EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000170854 (Gene tree)
Gene ID: 84864
Gene Symbol: RIOX2
Alias: MINA53|FLJ14393|mdig|NO52|JMJD10|MINA
Full Name: ribosomal oxygenase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 30,641 bases
Position: chr3:97,941,817-97,972,457
Accession: 19441
RBP type: non-canonical RBP
Summary: MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000503097	RIOX2-204	591	-	ENSP00000421347	27 (aa)	-	H0Y8K4
ENST00000333396	RIOX2-201	5347	XM_005247838	ENSP00000328251	465 (aa)	XP_005247895	Q8IUF8
ENST00000506682	RIOX2-207	1297	-	-	- (aa)	-	-
ENST00000503517	RIOX2-205	912	-	-	- (aa)	-	-
ENST00000360258	RIOX2-202	2232	-	ENSP00000353395	464 (aa)	-	Q8IUF8
ENST00000514314	RIOX2-209	1225	-	ENSP00000424955	280 (aa)	-	Q8IUF8
ENST00000507612	RIOX2-208	708	-	ENSP00000424530	108 (aa)	-	H0Y9L8
ENST00000394198	RIOX2-203	2341	-	ENSP00000377748	465 (aa)	-	Q8IUF8
ENST00000506099	RIOX2-206	664	-	ENSP00000423816	112 (aa)	-	D6RCB6

Gene Model

Click here to download ENSG00000170854's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000170854	Platelet Function Tests	2.7800000E-006	-
ENSG00000170854	Platelet Function Tests	1.3635900E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000170854's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000170854	RIOX2	94	45.794	WBGene00020902	jmjc-1	54	31.765	Caenorhabditis_elegans

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003714	transcription corepressor activity	-	IEA	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005667	transcription factor complex	-	IEA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0042254	ribosome biogenesis	-	IEA	Process
GO:0042802	identical protein binding	16189514.25416956.	IPI	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0051213	dioxygenase activity	-	IEA	Function
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:1903507	negative regulation of nucleic acid-templated transcription	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18629780	Expression of Mina53 and its significance in gastric carcinoma.	Int J Biol Markers	2008 Apr-Jun	Zhang Q	-
29099276	SETDB2 and RIOX2 are differentially expressed among renal cell tumor subtypes, associating with prognosis and metastization.	Epigenetics	2017	Ferreira MJ	doi: 10.1080/15592294.2017.1385685
19914733	Expression of Mina53, a novel c-Myc target gene, is a favorable prognostic marker in early stage lung cancer.	Lung Cancer	2010 Aug	Komiya K	doi: 10.1016/j.lungcan.2009.10.010
19756735	Mina53, a novel c-Myc target gene, is frequently expressed in lung cancers and exerts oncogenic property in NIH/3T3 cells.	J Cancer Res Clin Oncol	2010 Mar	Komiya K	doi: 10.1007/s00432-009-0679-0
14695334	Increased expression of a Myc target gene Mina53 in human colon cancer.	Am J Pathol	2004 Jan	Teye K	-
24309373	Increased expression of mdig predicts poorer survival of the breast cancer patients.	Gene	2014 Feb 10	Thakur C	doi: 10.1016/j.gene.2013.11.031
24522517	Potential effects of Mina53 on tumor growth in human pancreatic cancer.	Cell Biochem Biophys	2014 Jul	Tan XP	doi: 10.1007/s12013-014-9841-7.
19502796	Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3.	Cell Cycle	2009 Jul 1	Lu Y	-
25851349	Mdig, a lung cancer-associated gene, regulates cell cycle progression through p27(KIP1).	Tumour Biol	2015 Sep	Ma D	doi: 10.1007/s13277-015-3397-z
24505346	Paradoxical roles of mineral dust induced gene on cell proliferation and migration/invasion.	PLoS One	2014 Feb 4	Yu M	doi: 10.1371/journal.pone.0087998
29039479	Mdig suppresses epithelial-mesenchymal transition and inhibits the invasion and metastasis of nonsmall cell lung cancer via regulating GSK-3β/β-catenin signaling.	Int J Oncol	2017 Dec	Geng F	doi: 10.3892/ijo.2017.4154
29750310	Mina53 nuclear localization is an important indicator of prognosis in patients with colorectal cancer after adjuvant chemotherapy.	Oncol Rep	2018 Jul	Fujino S	doi: 10.3892/or.2018.6407

