EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000171421 (Gene tree)
Gene ID: 64979
Gene Symbol: MRPL36
Alias: BRIP1|RPMJ|L36mt|PRPL36|MRP-L36
Full Name: mitochondrial ribosomal protein L36
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 3,039 bases
Position: chr5:1,798,385-1,801,423
Accession: 14490
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 2p. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000372093	Ribosomal_L36	PF00444.18	4.7e-16	1	1
ENSP00000423152	Ribosomal_L36	PF00444.18	4.7e-16	1	1
ENSP00000423399	Ribosomal_L36	PF00444.18	4.7e-16	1	1
ENSP00000427152	Ribosomal_L36	PF00444.18	4.7e-16	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000505818	MRPL36-203	595	XM_011514080	ENSP00000427152	103 (aa)	XP_011512382	Q9P0J6
ENST00000508987	MRPL36-204	686	XM_017009750	ENSP00000423399	103 (aa)	XP_016865239	Q9P0J6
ENST00000505059	MRPL36-202	610	-	ENSP00000423152	103 (aa)	-	Q9P0J6
ENST00000510999	MRPL36-205	793	-	ENSP00000424366	35 (aa)	-	D6RB74
ENST00000382647	MRPL36-201	587	-	ENSP00000372093	103 (aa)	-	Q9P0J6

Gene Model

Click here to download ENSG00000171421's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000171421's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000171421	MRPL36	51	57.407	ENSAPOG00000005383	mrpl36	55	57.407	Acanthochromis_polyacanthus
ENSG00000171421	MRPL36	100	53.571	ENSAMEG00000018757	MRPL36	100	53.571	Ailuropoda_melanoleuca
ENSG00000171421	MRPL36	62	47.887	ENSATEG00000007174	mrpl36	80	47.887	Anabas_testudineus
ENSG00000171421	MRPL36	100	81.553	ENSANAG00000029891	-	100	81.553	Aotus_nancymaae
ENSG00000171421	MRPL36	100	51.887	ENSBTAG00000050317	MRPL36	100	51.887	Bos_taurus
ENSG00000171421	MRPL36	100	83.495	ENSCJAG00000022725	-	100	83.495	Callithrix_jacchus
ENSG00000171421	MRPL36	100	87.379	ENSCJAG00000047445	-	100	87.379	Callithrix_jacchus
ENSG00000171421	MRPL36	100	52.727	ENSCAFG00000010448	MRPL36	100	52.679	Canis_familiaris
ENSG00000171421	MRPL36	100	52.727	ENSCAFG00020022901	MRPL36	100	52.679	Canis_lupus_dingo
ENSG00000171421	MRPL36	79	58.025	ENSCPOG00000039695	-	75	58.025	Cavia_porcellus
ENSG00000171421	MRPL36	100	82.857	ENSCCAG00000034981	-	86	80.000	Cebus_capucinus
ENSG00000171421	MRPL36	100	86.408	ENSCSAG00000018986	MRPL36	100	86.408	Chlorocebus_sabaeus
ENSG00000171421	MRPL36	98	47.222	ENSCPBG00000016952	MRPL36	98	47.222	Chrysemys_picta_bellii
ENSG00000171421	MRPL36	100	56.075	ENSCGRG00001008138	Mrpl36	100	56.075	Cricetulus_griseus_chok1gshd
ENSG00000171421	MRPL36	100	56.075	ENSCGRG00000018482	Mrpl36	100	56.075	Cricetulus_griseus_crigri
ENSG00000171421	MRPL36	100	61.818	ENSDNOG00000030860	MRPL36	89	61.818	Dasypus_novemcinctus
ENSG00000171421	MRPL36	69	50.000	FBgn0042112	mRpL36	55	50.000	Drosophila_melanogaster
