EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000171793 (Gene tree)
Gene ID: 1503
Gene Symbol: CTPS1
Alias: GATD5|CTPS
Full Name: CTP synthase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 33,267 bases
Position: chr1:40,979,299-41,012,565
Accession: 2519
RBP type: non-canonical RBP
Summary: This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000649864	CTPS1-217	4790	-	ENSP00000496792	564 (aa)	-	-
ENST00000648914	CTPS1-214	2648	-	ENSP00000496963	451 (aa)	-	-
ENST00000464283	CTPS1-205	643	-	-	- (aa)	-	-
ENST00000498694	CTPS1-211	2855	-	-	- (aa)	-	-
ENST00000649124	CTPS1-215	2947	-	ENSP00000497744	591 (aa)	-	UPI0000132D63
ENST00000648020	CTPS1-212	4006	XM_024453561	ENSP00000497714	335 (aa)	XP_024309329	-
ENST00000648801	CTPS1-213	4009	-	-	- (aa)	-	-
ENST00000480420	CTPS1-209	2019	-	-	- (aa)	-	-
ENST00000470271	CTPS1-206	801	-	ENSP00000497901	111 (aa)	-	-
ENST00000463285	CTPS1-203	1607	-	ENSP00000497762	461 (aa)	-	-
ENST00000650634	CTPS1-219	4138	-	-	- (aa)	-	-
ENST00000372616	CTPS1-201	2037	-	ENSP00000361699	591 (aa)	-	P17812
ENST00000486889	CTPS1-210	5325	-	-	- (aa)	-	-
ENST00000479480	CTPS1-208	1242	-	-	- (aa)	-	-
ENST00000463423	CTPS1-204	1389	-	ENSP00000497446	89 (aa)	-	-
ENST00000372621	CTPS1-202	3201	XM_024453552	ENSP00000361704	591 (aa)	XP_024309320	P17812
ENST00000650070	CTPS1-218	2838	-	ENSP00000497602	591 (aa)	-	UPI0000132D63
ENST00000649215	CTPS1-216	1821	-	ENSP00000497698	435 (aa)	-	B4E1E0
ENST00000475060	CTPS1-207	813	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000171793's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00240	Pyrimidine metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000171793	rs61780429	1	40992021	?	Heel bone mineral density	30048462	[0.016-0.026] unit increase	0.0209349	EFO_0009270
ENSG00000171793	rs61780429	1	40992021	T	Heel bone mineral density	30598549	[0.014-0.023] unit increase	0.0186918	EFO_0009270
ENSG00000171793	rs61780431	1	40998462	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000171793's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000171793	CTPS1	100	76.577	YBL039C		98	58.730	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003883	CTP synthase activity	21873635.	IBA	Function
GO:0003883	CTP synthase activity	16179339.	IDA	Function
GO:0003883	CTP synthase activity	16179339.	IGI	Function
GO:0003883	CTP synthase activity	24870241.	IMP	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006139	nucleobase-containing compound metabolic process	2113467.	TAS	Process
GO:0006241	CTP biosynthetic process	21873635.	IBA	Process
GO:0006241	CTP biosynthetic process	16179339.	IDA	Process
GO:0006241	CTP biosynthetic process	24870241.	IMP	Process
GO:0006541	glutamine metabolic process	-	IEA	Process
GO:0015949	nucleobase-containing small molecule interconversion	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0019856	pyrimidine nucleobase biosynthetic process	21873635.	IBA	Process