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr3	97945187	Silent	novel	V465V	0.5
BLCA	chr3	97967514	In_Frame_Ins	novel	E25_A26dup	0.25
BLCA	chr3	97967536	Missense_Mutation	novel	K20E	0.41
BLCA	chr3	97942550	3'UTR	novel		0.1
BLCA	chr3	97942552	3'UTR	novel		0.09
BLCA	chr3	97949963	In_Frame_Ins	novel	R313dup	0.42
BLCA	chr3	97949921	Nonsense_Mutation	novel	S328*	0.13
BLCA	chr3	97949876	Missense_Mutation	NA	S343F	0.18
BLCA	chr3	97967182	Missense_Mutation	NA	H138Y	0.41
BLCA	chr3	97945319	Missense_Mutation	novel	L421F	0.34
BLCA	chr3	97945878	Missense_Mutation	novel	Q387E	0.19
BRCA	chr3	97954416	Missense_Mutation	NA	V254A	0.3
BRCA	chr3	97942778	3'UTR	novel		0.29
BRCA	chr3	97942778	3'UTR	novel		0.16
BRCA	chr3	97945189	In_Frame_Del	novel	E459_V464del	0.15
BRCA	chr3	97959101	Missense_Mutation	rs373581249	V211L	0.56
CESC	chr3	97943189	3'UTR	novel		0.65
CESC	chr3	97945116	3'UTR	novel		0.21
CESC	chr3	97952167	Intron	novel		0.39
CESC	chr3	97959093	Silent	rs773244845	A213A	0.14
CESC	chr3	97950862	Missense_Mutation	novel	T271I	0.42
CHOL	chr3	97967528	Missense_Mutation	novel	M22I	0.18
COAD	chr3	97959128	Frame_Shift_Ins	novel	*T202Hfs22**	0.36
COAD	chr3	97945870	Missense_Mutation	NA	K389N	0.27
COAD	chr3	97967507	Frame_Shift_Del	NA	*P30Lfs4**	0.36
COAD	chr3	97945798	Frame_Shift_Del	rs766649364	*E413Vfs20**	0.18
COAD	chr3	97950865	Missense_Mutation	NA	D270G	0.24
COAD	chr3	97942680	3'UTR	novel		0.35
COAD	chr3	97950825	Missense_Mutation	NA	D283E	0.31
COAD	chr3	97942180	3'UTR	novel		0.45
COAD	chr3	97945116	3'UTR	novel		0.09
COAD	chr3	97954417	Missense_Mutation	rs200630521	V254M	0.26
GBM	chr3	97959066	Silent	novel	H222H	0.31
GBM	chr3	97954395	Missense_Mutation	novel	N261S	0.14
GBM	chr3	97967384	Missense_Mutation	novel	D70E	0.21
GBM	chr3	97945266	Missense_Mutation	NA	K439R	0.12
KIRP	chr3	97954430	Silent	novel	A249A	0.12
KIRP	chr3	97954432	Frame_Shift_Del	novel	*A249Pfs6**	0.12
KIRP	chr3	97942465	3'UTR	rs759363790		0.12
LGG	chr3	97949988	Silent	novel	R306R	0.07
LIHC	chr3	97967516	Silent	novel	A26A	0.19
LIHC	chr3	97943132	3'UTR	novel		0.23
LIHC	chr3	97942158	3'UTR	novel		0.4
LUAD	chr3	97967323	Missense_Mutation	NA	S91C	0.32
LUAD	chr3	97959072	Silent	novel	P220P	0.14
LUAD	chr3	97959142	Missense_Mutation	novel	R197P	0.52
LUAD	chr3	97967508	Missense_Mutation	NA	G29V	0.16
LUAD	chr3	97967351	Silent	rs143209673	F81F	0.74
LUAD	chr3	97945276	Missense_Mutation	novel	I436F	0.16
LUSC	chr3	97959090	Silent	NA	E214E	0.58
LUSC	chr3	97945217	Silent	NA	S455S	0.08
LUSC	chr3	97967309	Nonsense_Mutation	novel	Y95*	0.35
LUSC	chr3	97967367	Missense_Mutation	novel	Y76F	0.31
LUSC	chr3	97967405	Frame_Shift_Ins	novel	*L64Sfs25**	0.04
