EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000172009 (Gene tree)
Gene ID: 7064
Gene Symbol: THOP1
Alias: N
Full Name: thimet oligopeptidase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 30,348 bases
Position: chr19:2,785,460-2,815,807
Accession: 11793
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000590533	THOP1-210	616	-	-	- (aa)	-	-
ENST00000586677	THOP1-205	1872	XM_011528228	ENSP00000467226	568 (aa)	XP_011526530	K7EP46
ENST00000586780	THOP1-206	421	-	-	- (aa)	-	-
ENST00000591149	THOP1-212	789	-	-	- (aa)	-	-
ENST00000591363	THOP1-213	639	-	ENSP00000466653	204 (aa)	-	K7EMU4
ENST00000592639	THOP1-214	431	-	-	- (aa)	-	-
ENST00000395212	THOP1-202	1877	-	ENSP00000378638	258 (aa)	-	P52888
ENST00000587401	THOP1-207	702	-	ENSP00000465895	216 (aa)	-	K7EL32
ENST00000585673	THOP1-204	784	-	-	- (aa)	-	-
ENST00000589087	THOP1-209	2977	-	-	- (aa)	-	-
ENST00000587468	THOP1-208	671	-	ENSP00000464786	169 (aa)	-	K7EIK4
ENST00000590970	THOP1-211	1104	-	ENSP00000465855	260 (aa)	-	K7EL02
ENST00000585338	THOP1-203	761	-	ENSP00000465545	176 (aa)	-	K7EKB6
ENST00000307741	THOP1-201	4804	-	ENSP00000304467	689 (aa)	-	P52888

Gene Model

Click here to download ENSG00000172009's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04614	Renin-angiotensin system	KEGG
hsa05143	African trypanosomiasis	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000172009	rs941408	19	2814183	T	Total cholesterol levels	28334899	[0.012-0.028] unit increase (EA Beta values)	0.02	EFO_0004574
ENSG00000172009	rs941408	19	2814183	C	Low density lipoprotein cholesterol levels	29507422	unit decrease	0.018	EFO_0004611
ENSG00000172009	rs941408	19	2814183	C	Total cholesterol levels	29507422	unit decrease	0.021	EFO_0004574

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172009's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000172009	THOP1	99	69.048	ENSG00000123213	NLN	99	65.050	Homo_sapiens
ENSG00000172009	THOP1	100	91.716	ENSMUSG00000004929	Thop1	99	89.605	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0004222	metalloendopeptidase activity	21873635.	IBA	Function
GO:0004222	metalloendopeptidase activity	-	TAS	Function
GO:0005758	mitochondrial intermembrane space	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006508	proteolysis	21873635.	IBA	Process
GO:0006518	peptide metabolic process	21873635.	IBA	Process
GO:0042277	peptide binding	-	IEA	Function
GO:0046872	metal ion binding	-	IEA	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr19	2790455	Silent	rs748415848	P17P	0.55
BLCA	chr19	2808409	Missense_Mutation	NA	E474Q	0.16
BLCA	chr19	2807012	Missense_Mutation	novel	M282I	0.54
BLCA	chr19	2794785	Missense_Mutation	NA	F84S	0.34
BLCA	chr19	2808387	Silent	rs373754322	D466D	0.33
BLCA	chr19	2794817	Missense_Mutation	novel	R95W	0.53
BLCA	chr19	2790549	Missense_Mutation	novel	D49N	0.22
BRCA	chr19	2812335	Intron	novel		0.13