ENSG00000171421	MRPL36	100	65.421	ENSEASG00005018550	MRPL36	100	65.421	Equus_asinus_asinus
ENSG00000171421	MRPL36	96	63.636	ENSECAG00000001222	MRPL36	100	63.636	Equus_caballus
ENSG00000171421	MRPL36	100	53.271	ENSFCAG00000026326	-	100	53.271	Felis_catus
ENSG00000171421	MRPL36	100	53.271	ENSFCAG00000026543	-	100	53.271	Felis_catus
ENSG00000171421	MRPL36	85	52.273	ENSGAFG00000018755	mrpl36	81	52.273	Gambusia_affinis
ENSG00000171421	MRPL36	99	45.872	ENSGAGG00000018117	MRPL36	99	45.872	Gopherus_agassizii
ENSG00000171421	MRPL36	100	96.117	ENSGGOG00000040090	-	100	96.117	Gorilla_gorilla
ENSG00000171421	MRPL36	100	98.058	ENSGGOG00000016949	MRPL36	100	98.058	Gorilla_gorilla
ENSG00000171421	MRPL36	59	56.452	ENSHCOG00000020562	mrpl36	53	56.452	Hippocampus_comes
ENSG00000171421	MRPL36	57	73.333	ENSSTOG00000031957	-	68	68.657	Ictidomys_tridecemlineatus
ENSG00000171421	MRPL36	100	51.818	ENSJJAG00000017543	Mrpl36	100	52.727	Jaculus_jaculus
ENSG00000171421	MRPL36	99	41.880	ENSKMAG00000001022	mrpl36	99	41.880	Kryptolebias_marmoratus
ENSG00000171421	MRPL36	99	41.228	ENSLACG00000004391	mrpl36	99	41.228	Latimeria_chalumnae
ENSG00000171421	MRPL36	87	42.857	ENSLOCG00000008869	mrpl36	81	42.857	Lepisosteus_oculatus
ENSG00000171421	MRPL36	59	60.656	ENSLAFG00000005707	-	100	60.656	Loxodonta_africana
ENSG00000171421	MRPL36	100	91.429	ENSMMUG00000004451	MRPL36	100	87.379	Macaca_mulatta
ENSG00000171421	MRPL36	100	59.813	ENSMOCG00000004885	Mrpl36	100	59.813	Microtus_ochrogaster
ENSG00000171421	MRPL36	51	71.698	ENSMODG00000025120	-	100	71.698	Monodelphis_domestica
ENSG00000171421	MRPL36	100	56.311	MGP_CAROLIEiJ_G0018701	Mrpl36	96	56.311	Mus_caroli
ENSG00000171421	MRPL36	100	57.009	ENSMUSG00000021607	Mrpl36	100	57.009	Mus_musculus
ENSG00000171421	MRPL36	100	58.879	MGP_PahariEiJ_G0015782	Mrpl36	100	58.879	Mus_pahari
ENSG00000171421	MRPL36	100	57.009	MGP_SPRETEiJ_G0019585	Mrpl36	100	57.009	Mus_spretus
ENSG00000171421	MRPL36	100	60.550	ENSNGAG00000000723	Mrpl36	100	60.550	Nannospalax_galili
ENSG00000171421	MRPL36	68	45.714	ENSNBRG00000001279	mrpl36	73	45.714	Neolamprologus_brichardi
ENSG00000171421	MRPL36	100	97.143	ENSNLEG00000011197	MRPL36	100	96.000	Nomascus_leucogenys
ENSG00000171421	MRPL36	100	52.727	ENSMEUG00000003007	-	99	52.727	Notamacropus_eugenii
ENSG00000171421	MRPL36	78	58.025	ENSODEG00000018308	-	71	58.025	Octodon_degus
ENSG00000171421	MRPL36	99	42.857	ENSOMEG00000013340	mrpl36	92	42.857	Oryzias_melastigma
ENSG00000171421	MRPL36	100	57.944	ENSOGAG00000032891	MRPL36	100	57.944	Otolemur_garnettii
ENSG00000171421	MRPL36	100	100.000	ENSPPAG00000012362	MRPL36	100	100.000	Pan_paniscus
ENSG00000171421	MRPL36	100	94.286	ENSPTRG00000046215	-	100	94.175	Pan_troglodytes
