EuRBPDB

Description

Ensembl ID: ENSG00000171566 (Gene tree)
Gene ID: 5356
Gene Symbol: PLRG1
Alias: PRL1|Prp46|PRPF46|Cwc1|TANGO4
Full Name: pleiotropic regulator 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 15,439 bases
Position: chr4:154,534,997-154,550,435
Accession: 9089
RBP type: non-canonical RBP
Summary: This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22578083	Discovery of novel glucose-regulated proteins in isolated human pancreatic islets using LC-MS/MS-based proteomics.	J Proteome Res	2012 Jul 6	Schrimpe-Rutledge AC	doi: 10.1021/pr3002996

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000504341	PLRG1-205	723	-	ENSP00000423454	212 (aa)	-	D6RA26
ENST00000302078	PLRG1-201	1673	-	ENSP00000303191	505 (aa)	-	O43660
ENST00000503251	PLRG1-203	365	-	ENSP00000426497	106 (aa)	-	H0YAA2
ENST00000512773	PLRG1-212	570	-	-	- (aa)	-	-
ENST00000515520	PLRG1-213	576	-	-	- (aa)	-	-
ENST00000506918	PLRG1-208	543	-	-	- (aa)	-	-
ENST00000506627	PLRG1-207	998	-	ENSP00000425914	156 (aa)	-	H0YA24
ENST00000507125	PLRG1-209	522	-	-	- (aa)	-	-
ENST00000503751	PLRG1-204	873	-	-	- (aa)	-	-
ENST00000509975	PLRG1-210	572	-	ENSP00000425147	58 (aa)	-	D6RE04
ENST00000512719	PLRG1-211	749	-	-	- (aa)	-	-
ENST00000506192	PLRG1-206	855	-	ENSP00000424616	131 (aa)	-	B7Z982
ENST00000499023	PLRG1-202	3351	-	ENSP00000424417	514 (aa)	-	O43660

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000171566	Fibrinogen	6.7800000E-180	26561523
ENSG00000171566	Fibrinogen	3.6640000E-040	26561523
ENSG00000171566	Fibrinogen	1.2560000E-038	26561523
ENSG00000171566	Fibrinogen	1.1940000E-038	26561523
ENSG00000171566	Fibrinogen	6E-6	23144326
ENSG00000171566	Pulmonary Disease, Chronic Obstructive	6E-6	23144326
ENSG00000171566	Fibrinogen	1E-180	26561523
ENSG00000171566	Fibrinogen	1E-142	28107422

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000171566	PLRG1	99	99.346	ENSMUSG00000027998	Plrg1	100	96.597	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	28076346.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0000974	Prp19 complex	21873635.	IBA	Component
GO:0001650	fibrillar center	-	IDA	Component
GO:0005515	protein binding	20176811.20467437.	IPI	Function
GO:0005634	nucleus	28076346.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005662	DNA replication factor A complex	21873635.	IBA	Component
GO:0005662	DNA replication factor A complex	24332808.	IDA	Component
GO:0016607	nuclear speck	-	IDA	Component
GO:0031965	nuclear membrane	-	IDA	Component
GO:0034504	protein localization to nucleus	-	IEA	Process
GO:0071007	U2-type catalytic step 2 spliceosome	28076346.	IDA	Component
GO:0071013	catalytic step 2 spliceosome	21873635.	IBA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	21873635.	IBA	Component
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	-	IEA	Process