EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000172262 (Gene tree)
Gene ID: 7690
Gene Symbol: ZNF131
Alias: ZBTB35|pHZ-10
Full Name: zinc finger protein 131
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 126,846 bases
Position: chr5:43,065,176-43,192,021
Accession: 12915
RBP type: canonical RBP
Summary: ZNF131 (Zinc Finger Protein 131) is a Protein Coding gene. Diseases associated with ZNF131 include Joubert Syndrome 1. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is ZKSCAN2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000305804	zf-met	PF12874.7	2.3e-06	1	2
ENSP00000305804	zf-met	PF12874.7	2.3e-06	2	2
ENSP00000421246	zf-met	PF12874.7	2.3e-06	1	2
ENSP00000421246	zf-met	PF12874.7	2.3e-06	2	2
ENSP00000423945	zf-met	PF12874.7	2.3e-06	1	2
ENSP00000423945	zf-met	PF12874.7	2.3e-06	2	2
ENSP00000426504	zf-met	PF12874.7	2.8e-06	1	2
ENSP00000426504	zf-met	PF12874.7	2.8e-06	2	2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000509156	ZNF131-212	2063	-	ENSP00000426504	623 (aa)	-	P52739
ENST00000508259	ZNF131-210	501	-	ENSP00000422659	151 (aa)	-	D6RBK1
ENST00000510026	ZNF131-216	2599	-	ENSP00000425623	253 (aa)	-	D6RJH2
ENST00000511736	ZNF131-218	956	-	ENSP00000426614	124 (aa)	-	D6RFI6
ENST00000510037	ZNF131-217	1927	-	-	- (aa)	-	-
ENST00000509634	ZNF131-214	3340	-	ENSP00000421246	589 (aa)	-	P52739
ENST00000507393	ZNF131-209	583	-	ENSP00000427003	79 (aa)	-	D6RD61
ENST00000499046	ZNF131-202	990	NR_102752	-	- (aa)	-	-
ENST00000515326	ZNF131-220	1050	-	ENSP00000422079	264 (aa)	-	D6R9I2
ENST00000514169	ZNF131-219	476	-	-	- (aa)	-	-
ENST00000508795	ZNF131-211	465	-	-	- (aa)	-	-
ENST00000509931	ZNF131-215	970	-	ENSP00000425722	66 (aa)	-	D6RJ09
ENST00000502623	ZNF131-203	760	-	ENSP00000423254	68 (aa)	-	H0Y974
ENST00000306938	ZNF131-201	2400	-	ENSP00000305804	589 (aa)	-	P52739
ENST00000509341	ZNF131-213	572	-	ENSP00000424771	139 (aa)	-	D6RAT8
ENST00000507231	ZNF131-208	538	-	-	- (aa)	-	-
ENST00000507218	ZNF131-207	1352	-	ENSP00000425139	83 (aa)	-	D6RE06
ENST00000505606	ZNF131-206	3209	-	ENSP00000423945	589 (aa)	-	P52739
ENST00000503599	ZNF131-204	750	-	-	- (aa)	-	-
ENST00000504359	ZNF131-205	565	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000172262's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000172262	Body Mass Index	9E-6	25673413

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000172262	rs1532331	5	43116728	G	Menarche (age at onset)	25231870	[0.02-0.04] unit increase	0.03	EFO_0004703
ENSG00000172262	rs782988	5	43167172	A	Educational attainment (MTAG)	30038396	[0.0064-0.013] unit increase	0.0097	EFO_0004784
ENSG00000172262	rs35375873	5	43190545	?	Menarche (age at onset)	30595370			EFO_0004703
ENSG00000172262	rs13176429	5	43152114	?	Body mass index	30595370			EFO_0004340
ENSG00000172262	rs35375873	5	43190545	C	Age of smoking initiation (MTAG)	30643251	[0.011-0.021] unit increase	0.0158053	EFO_0005670
