr15	85579684	Missense_Mutation	novel	A539V	0.38
CESC	chr15	85581829	Missense_Mutation	rs138629757	R1254H	0.37
CESC	chr15	85645895	Missense_Mutation	novel	S1439G	0.37
CESC	chr15	85715806	Missense_Mutation	novel	R1873H	0.36
CESC	chr15	85747397	3'UTR	novel		0.25
CESC	chr15	85747596	3'UTR	novel		0.22
CESC	chr15	85580001	Nonsense_Mutation	novel	Q645*	0.27
CESC	chr15	85723173	Missense_Mutation	NA	R2200C	0.45
CESC	chr15	85718147	Missense_Mutation	NA	E1997K	0.23
CESC	chr15	85744783	3'UTR	novel		0.44
CESC	chr15	85747586	3'UTR	novel		0.2
CESC	chr15	85585728	Missense_Mutation	novel	E1356K	0.06
CESC	chr15	85575224	Missense_Mutation	NA	I252M	0.45
CESC	chr15	85521538	Silent	rs116628862	R48R	0.26
CHOL	chr15	85582017	Missense_Mutation	novel	E1317K	0.34
COAD	chr15	85579756	Frame_Shift_Del	NA	*T565Qfs18**	0.46
COAD	chr15	85581765	Missense_Mutation	novel	M1233L	0.1
COAD	chr15	85580498	Missense_Mutation	novel	E810D	0.14
COAD	chr15	85579794	Nonsense_Mutation	novel	E576*	0.09
COAD	chr15	85741239	Missense_Mutation	rs369963716	R2601H	0.47
COAD	chr15	85579850	Missense_Mutation	novel	K594N	0.14
COAD	chr15	85722031	Missense_Mutation	novel	G2098D	0.26
COAD	chr15	85581652	Frame_Shift_Ins	novel	*T1197Hfs9**	0.33
COAD	chr15	85744721	3'UTR	novel		0.43
COAD	chr15	85578996	Missense_Mutation	novel	A310T	0.1
COAD	chr15	85582081	Missense_Mutation	NA	P1338H	0.67
COAD	chr15	85581691	Missense_Mutation	novel	A1208V	0.16
COAD	chr15	85658545	Missense_Mutation	rs181593659	R1585Q	0.34
COAD	chr15	85580017	Missense_Mutation	novel	S650L	0.05
COAD	chr15	85730691	Silent	NA	K2422K	0.36
COAD	chr15	85730617	Frame_Shift_Ins	NA	*T2400Nfs3**	0.33
COAD	chr15	85533932	Intron	rs762940749		0.36
COAD	chr15	85710616	Nonsense_Mutation	novel	S1857*	0.36
COAD	chr15	85580418	Missense_Mutation	novel	T784A	0.07
COAD	chr15	85743811	Missense_Mutation	rs368581372	R2793H	0.31
COAD	chr15	85669792	Missense_Mutation	novel	S1688C	0.06
COAD	chr15	85580501	Missense_Mutation	novel	K811N	0.05
COAD	chr15	85585816	Missense_Mutation	NA	T1385S	0.38
COAD	chr15	85741443	Missense_Mutation	rs746154680	R2669H	0.38
COAD	chr15	85580524	Missense_Mutation	rs769879931	H819R	0.43
COAD	chr15	85722227	Splice_Region	novel		0.34
COAD	chr15	85727452	Missense_Mutation	NA	R2359Q	0.08
COAD	chr15	85533688	Missense_Mutation	NA	A96T	0.24
COAD	chr15	85581109	Missense_Mutation	NA	A1014V	0.49
COAD	chr15	85684816	Silent	NA	K1744K	0.2
COAD	chr15	85719105	Missense_Mutation	novel	R2011C	0.19
COAD	chr15	85741482	Missense_Mutation	rs772008595	R2682Q	0.29
COAD	chr15	85580659	Missense_Mutation	NA	S864T	0.29
COAD	chr15	85664600	Missense_Mutation	rs777916874	G1613R	0.31
COAD	chr15	85723251	Missense_Mutation	novel	D2226Y	0.12
COAD	chr15	85723289	Silent	novel	V2238V	0.33
COAD	chr15	85580734	Missense_Mutation	novel	N889S	0.15
COAD	chr15	85708076	Missense_Mutation	NA	V1841A	0.13
COAD	chr15	85727219	Missense_Mutation	novel	Q2326K	0.1
COAD	chr15	85580754	Missense_Mutation	NA	S896C	0.26
COAD	chr15	85581453	Missense_Mutation	rs779149455	V1129I	0.33
COAD	chr15	85719261	Missense_Mutation	novel	S2063A	0.26
COAD	chr15	85727429	Missense_Mutation	rs780698233	K2351N	0.3
COAD	chr15	85575272	Silent	novel	P268P	0.27
COAD	chr15	85581035	Frame_Shift_Del	NA	*F990Lfs18**	0.38
COAD	chr15	85693291	Silent	novel	E1768E	0.2
COAD	chr15	85747796	3'UTR	novel		0.38
COAD	chr15	85579989	Missense_Mutation	novel	H641D	0.05
COAD	chr15	85579990	In_Frame_Ins	novel	H641delinsQILS	0.05
COAD	chr15	85743543	Missense_Mutation	novel	P2704T	0.09
COAD	chr15	85741453	Silent	novel	A2672A	0.34
COAD	chr15	85581631	Missense_Mutation	novel	L1188R	0.1
COAD	chr15	85744829	3'UTR	novel		0.45
