EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000170892 (Gene tree)
Gene ID: 79042
Gene Symbol: TSEN34
Alias: SEN34|SEN34L|LENG5
Full Name: tRNA splicing endonuclease subunit 34
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 5,020 bases
Position: chr19:54,189,517-54,194,536
Accession: 15506
RBP type: canonical RBP
Summary: This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Oct 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000305524	tRNA_int_endo	PF01974.17	2.8e-20	1	1
ENSP00000379667	tRNA_int_endo	PF01974.17	2.8e-20	1	1
ENSP00000379671	tRNA_int_endo	PF01974.17	2.8e-20	1	1
ENSP00000397402	tRNA_int_endo	PF01974.17	3.8e-19	1	1
ENSP00000408689	tRNA_int_endo	PF01974.17	1.5e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000496583	TSEN34-207	2372	-	-	- (aa)	-	-
ENST00000456872	TSEN34-206	853	XM_005278290	ENSP00000408689	251 (aa)	XP_005278347	A9C4B9
ENST00000429671	TSEN34-204	1912	-	ENSP00000397402	315 (aa)	-	E7EQB3
ENST00000455798	TSEN34-205	956	-	ENSP00000400743	242 (aa)	-	B0V3J0
ENST00000396388	TSEN34-203	1349	XM_011527294	ENSP00000379671	310 (aa)	XP_011525596	Q9BSV6
ENST00000302937	TSEN34-201	2294	-	ENSP00000305524	310 (aa)	-	Q9BSV6
ENST00000396383	TSEN34-202	1548	-	ENSP00000379667	310 (aa)	-	Q9BSV6

Gene Model

Click here to download ENSG00000170892's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000170892	Body Height	3E-8	23251661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000170892	rs7595	19	54193224	G	Obesity-related traits	23251661	[NR] cm/y increase	0.05	EFO_0004339

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000170892's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000170892	TSEN34	98	34.008	ENSAPOG00000008579	-	93	37.671	Acanthochromis_polyacanthus
ENSG00000170892	TSEN34	98	31.984	ENSAPOG00000012557	-	86	35.959	Acanthochromis_polyacanthus
ENSG00000170892	TSEN34	99	38.636	ENSAPOG00000001248	tsen34	93	38.636	Acanthochromis_polyacanthus
ENSG00000170892	TSEN34	95	89.520	ENSAMEG00000004585	TSEN34	100	90.493	Ailuropoda_melanoleuca
ENSG00000170892	TSEN34	99	39.623	ENSACIG00000007110	tsen34	87	39.623	Amphilophus_citrinellus
ENSG00000170892	TSEN34	99	40.909	ENSAOCG00000006905	tsen34	93	40.909	Amphiprion_ocellaris
ENSG00000170892	TSEN34	99	40.909	ENSAPEG00000019171	tsen34	93	41.234	Amphiprion_percula
ENSG00000170892	TSEN34	99	36.977	ENSATEG00000019800	tsen34	97	35.759	Anabas_testudineus
ENSG00000170892	TSEN34	100	44.728	ENSACAG00000016189	TSEN34	100	45.367	Anolis_carolinensis
ENSG00000170892	TSEN34	100	97.419	ENSANAG00000026113	TSEN34	100	97.419	Aotus_nancymaae
ENSG00000170892	TSEN34	99	38.585	ENSACLG00000009661	tsen34	91	38.141	Astatotilapia_calliptera
ENSG00000170892	TSEN34	99	39.355	ENSAMXG00000017568	tsen34	86	39.355	Astyanax_mexicanus
ENSG00000170892	TSEN34	100	90.997	ENSBTAG00000006486	TSEN34	100	90.997	Bos_taurus
ENSG00000170892	TSEN34	100	97.107	ENSCJAG00000001128	TSEN34	100	95.873	Callithrix_jacchus
ENSG00000170892	TSEN34	100	90.385	ENSCAFG00000002675	TSEN34	100	90.385	Canis_familiaris
ENSG00000170892	TSEN34	100	90.968	ENSCAFG00020018350	TSEN34	100	90.968	Canis_lupus_dingo