LUSC	chr3	97945269	Missense_Mutation	novel	V438G	0.31
LUSC	chr3	97945884	Missense_Mutation	novel	E385K	0.39
OV	chr3	97949882	Missense_Mutation	rs753392377	P341R	0.24
OV	chr3	97943131	3'UTR	novel		0.15
OV	chr3	97947406	Frame_Shift_Ins	novel	*F368Lfs40**	0.12
OV	chr3	97967169	Missense_Mutation	novel	R142I	0.05
OV	chr3	97950834	Silent	novel	A280A	0.04
PRAD	chr3	97949873	Missense_Mutation	rs149644546	A344V	0.17
PRAD	chr3	97967539	Frame_Shift_Del	novel	*P18Vfs4**	0.06
PRAD	chr3	97945241	Missense_Mutation	novel	E447D	0.3
PRAD	chr3	97959142	Missense_Mutation	rs199876198	R197H	0.41
READ	chr3	97942251	3'UTR	novel		0.21
READ	chr3	97942270	3'UTR	novel		0.06
READ	chr3	97967208	Missense_Mutation	novel	D129G	0.24
SARC	chr3	97949856	Missense_Mutation	novel	L350M	0.11
SKCM	chr3	97954473	Missense_Mutation	novel	P235L	0.46
SKCM	chr3	97967405	Silent	novel	P63P	0.44
SKCM	chr3	97945262	Silent	novel	D440D	0.5
SKCM	chr3	97967270	Silent	NA	G108G	0.36
SKCM	chr3	97945116	3'UTR	novel		0.35
SKCM	chr3	97959071	Missense_Mutation	NA	V221L	0.27
SKCM	chr3	97950806	Missense_Mutation	NA	I290L	0.3
STAD	chr3	97959103	Missense_Mutation	NA	S210N	0.45
STAD	chr3	97945800	Missense_Mutation	novel	E413K	0.36
STAD	chr3	97961693	Missense_Mutation	NA	I150F	0.09
STAD	chr3	97967323	Missense_Mutation	NA	S91G	0.31
STAD	chr3	97967549	Frame_Shift_Del	novel	*P16Rfs7**	0.12
STAD	chr3	97967395	Nonsense_Mutation	NA	Q67*	0.21
STAD	chr3	97961610	Silent	rs761343426	P177P	0.31
STAD	chr3	97967281	Missense_Mutation	NA	C105R	0.13
STAD	chr3	97942209	3'UTR	novel		0.42
STAD	chr3	97959092	Missense_Mutation	rs759544959	E214K	0.29
STAD	chr3	97967304	Missense_Mutation	NA	G97E	0.28
UCEC	chr3	97942576	3'UTR	novel		0.3
UCEC	chr3	97945186	Nonstop_Mutation	NA	466Qext27	0.25
UCEC	chr3	97961627	Missense_Mutation	novel	G172R	0.44
UCEC	chr3	97967220	Missense_Mutation	novel	R125I	0.27
UCEC	chr3	97950825	Silent	rs201634045	D283D	0.34
UCEC	chr3	97967215	Missense_Mutation	NA	D127Y	0.24
UCEC	chr3	97943175	3'UTR	novel		0.18
UCEC	chr3	97945272	Missense_Mutation	novel	S437Y	0.44
UCEC	chr3	97947376	Silent	rs534333594	P378P	0.35
UCEC	chr3	97952170	Intron	novel		0.4
UCEC	chr3	97967585	Missense_Mutation	novel	K3N	0.22
UCEC	chr3	97967600	5'UTR	novel		0.52
UCEC	chr3	97945225	Missense_Mutation	NA	V453I	0.43
UCEC	chr3	97942589	3'UTR	novel		0.2
UCEC	chr3	97945062	3'UTR	novel		0.21
UCEC	chr3	97947446	In_Frame_Ins	novel	G354_G355insE	0.07
UCEC	chr3	97947448	In_Frame_Ins	novel	G354_G355insD	0.05
UCEC	chr3	97967453	Silent	rs748639562	S47S	0.15
UCEC	chr3	97947432	Silent	novel	L360L	0.2
UCEC	chr3	97949882	Frame_Shift_Del	NA	*P341Lfs23**	0.58