DLBC	chr15	85533890	Intron	novel		0.31
ESCA	chr15	85533613	Missense_Mutation	novel	Q71K	0.27
ESCA	chr15	85579311	Missense_Mutation	novel	L415I	0.21
ESCA	chr15	85735034	Missense_Mutation	novel	T2442I	0.1
ESCA	chr15	85741106	Missense_Mutation	novel	A2557T	0.1
ESCA	chr15	85575260	Silent	rs139228217	E264E	0.38
ESCA	chr15	85579165	Missense_Mutation	novel	D366G	0.34
ESCA	chr15	85664724	Missense_Mutation	novel	D1654V	0.12
ESCA	chr15	85575196	Missense_Mutation	novel	S243F	0.61
ESCA	chr15	85744663	Missense_Mutation	novel	E2810Q	0.44
ESCA	chr15	85719134	Silent	novel	Y2020Y	0.43
ESCA	chr15	85533872	Missense_Mutation	NA	S157N	0.12
ESCA	chr15	85726433	Missense_Mutation	novel	D2257N	0.4
GBM	chr15	85581717	Nonsense_Mutation	rs777358897	R1217*	0.11
GBM	chr15	85744811	3'UTR	novel		0.3
GBM	chr15	85581346	Missense_Mutation	novel	G1093E	0.05
GBM	chr15	85580741	Silent	NA	D891D	0.45
GBM	chr15	85727451	Missense_Mutation	NA	R2359G	0.32
GBM	chr15	85580078	Missense_Mutation	novel	N670K	0.08
GBM	chr15	85580532	Missense_Mutation	novel	T822S	0.12
GBM	chr15	85581684	Missense_Mutation	novel	D1206H	0.2
GBM	chr15	85715900	Missense_Mutation	novel	S1904R	0.19
GBM	chr15	85645838	Missense_Mutation	novel	V1420L	0.08
GBM	chr15	85580296	Missense_Mutation	rs769554632	R743Q	0.31
GBM	chr15	85645865	Missense_Mutation	novel	K1429Q	0.4
GBM	chr15	85743689	Silent	novel	Q2752Q	0.37
GBM	chr15	85744647	Silent	rs753208276	V2804V	0.33
GBM	chr15	85579594	Missense_Mutation	novel	E509V	0.08
GBM	chr15	85580300	Silent	novel	K744K	0.31
GBM	chr15	85580818	Missense_Mutation	novel	V917D	0.12
GBM	chr15	85645934	Missense_Mutation	novel	D1452H	0.08
GBM	chr15	85580562	Missense_Mutation	novel	S832A	0.36
GBM	chr15	85743560	Silent	rs373781999	S2709S	0.16
GBM	chr15	85581829	Missense_Mutation	rs138629757	R1254H	0.46
GBM	chr15	85645939	Missense_Mutation	novel	S1453R	0.08
GBM	chr15	85581566	Missense_Mutation	novel	D1166E	0.04
GBM	chr15	85743685	Missense_Mutation	novel	S2751I	0.11
GBM	chr15	85580139	Missense_Mutation	rs774873759	E691K	0.42
GBM	chr15	85579512	Missense_Mutation	novel	M482L	0.14
GBM	chr15	85655657	Missense_Mutation	novel	D1539N	0.28
GBM	chr15	85533744	Missense_Mutation	NA	N114K	0.2
HNSC	chr15	85743533	Missense_Mutation	novel	F2700L	0.11
HNSC	chr15	85579780	Missense_Mutation	novel	S571L	0.4
HNSC	chr15	85717345	Missense_Mutation	novel	D1931N	0.38
HNSC	chr15	85740243	Missense_Mutation	novel	H2527Y	0.24
HNSC	chr15	85575255	Missense_Mutation	novel	H263D	0.27
HNSC	chr15	85581468	Missense_Mutation	novel	V1134M	0.78
HNSC	chr15	85658545	Missense_Mutation	novel	R1585L	0.05
HNSC	chr15	85730563	Missense_Mutation	novel	E2380Q	0.31
HNSC	chr15	85741400	Missense_Mutation	novel	R2655C	0.17
HNSC	chr15	85719100	Missense_Mutation	novel	H2009R	0.36
HNSC	chr15	85715807	Silent	novel	R1873R	0.2
HNSC	chr15	85580642	Missense_Mutation	novel	H858Q	0.14
HNSC	chr15	85645863	Nonsense_Mutation	NA	S1428*	0.3
HNSC	chr15	85579699	Missense_Mutation	novel	D544V	0.1
KIRC	chr15	85575204	Missense_Mutation	rs796265954	H246Y	0.21
KIRC	chr15	85580373	Missense_Mutation	NA	M769V	0.34
KIRC	chr15	85580413	Missense_Mutation	NA	D782G	0.17
KIRC	chr15	85693401	Nonsense_Mutation	novel	*C1805delinsWLF**	0.05
KIRP	chr15	85580082	Missense_Mutation	novel	V672L	0.46
KIRP	chr15	85579415	Silent	novel	D449D	0.39
KIRP	chr15	85726429	Silent	NA	L2255L	0.23
KIRP	chr15	85579312	Missense_Mutation	novel	L415P	0.3
KIRP	chr15	85579408	Missense_Mutation	novel	Q447P	0.46
LAML	chr15	85575182	Silent	rs374214307	P238P	0.33
LGG	chr15	85741130	Missense_Mutation	novel	P2565T	0.38
LGG	chr15	85719169	Missense_Mutation	NA	Q2032P	0.4