ENSG00000171421	MRPL36	100	100.000	ENSPTRG00000016705	MRPL36	100	100.000	Pan_troglodytes
ENSG00000171421	MRPL36	99	37.815	ENSPMGG00000003846	mrpl36	99	37.815	Periophthalmus_magnuspinnatus
ENSG00000171421	MRPL36	100	58.333	ENSPEMG00000006495	Mrpl36	100	58.333	Peromyscus_maniculatus_bairdii
ENSG00000171421	MRPL36	100	52.727	ENSPCIG00000006387	-	88	52.727	Phascolarctos_cinereus
ENSG00000171421	MRPL36	66	50.000	ENSPLAG00000006453	mrpl36	68	50.000	Poecilia_latipinna
ENSG00000171421	MRPL36	64	51.471	ENSPLAG00000018361	mrpl36	57	51.471	Poecilia_latipinna
ENSG00000171421	MRPL36	85	45.833	ENSPMEG00000020046	mrpl36	84	45.833	Poecilia_mexicana
ENSG00000171421	MRPL36	62	54.688	ENSPREG00000017338	mrpl36	51	54.688	Poecilia_reticulata
ENSG00000171421	MRPL36	100	97.143	ENSPPYG00000015322	MRPL36	100	96.117	Pongo_abelii
ENSG00000171421	MRPL36	100	61.818	ENSPVAG00000001723	MRPL36	100	61.818	Pteropus_vampyrus
ENSG00000171421	MRPL36	100	58.252	ENSRNOG00000047971	Mrpl36	100	58.252	Rattus_norvegicus
ENSG00000171421	MRPL36	100	58.252	ENSRNOG00000023407	LOC100910528	100	58.252	Rattus_norvegicus
ENSG00000171421	MRPL36	93	89.583	ENSRROG00000012518	-	99	89.583	Rhinopithecus_roxellana
ENSG00000171421	MRPL36	100	77.143	ENSSBOG00000020865	-	100	70.874	Saimiri_boliviensis_boliviensis
ENSG00000171421	MRPL36	100	54.545	ENSSHAG00000017748	MRPL36	97	54.545	Sarcophilus_harrisii
ENSG00000171421	MRPL36	87	43.564	ENSSFOG00015001447	mrpl36	93	43.564	Scleropages_formosus
ENSG00000171421	MRPL36	81	46.067	ENSSMAG00000020639	mrpl36	67	46.067	Scophthalmus_maximus
ENSG00000171421	MRPL36	81	48.276	ENSSDUG00000001925	mrpl36	67	48.276	Seriola_dumerili
ENSG00000171421	MRPL36	81	46.067	ENSSLDG00000004675	mrpl36	67	46.067	Seriola_lalandi_dorsalis
ENSG00000171421	MRPL36	100	55.660	ENSSSCG00000040154	-	100	55.660	Sus_scrofa
ENSG00000171421	MRPL36	81	45.783	ENSTRUG00000023106	mrpl36	91	45.783	Takifugu_rubripes
ENSG00000171421	MRPL36	100	50.000	ENSUAMG00000013957	MRPL36	100	52.679	Ursus_americanus
ENSG00000171421	MRPL36	100	50.000	ENSUMAG00000021510	MRPL36	100	52.679	Ursus_maritimus
ENSG00000171421	MRPL36	85	48.864	ENSXCOG00000002609	mrpl36	81	48.864	Xiphophorus_couchianus
ENSG00000171421	MRPL36	85	48.864	ENSXMAG00000024101	mrpl36	81	48.864	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003735	structural constituent of ribosome	-	IEA	Function
GO:0005739	mitochondrion	-	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005762	mitochondrial large ribosomal subunit	21873635.	IBA	Component
GO:0005762	mitochondrial large ribosomal subunit	25278503.	IDA	Component
GO:0005762	mitochondrial large ribosomal subunit	11279069.	NAS	Component
