EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000171103 (Gene tree)
Gene ID: 55006
Gene Symbol: TRMT61B
Alias: FLJ20628
Full Name: tRNA methyltransferase 61B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 20,489 bases
Position: chr2:28,849,821-28,870,309
Accession: 26070
RBP type: canonical RBP
Summary: (TRNA Methyltransferase 61B) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include protein-L-isoaspartate (D-aspartate) O-methyltransferase activity and tRNA (adenine-N1-)-methyltransferase activity. An important paralog of this gene is TRMT61A.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000302801	GCD14	PF08704.10	3.6e-19	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000490390	TRMT61B-205	573	-	-	- (aa)	-	-
ENST00000484060	TRMT61B-204	351	-	-	- (aa)	-	-
ENST00000419999	TRMT61B-202	685	-	ENSP00000405467	102 (aa)	-	H7C2E8
ENST00000306108	TRMT61B-201	1836	XM_005264393	ENSP00000302801	477 (aa)	XP_005264450	Q9BVS5
ENST00000439947	TRMT61B-203	1584	-	ENSP00000389617	366 (aa)	-	F8WDR2

Gene Model

Click here to download ENSG00000171103's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000171103	Platelet Function Tests	1.5386100E-005	-
ENSG00000171103	Platelet Function Tests	1.0600000E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000171103	rs147972440	2	28859270	G	Intraocular pressure	29617998	[0.069-0.149] unit decrease	0.109	EFO_0004695
ENSG00000171103	rs11690571	2	28852165	?	Red blood cell count	30595370			EFO_0004305
ENSG00000171103	rs10179580	2	28865472	?	Lung function (FEV1/FVC)	30595370			EFO_0004713

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000171103's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000171103	TRMT61B	93	41.053	ENSAPOG00000016887	trmt61b	63	47.962	Acanthochromis_polyacanthus
ENSG00000171103	TRMT61B	96	78.505	ENSAMEG00000005148	TRMT61B	100	74.739	Ailuropoda_melanoleuca
ENSG00000171103	TRMT61B	86	32.955	ENSACIG00000010860	trmt61b	71	45.245	Amphilophus_citrinellus
ENSG00000171103	TRMT61B	93	40.777	ENSAOCG00000006797	trmt61b	64	48.125	Amphiprion_ocellaris
ENSG00000171103	TRMT61B	93	41.748	ENSAPEG00000000518	trmt61b	64	48.012	Amphiprion_percula
ENSG00000171103	TRMT61B	93	41.837	ENSATEG00000010826	trmt61b	65	49.530	Anabas_testudineus
ENSG00000171103	TRMT61B	96	45.192	ENSACAG00000009345	TRMT61B	79	54.790	Anolis_carolinensis
ENSG00000171103	TRMT61B	100	88.703	ENSANAG00000019659	TRMT61B	100	88.703	Aotus_nancymaae
ENSG00000171103	TRMT61B	93	41.053	ENSACLG00000025694	trmt61b	76	43.351	Astatotilapia_calliptera
ENSG00000171103	TRMT61B	94	40.206	ENSAMXG00000030108	trmt61b	73	47.230	Astyanax_mexicanus
ENSG00000171103	TRMT61B	99	87.129	ENSBTAG00000053233	TRMT61B	100	73.237	Bos_taurus
ENSG00000171103	TRMT61B	100	86.583	ENSCJAG00000008980	TRMT61B	100	86.583	Callithrix_jacchus
ENSG00000171103	TRMT61B	84	66.346	ENSCAFG00000031908	-	92	64.412	Canis_familiaris
ENSG00000171103	TRMT61B	97	79.630	ENSCAFG00020024044	TRMT61B	99	70.455	Canis_lupus_dingo
ENSG00000171103	TRMT61B	99	85.149	ENSCHIG00000009342	TRMT61B	100	72.199	Capra_hircus
ENSG00000171103	TRMT61B	97	76.852	ENSTSYG00000006508	TRMT61B	99	76.190	Carlito_syrichta