ENSG00000170892	TSEN34	100	86.774	ENSCHIG00000020705	TSEN34	100	86.774	Capra_hircus
ENSG00000170892	TSEN34	100	91.736	ENSTSYG00000028200	TSEN34	99	90.705	Carlito_syrichta
ENSG00000170892	TSEN34	65	80.296	ENSCAPG00000012811	-	99	80.296	Cavia_aperea
ENSG00000170892	TSEN34	99	83.923	ENSCPOG00000012672	TSEN34	99	83.923	Cavia_porcellus
ENSG00000170892	TSEN34	100	96.452	ENSCCAG00000036023	TSEN34	100	96.452	Cebus_capucinus
ENSG00000170892	TSEN34	100	96.414	ENSCATG00000033390	TSEN34	100	96.190	Cercocebus_atys
ENSG00000170892	TSEN34	100	86.129	ENSCLAG00000000618	TSEN34	100	86.129	Chinchilla_lanigera
ENSG00000170892	TSEN34	100	97.419	ENSCSAG00000001891	TSEN34	100	97.419	Chlorocebus_sabaeus
ENSG00000170892	TSEN34	100	97.742	ENSCANG00000040984	TSEN34	100	97.742	Colobus_angolensis_palliatus
ENSG00000170892	TSEN34	100	87.937	ENSCGRG00001006296	Tsen34	100	87.937	Cricetulus_griseus_chok1gshd
ENSG00000170892	TSEN34	72	80.591	ENSCGRG00000008494	Tsen34	100	81.857	Cricetulus_griseus_crigri
ENSG00000170892	TSEN34	96	41.000	ENSCSEG00000006278	tsen34	86	41.000	Cynoglossus_semilaevis
ENSG00000170892	TSEN34	99	38.924	ENSDARG00000061370	tsen34	89	39.172	Danio_rerio
ENSG00000170892	TSEN34	100	88.387	ENSDNOG00000039332	TSEN34	100	88.387	Dasypus_novemcinctus
ENSG00000170892	TSEN34	100	87.419	ENSDORG00000029071	Tsen34	100	87.419	Dipodomys_ordii
ENSG00000170892	TSEN34	100	90.000	ENSEASG00005021580	TSEN34	100	90.000	Equus_asinus_asinus
ENSG00000170892	TSEN34	100	90.323	ENSECAG00000019651	TSEN34	86	90.323	Equus_caballus
ENSG00000170892	TSEN34	67	83.234	ENSEEUG00000005692	TSEN34	66	84.946	Erinaceus_europaeus
ENSG00000170892	TSEN34	99	38.608	ENSELUG00000006262	tsen34	92	38.608	Esox_lucius
ENSG00000170892	TSEN34	100	90.645	ENSFCAG00000014045	TSEN34	100	90.645	Felis_catus
ENSG00000170892	TSEN34	84	83.908	ENSFDAG00000017995	TSEN34	100	83.908	Fukomys_damarensis
ENSG00000170892	TSEN34	99	39.610	ENSGAFG00000016880	tsen34	93	39.610	Gambusia_affinis
ENSG00000170892	TSEN34	99	38.291	ENSGACG00000004800	tsen34	99	38.291	Gasterosteus_aculeatus
ENSG00000170892	TSEN34	100	46.519	ENSGAGG00000008982	TSEN34	73	46.519	Gopherus_agassizii
ENSG00000170892	TSEN34	100	100.000	ENSGGOG00000008197	TSEN34	100	100.000	Gorilla_gorilla
ENSG00000170892	TSEN34	100	87.580	ENSHGLG00000017619	TSEN34	100	87.580	Heterocephalus_glaber_female
ENSG00000170892	TSEN34	100	68.471	ENSHGLG00100008719	TSEN34	100	68.634	Heterocephalus_glaber_male
ENSG00000170892	TSEN34	96	39.869	ENSHCOG00000001368	tsen34	92	39.869	Hippocampus_comes
ENSG00000170892	TSEN34	96	37.143	ENSIPUG00000008359	tsen34	85	37.143	Ictalurus_punctatus
ENSG00000170892	TSEN34	100	87.097	ENSSTOG00000023816	TSEN34	100	87.097	Ictidomys_tridecemlineatus
ENSG00000170892	TSEN34	100	88.217	ENSJJAG00000016301	Tsen34	100	88.217	Jaculus_jaculus
ENSG00000170892	TSEN34	99	38.994	ENSKMAG00000007181	tsen34	82	40.968	Kryptolebias_marmoratus
ENSG00000170892	TSEN34	99	39.423	ENSLBEG00000015001	tsen34	94	39.423	Labrus_bergylta
ENSG00000170892	TSEN34	75	43.277	ENSLACG00000013346	-	100	43.277	Latimeria_chalumnae
ENSG00000170892	TSEN34	99	40.260	ENSLOCG00000001887	tsen34	97	40.260	Lepisosteus_oculatus