BRCA	chr19	2807036	Silent	rs201840395	T290T	0.26
BRCA	chr19	2799709	Missense_Mutation	NA	K169N	0.29
BRCA	chr19	2807657	Missense_Mutation	rs527473166	G368R	0.14
BRCA	chr19	2811610	Missense_Mutation	novel	P595L	0.32
CESC	chr19	2813160	Missense_Mutation	NA	E652Q	0.11
CESC	chr19	2790519	Nonsense_Mutation	novel	E39*	0.4
CESC	chr19	2808394	Missense_Mutation	novel	E469K	0.09
CESC	chr19	2790604	Missense_Mutation	rs374219260	A67V	0.52
CESC	chr19	2794783	Silent	rs774044849	D83D	0.35
CESC	chr19	2796110	Silent	rs371164634	P136P	0.15
CESC	chr19	2805038	Silent	novel	L204L	0.2
CESC	chr19	2810352	Missense_Mutation	novel	E502K	0.12
CESC	chr19	2794768	Missense_Mutation	NA	Q78H	0.33
COAD	chr19	2790512	Silent	novel	R36R	0.29
COAD	chr19	2810694	Missense_Mutation	rs182189341	T566M	0.24
COAD	chr19	2811641	Silent	NA	Y605Y	0.11
COAD	chr19	2808352	Missense_Mutation	rs762025666	P455S	0.41
COAD	chr19	2807511	Missense_Mutation	NA	A319V	0.31
COAD	chr19	2796034	Intron	rs762852817		0.44
COAD	chr19	2790477	Missense_Mutation	rs560375676	R25W	0.28
COAD	chr19	2813120	Silent	novel	G638G	0.33
COAD	chr19	2807713	Silent	rs749774222	G386G	0.43
COAD	chr19	2810655	Missense_Mutation	novel	R553H	0.38
COAD	chr19	2794858	Silent	rs199546012	F108F	0.27
COAD	chr19	2805101	Frame_Shift_Del	NA	*L227Sfs2**	0.26
COAD	chr19	2808338	Missense_Mutation	NA	A450V	0.18
COAD	chr19	2805166	Missense_Mutation	rs199648840	R247Q	0.45
COAD	chr19	2807545	Silent	novel	G330G	0.27
COAD	chr19	2808366	Silent	rs577622918	A459A	0.16
COAD	chr19	2805119	Silent	novel	C231C	0.07
ESCA	chr19	2807534	Missense_Mutation	novel	P327T	0.09
ESCA	chr19	2807605	Silent	novel	C350C	0.47
GBM	chr19	2796160	Missense_Mutation	novel	G153V	0.08
HNSC	chr19	2794846	Frame_Shift_Ins	novel	*E107Sfs8**	0.04
HNSC	chr19	2811701	Silent	rs373236316	T625T	0.18
HNSC	chr19	2810360	Silent	rs780216810	P504P	0.4
HNSC	chr19	2805088	Missense_Mutation	novel	Y221C	0.15
KIRC	chr19	2794800	Missense_Mutation	rs200973060	S89F	0.35
KIRP	chr19	2796022	Intron	novel		0.5
LGG	chr19	2808389	Missense_Mutation	novel	E467G	0.38
LGG	chr19	2810743	Missense_Mutation	NA	E582D	0.33
LGG	chr19	2799777	Missense_Mutation	rs772371484	T192M	0.21
LIHC	chr19	2785575	5'UTR	novel		0.53
LIHC	chr19	2811650	Missense_Mutation	novel	Q608H	0.3
LIHC	chr19	2810269	Splice_Site	novel	X486_splice	0.31
LIHC	chr19	2810302	Splice_Site	NA	X486_splice	0.43
LIHC	chr19	2794769	Silent	NA	R79R	0.16
LIHC	chr19	2813334	3'UTR	novel		0.13
LUAD	chr19	2790469	Missense_Mutation	NA	N22S	0.43
LUAD	chr19	2799688	Splice_Site	novel	X163_splice	0.39
LUAD	chr19	2790432	Missense_Mutation	novel	D10Y	0.23
LUAD	chr19	2799703	Silent	novel	I167I	0.34
LUAD	chr19	2796161	Silent	NA	G153G	0.66
LUAD	chr19	2790528	Missense_Mutation	rs142015327	E42K	0.2
LUAD	chr19	2810720	Nonsense_Mutation	novel	E575*	0.55
LUSC	chr19	2794888	Silent	novel	V118V	0.6
LUSC	chr19	2794783	Silent	rs774044849	D83D	0.25
