EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000171861 (Gene tree)
Gene ID: 55178
Gene Symbol: MRM3
Alias: FLJ10581|HC90|RMTL1|RNMTL1
Full Name: mitochondrial rRNA methyltransferase 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 10,237 bases
Position: chr17:782,273-792,509
Accession: 18485
RBP type: canonical RBP
Summary: Efficient translation of mitochondrial-derived transcripts requires proper assembly of the large subunit of the mitochondrial ribosome. Central to the biogenesis of this large subunit is the A-loop of mitochondrial 16S rRNA, which is modified by three rRNA methyltransferases located near mtDNA nucleoids. The protein encoded by this gene methylates G(1370) of 16S rRNA, and this modification is necessary for proper ribosomal large subnit assembly. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000306080	SpoU_methylase	PF00588.19	8.7e-21	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000574509	MRM3-203	727	-	ENSP00000458328	110 (aa)	-	I3L0T6
ENST00000574916	MRM3-204	770	-	-	- (aa)	-	-
ENST00000571157	MRM3-202	572	-	ENSP00000460957	177 (aa)	-	I3L443
ENST00000304478	MRM3-201	1809	-	ENSP00000306080	420 (aa)	-	Q9HC36

Gene Model

Click here to download ENSG00000171861's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000171861	Diabetes Mellitus, Type 2	4E-6	23300278

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000171861's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000171861	MRM3	95	90.058	ENSAMEG00000008346	MRM3	100	83.333	Ailuropoda_melanoleuca
ENSG00000171861	MRM3	95	94.643	ENSANAG00000014643	MRM3	97	90.120	Aotus_nancymaae
ENSG00000171861	MRM3	95	95.266	ENSCJAG00000021701	MRM3	97	85.301	Callithrix_jacchus
ENSG00000171861	MRM3	95	91.124	ENSCAFG00000019117	MRM3	100	83.924	Canis_familiaris
ENSG00000171861	MRM3	95	91.124	ENSCAFG00020010972	MRM3	100	83.924	Canis_lupus_dingo
ENSG00000171861	MRM3	93	91.463	ENSCHIG00000025241	MRM3	99	84.048	Capra_hircus
ENSG00000171861	MRM3	95	91.124	ENSTSYG00000006075	MRM3	100	85.986	Carlito_syrichta
ENSG00000171861	MRM3	66	88.172	ENSCAPG00000011399	MRM3	99	88.172	Cavia_aperea
ENSG00000171861	MRM3	95	88.757	ENSCPOG00000026540	MRM3	99	84.198	Cavia_porcellus
ENSG00000171861	MRM3	95	94.675	ENSCCAG00000038105	MRM3	99	89.639	Cebus_capucinus
ENSG00000171861	MRM3	100	95.000	ENSCATG00000032099	MRM3	100	95.000	Cercocebus_atys
ENSG00000171861	MRM3	100	83.294	ENSCLAG00000008589	MRM3	100	84.000	Chinchilla_lanigera
ENSG00000171861	MRM3	100	95.000	ENSCSAG00000014247	MRM3	100	95.000	Chlorocebus_sabaeus
ENSG00000171861	MRM3	95	88.166	ENSCHOG00000011403	MRM3	100	82.619	Choloepus_hoffmanni
ENSG00000171861	MRM3	100	93.571	ENSCANG00000040883	MRM3	100	93.571	Colobus_angolensis_palliatus