LGG	chr15	85543783	Nonsense_Mutation	rs576412136	R164*	0.3
LGG	chr15	85580246	Missense_Mutation	novel	Q726H	0.46
LGG	chr15	85581588	Missense_Mutation	rs147919379	A1174T	0.38
LGG	chr15	85581977	Missense_Mutation	novel	F1303L	0.42
LGG	chr15	85744786	3'UTR	rs558767406		0.47
LGG	chr15	85533707	Missense_Mutation	NA	F102S	0.48
LGG	chr15	85533986	Intron	novel		0.38
LIHC	chr15	85722288	Missense_Mutation	NA	V2146G	0.1
LIHC	chr15	85580741	Silent	NA	D891D	0.14
LIHC	chr15	85743746	Silent	NA	T2771T	0.17
LIHC	chr15	85580939	Silent	NA	G957G	0.29
LIHC	chr15	85580940	Nonsense_Mutation	NA	Q958*	0.29
LIHC	chr15	85581673	Nonsense_Mutation	novel	S1202*	0.2
LIHC	chr15	85579371	Missense_Mutation	novel	D435Y	0.39
LIHC	chr15	85730656	Missense_Mutation	NA	T2411A	0.2
LUAD	chr15	85533771	Silent	novel	G123G	0.14
LUAD	chr15	85582047	Missense_Mutation	novel	A1327S	0.12
LUAD	chr15	85581409	Missense_Mutation	novel	D1114G	0.31
LUAD	chr15	85722259	Missense_Mutation	novel	R2136S	0.32
LUAD	chr15	85693365	Frame_Shift_Ins	novel	*S1795Qfs12**	0.29
LUAD	chr15	85579624	Missense_Mutation	rs201778847	S519C	0.13
LUAD	chr15	85693445	Missense_Mutation	NA	C1820S	0.35
LUAD	chr15	85579995	Missense_Mutation	rs199949454	Q643E	0.08
LUAD	chr15	85743525	Missense_Mutation	NA	P2698A	0.06
LUAD	chr15	85655704	Silent	rs766774367	S1554S	0.23
LUAD	chr15	85684769	Missense_Mutation	novel	P1729S	0.27
LUAD	chr15	85717340	Missense_Mutation	novel	S1929L	0.17
LUAD	chr15	85533584	Missense_Mutation	novel	G61D	0.35
LUAD	chr15	85723317	Splice_Site	novel	X2248_splice	0.07
LUAD	chr15	85585824	Splice_Site	novel	X1387_splice	0.15
LUAD	chr15	85723285	Missense_Mutation	NA	S2237N	0.06
LUAD	chr15	85580043	Missense_Mutation	NA	D659N	0.19
LUAD	chr15	85521573	Missense_Mutation	novel	P60L	0.39
LUAD	chr15	85581024	Missense_Mutation	NA	A986S	0.13
LUAD	chr15	85485716	5'UTR	novel		0.31
LUAD	chr15	85727111	Missense_Mutation	novel	E2290Q	0.21
LUAD	chr15	85579549	Missense_Mutation	NA	W494L	0.37
LUAD	chr15	85723095	Missense_Mutation	NA	L2174I	0.29
LUAD	chr15	85719119	Silent	NA	I2015I	0.2
LUSC	chr15	85719173	Missense_Mutation	NA	Q2033H	0.33
LUSC	chr15	85580347	Missense_Mutation	NA	S760L	0.13
LUSC	chr15	85579662	Missense_Mutation	novel	S532C	0.73
LUSC	chr15	85639413	Missense_Mutation	novel	D1401N	0.69
LUSC	chr15	85581886	Missense_Mutation	novel	G1273V	0.22
LUSC	chr15	85581887	Silent	novel	G1273G	0.21
LUSC	chr15	85579034	Silent	rs371691695	P322P	0.07
LUSC	chr15	85664592	Missense_Mutation	novel	A1610V	0.57
LUSC	chr15	85717355	Missense_Mutation	novel	N1934S	0.23
LUSC	chr15	85664703	Missense_Mutation	NA	S1647L	0.07
LUSC	chr15	85581721	Missense_Mutation	NA	A1218V	0.14
LUSC	chr15	85581958	Missense_Mutation	NA	T1297I	0.15
LUSC	chr15	85664642	Missense_Mutation	novel	A1627S	0.28
LUSC	chr15	85579467	Missense_Mutation	NA	G467S	0.16
LUSC	chr15	85655600	Missense_Mutation	rs769400321	G1520S	0.11
LUSC	chr15	85741411	Missense_Mutation	NA	Q2658H	0.15
LUSC	chr15	85655597	Missense_Mutation	novel	E1519Q	0.16
LUSC	chr15	85743596	Missense_Mutation	novel	L2721F	0.04
LUSC	chr15	85580895	Missense_Mutation	NA	S943P	0.29
LUSC	chr15	85582087	Missense_Mutation	novel	Q1340L	0.27
LUSC	chr15	85533669	Missense_Mutation	NA	F89L	0.09
LUSC	chr15	85533670	Missense_Mutation	NA	H90Y	0.09
LUSC	chr15	85543935	Missense_Mutation	novel	K214N	0.17
LUSC	chr15	85581673	Missense_Mutation	NA	S1202L	0.17
LUSC	chr15	85533791	Missense_Mutation	novel	N130S	0.23
LUSC	chr15	85655721	Missense_Mutation	NA	P1560L	0.23
LUSC	chr15	85735089	Silent	NA	S2460S	0.32
LUSC	chr15	85579238	Silent	NA	D390D	0.07
LUSC	chr15	85723173	Missense_Mutation	NA	R2200C	0.28
LUSC	chr15	85543870	Missense_Mutation	NA	L193F	0.47
