EuRBPDB

Description

Ensembl ID: ENSG00000172171 (Gene tree)
Gene ID: 79736
Gene Symbol: TEFM
Alias: FLJ22729|C17orf42
Full Name: transcription elongation factor, mitochondrial
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 9,485 bases
Position: chr17:30,897,336-30,906,820
Accession: 26223
RBP type: non-canonical RBP
Summary: (Transcription Elongation Factor, Mitochondrial) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and crossover junction endodeoxyribonuclease activity.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30190598	Structural basis of mitochondrial transcription.	Nat Struct Mol Biol	2018 Sep	Hillen HS	doi: 10.1038/s41594-018-0122-9

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000580840	TEFM-204	2109	-	ENSP00000462973	226 (aa)	-	J3KTG7
ENST00000306049	TEFM-201	1262	-	ENSP00000306574	171 (aa)	-	Q96QE5
ENST00000579183	TEFM-203	633	-	-	- (aa)	-	-
ENST00000581216	TEFM-205	1891	XM_006722084	ENSP00000462963	360 (aa)	XP_006722147	Q96QE5
ENST00000541382	TEFM-202	559	-	-	- (aa)	-	-

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000172171	rs146699004	17	30903503	GGT	Breast cancer	29059683	[1.01-1.05] (Oncoarray)	1.0309278	EFO_0000305

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000172171	TEFM	96	67.723	ENSMUSG00000046909	Tefm	94	67.723	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	21278163.	IPI	Function
GO:0005739	mitochondrion	-	IDA	Component
GO:0005759	mitochondrial matrix	21278163.	IDA	Component
GO:0006119	oxidative phosphorylation	21278163.	IMP	Process
GO:0006264	mitochondrial DNA replication	21278163.	IMP	Process
GO:0006390	mitochondrial transcription	21278163.	IMP	Process
GO:0006392	transcription elongation from mitochondrial promoter	-	IEA	Process
GO:0008821	crossover junction endodeoxyribonuclease activity	21278163.	IDA	Function
GO:0030337	DNA polymerase processivity factor activity	21278163.	IDA	Function
GO:0042645	mitochondrial nucleoid	21278163.	IDA	Component
GO:1990904	ribonucleoprotein complex	21278163.	IDA	Component