ENSG00000170892	TSEN34	100	87.975	ENSLAFG00000015215	TSEN34	100	87.975	Loxodonta_africana
ENSG00000170892	TSEN34	100	97.742	ENSMFAG00000044825	TSEN34	100	97.742	Macaca_fascicularis
ENSG00000170892	TSEN34	100	97.742	ENSMMUG00000016571	TSEN34	100	97.742	Macaca_mulatta
ENSG00000170892	TSEN34	100	97.742	ENSMNEG00000045457	TSEN34	100	97.742	Macaca_nemestrina
ENSG00000170892	TSEN34	100	81.905	ENSMLEG00000034295	TSEN34	100	81.905	Mandrillus_leucophaeus
ENSG00000170892	TSEN34	99	39.623	ENSMAMG00000018407	tsen34	95	38.217	Mastacembelus_armatus
ENSG00000170892	TSEN34	100	84.898	ENSMAUG00000019716	Tsen34	81	84.980	Mesocricetus_auratus
ENSG00000170892	TSEN34	100	94.516	ENSMICG00000002409	TSEN34	100	94.516	Microcebus_murinus
ENSG00000170892	TSEN34	100	86.792	ENSMOCG00000022190	Tsen34	100	87.736	Microtus_ochrogaster
ENSG00000170892	TSEN34	99	38.835	ENSMMOG00000009551	tsen34	99	38.835	Mola_mola
ENSG00000170892	TSEN34	99	58.387	ENSMODG00000003984	-	76	59.677	Monodelphis_domestica
ENSG00000170892	TSEN34	99	38.141	ENSMALG00000018918	tsen34	94	38.141	Monopterus_albus
ENSG00000170892	TSEN34	100	88.462	MGP_CAROLIEiJ_G0029099	Tsen34	100	88.462	Mus_caroli
ENSG00000170892	TSEN34	100	88.462	ENSMUSG00000035585	Tsen34	100	88.462	Mus_musculus
ENSG00000170892	TSEN34	100	88.498	MGP_PahariEiJ_G0020968	Tsen34	100	88.498	Mus_pahari
ENSG00000170892	TSEN34	100	88.462	MGP_SPRETEiJ_G0030152	Tsen34	100	88.462	Mus_spretus
ENSG00000170892	TSEN34	100	90.323	ENSMPUG00000010373	TSEN34	100	90.323	Mustela_putorius_furo
ENSG00000170892	TSEN34	100	89.744	ENSMLUG00000016894	TSEN34	100	89.744	Myotis_lucifugus
ENSG00000170892	TSEN34	100	88.477	ENSNGAG00000016187	Tsen34	97	84.151	Nannospalax_galili
ENSG00000170892	TSEN34	100	97.419	ENSNLEG00000006309	TSEN34	100	97.419	Nomascus_leucogenys
ENSG00000170892	TSEN34	99	61.812	ENSMEUG00000002978	TSEN34	99	61.812	Notamacropus_eugenii
ENSG00000170892	TSEN34	100	78.302	ENSODEG00000000096	TSEN34	100	78.616	Octodon_degus
ENSG00000170892	TSEN34	99	38.730	ENSONIG00000017253	tsen34	98	39.365	Oreochromis_niloticus
ENSG00000170892	TSEN34	74	53.947	ENSOANG00000014747	-	96	53.947	Ornithorhynchus_anatinus
ENSG00000170892	TSEN34	99	39.355	ENSORLG00015012740	tsen34	94	39.355	Oryzias_latipes_hsok
ENSG00000170892	TSEN34	100	92.581	ENSOGAG00000006966	TSEN34	100	92.581	Otolemur_garnettii
ENSG00000170892	TSEN34	91	85.106	ENSOARG00000002763	TSEN34	95	85.106	Ovis_aries
ENSG00000170892	TSEN34	100	99.677	ENSPPAG00000036935	TSEN34	100	99.677	Pan_paniscus
ENSG00000170892	TSEN34	100	90.968	ENSPPRG00000011779	TSEN34	100	90.968	Panthera_pardus
ENSG00000170892	TSEN34	100	100.000	ENSPTRG00000011448	TSEN34	100	100.000	Pan_troglodytes
ENSG00000170892	TSEN34	100	100.000	ENSPTRG00000044768	-	100	100.000	Pan_troglodytes
ENSG00000170892	TSEN34	100	98.065	ENSPANG00000012101	TSEN34	100	98.065	Papio_anubis
ENSG00000170892	TSEN34	96	39.404	ENSPKIG00000014674	tsen34	90	39.404	Paramormyrops_kingsleyae
ENSG00000170892	TSEN34	100	89.711	ENSPEMG00000014535	Tsen34	100	89.711	Peromyscus_maniculatus_bairdii
ENSG00000170892	TSEN34	99	40.260	ENSPFOG00000008679	tsen34	93	39.423	Poecilia_formosa