GO:0042098	T cell proliferation	24870241.	IMP	Process
GO:0042100	B cell proliferation	24870241.	IMP	Process
GO:0042493	response to drug	7981751.	TAS	Process
GO:0042802	identical protein binding	21873635.	IBA	Function
GO:0042802	identical protein binding	25416956.	IPI	Function
GO:0044210	'de novo' CTP biosynthetic process	-	IEA	Process
GO:0097268	cytoophidium	21873635.	IBA	Component
GO:0097268	cytoophidium	25223282.	IDA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	40983271	5'UTR	novel		0.14
BLCA	chr1	40996138	Intron	novel		0.32
BLCA	chr1	40995999	Missense_Mutation	rs376715076	R268Q	0.6
BLCA	chr1	41001076	Silent	rs746923692	P351P	0.29
BRCA	chr1	40988590	Splice_Region	novel		0.2
BRCA	chr1	40991834	Missense_Mutation	NA	E237K	0.26
BRCA	chr1	40984825	Missense_Mutation	NA	E57D	0.47
BRCA	chr1	41007513	Missense_Mutation	NA	R454K	0.21
CESC	chr1	41009581	Silent	NA	L561L	0.06
CESC	chr1	41009563	Silent	novel	L555L	0.13
COAD	chr1	40988674	Missense_Mutation	NA	E173D	0.36
COAD	chr1	41002215	Missense_Mutation	NA	A384S	0.44
COAD	chr1	41007532	Silent	NA	K460K	0.37
COAD	chr1	41010192	Frame_Shift_Ins	NA	D577*	0.1
COAD	chr1	40996082	Intron	novel		0.32
COAD	chr1	41002221	Missense_Mutation	rs756273124	A386T	0.11
COAD	chr1	41001088	Silent	rs771600893	H355H	0.51
COAD	chr1	40997428	Missense_Mutation	NA	L303I	0.29
COAD	chr1	40983211	5'UTR	novel		0.27
COAD	chr1	40996080	Intron	rs750050175		0.17
COAD	chr1	41001081	Missense_Mutation	rs759359795	R353H	0.31
COAD	chr1	40996034	Missense_Mutation	NA	K280E	0.45
COAD	chr1	40984938	Frame_Shift_Ins	novel	*Q95Hfs33**	0.04
COAD	chr1	40984940	Frame_Shift_Ins	novel	*Y96Lfs7**	0.03
COAD	chr1	40991841	Nonsense_Mutation	novel	*E239Dfs2**	0.04
GBM	chr1	40996032	Frame_Shift_Ins	novel	*M281Nfs10**	0.49
GBM	chr1	41003151	Silent	novel	F409F	0.1
GBM	chr1	41008701	Missense_Mutation	novel	R479H	0.2
GBM	chr1	40984942	Frame_Shift_Del	novel	*V97Hfs2**	0.15
GBM	chr1	41003143	Missense_Mutation	novel	V407L	0.38
GBM	chr1	40983310	Missense_Mutation	novel	T7N	0.44
HNSC	chr1	40988699	Missense_Mutation	novel	L182V	0.07
HNSC	chr1	41006079	Silent	novel	T427T	0.18
KIRC	chr1	41006062	Missense_Mutation	novel	T422A	0.39
KIRC	chr1	40987450	In_Frame_Ins	novel	E139_P140insRV	0.04
KIRC	chr1	40987452	Missense_Mutation	novel	P140A	0.02
LAML	chr1	40991166	Missense_Mutation	novel	P186Q	0.28
LIHC	chr1	40983377	Silent	novel	S29S	0.32
LIHC	chr1	40991820	Missense_Mutation	NA	M232T	0.34
LUAD	chr1	40996050	Missense_Mutation	NA	W285L	0.18
LUAD	chr1	40984900	Silent	NA	L82L	0.09
LUAD	chr1	40996073	Splice_Region	novel		0.11
LUAD	chr1	41008673	Missense_Mutation	NA	D470N	0.06
LUAD	chr1	40984973	Missense_Mutation	novel	L107M	0.41
LUAD	chr1	40987419	Missense_Mutation	NA	A129S	0.36
LUAD	chr1	40997420	Missense_Mutation	rs201674363	S300C	0.26
LUAD	chr1	40995932	Missense_Mutation	novel	D246N	0.47