GO:0006412	translation	11279069.	NAS	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0042254	ribosome biogenesis	21873635.	IBA	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
CESC	chr5	1798603	3'UTR	novel		0.36
CESC	chr5	1798791	Missense_Mutation	NA	R49C	0.28
COAD	chr5	1798648	Silent	rs760603990	P96P	0.07
COAD	chr5	1798552	3'UTR	novel		0.23
GBM	chr5	1798868	Missense_Mutation	novel	P23H	0.11
LGG	chr5	1798748	Missense_Mutation	rs777500156	A63V	0.27
LUSC	chr5	1798544	3'UTR	novel		0.1
LUSC	chr5	1798808	Missense_Mutation	NA	E43G	0.35
LUSC	chr5	1798741	Silent	rs751409392	G65G	0.08
OV	chr5	1798628	Missense_Mutation	novel	M103K	0.35	Ribosomal_L36
OV	chr5	1798675	Silent	novel	R87R	0.52
OV	chr5	1798568	3'UTR	novel		0.11
SKCM	chr5	1798624	Silent	novel	*104*	0.16
SKCM	chr5	1798948	Splice_Site	novel		0.25
SKCM	chr5	1798761	Missense_Mutation	rs748960433	H59Y	0.37
STAD	chr5	1798602	3'UTR	rs756275231		0.45
STAD	chr5	1798846	Silent	rs749561344	L30L	0.18
STAD	chr5	1798846	Silent	rs749561344	L30L	0.18
STAD	chr5	1798937	5'UTR	novel		0.43
STAD	chr5	1798603	3'UTR	novel		0.28
UCEC	chr5	1798791	Missense_Mutation	NA	R49C	0.45
UCEC	chr5	1798683	Missense_Mutation	rs367987549	R85W	0.43	Ribosomal_L36
UCEC	chr5	1798668	Missense_Mutation	rs200540489	V90I	0.11	Ribosomal_L36
UCEC	chr5	1798543	3'UTR	novel		0.17
UCEC	chr5	1798602	3'UTR	rs756275231		0.22
UCEC	chr5	1798748	Missense_Mutation	rs777500156	A63V	0.38
UCEC	chr5	1798726	Silent	rs758125732	T70T	0.4
UCEC	chr5	1798654	Silent	novel	T94T	0.33
UCEC	chr5	1798819	Frame_Shift_Del	rs557878269	*V40Wfs43**	0.55
UCEC	chr5	1798814	Missense_Mutation	novel	A41V	0.38
UCEC	chr5	1798683	Missense_Mutation	rs367987549	R85W	0.4	Ribosomal_L36
UCEC	chr5	1798415	3'UTR	novel		0.47
UCEC	chr5	1798852	Silent	rs771167784	T28T	0.26
UCEC	chr5	1798515	3'UTR	novel		0.09

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.4657	0.00012456
BRCA	AMP	0.3139	0.12333
DLBC	DEL	0.0208	0.18166
KIRP	AMP	0.1076	0.14801
KIRP	DEL	0.0347	0.09673
LGG	DEL	0.0799	0.0003285
PRAD	AMP	0.0508	0.0039738
READ	AMP	0.2121	0.15915
SARC	AMP	0.358	0.032181
SARC	DEL	0.1167	0.054392
SKCM	DEL	0.1526	0.011094
STAD	AMP	0.2472	0.0018322
TGCT	DEL	0.5667	0.098913
THCA	DEL	0.006	0.23456
UVM	AMP	0.0375	0.054583

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0026	Kaplan-Meier Survival Analysis
HNSC	0.029	Kaplan-Meier Survival Analysis
SKCM	0.03	Kaplan-Meier Survival Analysis
BRCA	0.018	Kaplan-Meier Survival Analysis
LAML	0.013	Kaplan-Meier Survival Analysis
KICH	0.038	Kaplan-Meier Survival Analysis
UCEC	0.033	Kaplan-Meier Survival Analysis
GBM	0.019	Kaplan-Meier Survival Analysis
LIHC	0.00019	Kaplan-Meier Survival Analysis
LGG	0.001	Kaplan-Meier Survival Analysis
UVM	0.00012	Kaplan-Meier Survival Analysis
OV	0.044	Kaplan-Meier Survival Analysis