ENSG00000172262	rs35375873	5	43190545	C	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.012-0.019] unit decrease	0.0155526	EFO_0006527
ENSG00000172262	rs35375873	5	43190545	C	Smoking initiation (ever regular vs never regular)	30643251	[0.019-0.035] unit decrease	0.02701025	EFO_0006527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172262's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000172262	ZNF131	97	72.500	ENSAPOG00000016957	znf131	93	54.225	Acanthochromis_polyacanthus
ENSG00000172262	ZNF131	100	97.638	ENSAMEG00000003882	ZNF131	100	95.873	Ailuropoda_melanoleuca
ENSG00000172262	ZNF131	89	76.364	ENSACIG00000003694	znf131	97	54.204	Amphilophus_citrinellus
ENSG00000172262	ZNF131	88	77.064	ENSAOCG00000018972	znf131	91	53.846	Amphiprion_ocellaris
ENSG00000172262	ZNF131	88	77.064	ENSAPEG00000006034	znf131	93	53.943	Amphiprion_percula
ENSG00000172262	ZNF131	97	74.167	ENSATEG00000017187	znf131	93	55.338	Anabas_testudineus
ENSG00000172262	ZNF131	100	91.935	ENSACAG00000010702	ZNF131	94	74.956	Anolis_carolinensis
ENSG00000172262	ZNF131	100	100.000	ENSANAG00000021961	ZNF131	100	98.716	Aotus_nancymaae
ENSG00000172262	ZNF131	89	75.455	ENSACLG00000014569	znf131	95	54.787	Astatotilapia_calliptera
ENSG00000172262	ZNF131	89	77.273	ENSAMXG00000005882	znf131	95	58.457	Astyanax_mexicanus
ENSG00000172262	ZNF131	100	100.000	ENSBTAG00000015504	ZNF131	100	96.441	Bos_taurus
ENSG00000172262	ZNF131	100	100.000	ENSCJAG00000001280	ZNF131	97	97.913	Callithrix_jacchus
ENSG00000172262	ZNF131	100	100.000	ENSCAFG00000018578	ZNF131	100	95.847	Canis_familiaris
ENSG00000172262	ZNF131	87	95.303	ENSCAFG00020022510	-	100	95.303	Canis_lupus_dingo
ENSG00000172262	ZNF131	100	100.000	ENSCHIG00000020006	-	100	96.795	Capra_hircus
ENSG00000172262	ZNF131	100	100.000	ENSCHIG00000024065	-	100	95.085	Capra_hircus
ENSG00000172262	ZNF131	100	100.000	ENSTSYG00000014468	ZNF131	100	97.596	Carlito_syrichta
ENSG00000172262	ZNF131	84	93.359	ENSCAPG00000000381	ZNF131	93	93.359	Cavia_aperea
ENSG00000172262	ZNF131	100	100.000	ENSCPOG00000033475	ZNF131	100	94.551	Cavia_porcellus
ENSG00000172262	ZNF131	100	100.000	ENSCCAG00000034999	ZNF131	100	98.555	Cebus_capucinus
ENSG00000172262	ZNF131	100	97.111	ENSCATG00000041809	ZNF131	100	98.950	Cercocebus_atys
ENSG00000172262	ZNF131	100	100.000	ENSCLAG00000016740	ZNF131	100	96.154	Chinchilla_lanigera
ENSG00000172262	ZNF131	100	100.000	ENSCSAG00000016781	ZNF131	99	98.981	Chlorocebus_sabaeus
ENSG00000172262	ZNF131	100	96.774	ENSCHOG00000008150	ZNF131	100	94.712	Choloepus_hoffmanni
ENSG00000172262	ZNF131	100	91.935	ENSCPBG00000007722	ZNF131	100	80.968	Chrysemys_picta_bellii
ENSG00000172262	ZNF131	93	98.720	ENSCANG00000039508	ZNF131	100	98.720	Colobus_angolensis_palliatus
ENSG00000172262	ZNF131	100	99.338	ENSCGRG00001021210	Zfp131	100	93.888	Cricetulus_griseus_chok1gshd
ENSG00000172262	ZNF131	100	100.000	ENSCGRG00000015951	Zfp131	100	94.382	Cricetulus_griseus_crigri
ENSG00000172262	ZNF131	92	70.175	ENSCSEG00000009274	-	95	49.434	Cynoglossus_semilaevis