LUAD	chr1	40991223	Missense_Mutation	NA	R205K	0.22
LUAD	chr1	40991840	Missense_Mutation	rs756348375	E239Q	0.13
LUAD	chr1	41009581	Silent	novel	L561L	0.11
LUSC	chr1	40987376	Silent	rs748480280	V114V	0.41
LUSC	chr1	40987408	Missense_Mutation	novel	V125G	0.33
LUSC	chr1	41008714	Missense_Mutation	NA	E483D	0.39
LUSC	chr1	40997418	Silent	novel	C299C	0.42
LUSC	chr1	41001063	Missense_Mutation	novel	S347L	0.39
LUSC	chr1	41001065	Frame_Shift_Del	novel	*Q348Kfs53**	0.4
LUSC	chr1	40988674	Silent	novel	E173E	0.32
LUSC	chr1	41007469	Silent	novel	H439H	0.31
OV	chr1	40997401	Missense_Mutation	rs372743741	R294C	0.1
OV	chr1	40996065	Frame_Shift_Ins	novel	*D290Efs4**	0.07
OV	chr1	41008797	Missense_Mutation	novel	N485Y	0.12
OV	chr1	41009535	Missense_Mutation	novel	A546V	0.07
OV	chr1	41009533	In_Frame_Ins	novel	L545_A546insPRSQGL	0.04
PAAD	chr1	40995971	Missense_Mutation	novel	E259K	0.09
PAAD	chr1	41001103	Silent	novel	K360K	0.23
PAAD	chr1	41008850	Missense_Mutation	novel	Q502H	0.22
PRAD	chr1	40988539	Intron	novel		0.11
PRAD	chr1	41009581	Silent	NA	L561L	0.44
PRAD	chr1	41001077	Missense_Mutation	rs150289603	V352M	0.36
PRAD	chr1	41001071	Missense_Mutation	novel	E350Q	0.32
READ	chr1	40988621	Missense_Mutation	novel	S156G	0.05
READ	chr1	40983334	Missense_Mutation	NA	G15E	0.2
READ	chr1	40995999	Missense_Mutation	rs376715076	R268Q	0.13
SARC	chr1	41002191	Nonsense_Mutation	NA	R376*	0.17
SARC	chr1	41010166	Missense_Mutation	novel	T566I	0.32
SARC	chr1	41010167	Silent	novel	T566T	0.31
SKCM	chr1	40984960	Silent	NA	R102R	0.42
SKCM	chr1	40988669	Missense_Mutation	NA	R172G	0.16
SKCM	chr1	40988604	Missense_Mutation	novel	T150I	0.42
SKCM	chr1	40988605	Silent	rs779429212	T150T	0.42
SKCM	chr1	40984907	Missense_Mutation	novel	D85N	0.27
SKCM	chr1	41008685	Frame_Shift_Del	novel	*L474Rfs2**	0.05
SKCM	chr1	40984936	Silent	NA	Y94Y	0.12
SKCM	chr1	41002236	Missense_Mutation	novel	Q391K	0.24
SKCM	chr1	40996105	Intron	novel		0.3
STAD	chr1	41002246	Frame_Shift_Ins	rs755362280	*L396Ffs13**	0.5
STAD	chr1	41010213	Missense_Mutation	rs753610646	E582K	0.3
STAD	chr1	40996032	Frame_Shift_Ins	novel	*M281Nfs10**	0.37
STAD	chr1	41010213	Missense_Mutation	rs753610646	E582K	0.39
STAD	chr1	41009509	Silent	novel	S537S	0.09
STAD	chr1	40997401	Missense_Mutation	rs372743741	R294C	0.34
STAD	chr1	41010196	Missense_Mutation	novel	P576H	0.32
STAD	chr1	40997422	Missense_Mutation	novel	I301V	0.06
THCA	chr1	40984982	Frame_Shift_Ins	novel	*T110Nfs29**	0.09
UCEC	chr1	40991809	Missense_Mutation	NA	E228D	0.31
UCEC	chr1	40988674	Missense_Mutation	NA	E173D	0.26
UCEC	chr1	41009451	Missense_Mutation	novel	P518L	0.2
UCEC	chr1	41003116	Missense_Mutation	novel	V398L	0.34
UCEC	chr1	40996122	Intron	novel		0.13
UCEC	chr1	40997393	Splice_Site	NA	X291_splice	0.35
UCEC	chr1	41007532	Missense_Mutation	novel	K460N	0.07
UCEC	chr1	40988562	Intron	novel		0.35
