EuRBPDB

Description

Ensembl ID: ENSG00000171681 (Gene tree)
Gene ID: 55729
Gene Symbol: ATF7IP
Alias: FLJ10688|p621
Full Name: activating transcription factor 7 interacting protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 137,304 bases
Position: chr12:14,365,632-14,502,935
Accession: 20092
RBP type: non-canonical RBP
Summary: ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000536444	ATF7IP-209	8774	XM_017019639	ENSP00000445955	1269 (aa)	XP_016875128	Q6VMQ6
ENST00000535179	ATF7IP-206	746	-	-	- (aa)	-	-
ENST00000541654	ATF7IP-216	2688	-	-	- (aa)	-	-
ENST00000539659	ATF7IP-213	2298	-	-	- (aa)	-	-
ENST00000539057	ATF7IP-212	573	-	ENSP00000439578	176 (aa)	-	F5H1K9
ENST00000535132	ATF7IP-205	572	-	ENSP00000445604	103 (aa)	-	F5H221
ENST00000537653	ATF7IP-210	3563	-	-	- (aa)	-	-
ENST00000543189	ATF7IP-221	4887	XM_011520756	ENSP00000443179	1105 (aa)	XP_011519058	Q6VMQ6
ENST00000542514	ATF7IP-218	575	-	ENSP00000443540	132 (aa)	-	F5H8I0
ENST00000534828	ATF7IP-204	550	-	ENSP00000439279	152 (aa)	-	F5H2W9
ENST00000396279	ATF7IP-202	1727	-	ENSP00000379575	515 (aa)	-	A8MV73
ENST00000428217	ATF7IP-203	555	-	ENSP00000414158	125 (aa)	-	F8WE35
ENST00000261168	ATF7IP-201	8878	XM_006719108	ENSP00000261168	1270 (aa)	XP_006719171	Q6VMQ6
ENST00000538511	ATF7IP-211	558	-	ENSP00000440587	96 (aa)	-	F5GYR7
ENST00000542967	ATF7IP-219	564	-	ENSP00000444784	176 (aa)	-	F5H502
ENST00000535738	ATF7IP-207	619	-	ENSP00000437711	115 (aa)	-	H0YFA3
ENST00000545723	ATF7IP-223	577	-	ENSP00000444620	143 (aa)	-	F5H592
ENST00000541056	ATF7IP-215	570	-	ENSP00000441483	169 (aa)	-	F5GZ10
ENST00000544627	ATF7IP-222	4847	XM_005253424	ENSP00000440440	1278 (aa)	XP_005253481	Q6VMQ6
ENST00000536279	ATF7IP-208	571	-	ENSP00000442958	89 (aa)	-	F5H6X8
ENST00000542508	ATF7IP-217	580	-	ENSP00000439192	32 (aa)	-	F5H3C4
ENST00000542991	ATF7IP-220	574	-	ENSP00000443855	59 (aa)	-	F5GZ98
ENST00000545769	ATF7IP-224	568	-	ENSP00000446260	168 (aa)	-	F5H2H9
ENST00000540793	ATF7IP-214	4142	-	ENSP00000444589	1270 (aa)	-	Q6VMQ6

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000171681	Prostate-Specific Antigen	2E-9	23359319
ENSG00000171681	Testicular Neoplasms	1E-13	23666240
ENSG00000171681	Education	4E-13	27225129
ENSG00000171681	Testicular Neoplasms	6E-10	20543847

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000171681	rs7313259	12	14475839	?	Cognitive ability (MTAG)	29186694	z score increase	5.878	EFO_0004337\|EFO_0004784
ENSG00000171681	rs7964899	12	14442822	A	Educational attainment (years of education)	27225129	NR unit increase	0.016193815	EFO_0004784
ENSG00000171681	rs2900333	12	14500933	C	Testicular germ cell tumor	23666240	[1.20-1.46]	1.32	EFO_0005088
ENSG00000171681	rs3213764	12	14434367	G	Prostate-specific antigen levels	23359319	% increase	0.049	EFO_0004624
ENSG00000171681	rs2900333	12	14500933	C	Testicular germ cell cancer	20543847	[1.12-1.44]	1.27	EFO_0005088
ENSG00000171681	rs10845988	12	14368248	T	Intelligence (MTAG)	29326435	[0.013-0.024] unit decrease	0.018609567	EFO_0004337
ENSG00000171681	rs11055991	12	14480289	A	Highest math class taken (MTAG)	30038396	[0.011-0.018] unit increase	0.0143	EFO_0004875
ENSG00000171681	rs7299037	12	14442522	A	Cognitive performance (MTAG)	30038396	[0.013-0.022] unit decrease	0.0175	EFO_0008354
ENSG00000171681	rs2900333	12	14500933	T	Testicular germ cell tumor	28604732	[1.11-1.25]	1.1764705	EFO_1000566
ENSG00000171681	rs4764094	12	14490783	?	General cognitive ability	29844566	z-score increase	4.855	EFO_0004337
ENSG00000171681	rs7966054	12	14398091	?	Educational attainment (years of education)	30595370			EFO_0004784
ENSG00000171681	rs7313259	12	14475839	T	Male-pattern baldness	30573740	[0.013-0.025] unit decrease	0.0193306	EFO_0007825
ENSG00000171681	rs11055989	12	14469068	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0003714	transcription corepressor activity	-	IEA	Function
GO:0005515	protein binding	12665582.12812986.26275350.27732843.	IPI	Function
GO:0005634	nucleus	12665582.	IDA	Component
GO:0005634	nucleus	27732843.	IMP	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005667	transcription factor complex	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006306	DNA methylation	12665582.	IDA	Process
GO:0016032	viral process	-	IEA	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0016887	ATPase activity	-	IEA	Function
GO:0031647	regulation of protein stability	27732843.	IMP	Process
GO:0045892	negative regulation of transcription, DNA-templated	12665582.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	12665582.	IDA	Process
GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly	12665582.	IDA	Process
GO:0050821	protein stabilization	27732843.	IMP	Process
GO:0090309	positive regulation of methylation-dependent chromatin silencing	27732843.	IMP	Process