ENSG00000172262	ZNF131	100	70.161	ENSDARG00000068400	znf131	100	57.542	Danio_rerio
ENSG00000172262	ZNF131	100	97.638	ENSDNOG00000032854	ZNF131	99	94.896	Dasypus_novemcinctus
ENSG00000172262	ZNF131	100	100.000	ENSDORG00000028178	-	99	98.295	Dipodomys_ordii
ENSG00000172262	ZNF131	86	76.181	ENSETEG00000015357	ZNF131	99	76.181	Echinops_telfairi
ENSG00000172262	ZNF131	100	100.000	ENSEASG00005013512	ZNF131	100	96.441	Equus_asinus_asinus
ENSG00000172262	ZNF131	100	100.000	ENSECAG00000019558	ZNF131	100	96.441	Equus_caballus
ENSG00000172262	ZNF131	65	100.000	ENSEEUG00000000034	-	61	100.000	Erinaceus_europaeus
ENSG00000172262	ZNF131	100	100.000	ENSFCAG00000029728	ZNF131	100	96.795	Felis_catus
ENSG00000172262	ZNF131	100	90.323	ENSFALG00000011128	ZNF131	100	77.568	Ficedula_albicollis
ENSG00000172262	ZNF131	100	100.000	ENSFDAG00000015028	ZNF131	100	94.416	Fukomys_damarensis
ENSG00000172262	ZNF131	97	74.167	ENSGMOG00000007667	znf131	81	61.926	Gadus_morhua
ENSG00000172262	ZNF131	100	90.323	ENSGALG00000014859	ZNF131	100	79.288	Gallus_gallus
ENSG00000172262	ZNF131	92	74.561	ENSGACG00000006824	znf131	88	57.760	Gasterosteus_aculeatus
ENSG00000172262	ZNF131	100	91.935	ENSGAGG00000002255	ZNF131	100	80.291	Gopherus_agassizii
ENSG00000172262	ZNF131	100	100.000	ENSGGOG00000002252	ZNF131	100	99.518	Gorilla_gorilla
ENSG00000172262	ZNF131	89	75.455	ENSHBUG00000003921	znf131	95	54.787	Haplochromis_burtoni
ENSG00000172262	ZNF131	95	85.714	ENSHGLG00000005956	-	100	79.487	Heterocephalus_glaber_female
ENSG00000172262	ZNF131	95	85.714	ENSHGLG00100015342	-	100	74.679	Heterocephalus_glaber_male
ENSG00000172262	ZNF131	89	77.273	ENSHCOG00000013956	znf131	81	59.831	Hippocampus_comes
ENSG00000172262	ZNF131	91	74.336	ENSIPUG00000019221	znf131	76	59.298	Ictalurus_punctatus
ENSG00000172262	ZNF131	100	100.000	ENSSTOG00000015383	-	100	96.795	Ictidomys_tridecemlineatus
ENSG00000172262	ZNF131	100	100.000	ENSJJAG00000011423	-	99	98.011	Jaculus_jaculus
ENSG00000172262	ZNF131	98	68.852	ENSKMAG00000022244	znf131	89	56.250	Kryptolebias_marmoratus
ENSG00000172262	ZNF131	97	69.167	ENSLBEG00000004164	znf131	82	60.291	Labrus_bergylta
ENSG00000172262	ZNF131	100	80.645	ENSLACG00000001147	ZNF131	99	68.259	Latimeria_chalumnae
ENSG00000172262	ZNF131	100	60.000	ENSLOCG00000008117	znf131	82	62.628	Lepisosteus_oculatus
ENSG00000172262	ZNF131	100	100.000	ENSLAFG00000004927	ZNF131	100	92.468	Loxodonta_africana
ENSG00000172262	ZNF131	100	100.000	ENSMFAG00000046336	ZNF131	100	99.037	Macaca_fascicularis
ENSG00000172262	ZNF131	100	100.000	ENSMMUG00000014251	ZNF131	94	98.981	Macaca_mulatta
ENSG00000172262	ZNF131	100	100.000	ENSMNEG00000017333	ZNF131	100	98.981	Macaca_nemestrina
ENSG00000172262	ZNF131	100	100.000	ENSMLEG00000044036	ZNF131	100	98.132	Mandrillus_leucophaeus
ENSG00000172262	ZNF131	97	74.167	ENSMAMG00000020805	znf131	86	58.350	Mastacembelus_armatus