UCEC	chr1	41007521	Missense_Mutation	novel	F457L	0.55
UCEC	chr1	40997445	Silent	rs201952022	T308T	0.47
UCEC	chr1	41006079	Silent	rs145143197	T427T	0.41
UCEC	chr1	40983457	Splice_Site	novel	X56_splice	0.49
UCEC	chr1	40983243	5'UTR	novel		0.04
UCEC	chr1	40988693	Missense_Mutation	NA	V180I	0.19
UCEC	chr1	41001042	Missense_Mutation	NA	A340V	0.27
UCEC	chr1	40996084	Intron	novel		0.2
UCEC	chr1	40987421	Silent	rs759635738	A129A	0.29
UCEC	chr1	41001089	Missense_Mutation	novel	E356K	0.47
UCEC	chr1	40991809	Missense_Mutation	NA	E228D	0.42
UCEC	chr1	40983161	5'UTR	novel		0.26
UCEC	chr1	40996061	Missense_Mutation	novel	A289T	0.36
UCEC	chr1	41001064	Silent	novel	S347S	0.33
UCEC	chr1	40983352	Missense_Mutation	NA	S21N	0.45
UCEC	chr1	41010213	Missense_Mutation	rs753610646	E582K	0.34
UCEC	chr1	40996068	Nonsense_Mutation	novel	*Y292Afs4**	0.07
UCEC	chr1	41007464	Nonsense_Mutation	novel	E438*	0.53
UCEC	chr1	41010213	Missense_Mutation	rs753610646	E582K	0.4
UCEC	chr1	41010213	Missense_Mutation	rs753610646	E582K	0.26
UCEC	chr1	40983420	Missense_Mutation	novel	N44H	0.12
UCEC	chr1	40997487	Missense_Mutation	novel	E322D	0.35
UCEC	chr1	40988645	Missense_Mutation	NA	R164C	0.25
UCEC	chr1	40991206	Silent	novel	N199N	0.44
UCEC	chr1	41009453	Frame_Shift_Del	novel	*F520Lfs64**	0.35
UCEC	chr1	41009453	Frame_Shift_Del	novel	*F520Lfs64**	0.21
UCEC	chr1	41002191	Nonsense_Mutation	NA	R376*	0.36
UCEC	chr1	40996092	Intron	novel		0.29
UCEC	chr1	41002229	Frame_Shift_Ins	novel	*R389Gfs20**	0.04
UCEC	chr1	40984881	Missense_Mutation	novel	R76L	0.23
UCEC	chr1	40988520	Intron	novel		0.26
UCEC	chr1	40997460	Silent	novel	S313S	0.19
UCEC	chr1	41008707	Missense_Mutation	novel	R481Q	0.34
UCEC	chr1	40997445	Silent	rs201952022	T308T	0.34
UCEC	chr1	41010213	Missense_Mutation	rs753610646	E582K	0.35
UCEC	chr1	40991847	Splice_Site	novel	X240_splice	0.17
UCEC	chr1	41007484	Missense_Mutation	NA	M444I	0.37
UCEC	chr1	40984960	Silent	novel	R102R	0.4
UCEC	chr1	40988614	Silent	novel	D153D	0.37
UCEC	chr1	41008701	Missense_Mutation	novel	R479H	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.1042	0.011841
LUAD	AMP	0.1802	0.040181
PAAD	AMP	0.0272	0.22288
TGCT	DEL	0.1533	0.00046313
UCEC	AMP	0.102	0.00024587

Survival Analysis

Cancer	P-value	Q-value
THYM	0.019	Kaplan-Meier Survival Analysis
STAD	0.019	Kaplan-Meier Survival Analysis
SARC	0.022	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00019	Kaplan-Meier Survival Analysis
SKCM	0.00027	Kaplan-Meier Survival Analysis
PRAD	0.033	Kaplan-Meier Survival Analysis
PAAD	0.015	Kaplan-Meier Survival Analysis
PCPG	0.023	Kaplan-Meier Survival Analysis
BLCA	0.03	Kaplan-Meier Survival Analysis
LAML	0.017	Kaplan-Meier Survival Analysis
UCEC	0.0034	Kaplan-Meier Survival Analysis
LIHC	0.037	Kaplan-Meier Survival Analysis
LGG	0.00037	Kaplan-Meier Survival Analysis
UVM	0.00021	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742