EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000172409 (Gene tree)
Gene ID: 10978
Gene Symbol: CLP1
Alias: HEAB|hClp1
Full Name: cleavage and polyadenylation factor I subunit 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 12,877 bases
Position: chr11:57,648,992-57,661,868
Accession: 16999
RBP type: canonical RBP
Summary: This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000304704	Clp1	PF06807.14	4.3e-30	1	1
ENSP00000434995	Clp1	PF06807.14	5.8e-30	1	1
ENSP00000436066	Clp1	PF06807.14	5.8e-30	1	1
ENSP00000433406	Clp1	PF06807.14	6e-30	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25266383	Structures of bacterial polynucleotide kinase in a michaelis complex with nucleoside triphosphate (NTP)-Mg2+ and 5'-OH RNA and a mixed substrate-product complex with NTP-Mg2+ and a 5'-phosphorylated oligonucleotide.	J Bacteriol	2014 Dec	Das U	doi: 10.1128/JB.02197-14

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000302731	CLP1-201	1634	-	ENSP00000304704	361 (aa)	-	Q92989
ENST00000525602	CLP1-202	1392	-	ENSP00000436066	425 (aa)	-	Q92989
ENST00000529430	CLP1-203	1778	-	ENSP00000433406	436 (aa)	-	E9PL17
ENST00000533682	CLP1-205	2435	-	ENSP00000434995	425 (aa)	-	Q92989
ENST00000529773	CLP1-204	566	-	ENSP00000435287	92 (aa)	-	E9PKV5
ENST00000533905	CLP1-206	553	-	ENSP00000431744	132 (aa)	-	E9PJM4

Gene Model

Click here to download ENSG00000172409's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000172409	rs7117878	11	57653985	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000172409	rs10896633	11	57656568	C	Positive affect	30643256	[0.0058-0.0113] unit increase	0.00856035	EFO_0007869

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172409's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000172409	CLP1	98	77.123	ENSAPOG00000008242	clp1	99	75.632	Acanthochromis_polyacanthus
ENSG00000172409	CLP1	100	99.529	ENSAMEG00000014551	CLP1	99	99.306	Ailuropoda_melanoleuca
ENSG00000172409	CLP1	98	76.415	ENSACIG00000006310	clp1	98	74.943	Amphilophus_citrinellus
ENSG00000172409	CLP1	100	75.751	ENSAOCG00000010681	clp1	100	75.751	Amphiprion_ocellaris
ENSG00000172409	CLP1	98	77.123	ENSAPEG00000012165	clp1	99	77.123	Amphiprion_percula
ENSG00000172409	CLP1	99	76.566	ENSATEG00000012374	clp1	99	76.092	Anabas_testudineus
ENSG00000172409	CLP1	100	94.353	ENSACAG00000007139	CLP1	100	94.353	Anolis_carolinensis
ENSG00000172409	CLP1	100	100.000	ENSANAG00000034935	CLP1	100	100.000	Aotus_nancymaae
ENSG00000172409	CLP1	99	75.638	ENSACLG00000013573	clp1	99	75.172	Astatotilapia_calliptera
ENSG00000172409	CLP1	97	78.860	ENSAMXG00000014194	clp1	98	78.860	Astyanax_mexicanus
ENSG00000172409	CLP1	100	99.529	ENSBTAG00000006493	CLP1	100	99.529	Bos_taurus
ENSG00000172409	CLP1	96	47.962	WBGene00010304	clpf-1	97	47.962	Caenorhabditis_elegans
ENSG00000172409	CLP1	100	100.000	ENSCJAG00000008748	CLP1	100	100.000	Callithrix_jacchus
ENSG00000172409	CLP1	100	99.529	ENSCAFG00000007815	CLP1	100	99.529	Canis_familiaris
ENSG00000172409	CLP1	100	99.529	ENSCAFG00020000903	CLP1	100	99.529	Canis_lupus_dingo