LUSC	chr19	2807759	Missense_Mutation	rs753980550	A402T	0.12
LUSC	chr19	2790495	Missense_Mutation	novel	Q31E	0.19
LUSC	chr19	2808388	Missense_Mutation	novel	E467K	0.19
LUSC	chr19	2799760	Silent	NA	T186T	0.1
LUSC	chr19	2810342	Silent	NA	R498R	0.24
LUSC	chr19	2790528	Nonsense_Mutation	novel	E42*	0.12
LUSC	chr19	2799766	Silent	NA	F188F	0.2
LUSC	chr19	2807453	Nonsense_Mutation	novel	Q300*	0.34
OV	chr19	2794797	Missense_Mutation	novel	V88D	0.23
OV	chr19	2796123	Missense_Mutation	novel	Y141N	0.38
OV	chr19	2796124	In_Frame_Ins	novel	Y141_L142insFAQV	0.38
OV	chr19	2799746	Missense_Mutation	NA	L182M	0.25
OV	chr19	2794859	Missense_Mutation	rs748495490	D109N	0.52
PAAD	chr19	2790605	Silent	rs368257927	A67A	0.09
PAAD	chr19	2794886	Missense_Mutation	novel	V118M	0.2
PRAD	chr19	2806992	Missense_Mutation	rs746532359	A276T	0.1
PRAD	chr19	2807566	Missense_Mutation	novel	M337I	0.41
READ	chr19	2796132	Missense_Mutation	rs777819244	R144W	0.3
READ	chr19	2813185	Missense_Mutation	NA	R660H	0.36
SARC	chr19	2790522	Missense_Mutation	novel	L40F	0.12
SKCM	chr19	2799785	Missense_Mutation	NA	E195K	0.08
SKCM	chr19	2811641	Silent	NA	Y605Y	0.21
SKCM	chr19	2790451	Missense_Mutation	NA	S16F	0.33
SKCM	chr19	2808347	Missense_Mutation	NA	T453I	0.53
SKCM	chr19	2790613	Missense_Mutation	rs762129222	D70G	0.62
SKCM	chr19	2811695	Silent	NA	F623F	0.39
SKCM	chr19	2806931	Silent	novel	I255I	0.21
SKCM	chr19	2794787	Frame_Shift_Del	novel	*P85Lfs2**	0.12
SKCM	chr19	2807537	Frame_Shift_Ins	novel	*G330Sfs14**	0.38
SKCM	chr19	2808441	Silent	novel	S484S	0.5
SKCM	chr19	2808368	Missense_Mutation	NA	P460L	0.25
SKCM	chr19	2807715	Missense_Mutation	novel	A387V	0.42
STAD	chr19	2807739	Missense_Mutation	rs373946615	R395Q	0.32
STAD	chr19	2813171	Silent	rs760592493	S655S	0.31
STAD	chr19	2810727	Missense_Mutation	rs571489169	A577V	0.25
STAD	chr19	2805101	Frame_Shift_Del	NA	*L227Sfs2**	0.43
STAD	chr19	2807518	Silent	rs758609649	C321C	0.52
STAD	chr19	2807767	Frame_Shift_Del	novel	*E406Rfs73**	0.31
STAD	chr19	2807512	Silent	rs540474976	A319A	0.26
STAD	chr19	2807488	Silent	rs759198628	A311A	0.45
STAD	chr19	2796050	Intron	rs576466514		0.25
UCEC	chr19	2794858	Silent	rs199546012	F108F	0.4
UCEC	chr19	2808319	Missense_Mutation	novel	A444T	0.16
UCEC	chr19	2813261	Missense_Mutation	rs531925340	E685D	0.12
UCEC	chr19	2806952	Silent	rs766428675	L262L	0.46
UCEC	chr19	2810334	Missense_Mutation	NA	V496M	0.32
UCEC	chr19	2807030	Silent	novel	S288S	0.42
UCEC	chr19	2807483	Missense_Mutation	rs573052024	R310C	0.3
UCEC	chr19	2807645	Missense_Mutation	novel	V364M	0.48
UCEC	chr19	2796125	Silent	NA	Y141Y	0.23
UCEC	chr19	2807484	Missense_Mutation	rs370445695	R310H	0.38
UCEC	chr19	2790559	Missense_Mutation	NA	G52D	0.31
UCEC	chr19	2807522	Missense_Mutation	rs747083037	R323C	0.26
UCEC	chr19	2810363	Silent	rs371508092	S505S	0.12
UCEC	chr19	2794792	Silent	novel	Q86Q	0.11
UCEC	chr19	2796034	Intron	rs762852817		0.31