ENSG00000171861	MRM3	95	91.667	ENSCGRG00001014632	Mrm3	100	83.333	Cricetulus_griseus_chok1gshd
ENSG00000171861	MRM3	95	91.667	ENSCGRG00000016619	Mrm3	100	83.333	Cricetulus_griseus_crigri
ENSG00000171861	MRM3	95	87.574	ENSDNOG00000004294	MRM3	99	83.055	Dasypus_novemcinctus
ENSG00000171861	MRM3	93	86.667	ENSDORG00000007555	Mrm3	99	80.976	Dipodomys_ordii
ENSG00000171861	MRM3	95	90.533	ENSEASG00005009647	MRM3	100	85.238	Equus_asinus_asinus
ENSG00000171861	MRM3	95	91.124	ENSECAG00000024378	MRM3	92	86.241	Equus_caballus
ENSG00000171861	MRM3	95	90.476	ENSFCAG00000001673	MRM3	100	83.610	Felis_catus
ENSG00000171861	MRM3	100	100.000	ENSGGOG00000015518	MRM3	100	100.000	Gorilla_gorilla
ENSG00000171861	MRM3	99	85.071	ENSHGLG00000009544	MRM3	100	85.071	Heterocephalus_glaber_female
ENSG00000171861	MRM3	99	85.442	ENSHGLG00100019310	MRM3	100	85.442	Heterocephalus_glaber_male
ENSG00000171861	MRM3	100	85.238	ENSSTOG00000016426	MRM3	100	85.238	Ictidomys_tridecemlineatus
ENSG00000171861	MRM3	95	86.391	ENSJJAG00000024189	Mrm3	100	78.095	Jaculus_jaculus
ENSG00000171861	MRM3	86	68.627	ENSLACG00000007157	MRM3	95	54.462	Latimeria_chalumnae
ENSG00000171861	MRM3	95	87.719	ENSLAFG00000016652	MRM3	100	82.547	Loxodonta_africana
ENSG00000171861	MRM3	100	94.048	ENSMFAG00000045382	MRM3	100	94.048	Macaca_fascicularis
ENSG00000171861	MRM3	100	93.810	ENSMNEG00000032873	MRM3	100	93.810	Macaca_nemestrina
ENSG00000171861	MRM3	100	94.524	ENSMLEG00000034316	MRM3	100	94.524	Mandrillus_leucophaeus
ENSG00000171861	MRM3	95	89.941	ENSMAUG00000018823	Mrm3	100	82.619	Mesocricetus_auratus
ENSG00000171861	MRM3	100	86.429	ENSMICG00000031420	MRM3	100	86.429	Microcebus_murinus
ENSG00000171861	MRM3	95	91.124	ENSMOCG00000018749	Mrm3	100	82.619	Microtus_ochrogaster
ENSG00000171861	MRM3	91	85.093	ENSMODG00000010029	MRM3	93	72.115	Monodelphis_domestica
ENSG00000171861	MRM3	95	90.533	MGP_CAROLIEiJ_G0016758	Mrm3	97	84.236	Mus_caroli
ENSG00000171861	MRM3	95	89.941	ENSMUSG00000038046	Mrm3	97	83.251	Mus_musculus
ENSG00000171861	MRM3	95	90.533	MGP_PahariEiJ_G0017895	Mrm3	100	82.143	Mus_pahari
ENSG00000171861	MRM3	95	89.941	MGP_SPRETEiJ_G0017601	Mrm3	97	83.251	Mus_spretus
ENSG00000171861	MRM3	95	91.716	ENSMPUG00000013793	MRM3	100	80.601	Mustela_putorius_furo
ENSG00000171861	MRM3	99	83.333	ENSMLUG00000001504	MRM3	100	83.333	Myotis_lucifugus
ENSG00000171861	MRM3	95	92.899	ENSNGAG00000011304	Mrm3	100	85.714	Nannospalax_galili
ENSG00000171861	MRM3	100	95.952	ENSNLEG00000033176	MRM3	100	95.952	Nomascus_leucogenys
ENSG00000171861	MRM3	77	86.131	ENSMEUG00000012224	MRM3	99	82.000	Notamacropus_eugenii
ENSG00000171861	MRM3	100	75.238	ENSODEG00000009411	MRM3	100	75.238	Octodon_degus