ENSG00000172409	CLP1	100	98.824	ENSCHIG00000023497	CLP1	100	98.824	Capra_hircus
ENSG00000172409	CLP1	100	99.529	ENSTSYG00000006824	CLP1	100	99.304	Carlito_syrichta
ENSG00000172409	CLP1	100	99.294	ENSCAPG00000009703	CLP1	100	99.294	Cavia_aperea
ENSG00000172409	CLP1	98	99.519	ENSCPOG00000012554	CLP1	99	99.519	Cavia_porcellus
ENSG00000172409	CLP1	100	99.529	ENSCCAG00000031957	CLP1	100	99.529	Cebus_capucinus
ENSG00000172409	CLP1	100	100.000	ENSCATG00000044628	CLP1	100	100.000	Cercocebus_atys
ENSG00000172409	CLP1	100	99.765	ENSCLAG00000004094	CLP1	100	99.765	Chinchilla_lanigera
ENSG00000172409	CLP1	100	100.000	ENSCSAG00000005994	CLP1	100	100.000	Chlorocebus_sabaeus
ENSG00000172409	CLP1	100	94.353	ENSCPBG00000016843	CLP1	100	94.353	Chrysemys_picta_bellii
ENSG00000172409	CLP1	99	63.507	ENSCING00000003779	-	98	63.507	Ciona_intestinalis
ENSG00000172409	CLP1	99	63.270	ENSCSAVG00000003437	-	99	63.270	Ciona_savignyi
ENSG00000172409	CLP1	100	100.000	ENSCANG00000034335	CLP1	100	100.000	Colobus_angolensis_palliatus
ENSG00000172409	CLP1	100	98.824	ENSCGRG00001002227	CLP1	100	98.824	Cricetulus_griseus_chok1gshd
ENSG00000172409	CLP1	100	98.824	ENSCGRG00000004328	CLP1	100	98.824	Cricetulus_griseus_crigri
ENSG00000172409	CLP1	99	74.942	ENSCSEG00000008614	clp1	99	74.483	Cynoglossus_semilaevis
ENSG00000172409	CLP1	99	76.102	ENSCVAG00000020101	clp1	99	75.632	Cyprinodon_variegatus
ENSG00000172409	CLP1	97	79.952	ENSDARG00000063663	clp1	95	79.952	Danio_rerio
ENSG00000172409	CLP1	99	99.528	ENSDNOG00000042415	CLP1	91	98.840	Dasypus_novemcinctus
ENSG00000172409	CLP1	100	99.294	ENSDORG00000014685	Clp1	100	99.294	Dipodomys_ordii
ENSG00000172409	CLP1	96	56.553	FBgn0033842	cbc	97	56.553	Drosophila_melanogaster
ENSG00000172409	CLP1	100	99.765	ENSETEG00000003009	CLP1	100	99.765	Echinops_telfairi
ENSG00000172409	CLP1	97	72.155	ENSEBUG00000011648	clp1	97	72.155	Eptatretus_burgeri
ENSG00000172409	CLP1	100	99.765	ENSEASG00005002093	CLP1	100	99.765	Equus_asinus_asinus
ENSG00000172409	CLP1	100	99.765	ENSECAG00000011597	CLP1	100	99.765	Equus_caballus
ENSG00000172409	CLP1	100	98.588	ENSEEUG00000012771	CLP1	100	98.588	Erinaceus_europaeus
ENSG00000172409	CLP1	97	79.810	ENSELUG00000024048	clp1	95	79.810	Esox_lucius
ENSG00000172409	CLP1	100	99.294	ENSFCAG00000006633	CLP1	100	99.294	Felis_catus
ENSG00000172409	CLP1	100	92.706	ENSFALG00000011145	CLP1	100	92.706	Ficedula_albicollis
ENSG00000172409	CLP1	100	99.765	ENSFDAG00000000234	CLP1	100	99.765	Fukomys_damarensis
ENSG00000172409	CLP1	99	75.406	ENSFHEG00000014760	CLP1	99	74.943	Fundulus_heteroclitus
ENSG00000172409	CLP1	97	80.144	ENSGMOG00000019340	clp1	100	76.941	Gadus_morhua
ENSG00000172409	CLP1	100	93.412	ENSGALG00000007370	CLP1	100	93.412	Gallus_gallus
ENSG00000172409	CLP1	99	75.870	ENSGAFG00000003020	clp1	99	75.870	Gambusia_affinis
ENSG00000172409	CLP1	99	77.030	ENSGACG00000017832	clp1	99	76.552	Gasterosteus_aculeatus
ENSG00000172409	CLP1	100	94.353	ENSGAGG00000013279	CLP1	100	94.353	Gopherus_agassizii
ENSG00000172409	CLP1	100	100.000	ENSGGOG00000023006	CLP1	100	100.000	Gorilla_gorilla
ENSG00000172409	CLP1	99	75.638	ENSHBUG00000010436	clp1	99	75.172	Haplochromis_burtoni