UCEC	chr19	2805175	Missense_Mutation	novel	E250G	0.35
UCEC	chr19	2806992	Missense_Mutation	rs746532359	A276T	0.44
UCEC	chr19	2807567	Missense_Mutation	novel	R338C	0.29
UCEC	chr19	2810208	Intron	rs562349962		0.42
UCEC	chr19	2807451	Missense_Mutation	rs142317993	A299V	0.32
UCEC	chr19	2794858	Silent	rs199546012	F108F	0.13
UCEC	chr19	2806924	Missense_Mutation	novel	C253Y	0.53
UCEC	chr19	2790451	Missense_Mutation	novel	S16Y	0.47
UCEC	chr19	2813310	3'UTR	novel		0.43
UCEC	chr19	2794835	Missense_Mutation	novel	A101S	0.39
UCEC	chr19	2806965	Missense_Mutation	novel	S267T	0.16
UCEC	chr19	2810763	Missense_Mutation	rs368086026	T589M	0.67
UCEC	chr19	2813240	Missense_Mutation	novel	Q678H	0.58
UCEC	chr19	2807511	Missense_Mutation	NA	A319V	0.32
UCEC	chr19	2796189	Splice_Site	novel	X162_splice	0.42
UCEC	chr19	2807767	Silent	novel	S404S	0.63
UCEC	chr19	2813258	Silent	rs766778404	P684P	0.63
UCEC	chr19	2790493	Missense_Mutation	rs768045466	A30V	0.48
UCEC	chr19	2808365	Missense_Mutation	NA	A459V	0.35
UCEC	chr19	2813133	Missense_Mutation	novel	S643G	0.36
UCEC	chr19	2806949	Silent	rs200372786	T261T	0.48
UCEC	chr19	2807562	Missense_Mutation	novel	D336G	0.57
UCEC	chr19	2806926	Missense_Mutation	rs771666514	A254T	0.36
UCEC	chr19	2794884	Missense_Mutation	novel	D117V	0.23
UCEC	chr19	2805154	Missense_Mutation	novel	A243V	0.49
UCEC	chr19	2810305	Missense_Mutation	novel	A486V	0.07
UCEC	chr19	2810476	Missense_Mutation	rs763997610	R543Q	0.38
UCEC	chr19	2807508	Missense_Mutation	rs796880434	R318H	0.32
UCEC	chr19	2806954	Missense_Mutation	novel	R263L	0.07
UCEC	chr19	2810255	Intron	novel		0.32
UCEC	chr19	2806995	Missense_Mutation	rs781343977	D277N	0.15
UCEC	chr19	2813236	Missense_Mutation	novel	L677P	0.25
UCEC	chr19	2807530	Silent	NA	G325G	0.22
UCEC	chr19	2794858	Silent	rs199546012	F108F	0.32
UCEC	chr19	2796066	Intron	novel		0.23
UCEC	chr19	2790476	Silent	rs773299423	L24L	0.45
UCEC	chr19	2794838	Missense_Mutation	rs779946739	D102N	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0521	0.058467
LIHC	DEL	0.1865	4.7028e-08
PAAD	DEL	0.1467	0.0060878
READ	DEL	0.1333	0.23023
STAD	DEL	0.2812	1.5798e-05
THCA	DEL	0.014	0.10598
UCEC	DEL	0.2783	4.5149e-49
UCS	DEL	0.7679	8.0449e-14

Survival Analysis

Cancer	P-value	Q-value
THYM	0.027	Kaplan-Meier Survival Analysis
KIRC	0.00011	Kaplan-Meier Survival Analysis
STAD	0.0011	Kaplan-Meier Survival Analysis
MESO	0.00053	Kaplan-Meier Survival Analysis
ACC	0.011	Kaplan-Meier Survival Analysis
HNSC	0.0047	Kaplan-Meier Survival Analysis
PAAD	0.001	Kaplan-Meier Survival Analysis
CESC	0.00092	Kaplan-Meier Survival Analysis
READ	0.043	Kaplan-Meier Survival Analysis
LAML	0.0065	Kaplan-Meier Survival Analysis
UCEC	0.001	Kaplan-Meier Survival Analysis
DLBC	0.013	Kaplan-Meier Survival Analysis
LGG	0.039	Kaplan-Meier Survival Analysis
LUAD	0.0051	Kaplan-Meier Survival Analysis
UVM	0.0001	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742