LUSC	chr15	85669811	Missense_Mutation	NA	I1694M	0.58
LUSC	chr15	85581359	Silent	NA	L1097L	0.13
LUSC	chr15	85581097	Missense_Mutation	NA	Q1010P	0.23
LUSC	chr15	85581345	Missense_Mutation	NA	G1093W	0.41
LUSC	chr15	85727155	Silent	NA	G2304G	0.25
LUSC	chr15	85581397	Missense_Mutation	novel	H1110R	0.19
LUSC	chr15	85719115	Missense_Mutation	novel	K2014M	0.11
LUSC	chr15	85662389	Intron	novel		0.24
LUSC	chr15	85723305	Missense_Mutation	novel	A2244S	0.44
LUSC	chr15	85579683	Missense_Mutation	NA	A539T	0.24
LUSC	chr15	85580642	Silent	rs202087369	H858H	0.08
LUSC	chr15	85579077	Missense_Mutation	novel	E337Q	0.21
OV	chr15	85581392	Silent	novel	I1108I	0.06
OV	chr15	85662389	Intron	novel		0.04
OV	chr15	85581990	Missense_Mutation	novel	S1308C	0.12
OV	chr15	85684821	Missense_Mutation	NA	S1746I	0.11
OV	chr15	85580030	Silent	novel	S654S	0.05
OV	chr15	85580945	Frame_Shift_Ins	novel	*T960Hfs6**	0.03
OV	chr15	85579989	Missense_Mutation	novel	H641Y	0.1
OV	chr15	85581373	Missense_Mutation	novel	E1102G	0.04
OV	chr15	85580009	Silent	novel	G647G	0.05
OV	chr15	85580562	Missense_Mutation	novel	S832P	0.08
OV	chr15	85579881	Missense_Mutation	novel	T605P	0.46
OV	chr15	85579938	Missense_Mutation	novel	G624R	0.3
OV	chr15	85581469	Missense_Mutation	novel	V1134E	0.06
OV	chr15	85581470	Silent	novel	V1134V	0.05
OV	chr15	85581148	Missense_Mutation	novel	E1027G	0.04
OV	chr15	85580945	Frame_Shift_Ins	novel	*T960Hfs6**	0.04
OV	chr15	85581012	Frame_Shift_Del	novel	*N982Ifs27**	0.2
OV	chr15	85743682	Missense_Mutation	novel	T2750N	0.08
OV	chr15	85579924	Missense_Mutation	novel	D619V	0.05
OV	chr15	85730524	Nonsense_Mutation	NA	Q2367*	0.28
OV	chr15	85580275	Missense_Mutation	novel	V736E	0.21
OV	chr15	85715839	Missense_Mutation	NA	T1884I	0.22
OV	chr15	85730575	Missense_Mutation	novel	R2384G	0.1
OV	chr15	85580011	Missense_Mutation	novel	K648I	0.05
OV	chr15	85581061	Missense_Mutation	novel	N998T	0.06
OV	chr15	85579795	Missense_Mutation	novel	E576G	0.05
OV	chr15	85580304	Missense_Mutation	novel	V746M	0.22
OV	chr15	85580879	Missense_Mutation	novel	I937M	0.07
OV	chr15	85580265	Missense_Mutation	rs775639445	P733A	0.12
PAAD	chr15	85723272	Missense_Mutation	novel	V2233I	0.45
PAAD	chr15	85669751	Silent	novel	F1674F	0.17
PAAD	chr15	85533615	Missense_Mutation	novel	Q71H	0.06
PAAD	chr15	85579708	Missense_Mutation	novel	K547R	0.18
PAAD	chr15	85581868	Missense_Mutation	novel	G1267E	0.2
PCPG	chr15	85655733	Missense_Mutation	rs555050692	H1564R	0.47
PRAD	chr15	85741455	Missense_Mutation	NA	E2673G	0.11
PRAD	chr15	85723140	Missense_Mutation	novel	D2189N	0.07
PRAD	chr15	85744796	3'UTR	novel		0.13
PRAD	chr15	85664585	Missense_Mutation	novel	G1608R	0.21
PRAD	chr15	85723173	Missense_Mutation	NA	R2200C	0.38
READ	chr15	85585713	Missense_Mutation	NA	V1351M	0.2
READ	chr15	85726424	Missense_Mutation	NA	L2254I	0.75
READ	chr15	85719106	Missense_Mutation	rs778424032	R2011H	0.33
READ	chr15	85580511	Missense_Mutation	novel	T815S	0.12
READ	chr15	85579200	Missense_Mutation	novel	R378G	0.09
READ	chr15	85534003	Intron	novel		0.27
READ	chr15	85693309	Missense_Mutation	NA	E1774D	0.36
READ	chr15	85727111	Nonsense_Mutation	novel	E2290*	0.37
READ	chr15	85580552	Silent	novel	P828P	0.28
SARC	chr15	85575190	Missense_Mutation	novel	D241G	0.4
SARC	chr15	85723172	Silent	novel	V2199V	0.13
SARC	chr15	85743797	Missense_Mutation	rs35204082	K2788N	0.55
SKCM	chr15	85581750	Missense_Mutation	novel	P1228S	0.48
SKCM	chr15	85543872	Silent	rs754330702	L193L	0.17
SKCM	chr15	85693375	Silent	novel	S1796S	0.41
SKCM	chr15	85727450	Silent	NA	A2358A	0.21
SKCM	chr15	85575270	Missense_Mutation	novel	P268S	0.36