ENSG00000172409	CLP1	100	99.765	ENSHGLG00000009914	CLP1	100	99.765	Heterocephalus_glaber_female
ENSG00000172409	CLP1	100	99.765	ENSHGLG00100006105	CLP1	100	99.765	Heterocephalus_glaber_male
ENSG00000172409	CLP1	99	77.011	ENSHCOG00000010072	clp1	99	77.011	Hippocampus_comes
ENSG00000172409	CLP1	97	79.286	ENSIPUG00000016238	clp1	94	79.097	Ictalurus_punctatus
ENSG00000172409	CLP1	100	99.765	ENSSTOG00000029257	CLP1	100	99.765	Ictidomys_tridecemlineatus
ENSG00000172409	CLP1	100	99.059	ENSJJAG00000023691	Clp1	100	99.059	Jaculus_jaculus
ENSG00000172409	CLP1	99	75.406	ENSKMAG00000011990	clp1	99	74.943	Kryptolebias_marmoratus
ENSG00000172409	CLP1	99	76.798	ENSLBEG00000010201	clp1	99	76.322	Labrus_bergylta
ENSG00000172409	CLP1	100	85.647	ENSLACG00000003160	CLP1	100	85.647	Latimeria_chalumnae
ENSG00000172409	CLP1	73	76.708	ENSLOCG00000008074	clp1	100	77.640	Lepisosteus_oculatus
ENSG00000172409	CLP1	100	99.529	ENSLAFG00000014907	CLP1	100	99.529	Loxodonta_africana
ENSG00000172409	CLP1	100	100.000	ENSMFAG00000046074	CLP1	100	100.000	Macaca_fascicularis
ENSG00000172409	CLP1	100	100.000	ENSMMUG00000038007	CLP1	100	100.000	Macaca_mulatta
ENSG00000172409	CLP1	100	100.000	ENSMNEG00000000259	CLP1	100	100.000	Macaca_nemestrina
ENSG00000172409	CLP1	100	100.000	ENSMLEG00000043556	CLP1	100	100.000	Mandrillus_leucophaeus
ENSG00000172409	CLP1	100	75.982	ENSMAMG00000002149	clp1	99	75.862	Mastacembelus_armatus
ENSG00000172409	CLP1	99	75.638	ENSMZEG00005002850	clp1	99	75.172	Maylandia_zebra
ENSG00000172409	CLP1	100	93.412	ENSMGAG00000009643	CLP1	100	93.412	Meleagris_gallopavo
ENSG00000172409	CLP1	100	98.118	ENSMAUG00000016261	Clp1	100	98.118	Mesocricetus_auratus
ENSG00000172409	CLP1	100	99.529	ENSMICG00000004895	CLP1	100	99.529	Microcebus_murinus
ENSG00000172409	CLP1	100	99.059	ENSMOCG00000005498	Clp1	100	99.059	Microtus_ochrogaster
ENSG00000172409	CLP1	98	78.538	ENSMMOG00000003229	clp1	96	78.538	Mola_mola
ENSG00000172409	CLP1	100	97.412	ENSMODG00000024148	-	100	97.412	Monodelphis_domestica
ENSG00000172409	CLP1	100	97.412	ENSMODG00000020107	-	100	97.412	Monodelphis_domestica
ENSG00000172409	CLP1	99	75.172	ENSMALG00000014239	clp1	99	75.172	Monopterus_albus
ENSG00000172409	CLP1	100	98.588	MGP_CAROLIEiJ_G0023726	Clp1	100	98.588	Mus_caroli
ENSG00000172409	CLP1	100	98.588	ENSMUSG00000027079	Clp1	100	98.588	Mus_musculus
ENSG00000172409	CLP1	100	98.353	MGP_PahariEiJ_G0025177	Clp1	100	98.353	Mus_pahari
ENSG00000172409	CLP1	100	98.588	MGP_SPRETEiJ_G0024646	Clp1	100	98.588	Mus_spretus
ENSG00000172409	CLP1	100	99.529	ENSMPUG00000000268	CLP1	100	99.529	Mustela_putorius_furo
ENSG00000172409	CLP1	100	99.059	ENSMLUG00000007904	CLP1	100	99.059	Myotis_lucifugus
ENSG00000172409	CLP1	100	99.294	ENSNGAG00000006165	Clp1	100	99.294	Nannospalax_galili
ENSG00000172409	CLP1	99	75.638	ENSNBRG00000005225	clp1	99	75.172	Neolamprologus_brichardi
ENSG00000172409	CLP1	100	100.000	ENSNLEG00000012809	-	100	97.980	Nomascus_leucogenys
ENSG00000172409	CLP1	100	97.412	ENSMEUG00000010949	CLP1	100	97.183	Notamacropus_eugenii