ENSG00000171103	TRMT61B	96	71.460	ENSCPOG00000010849	TRMT61B	100	70.208	Cavia_porcellus
ENSG00000171103	TRMT61B	100	87.631	ENSCCAG00000022634	TRMT61B	100	87.631	Cebus_capucinus
ENSG00000171103	TRMT61B	100	89.518	ENSCATG00000035064	TRMT61B	99	89.518	Cercocebus_atys
ENSG00000171103	TRMT61B	99	72.072	ENSCLAG00000010411	TRMT61B	97	72.163	Chinchilla_lanigera
ENSG00000171103	TRMT61B	100	89.308	ENSCSAG00000010655	TRMT61B	99	89.308	Chlorocebus_sabaeus
ENSG00000171103	TRMT61B	95	47.321	ENSCPBG00000000332	TRMT61B	86	50.210	Chrysemys_picta_bellii
ENSG00000171103	TRMT61B	99	84.842	ENSCANG00000035833	TRMT61B	100	84.842	Colobus_angolensis_palliatus
ENSG00000171103	TRMT61B	93	42.857	ENSCSEG00000016389	trmt61b	65	47.385	Cynoglossus_semilaevis
ENSG00000171103	TRMT61B	93	43.158	ENSCVAG00000016488	trmt61b	66	46.082	Cyprinodon_variegatus
ENSG00000171103	TRMT61B	94	41.000	ENSDARG00000097465	trmt61b	70	45.399	Danio_rerio
ENSG00000171103	TRMT61B	90	60.121	ENSETEG00000004852	-	77	65.854	Echinops_telfairi
ENSG00000171103	TRMT61B	99	80.000	ENSEASG00005009055	TRMT61B	100	77.178	Equus_asinus_asinus
ENSG00000171103	TRMT61B	99	80.000	ENSECAG00000013254	TRMT61B	100	76.971	Equus_caballus
ENSG00000171103	TRMT61B	85	55.208	ENSEEUG00000006010	-	79	71.304	Erinaceus_europaeus
ENSG00000171103	TRMT61B	97	44.554	ENSELUG00000019782	trmt61b	60	49.096	Esox_lucius
ENSG00000171103	TRMT61B	99	77.273	ENSFCAG00000015265	TRMT61B	83	69.087	Felis_catus
ENSG00000171103	TRMT61B	99	33.663	ENSFALG00000011196	TRMT61B	100	50.610	Ficedula_albicollis
ENSG00000171103	TRMT61B	99	73.394	ENSFDAG00000007330	TRMT61B	100	69.854	Fukomys_damarensis
ENSG00000171103	TRMT61B	93	40.000	ENSFHEG00000021881	trmt61b	69	45.190	Fundulus_heteroclitus
ENSG00000171103	TRMT61B	93	50.000	ENSGMOG00000001720	trmt61b	92	48.607	Gadus_morhua
ENSG00000171103	TRMT61B	99	47.009	ENSGALG00000008979	TRMT61B	94	49.389	Gallus_gallus
ENSG00000171103	TRMT61B	86	35.227	ENSGAFG00000019524	trmt61b	79	41.067	Gambusia_affinis
ENSG00000171103	TRMT61B	93	44.792	ENSGACG00000012868	trmt61b	69	46.809	Gasterosteus_aculeatus
ENSG00000171103	TRMT61B	100	98.952	ENSGGOG00000015954	TRMT61B	100	98.952	Gorilla_gorilla
ENSG00000171103	TRMT61B	93	40.000	ENSHBUG00000011573	trmt61b	76	42.819	Haplochromis_burtoni
ENSG00000171103	TRMT61B	99	72.727	ENSHGLG00000006295	TRMT61B	100	71.369	Heterocephalus_glaber_female
ENSG00000171103	TRMT61B	99	72.727	ENSHGLG00100017996	TRMT61B	100	71.369	Heterocephalus_glaber_male
ENSG00000171103	TRMT61B	93	43.299	ENSHCOG00000008607	trmt61b	62	47.812	Hippocampus_comes
ENSG00000171103	TRMT61B	94	42.857	ENSIPUG00000015532	trmt61b	67	46.201	Ictalurus_punctatus
ENSG00000171103	TRMT61B	99	77.273	ENSSTOG00000014681	TRMT61B	91	72.961	Ictidomys_tridecemlineatus
ENSG00000171103	TRMT61B	93	43.434	ENSKMAG00000009359	trmt61b	75	43.915	Kryptolebias_marmoratus
ENSG00000171103	TRMT61B	93	39.048	ENSLBEG00000022838	trmt61b	63	47.352	Labrus_bergylta
ENSG00000171103	TRMT61B	96	44.898	ENSLACG00000012303	TRMT61B	90	50.275	Latimeria_chalumnae
ENSG00000171103	TRMT61B	99	70.909	ENSLAFG00000005454	TRMT61B	100	69.180	Loxodonta_africana
ENSG00000171103	TRMT61B	99	89.873	ENSMFAG00000039558	TRMT61B	99	89.873	Macaca_fascicularis