SKCM	chr15	85682183	Silent	NA	F1709F	0.3
SKCM	chr15	85581256	Missense_Mutation	NA	S1063F	0.13
SKCM	chr15	85581567	Missense_Mutation	rs771647350	H1167Y	0.45
SKCM	chr15	85581692	Silent	NA	A1208A	0.2
SKCM	chr15	85727063	Splice_Region	novel		0.09
SKCM	chr15	85727444	Silent	NA	T2356T	0.19
SKCM	chr15	85722314	Missense_Mutation	NA	V2155I	0.4
SKCM	chr15	85581911	Silent	rs761455307	S1281S	0.33
SKCM	chr15	85585775	Silent	novel	G1371G	0.24
SKCM	chr15	85533631	Missense_Mutation	NA	E77K	0.45
SKCM	chr15	85581671	Silent	NA	L1201L	0.25
SKCM	chr15	85655437	Silent	NA	A1465A	0.47
SKCM	chr15	85718132	Missense_Mutation	novel	V1992M	0.14
SKCM	chr15	85718133	Missense_Mutation	novel	V1992E	0.14
SKCM	chr15	85743740	Silent	NA	A2769A	0.56
SKCM	chr15	85581363	Missense_Mutation	NA	G1099S	0.11
SKCM	chr15	85684831	Silent	NA	F1749F	0.17
SKCM	chr15	85582069	Missense_Mutation	novel	K1334R	0.39
SKCM	chr15	85735095	Silent	novel	P2462P	0.32
SKCM	chr15	85735096	Missense_Mutation	rs759792670	R2463W	0.32
SKCM	chr15	85743549	Missense_Mutation	NA	E2706K	0.44
SKCM	chr15	85579171	Missense_Mutation	rs144259676	S368F	0.45
SKCM	chr15	85581608	Missense_Mutation	NA	D1180E	0.21
SKCM	chr15	85735100	Missense_Mutation	NA	R2464K	0.33
SKCM	chr15	85645896	Missense_Mutation	rs373476329	S1439N	0.41
SKCM	chr15	85582059	Missense_Mutation	NA	E1331K	0.18
SKCM	chr15	85533685	Nonsense_Mutation	novel	E95*	0.12
SKCM	chr15	85575258	Missense_Mutation	NA	E264K	0.15
SKCM	chr15	85740246	Missense_Mutation	NA	L2528F	0.75
SKCM	chr15	85715811	Missense_Mutation	rs760882035	R1875W	0.2
SKCM	chr15	85723175	Silent	novel	R2200R	0.5
SKCM	chr15	85580366	Silent	NA	V766V	0.17
SKCM	chr15	85543826	Missense_Mutation	NA	R178K	0.28
SKCM	chr15	85533641	Missense_Mutation	NA	P80L	0.12
SKCM	chr15	85715808	Missense_Mutation	NA	P1874S	0.17
SKCM	chr15	85580635	Missense_Mutation	NA	L856R	0.29
SKCM	chr15	85581258	Missense_Mutation	NA	P1064S	0.17
SKCM	chr15	85715815	Missense_Mutation	novel	S1876F	0.32
SKCM	chr15	85715816	Silent	rs764970319	S1876S	0.32
SKCM	chr15	85723320	Missense_Mutation	NA	E2249K	0.45
SKCM	chr15	85741259	Missense_Mutation	rs750119172	R2608C	0.4
SKCM	chr15	85743619	Missense_Mutation	NA	P2729L	0.36
SKCM	chr15	85744693	3'UTR	novel		0.26
SKCM	chr15	85533682	Missense_Mutation	novel	D94N	0.47
STAD	chr15	85723083	Missense_Mutation	rs764296768	E2170Q	0.2
STAD	chr15	85579635	Missense_Mutation	rs759395748	V523I	0.14
STAD	chr15	85579374	In_Frame_Ins	novel	Q436delinsPE	0.26
STAD	chr15	85723173	Missense_Mutation	NA	R2200C	0.1
STAD	chr15	85735605	Missense_Mutation	rs371824645	T2496M	0.29
STAD	chr15	85575235	Frame_Shift_Ins	novel	*E258Lfs24**	0.31
STAD	chr15	85662397	Intron	novel		0.39
STAD	chr15	85581089	Silent	rs568102019	L1007L	0.16
STAD	chr15	85741378	Silent	novel	Y2647Y	0.22
STAD	chr15	85730625	Silent	novel	T2400T	0.13
STAD	chr15	85723173	Missense_Mutation	NA	R2200C	0.09
STAD	chr15	85533932	Intron	novel		0.14
STAD	chr15	85743640	Missense_Mutation	NA	R2736L	0.16
STAD	chr15	85485746	Missense_Mutation	NA	P9L	0.33
STAD	chr15	85645829	Missense_Mutation	NA	F1417L	0.25
STAD	chr15	85581278	Missense_Mutation	NA	K1070N	0.23
STAD	chr15	85580923	Missense_Mutation	novel	R952I	0.11
STAD	chr15	85581680	Silent	rs202239836	H1204H	0.44
STAD	chr15	85727182	Silent	NA	V2313V	0.36
STAD	chr15	85579365	Missense_Mutation	NA	P433S	0.09
STAD	chr15	85735624	Frame_Shift_Del	NA	*K2504Rfs50**	0.24
STAD	chr15	85735564	Silent	rs201887818	G2482G	0.25
STAD	chr15	85533828	Missense_Mutation	NA	H142Q	0.16
STAD	chr15	85718028	Missense_Mutation	NA	E1957G	0.11
STAD	chr15	85578943	Missense_Mutation	novel	K292R	0.11
STAD	chr15	85581513	Frame_Shift_Del	novel	*P1150Sfs2**	0.24
