EuRBPDB

Description

Ensembl ID: ENSG00000171530 (Gene tree)
Gene ID: 6902
Gene Symbol: TBCA
Alias: N
Full Name: tubulin folding cofactor A
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 177,615 bases
Position: chr5:77,691,166-77,868,780
Accession: 11579
RBP type: non-canonical RBP
Summary: The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000517881	TBCA-204	359	-	-	- (aa)	-	-
ENST00000306388	TBCA-201	2301	-	ENSP00000306362	129 (aa)	-	O75347
ENST00000522370	TBCA-209	435	-	ENSP00000429313	84 (aa)	-	E5RIW3
ENST00000380377	TBCA-202	683	-	ENSP00000369736	108 (aa)	-	O75347
ENST00000517679	TBCA-203	545	-	ENSP00000429083	119 (aa)	-	E5RJD8
ENST00000520361	TBCA-208	446	-	ENSP00000429288	79 (aa)	-	E5RIX8
ENST00000518218	TBCA-205	717	-	-	- (aa)	-	-
ENST00000520039	TBCA-207	157	-	ENSP00000429046	26 (aa)	-	E5RJM1
ENST00000518338	TBCA-206	551	-	ENSP00000429793	131 (aa)	-	E5RHG6

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000171530	Cholesterol, HDL	6.20174811485352E-5	17903299
ENSG00000171530	C-Reactive Protein	6.41503010231E-5	17903293

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000171530	rs7700998	5	77851963	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000171530	rs199929635	5	77846964	?	High density lipoprotein cholesterol levels	30498476			EFO_0004612

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000171530	TBCA	100	92.857	ENSMUSG00000042043	Tbca	100	92.857	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	21044950.	IPI	Function
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	16130169.	TAS	Component
GO:0005874	microtubule	-	IEA	Component
GO:0006457	protein folding	8706133.	TAS	Process
GO:0007021	tubulin complex assembly	-	IEA	Process
GO:0007023	post-chaperonin tubulin folding pathway	-	IEA	Process
GO:0015630	microtubule cytoskeleton	-	IDA	Component
GO:0048487	beta-tubulin binding	-	IEA	Function
GO:0051087	chaperone binding	8706133.	TAS	Function