ENSG00000171103	TRMT61B	100	89.727	ENSMMUG00000020563	TRMT61B	99	89.727	Macaca_mulatta
ENSG00000171103	TRMT61B	100	89.308	ENSMNEG00000022511	TRMT61B	99	89.308	Macaca_nemestrina
ENSG00000171103	TRMT61B	99	85.294	ENSMLEG00000037602	TRMT61B	100	85.294	Mandrillus_leucophaeus
ENSG00000171103	TRMT61B	93	40.206	ENSMAMG00000014144	trmt61b	69	45.821	Mastacembelus_armatus
ENSG00000171103	TRMT61B	93	41.053	ENSMZEG00005009108	trmt61b	68	43.351	Maylandia_zebra
ENSG00000171103	TRMT61B	99	44.144	ENSMGAG00000005245	TRMT61B	99	56.047	Meleagris_gallopavo
ENSG00000171103	TRMT61B	99	77.273	ENSMICG00000014265	TRMT61B	100	77.386	Microcebus_murinus
ENSG00000171103	TRMT61B	86	37.363	ENSMMOG00000004795	trmt61b	73	40.705	Mola_mola
ENSG00000171103	TRMT61B	97	54.955	ENSMODG00000028065	-	69	60.623	Monodelphis_domestica
ENSG00000171103	TRMT61B	93	38.384	ENSMALG00000014229	trmt61b	99	45.875	Monopterus_albus
ENSG00000171103	TRMT61B	99	78.182	ENSMPUG00000017986	TRMT61B	92	73.859	Mustela_putorius_furo
ENSG00000171103	TRMT61B	99	78.182	ENSMLUG00000001636	TRMT61B	99	73.029	Myotis_lucifugus
ENSG00000171103	TRMT61B	93	40.000	ENSNBRG00000011097	trmt61b	77	43.194	Neolamprologus_brichardi
ENSG00000171103	TRMT61B	100	95.807	ENSNLEG00000015352	TRMT61B	100	95.807	Nomascus_leucogenys
ENSG00000171103	TRMT61B	96	51.818	ENSOANG00000014466	-	85	56.911	Ornithorhynchus_anatinus
ENSG00000171103	TRMT61B	93	41.053	ENSORLG00000029149	trmt61b	64	47.649	Oryzias_latipes
ENSG00000171103	TRMT61B	93	41.053	ENSORLG00020008199	trmt61b	65	47.335	Oryzias_latipes_hni
ENSG00000171103	TRMT61B	93	40.625	ENSORLG00015005289	trmt61b	64	47.649	Oryzias_latipes_hsok
ENSG00000171103	TRMT61B	95	40.206	ENSOMEG00000009895	trmt61b	67	46.626	Oryzias_melastigma
ENSG00000171103	TRMT61B	99	79.091	ENSOARG00000019561	TRMT61B	100	73.859	Ovis_aries
ENSG00000171103	TRMT61B	100	99.371	ENSPPAG00000037752	TRMT61B	100	99.371	Pan_paniscus
ENSG00000171103	TRMT61B	99	76.364	ENSPPRG00000001882	TRMT61B	100	76.141	Panthera_pardus
ENSG00000171103	TRMT61B	99	77.273	ENSPTIG00000007509	TRMT61B	99	78.308	Panthera_tigris_altaica
ENSG00000171103	TRMT61B	100	98.952	ENSPTRG00000011790	TRMT61B	100	98.952	Pan_troglodytes
ENSG00000171103	TRMT61B	100	89.099	ENSPANG00000018844	TRMT61B	94	89.099	Papio_anubis
ENSG00000171103	TRMT61B	97	43.689	ENSPKIG00000022965	trmt61b	75	45.780	Paramormyrops_kingsleyae
ENSG00000171103	TRMT61B	95	48.305	ENSPSIG00000014436	TRMT61B	87	49.153	Pelodiscus_sinensis
ENSG00000171103	TRMT61B	93	30.935	ENSPMGG00000001190	trmt61b	68	40.209	Periophthalmus_magnuspinnatus
ENSG00000171103	TRMT61B	97	56.881	ENSPCIG00000011955	-	71	60.845	Phascolarctos_cinereus
ENSG00000171103	TRMT61B	93	40.000	ENSPFOG00000011353	trmt61b	95	43.750	Poecilia_formosa
ENSG00000171103	TRMT61B	93	40.000	ENSPLAG00000002048	trmt61b	74	43.603	Poecilia_latipinna
ENSG00000171103	TRMT61B	93	40.000	ENSPMEG00000020923	trmt61b	78	44.010	Poecilia_mexicana
ENSG00000171103	TRMT61B	94	40.625	ENSPREG00000004948	trmt61b	78	43.896	Poecilia_reticulata
ENSG00000171103	TRMT61B	99	97.895	ENSPPYG00000012527	TRMT61B	100	97.895	Pongo_abelii
ENSG00000171103	TRMT61B	100	78.216	ENSPCOG00000008800	TRMT61B	100	78.216	Propithecus_coquereli