STAD	chr15	85579206	Frame_Shift_Del	novel	*E381Kfs29**	0.45
STAD	chr15	85743786	Frame_Shift_Del	NA	*K2787Rfs34**	0.53
STAD	chr15	85581748	Missense_Mutation	novel	T1227S	0.51
STAD	chr15	85735056	Silent	NA	S2449S	0.35
STAD	chr15	85719133	Missense_Mutation	NA	Y2020C	0.08
STAD	chr15	85581364	Missense_Mutation	novel	G1099V	0.24
STAD	chr15	85581164	Silent	NA	A1032A	0.08
STAD	chr15	85741182	Missense_Mutation	NA	Q2582R	0.29
STAD	chr15	85521519	Missense_Mutation	rs142964345	R42H	0.16
STAD	chr15	85734992	Missense_Mutation	rs780717590	V2428A	0.03
STAD	chr15	85741050	Missense_Mutation	rs777033018	V2538A	0.11
STAD	chr15	85682184	Missense_Mutation	NA	H1710Y	0.17
STAD	chr15	85682164	Missense_Mutation	NA	R1703Q	0.45
STAD	chr15	85719112	Frame_Shift_Del	novel	*L2013Pfs4**	0.12
STAD	chr15	85735624	Frame_Shift_Del	NA	*K2504Rfs50**	0.47
STAD	chr15	85655635	Silent	rs750404650	G1531G	0.15
STAD	chr15	85580795	Silent	NA	T909T	0.13
TGCT	chr15	85533722	Missense_Mutation	novel	A107G	0.12
THCA	chr15	85575245	In_Frame_Ins	novel	S259_D260insYF	0.06
THCA	chr15	85727128	Silent	NA	E2295E	0.11
THCA	chr15	85662430	Intron	NA		0.25
THCA	chr15	85575232	In_Frame_Ins	novel	L255delinsFCLP	0.03
THCA	chr15	85581586	Frame_Shift_Ins	novel	*A1174Ifs6**	0.04
UCEC	chr15	85579742	Silent	novel	E558E	0.32
UCEC	chr15	85580175	Missense_Mutation	novel	P703T	0.22
UCEC	chr15	85533932	Intron	rs762940749		0.56
UCEC	chr15	85744738	3'UTR	novel		0.49
UCEC	chr15	85710596	Silent	NA	L1850L	0.29
UCEC	chr15	85580296	Missense_Mutation	rs769554632	R743Q	0.27
UCEC	chr15	85580548	Missense_Mutation	NA	G827D	0.49
UCEC	chr15	85579320	Missense_Mutation	novel	C418R	0.42
UCEC	chr15	85581391	Missense_Mutation	novel	I1108T	0.06
UCEC	chr15	85719177	Missense_Mutation	novel	V2035I	0.2
UCEC	chr15	85743597	Missense_Mutation	novel	D2722N	0.34
UCEC	chr15	85747865	3'UTR	novel		0.48
UCEC	chr15	85580203	Missense_Mutation	novel	P712Q	0.29
UCEC	chr15	85727454	Nonsense_Mutation	NA	E2360*	0.39
UCEC	chr15	85655779	Silent	novel	N1579N	0.39
UCEC	chr15	85718148	Missense_Mutation	novel	E1997G	0.41
UCEC	chr15	85580970	Missense_Mutation	novel	I968F	0.31
UCEC	chr15	85579178	Silent	NA	R370R	0.13
UCEC	chr15	85735624	Frame_Shift_Del	NA	*K2504Rfs50**	0.24
UCEC	chr15	85715912	Missense_Mutation	novel	Q1908H	0.29
UCEC	chr15	85740240	Missense_Mutation	novel	V2526I	0.43
UCEC	chr15	85521519	Missense_Mutation	rs142964345	R42H	0.18
UCEC	chr15	85710582	Missense_Mutation	rs112971613	P1846S	0.21
UCEC	chr15	85533643	Missense_Mutation	rs146142499	V81M	0.27
UCEC	chr15	85521531	Missense_Mutation	novel	S46I	0.03
UCEC	chr15	85723261	Missense_Mutation	rs767950472	R2229Q	0.25
UCEC	chr15	85740235	Missense_Mutation	NA	S2524I	0.19
UCEC	chr15	85533929	Intron	novel		0.23
UCEC	chr15	85575211	Missense_Mutation	rs756880152	R248Q	0.2
UCEC	chr15	85579245	Frame_Shift_Ins	novel	*T393Rfs19**	0.14
UCEC	chr15	85581613	Missense_Mutation	NA	E1182G	0.26
UCEC	chr15	85693433	Missense_Mutation	NA	D1816Y	0.31
UCEC	chr15	85727117	Missense_Mutation	novel	A2292T	0.09
UCEC	chr15	85740237	Missense_Mutation	rs761515628	V2525I	0.28
UCEC	chr15	85715923	Missense_Mutation	novel	G1912V	0.11
UCEC	chr15	85743757	Missense_Mutation	NA	G2775E	0.27
UCEC	chr15	85581065	Missense_Mutation	novel	K999N	0.18
UCEC	chr15	85723184	Missense_Mutation	novel	E2203D	0.24
UCEC	chr15	85579743	Missense_Mutation	rs74597724	E559K	0.48
UCEC	chr15	85645852	Silent	novel	R1424R	0.61
UCEC	chr15	85708057	Silent	rs752671158	L1835L	0.41
UCEC	chr15	85579285	Missense_Mutation	novel	D406G	0.3
UCEC	chr15	85580923	Missense_Mutation	novel	R952I	0.5
UCEC	chr15	85582030	Missense_Mutation	rs779156339	S1321N	0.3