ENSG00000172262	ZNF131	89	75.455	ENSMZEG00005006971	znf131	95	54.787	Maylandia_zebra
ENSG00000172262	ZNF131	79	74.526	ENSMGAG00000003601	ZNF131	100	74.419	Meleagris_gallopavo
ENSG00000172262	ZNF131	100	100.000	ENSMAUG00000000415	Zfp131	100	94.382	Mesocricetus_auratus
ENSG00000172262	ZNF131	100	100.000	ENSMICG00000042242	ZNF131	100	96.314	Microcebus_murinus
ENSG00000172262	ZNF131	100	100.000	ENSMOCG00000016567	Zfp131	100	93.258	Microtus_ochrogaster
ENSG00000172262	ZNF131	90	76.577	ENSMMOG00000001237	znf131	94	56.274	Mola_mola
ENSG00000172262	ZNF131	100	95.968	ENSMODG00000020281	ZNF131	99	87.329	Monodelphis_domestica
ENSG00000172262	ZNF131	98	71.074	ENSMALG00000017515	znf131	81	61.290	Monopterus_albus
ENSG00000172262	ZNF131	100	100.000	MGP_CAROLIEiJ_G0018933	Zfp131	100	93.579	Mus_caroli
ENSG00000172262	ZNF131	100	100.000	ENSMUSG00000094870	Zfp131	99	96.875	Mus_musculus
ENSG00000172262	ZNF131	100	99.338	MGP_PahariEiJ_G0016002	Zfp131	100	93.419	Mus_pahari
ENSG00000172262	ZNF131	100	100.000	MGP_SPRETEiJ_G0019811	Zfp131	100	93.740	Mus_spretus
ENSG00000172262	ZNF131	100	95.161	ENSMPUG00000017447	-	100	90.153	Mustela_putorius_furo
ENSG00000172262	ZNF131	100	100.000	ENSMPUG00000014433	-	99	96.480	Mustela_putorius_furo
ENSG00000172262	ZNF131	98	92.320	ENSMLUG00000017183	ZNF131	100	92.320	Myotis_lucifugus
ENSG00000172262	ZNF131	100	99.194	ENSNGAG00000016975	Zfp131	100	95.185	Nannospalax_galili
ENSG00000172262	ZNF131	90	74.775	ENSNBRG00000014299	znf131	85	60.638	Neolamprologus_brichardi
ENSG00000172262	ZNF131	100	100.000	ENSNLEG00000010402	ZNF131	100	99.679	Nomascus_leucogenys
ENSG00000172262	ZNF131	93	86.689	ENSMEUG00000006759	ZNF131	100	86.689	Notamacropus_eugenii
ENSG00000172262	ZNF131	90	75.676	ENSONIG00000015187	znf131	84	58.600	Oreochromis_niloticus
ENSG00000172262	ZNF131	100	100.000	ENSOCUG00000017804	ZNF131	100	94.737	Oryctolagus_cuniculus
ENSG00000172262	ZNF131	90	74.775	ENSORLG00000004007	znf131	96	53.004	Oryzias_latipes
ENSG00000172262	ZNF131	90	74.775	ENSORLG00020002467	znf131	92	53.004	Oryzias_latipes_hni
ENSG00000172262	ZNF131	90	74.775	ENSORLG00015011016	znf131	92	52.827	Oryzias_latipes_hsok
ENSG00000172262	ZNF131	88	74.312	ENSOMEG00000021225	znf131	88	59.789	Oryzias_melastigma
ENSG00000172262	ZNF131	100	100.000	ENSOARG00000008729	ZNF131	100	96.780	Ovis_aries
ENSG00000172262	ZNF131	100	100.000	ENSPPAG00000024198	ZNF131	100	99.839	Pan_paniscus
ENSG00000172262	ZNF131	100	100.000	ENSPTIG00000021445	ZNF131	100	96.795	Panthera_tigris_altaica
ENSG00000172262	ZNF131	100	100.000	ENSPTRG00000016842	ZNF131	100	99.839	Pan_troglodytes
ENSG00000172262	ZNF131	100	100.000	ENSPANG00000011134	ZNF131	99	99.151	Papio_anubis
ENSG00000172262	ZNF131	92	76.316	ENSPKIG00000017455	znf131	94	58.156	Paramormyrops_kingsleyae
ENSG00000172262	ZNF131	100	91.935	ENSPSIG00000018191	ZNF131	98	80.161	Pelodiscus_sinensis
ENSG00000172262	ZNF131	100	95.968	ENSPCIG00000030602	ZNF131	82	87.031	Phascolarctos_cinereus