ENSG00000172409	CLP1	70	99.329	ENSOPRG00000007329	CLP1	100	99.329	Ochotona_princeps
ENSG00000172409	CLP1	100	99.765	ENSODEG00000011410	CLP1	100	99.765	Octodon_degus
ENSG00000172409	CLP1	99	75.406	ENSONIG00000005089	clp1	99	74.943	Oreochromis_niloticus
ENSG00000172409	CLP1	100	99.529	ENSOCUG00000007045	CLP1	100	99.529	Oryctolagus_cuniculus
ENSG00000172409	CLP1	99	74.710	ENSORLG00000003647	clp1	99	74.253	Oryzias_latipes
ENSG00000172409	CLP1	99	74.478	ENSORLG00020016676	clp1	99	74.023	Oryzias_latipes_hni
ENSG00000172409	CLP1	99	74.710	ENSORLG00015019484	clp1	99	74.253	Oryzias_latipes_hsok
ENSG00000172409	CLP1	99	75.406	ENSOMEG00000021303	clp1	99	74.943	Oryzias_melastigma
ENSG00000172409	CLP1	100	99.294	ENSOGAG00000004508	CLP1	100	99.294	Otolemur_garnettii
ENSG00000172409	CLP1	100	97.882	ENSOARG00000010145	CLP1	99	97.216	Ovis_aries
ENSG00000172409	CLP1	100	100.000	ENSPPAG00000041519	CLP1	100	100.000	Pan_paniscus
ENSG00000172409	CLP1	100	99.294	ENSPPRG00000006135	CLP1	100	99.294	Panthera_pardus
ENSG00000172409	CLP1	100	99.294	ENSPTIG00000015866	CLP1	100	99.294	Panthera_tigris_altaica
ENSG00000172409	CLP1	100	100.000	ENSPTRG00000047318	CLP1	100	100.000	Pan_troglodytes
ENSG00000172409	CLP1	100	100.000	ENSPANG00000017078	CLP1	100	99.771	Papio_anubis
ENSG00000172409	CLP1	97	80.630	ENSPKIG00000007697	clp1	99	77.829	Paramormyrops_kingsleyae
ENSG00000172409	CLP1	100	91.667	ENSPSIG00000005468	CLP1	100	92.289	Pelodiscus_sinensis
ENSG00000172409	CLP1	99	76.267	ENSPMGG00000012171	clp1	99	76.267	Periophthalmus_magnuspinnatus
ENSG00000172409	CLP1	100	99.059	ENSPEMG00000011213	-	100	99.059	Peromyscus_maniculatus_bairdii
ENSG00000172409	CLP1	100	76.291	ENSPMAG00000006707	clp1	100	76.291	Petromyzon_marinus
ENSG00000172409	CLP1	100	96.941	ENSPCIG00000011899	CLP1	99	96.941	Phascolarctos_cinereus
ENSG00000172409	CLP1	99	75.406	ENSPFOG00000008169	clp1	99	74.943	Poecilia_formosa
ENSG00000172409	CLP1	99	75.406	ENSPLAG00000022388	clp1	99	75.406	Poecilia_latipinna
ENSG00000172409	CLP1	99	75.406	ENSPMEG00000021088	clp1	99	75.406	Poecilia_mexicana
ENSG00000172409	CLP1	99	75.638	ENSPREG00000017802	clp1	99	75.172	Poecilia_reticulata
ENSG00000172409	CLP1	62	100.000	ENSPPYG00000003266	-	100	99.554	Pongo_abelii
ENSG00000172409	CLP1	100	99.529	ENSPCOG00000000360	CLP1	100	99.306	Propithecus_coquereli
ENSG00000172409	CLP1	100	99.529	ENSPVAG00000016270	CLP1	100	99.529	Pteropus_vampyrus
ENSG00000172409	CLP1	99	75.638	ENSPNYG00000017274	clp1	100	73.874	Pundamilia_nyererei
ENSG00000172409	CLP1	97	80.000	ENSPNAG00000026460	clp1	98	78.161	Pygocentrus_nattereri
ENSG00000172409	CLP1	100	98.588	ENSRNOG00000007416	Clp1	100	98.588	Rattus_norvegicus
ENSG00000172409	CLP1	100	100.000	ENSRBIG00000018191	CLP1	100	100.000	Rhinopithecus_bieti
ENSG00000172409	CLP1	100	100.000	ENSRROG00000039265	CLP1	100	100.000	Rhinopithecus_roxellana
ENSG00000172409	CLP1	96	79.803	ENSSBOG00000010558	-	93	79.803	Saimiri_boliviensis_boliviensis
ENSG00000172409	CLP1	100	100.000	ENSSBOG00000032517	-	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000172409	CLP1	100	97.647	ENSSHAG00000015695	CLP1	100	97.647	Sarcophilus_harrisii