UCEC	chr15	85579851	Missense_Mutation	novel	D595Y	0.5
UCEC	chr15	85582038	Missense_Mutation	novel	G1324R	0.3
UCEC	chr15	85655560	Silent	rs772184636	Q1506Q	0.32
UCEC	chr15	85655710	Silent	novel	R1556R	0.12
UCEC	chr15	85723166	Missense_Mutation	novel	K2197N	0.43
UCEC	chr15	85723291	Missense_Mutation	novel	F2239C	0.45
UCEC	chr15	85735627	Missense_Mutation	novel	K2503N	0.47
UCEC	chr15	85579233	Missense_Mutation	rs770701124	V389M	0.47
UCEC	chr15	85579442	Silent	novel	Q458Q	0.39
UCEC	chr15	85580223	Missense_Mutation	novel	S719P	0.22
UCEC	chr15	85655638	Silent	rs752578910	D1532D	0.24
UCEC	chr15	85662431	Intron	novel		0.26
UCEC	chr15	85718076	Missense_Mutation	novel	A1973V	0.23
UCEC	chr15	85579450	Missense_Mutation	NA	S461F	0.39
UCEC	chr15	85581020	Silent	rs201078519	P984P	0.28
UCEC	chr15	85723276	Missense_Mutation	rs750905368	R2234H	0.38
UCEC	chr15	85747473	3'UTR	novel		0.13
UCEC	chr15	85747606	3'UTR	rs553031901		0.32
UCEC	chr15	85743798	In_Frame_Del	NA	N2789del	0.26
UCEC	chr15	85582081	Missense_Mutation	NA	P1338H	0.49
UCEC	chr15	85578929	Splice_Site	novel	X288_splice	0.27
UCEC	chr15	85746166	3'UTR	novel		0.26
UCEC	chr15	85746284	3'UTR	novel		0.38
UCEC	chr15	85718065	Frame_Shift_Del	novel	*K1969Nfs31**	0.41
UCEC	chr15	85684843	Missense_Mutation	novel	K1753N	0.09
UCEC	chr15	85579338	Missense_Mutation	novel	E424K	0.33
UCEC	chr15	85718018	Missense_Mutation	novel	D1954Y	0.4
UCEC	chr15	85743631	Missense_Mutation	novel	S2733I	0.49
UCEC	chr15	85727166	Missense_Mutation	NA	P2308L	0.28
UCEC	chr15	85658545	Missense_Mutation	rs181593659	R1585Q	0.45
UCEC	chr15	85719291	Missense_Mutation	novel	L2073I	0.32
UCEC	chr15	85578978	Missense_Mutation	NA	A304T	0.31
UCEC	chr15	85581511	Missense_Mutation	novel	G1148A	0.08
UCEC	chr15	85747888	3'UTR	novel		0.1
UCEC	chr15	85735624	Frame_Shift_Del	NA	*K2504Rfs50**	0.42
UCEC	chr15	85581745	Missense_Mutation	NA	S1226N	0.43
UCEC	chr15	85655441	Missense_Mutation	novel	D1467Y	0.4
UCEC	chr15	85533736	Missense_Mutation	novel	A112T	0.29
UCEC	chr15	85575323	Silent	novel	Q285Q	0.3
UCEC	chr15	85579801	Missense_Mutation	novel	A578V	0.43
UCEC	chr15	85747866	3'UTR	rs188134109		0.21
UCEC	chr15	85580578	Frame_Shift_Del	NA	*T837Sfs4**	0.36
UCEC	chr15	85581901	Missense_Mutation	NA	M1278T	0.36
UCEC	chr15	85533676	Missense_Mutation	rs114690403	V92I	0.22
UCEC	chr15	85579371	Missense_Mutation	rs754487409	D435N	0.26
UCEC	chr15	85580395	Missense_Mutation	novel	D776G	0.26
UCEC	chr15	85727171	Missense_Mutation	novel	M2310V	0.11
UCEC	chr15	85693388	Missense_Mutation	NA	G1801S	0.16
UCEC	chr15	85715887	Missense_Mutation	rs371321602	S1900L	0.24
UCEC	chr15	85533806	Missense_Mutation	novel	K135T	0.28
UCEC	chr15	85578983	Missense_Mutation	novel	Q305H	0.21
UCEC	chr15	85747437	3'UTR	rs528467009		0.5
UCEC	chr15	85579588	Missense_Mutation	novel	R507I	0.44
UCEC	chr15	85580610	Missense_Mutation	novel	S848P	0.38
UCEC	chr15	85581696	Missense_Mutation	novel	A1210S	0.61
UCEC	chr15	85669742	Silent	novel	Q1671Q	0.47
UCEC	chr15	85743673	Missense_Mutation	novel	L2747R	0.28
UCEC	chr15	85380776	5'UTR	novel		0.33
UCEC	chr15	85747640	3'UTR	novel		0.37
UCEC	chr15	85723173	Missense_Mutation	NA	R2200C	0.5
UCEC	chr15	85747761	3'UTR	rs750228184		0.4
UCEC	chr15	85747774	3'UTR	novel		0.47
UCEC	chr15	85579262	Silent	NA	D398D	0.14
UCEC	chr15	85579783	Missense_Mutation	rs779495573	R572Q	0.07
UCEC	chr15	85581519	Nonsense_Mutation	NA	E1151*	0.3
UCEC	chr15	85581949	Missense_Mutation	novel	S1294I	0.1
UCEC	chr15	85684753	Missense_Mutation	rs767513056	E1723D	0.3
UCEC	chr15	85726439	Missense_Mutation	NA	L2259V	0.31