ENSG00000170892	TSEN34	99	39.482	ENSPLAG00000017309	tsen34	93	39.935	Poecilia_latipinna
ENSG00000170892	TSEN34	99	40.260	ENSPMEG00000005235	tsen34	93	39.423	Poecilia_mexicana
ENSG00000170892	TSEN34	99	40.129	ENSPREG00000021784	tsen34	93	40.129	Poecilia_reticulata
ENSG00000170892	TSEN34	100	98.760	ENSPPYG00000010376	TSEN34	96	98.710	Pongo_abelii
ENSG00000170892	TSEN34	99	89.968	ENSPCAG00000012359	TSEN34	100	89.968	Procavia_capensis
ENSG00000170892	TSEN34	100	94.839	ENSPCOG00000013843	TSEN34	100	94.839	Propithecus_coquereli
ENSG00000170892	TSEN34	100	87.742	ENSPVAG00000015570	TSEN34	100	87.742	Pteropus_vampyrus
ENSG00000170892	TSEN34	93	37.884	ENSPNYG00000024090	tsen34	72	39.048	Pundamilia_nyererei
ENSG00000170892	TSEN34	99	35.759	ENSPNAG00000028698	tsen34	86	35.759	Pygocentrus_nattereri
ENSG00000170892	TSEN34	100	89.103	ENSRNOG00000059572	Tsen34l1	100	89.103	Rattus_norvegicus
ENSG00000170892	TSEN34	100	89.103	ENSRNOG00000055179	Tsen34	100	89.103	Rattus_norvegicus
ENSG00000170892	TSEN34	100	97.742	ENSRBIG00000034430	TSEN34	100	97.742	Rhinopithecus_bieti
ENSG00000170892	TSEN34	100	97.742	ENSRROG00000024217	TSEN34	100	97.742	Rhinopithecus_roxellana
ENSG00000170892	TSEN34	100	96.281	ENSSBOG00000016017	TSEN34	99	96.154	Saimiri_boliviensis_boliviensis
ENSG00000170892	TSEN34	70	59.259	ENSSHAG00000009295	-	99	60.092	Sarcophilus_harrisii
ENSG00000170892	TSEN34	96	39.535	ENSSMAG00000005214	tsen34	93	39.535	Scophthalmus_maximus
ENSG00000170892	TSEN34	99	39.677	ENSSDUG00000005391	tsen34	91	39.355	Seriola_dumerili
ENSG00000170892	TSEN34	99	40.000	ENSSLDG00000006144	tsen34	88	39.677	Seriola_lalandi_dorsalis
ENSG00000170892	TSEN34	100	85.185	ENSSARG00000005857	TSEN34	83	78.135	Sorex_araneus
ENSG00000170892	TSEN34	100	40.810	ENSSPUG00000008447	TSEN34	100	40.810	Sphenodon_punctatus
ENSG00000170892	TSEN34	99	39.935	ENSSPAG00000010512	tsen34	92	39.610	Stegastes_partitus
ENSG00000170892	TSEN34	100	89.068	ENSSSCG00000003268	TSEN34	100	89.389	Sus_scrofa
ENSG00000170892	TSEN34	87	37.269	ENSTRUG00000000787	tsen34	81	37.269	Takifugu_rubripes
ENSG00000170892	TSEN34	99	40.446	ENSTNIG00000011201	tsen34	99	39.688	Tetraodon_nigroviridis
ENSG00000170892	TSEN34	99	38.854	ENSTNIG00000001937	-	99	39.628	Tetraodon_nigroviridis
ENSG00000170892	TSEN34	100	91.935	ENSTTRG00000006571	TSEN34	100	91.935	Tursiops_truncatus
ENSG00000170892	TSEN34	100	91.935	ENSUAMG00000008701	TSEN34	100	91.935	Ursus_americanus
ENSG00000170892	TSEN34	100	90.968	ENSVVUG00000008211	TSEN34	100	90.968	Vulpes_vulpes
ENSG00000170892	TSEN34	100	44.551	ENSXETG00000004597	tsen34	100	44.551	Xenopus_tropicalis
ENSG00000170892	TSEN34	99	40.260	ENSXMAG00000024266	tsen34	93	40.260	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000213	tRNA-intron endonuclease activity	21873635.	IBA	Function
GO:0000214	tRNA-intron endonuclease complex	-	IEA	Component
GO:0000379	tRNA-type intron splice site recognition and cleavage	21873635.	IBA	Process
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	-	TAS	Process
GO:0006397	mRNA processing	-	IEA	Process
GO:0016829	lyase activity	-	IEA	Function
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process