ENSG00000171103	TRMT61B	99	78.182	ENSPVAG00000013849	TRMT61B	100	75.311	Pteropus_vampyrus
ENSG00000171103	TRMT61B	93	40.000	ENSPNYG00000023092	trmt61b	76	43.536	Pundamilia_nyererei
ENSG00000171103	TRMT61B	94	43.564	ENSPNAG00000023646	trmt61b	67	46.319	Pygocentrus_nattereri
ENSG00000171103	TRMT61B	100	90.985	ENSRBIG00000033023	TRMT61B	99	90.985	Rhinopithecus_bieti
ENSG00000171103	TRMT61B	100	90.985	ENSRROG00000040460	TRMT61B	99	90.985	Rhinopithecus_roxellana
ENSG00000171103	TRMT61B	99	88.119	ENSSBOG00000017235	TRMT61B	100	87.212	Saimiri_boliviensis_boliviensis
ENSG00000171103	TRMT61B	97	39.394	ENSSHAG00000009550	-	92	52.762	Sarcophilus_harrisii
ENSG00000171103	TRMT61B	97	43.396	ENSSFOG00015007203	trmt61b	74	47.429	Scleropages_formosus
ENSG00000171103	TRMT61B	93	42.574	ENSSMAG00000015317	trmt61b	63	49.062	Scophthalmus_maximus
ENSG00000171103	TRMT61B	93	40.385	ENSSDUG00000018591	trmt61b	63	47.188	Seriola_dumerili
ENSG00000171103	TRMT61B	93	41.748	ENSSLDG00000015650	trmt61b	65	46.875	Seriola_lalandi_dorsalis
ENSG00000171103	TRMT61B	99	70.093	ENSSARG00000000247	-	90	72.561	Sorex_araneus
ENSG00000171103	TRMT61B	96	46.429	ENSSPUG00000006215	TRMT61B	99	48.622	Sphenodon_punctatus
ENSG00000171103	TRMT61B	86	37.634	ENSSPAG00000002810	trmt61b	63	45.659	Stegastes_partitus
ENSG00000171103	TRMT61B	99	77.273	ENSSSCG00000030147	TRMT61B	96	74.274	Sus_scrofa
ENSG00000171103	TRMT61B	99	32.673	ENSTGUG00000005482	TRMT61B	99	51.976	Taeniopygia_guttata
ENSG00000171103	TRMT61B	93	44.792	ENSTRUG00000022649	trmt61b	79	44.357	Takifugu_rubripes
ENSG00000171103	TRMT61B	74	45.018	ENSTNIG00000008906	trmt61b	67	44.444	Tetraodon_nigroviridis
ENSG00000171103	TRMT61B	99	79.091	ENSTTRG00000008261	TRMT61B	99	77.474	Tursiops_truncatus
ENSG00000171103	TRMT61B	92	70.920	ENSUAMG00000015502	TRMT61B	97	69.806	Ursus_americanus
ENSG00000171103	TRMT61B	96	78.505	ENSUMAG00000020093	TRMT61B	100	75.992	Ursus_maritimus
ENSG00000171103	TRMT61B	99	78.182	ENSVPAG00000001631	TRMT61B	100	74.481	Vicugna_pacos
ENSG00000171103	TRMT61B	97	79.630	ENSVVUG00000002885	TRMT61B	83	71.310	Vulpes_vulpes
ENSG00000171103	TRMT61B	86	36.364	ENSXCOG00000011241	trmt61b	77	41.270	Xiphophorus_couchianus
ENSG00000171103	TRMT61B	93	42.105	ENSXMAG00000018398	trmt61b	78	42.487	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	21903422.25416956.	IPI	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	23097428.	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0016429	tRNA (adenine-N1-)-methyltransferase activity	21873635.	IBA	Function
GO:0016429	tRNA (adenine-N1-)-methyltransferase activity	23097428.	IDA	Function
GO:0016433	rRNA (adenine) methyltransferase activity	27631568.	IMP	Function
GO:0030488	tRNA methylation	21873635.	IBA	Process
GO:0031167	rRNA methylation	-	IEA	Process
GO:0031515	tRNA (m1A) methyltransferase complex	21873635.	IBA	Component
GO:0051260	protein homooligomerization	23097428.	IDA	Process
GO:0061953	mRNA (adenine-N1-)-methyltransferase activity	29107537.	IDA	Function
GO:0070901	mitochondrial tRNA methylation	21873635.	IBA	Process
GO:0070901	mitochondrial tRNA methylation	23097428.	IDA	Process
GO:0070901	mitochondrial tRNA methylation	-	TAS	Process
GO:0080009	mRNA methylation	29107537.	IDA	Process