UCEC	chr15	85579770	Missense_Mutation	novel	T568A	0.25
UCEC	chr15	85580406	Missense_Mutation	novel	I780L	0.28
UCEC	chr15	85580970	Missense_Mutation	novel	I968L	0.17
UCEC	chr15	85684790	Missense_Mutation	novel	D1736Y	0.15
UCEC	chr15	85741232	Missense_Mutation	novel	R2599C	0.2
UCEC	chr15	85747955	3'UTR	novel		0.42
UCEC	chr15	85575134	Missense_Mutation	novel	E222D	0.2
UCEC	chr15	85581614	Missense_Mutation	novel	E1182D	0.48
UCEC	chr15	85710592	Missense_Mutation	novel	S1849I	0.27
UCEC	chr15	85575219	Missense_Mutation	novel	D251N	0.5
UCEC	chr15	85580414	Silent	novel	D782D	0.09
UCEC	chr15	85727204	Nonsense_Mutation	rs770562501	R2321*	0.31
UCEC	chr15	85533700	Missense_Mutation	novel	A100T	0.27
UCEC	chr15	85579181	Frame_Shift_Ins	novel	*N373Kfs2**	0.37
UCEC	chr15	85655665	Silent	novel	I1541I	0.42
UCEC	chr15	85533655	Missense_Mutation	novel	A85T	0.34
UCEC	chr15	85543814	Missense_Mutation	NA	L174P	0.44
UCEC	chr15	85693296	Missense_Mutation	novel	D1770V	0.42
UCEC	chr15	85579076	Silent	novel	T336T	0.45
UCEC	chr15	85684824	Missense_Mutation	novel	R1747H	0.19
UCEC	chr15	85655639	Missense_Mutation	rs147374322	V1533M	0.2
UCEC	chr15	85533661	Nonsense_Mutation	NA	E87*	0.38
UCEC	chr15	85580301	Missense_Mutation	rs747774362	D745Y	0.49
UCEC	chr15	85580449	Missense_Mutation	NA	E794A	0.54
UCEC	chr15	85747796	3'UTR	novel		0.47
UCEC	chr15	85579553	Missense_Mutation	novel	K495N	0.3
UCEC	chr15	85719230	Missense_Mutation	NA	F2052L	0.44
UCEC	chr15	85662409	Intron	rs767998379		0.3
UCEC	chr15	85543811	Missense_Mutation	novel	R173L	0.21
UCEC	chr15	85579052	Missense_Mutation	novel	Q328H	0.22
UCEC	chr15	85579252	Missense_Mutation	novel	S395Y	0.17
UCEC	chr15	85579614	Missense_Mutation	novel	A516S	0.45
UCEC	chr15	85580846	Silent	novel	Q926Q	0.22
UCEC	chr15	85581164	Silent	NA	A1032A	0.11
UCEC	chr15	85684860	Missense_Mutation	novel	S1759I	0.15
UCEC	chr15	85717293	Silent	novel	V1913V	0.05
UCEC	chr15	85743561	Missense_Mutation	novel	P2710S	0.26
UCEC	chr15	85708026	Silent	rs542222585	S1824S	0.32
UCEC	chr15	85735097	Missense_Mutation	rs140687997	R2463Q	0.38
UCEC	chr15	85533752	Missense_Mutation	NA	R117H	0.25
UCEC	chr15	85581329	Silent	NA	V1087V	0.36
UCEC	chr15	85669760	Silent	NA	C1677C	0.28
UCEC	chr15	85717387	Missense_Mutation	novel	S1945P	0.09
UCEC	chr15	85735142	Missense_Mutation	NA	A2478D	0.29
UCEC	chr15	85730575	Missense_Mutation	rs779871275	R2384W	0.37
UCEC	chr15	85715887	Missense_Mutation	rs371321602	S1900L	0.44
UCEC	chr15	85723260	Missense_Mutation	rs199748104	R2229W	0.31
UCEC	chr15	85746094	3'UTR	novel		0.39
UCEC	chr15	85747526	3'UTR	novel		0.17
UCEC	chr15	85579054	Missense_Mutation	rs115657055	R329Q	0.3
UCEC	chr15	85715841	Missense_Mutation	rs374094093	A1885T	0.3
UCEC	chr15	85722314	Missense_Mutation	NA	V2155I	0.37
UCS	chr15	85682162	Silent	novel	S1702S	0.18
UCS	chr15	85579304	Silent	rs140888795	T412T	0.49
UCS	chr15	85715840	Silent	novel	T1884T	0.23
UVM	chr15	85581803	Silent	novel	A1245A	0.26
UVM	chr15	85581231	Missense_Mutation	rs753131765	D1055N	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2136	0.0058042
LGG	AMP	0.0214	0.19963
PAAD	AMP	0.0761	0.20695
PAAD	DEL	0.1033	0.13216
SKCM	AMP	0.2534	9.6912e-06

Survival Analysis

Cancer	P-value	Q-value
THYM	0.028	Kaplan-Meier Survival Analysis
KIRC	0.00047	Kaplan-Meier Survival Analysis
MESO	0.017	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
BLCA	0.019	Kaplan-Meier Survival Analysis
LIHC	0.0067	Kaplan-Meier Survival Analysis
DLBC	0.045	Kaplan-Meier Survival Analysis
LGG	0.0053	Kaplan-Meier Survival Analysis
LUAD	0.0084	Kaplan-Meier Survival Analysis
UVM	0.00038	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742