UCEC	chr3	97967166	Missense_Mutation	novel	F143C	0.27
UCEC	chr3	97945329	Missense_Mutation	rs139785839	R418H	0.5
UCEC	chr3	97949934	Nonsense_Mutation	rs767181152	E324*	0.25
UCEC	chr3	97945226	Silent	novel	L452L	0.14
UCEC	chr3	97959095	Missense_Mutation	novel	A213T	0.35
UCEC	chr3	97945329	Missense_Mutation	rs139785839	R418H	0.33
UCEC	chr3	97967546	Silent	rs753489865	P16P	0.31
UCEC	chr3	97945008	3'UTR	novel		0.42
UCEC	chr3	97944968	3'UTR	novel		0.31
UCEC	chr3	97945272	Missense_Mutation	novel	S437Y	0.16
UCEC	chr3	97949908	Missense_Mutation	novel	K332N	0.16
UCEC	chr3	97949934	Nonsense_Mutation	rs767181152	E324*	0.31
UCEC	chr3	97949882	Frame_Shift_Del	NA	*P341Lfs23**	0.29
UCEC	chr3	97967192	Silent	rs776111591	T134T	0.38
UCEC	chr3	97959125	Missense_Mutation	novel	V203M	0.39
UCEC	chr3	97961685	Missense_Mutation	novel	E152D	0.2
UCEC	chr3	97942605	3'UTR	novel		0.22
UCEC	chr3	97942606	3'UTR	novel		0.22
UCEC	chr3	97945148	3'UTR	novel		0.38
UCEC	chr3	97950852	Silent	novel	G274G	0.37
UCEC	chr3	97959090	Missense_Mutation	novel	E214D	0.26
UCEC	chr3	97967633	Splice_Site	novel		0.62
UCEC	chr3	97945221	Missense_Mutation	novel	L454S	0.16
UCEC	chr3	97944999	3'UTR	novel		0.29
UCEC	chr3	97945020	3'UTR	rs564490743		0.28
UCEC	chr3	97967248	Missense_Mutation	NA	D116Y	0.28
UCEC	chr3	97942270	3'UTR	novel		0.38
UCEC	chr3	97967382	Missense_Mutation	NA	P71H	0.06
UCEC	chr3	97942589	3'UTR	novel		0.29
UCEC	chr3	97967215	Missense_Mutation	NA	D127Y	0.33
UCEC	chr3	97943111	3'UTR	novel		0.19
UCEC	chr3	97967169	Missense_Mutation	novel	R142K	0.21
UCEC	chr3	97945086	3'UTR	novel		0.08
UCEC	chr3	97967533	Nonsense_Mutation	NA	Q21*	0.3
UCEC	chr3	97945192	Missense_Mutation	novel	V464I	0.1
UCEC	chr3	97942581	3'UTR	novel		0.23
UCEC	chr3	97961623	Missense_Mutation	novel	S173Y	0.33
UCEC	chr3	97967283	Missense_Mutation	rs746870428	R104Q	0.23

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	DEL	0.2708	0.11092
LGG	DEL	0.0624	0.04374
TGCT	AMP	0.14	0.23596

Survival Analysis

Cancer	P-value	Q-value
THYM	0.025	Kaplan-Meier Survival Analysis
KIRC	0.02	Kaplan-Meier Survival Analysis
SARC	0.004	Kaplan-Meier Survival Analysis
HNSC	0.035	Kaplan-Meier Survival Analysis
SKCM	0.045	Kaplan-Meier Survival Analysis
BRCA	0.0012	Kaplan-Meier Survival Analysis
KIRP	0.00023	Kaplan-Meier Survival Analysis
PAAD	0.0031	Kaplan-Meier Survival Analysis
READ	0.00011	Kaplan-Meier Survival Analysis
LAML	0.042	Kaplan-Meier Survival Analysis
UCEC	0.019	Kaplan-Meier Survival Analysis
LIHC	0.0019	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
THCA	0.018	Kaplan-Meier Survival Analysis
UVM	0.0022	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742