ENSG00000171861	MRM3	77	77.372	ENSOANG00000009926	MRM3	97	73.684	Ornithorhynchus_anatinus
ENSG00000171861	MRM3	95	85.207	ENSOCUG00000002219	MRM3	100	78.673	Oryctolagus_cuniculus
ENSG00000171861	MRM3	99	86.190	ENSOGAG00000001360	MRM3	100	86.190	Otolemur_garnettii
ENSG00000171861	MRM3	95	88.235	ENSOARG00000011376	MRM3	99	82.938	Ovis_aries
ENSG00000171861	MRM3	100	99.524	ENSPPAG00000038493	MRM3	100	99.524	Pan_paniscus
ENSG00000171861	MRM3	95	89.881	ENSPPRG00000008082	MRM3	100	82.898	Panthera_pardus
ENSG00000171861	MRM3	95	90.476	ENSPTIG00000021325	MRM3	100	83.135	Panthera_tigris_altaica
ENSG00000171861	MRM3	100	99.762	ENSPTRG00000008512	MRM3	100	99.762	Pan_troglodytes
ENSG00000171861	MRM3	100	95.238	ENSPANG00000024613	MRM3	100	95.238	Papio_anubis
ENSG00000171861	MRM3	86	62.745	ENSPKIG00000012704	MRM3	97	47.921	Paramormyrops_kingsleyae
ENSG00000171861	MRM3	95	88.824	ENSPEMG00000022505	Mrm3	100	83.135	Peromyscus_maniculatus_bairdii
ENSG00000171861	MRM3	86	55.195	ENSPMAG00000001598	MRM3	99	45.858	Petromyzon_marinus
ENSG00000171861	MRM3	95	82.738	ENSPCIG00000025698	MRM3	88	73.684	Phascolarctos_cinereus
ENSG00000171861	MRM3	95	88.166	ENSPCAG00000008042	MRM3	100	81.473	Procavia_capensis
ENSG00000171861	MRM3	100	86.936	ENSPCOG00000012539	MRM3	100	86.936	Propithecus_coquereli
ENSG00000171861	MRM3	95	88.757	ENSPVAG00000011709	MRM3	100	83.135	Pteropus_vampyrus
ENSG00000171861	MRM3	86	66.013	ENSPNAG00000019511	MRM3	94	46.729	Pygocentrus_nattereri
ENSG00000171861	MRM3	95	92.899	ENSRNOG00000037238	Mrm3	100	82.619	Rattus_norvegicus
ENSG00000171861	MRM3	99	93.317	ENSRBIG00000044238	MRM3	99	93.317	Rhinopithecus_bieti
ENSG00000171861	MRM3	99	94.033	ENSRROG00000041720	MRM3	98	94.033	Rhinopithecus_roxellana
ENSG00000171861	MRM3	95	94.083	ENSSBOG00000029574	MRM3	99	89.157	Saimiri_boliviensis_boliviensis
ENSG00000171861	MRM3	67	82.203	ENSSHAG00000011624	MRM3	90	77.739	Sarcophilus_harrisii
ENSG00000171861	MRM3	91	85.714	ENSSARG00000006188	MRM3	100	77.889	Sorex_araneus
ENSG00000171861	MRM3	95	89.941	ENSSSCG00000017806	MRM3	100	82.506	Sus_scrofa
ENSG00000171861	MRM3	100	82.033	ENSTTRG00000003844	MRM3	100	82.270	Tursiops_truncatus
ENSG00000171861	MRM3	95	91.716	ENSUAMG00000013654	MRM3	100	83.019	Ursus_americanus
ENSG00000171861	MRM3	95	91.716	ENSUMAG00000010052	MRM3	100	83.255	Ursus_maritimus
ENSG00000171861	MRM3	86	67.105	ENSXETG00000022451	mrm3	98	54.940	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000451	rRNA 2'-O-methylation	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005739	mitochondrion	-	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0070039	rRNA (guanosine-2'-O-)-methyltransferase activity	24036117.25074936.	EXP	Function