ENSG00000172262	ZNF131	100	100.000	ENSPPYG00000015437	ZNF131	100	99.491	Pongo_abelii
ENSG00000172262	ZNF131	100	100.000	ENSPCOG00000013460	ZNF131	100	96.154	Propithecus_coquereli
ENSG00000172262	ZNF131	89	75.455	ENSPNYG00000015689	znf131	96	54.120	Pundamilia_nyererei
ENSG00000172262	ZNF131	99	71.545	ENSPNAG00000024014	znf131	98	54.688	Pygocentrus_nattereri
ENSG00000172262	ZNF131	100	100.000	ENSRNOG00000015925	Zfp131	100	92.135	Rattus_norvegicus
ENSG00000172262	ZNF131	100	100.000	ENSRBIG00000033767	ZNF131	100	99.037	Rhinopithecus_bieti
ENSG00000172262	ZNF131	100	100.000	ENSRROG00000029295	ZNF131	100	99.037	Rhinopithecus_roxellana
ENSG00000172262	ZNF131	100	100.000	ENSSBOG00000021812	ZNF131	100	98.234	Saimiri_boliviensis_boliviensis
ENSG00000172262	ZNF131	100	95.968	ENSSHAG00000011534	ZNF131	99	88.527	Sarcophilus_harrisii
ENSG00000172262	ZNF131	91	76.991	ENSSFOG00015006767	znf131	77	64.286	Scleropages_formosus
ENSG00000172262	ZNF131	97	69.167	ENSSMAG00000002899	znf131	80	60.600	Scophthalmus_maximus
ENSG00000172262	ZNF131	89	75.455	ENSSDUG00000002796	znf131	97	53.130	Seriola_dumerili
ENSG00000172262	ZNF131	89	75.455	ENSSLDG00000018959	znf131	97	53.130	Seriola_lalandi_dorsalis
ENSG00000172262	ZNF131	79	89.079	ENSSARG00000004599	ZNF131	100	89.079	Sorex_araneus
ENSG00000172262	ZNF131	100	91.129	ENSSPUG00000017446	ZNF131	99	79.483	Sphenodon_punctatus
ENSG00000172262	ZNF131	97	73.333	ENSSPAG00000006296	znf131	91	54.562	Stegastes_partitus
ENSG00000172262	ZNF131	100	100.000	ENSSSCG00000040959	ZNF131	100	97.111	Sus_scrofa
ENSG00000172262	ZNF131	100	91.129	ENSTGUG00000002273	ZNF131	100	79.739	Taeniopygia_guttata
ENSG00000172262	ZNF131	96	65.854	ENSTRUG00000015099	znf131	93	53.565	Takifugu_rubripes
ENSG00000172262	ZNF131	90	73.874	ENSTNIG00000016665	znf131	94	53.805	Tetraodon_nigroviridis
ENSG00000172262	ZNF131	87	92.368	ENSTBEG00000015451	ZNF131	100	92.368	Tupaia_belangeri
ENSG00000172262	ZNF131	100	99.194	ENSTTRG00000009644	ZNF131	100	97.846	Tursiops_truncatus
ENSG00000172262	ZNF131	87	96.330	ENSUAMG00000019226	-	100	96.330	Ursus_americanus
ENSG00000172262	ZNF131	100	100.000	ENSUMAG00000007169	ZNF131	100	96.610	Ursus_maritimus
ENSG00000172262	ZNF131	100	100.000	ENSVPAG00000007062	ZNF131	100	97.610	Vicugna_pacos
ENSG00000172262	ZNF131	100	100.000	ENSVVUG00000025370	ZNF131	100	95.994	Vulpes_vulpes
ENSG00000172262	ZNF131	100	83.871	ENSXETG00000032207	ZNF131	100	66.667	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	21873635.	IBA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	21873635.	IBA	Function
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003700	DNA-binding transcription factor activity	7557990.	NAS	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	7557990.	NAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006355	regulation of transcription, DNA-templated	7557990.	NAS	Process
GO:0045111	intermediate filament cytoskeleton	-	IDA	Component
GO:0046872	metal ion binding	-	IEA	Function