ENSG00000172409	CLP1	97	79.294	ENSSFOG00015000628	clp1	96	79.294	Scleropages_formosus
ENSG00000172409	CLP1	99	75.638	ENSSMAG00000019423	clp1	98	75.172	Scophthalmus_maximus
ENSG00000172409	CLP1	98	77.830	ENSSDUG00000014495	clp1	99	76.322	Seriola_dumerili
ENSG00000172409	CLP1	98	77.594	ENSSLDG00000000937	clp1	99	76.092	Seriola_lalandi_dorsalis
ENSG00000172409	CLP1	62	99.103	ENSSARG00000002459	CLP1	100	99.103	Sorex_araneus
ENSG00000172409	CLP1	100	93.647	ENSSPUG00000016811	CLP1	100	93.647	Sphenodon_punctatus
ENSG00000172409	CLP1	98	76.651	ENSSPAG00000016052	clp1	99	75.172	Stegastes_partitus
ENSG00000172409	CLP1	100	99.529	ENSSSCG00000031442	CLP1	100	99.529	Sus_scrofa
ENSG00000172409	CLP1	100	92.471	ENSTGUG00000007002	CLP1	100	92.471	Taeniopygia_guttata
ENSG00000172409	CLP1	99	77.049	ENSTRUG00000012602	clp1	98	77.049	Takifugu_rubripes
ENSG00000172409	CLP1	99	76.581	ENSTNIG00000013125	clp1	98	76.581	Tetraodon_nigroviridis
ENSG00000172409	CLP1	100	98.353	ENSTBEG00000009975	CLP1	100	98.353	Tupaia_belangeri
ENSG00000172409	CLP1	100	99.059	ENSTTRG00000002096	CLP1	100	99.059	Tursiops_truncatus
ENSG00000172409	CLP1	100	99.529	ENSUAMG00000011388	CLP1	100	99.529	Ursus_americanus
ENSG00000172409	CLP1	100	99.529	ENSUMAG00000018317	CLP1	100	99.529	Ursus_maritimus
ENSG00000172409	CLP1	100	99.529	ENSVVUG00000017138	CLP1	99	98.394	Vulpes_vulpes
ENSG00000172409	CLP1	98	77.938	ENSXETG00000007088	clp1	95	78.657	Xenopus_tropicalis
ENSG00000172409	CLP1	99	75.638	ENSXCOG00000002287	clp1	99	75.172	Xiphophorus_couchianus
ENSG00000172409	CLP1	99	75.638	ENSXMAG00000009783	clp1	99	75.172	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000214	tRNA-intron endonuclease complex	17495927.	IDA	Component
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0005524	ATP binding	8896421.	TAS	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	24766810.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005849	mRNA cleavage factor complex	-	IEA	Component
GO:0006369	termination of RNA polymerase II transcription	-	TAS	Process
GO:0006378	mRNA polyadenylation	21873635.	IBA	Process
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	21873635.	IBA	Process
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	17495927.	IDA	Process
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	24766809.24766810.	IMP	Process
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	-	TAS	Process
GO:0016310	phosphorylation	-	IEA	Process
GO:0021695	cerebellar cortex development	24766809.24766810.	IMP	Process
GO:0030423	targeting of mRNA for destruction involved in RNA interference	17495927.	IMP	Process
GO:0031124	mRNA 3'-end processing	17495927.	TAS	Process
GO:0035087	siRNA loading onto RISC involved in RNA interference	17495927.	IDA	Process
GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity	-	IEA	Function
GO:0051733	polydeoxyribonucleotide kinase activity	17495927.	IDA	Function
GO:0051736	ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity	17495927.	IDA	Function
GO:0051736	ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity	24766809.24766810.	IMP	Function