EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000172493 (Gene tree)
Gene ID: 4299
Gene Symbol: AFF1
Alias: AF-4|AF4|PBM1|MLLT2
Full Name: AF4/FMR2 family member 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 206,544 bases
Position: chr4:86,934,511-87,141,054
Accession: 7135
RBP type: canonical RBP
Summary: This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000378578	AF-4	PF05110.13	0	1	1
ENSP00000305689	AF-4	PF05110.13	0	1	1
ENSP00000440843	AF-4	PF05110.13	0	1	1
ENSP00000427593	AF-4	PF05110.13	1.5e-163	1	1
ENSP00000424483	AF-4	PF05110.13	2.7e-146	1	2
ENSP00000424483	AF-4	PF05110.13	2.7e-146	2	2
ENSP00000424881	AF-4	PF05110.13	1.6e-71	1	1
ENSP00000424766	AF-4	PF05110.13	1.9e-56	1	1
ENSP00000425755	AF-4	PF05110.13	9.7e-10	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21330300	Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the molecular pathology of FRAXE intellectual disability.	Hum Mol Genet	2011 May 15	Melko M	doi: 10.1093/hmg/ddr069
21030982	The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.	Leukemia	2011 Jan	Benedikt A	doi: 10.1038/leu.2010.249
26593443	AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription.	Nat Commun	2015 Nov 23	Okuda H	doi: 10.1038/ncomms9869.
27856324	MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27acetylation.	Exp Hematol	2017 Mar	Godfrey L	doi: 10.1016/j.exphem.2016.11.003

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000511722	AFF1-208	638	-	ENSP00000424766	137 (aa)	-	D6RAU0
ENST00000503477	AFF1-204	1478	-	ENSP00000424483	417 (aa)	-	E7EMC5
ENST00000503369	AFF1-203	598	-	-	- (aa)	-	-
ENST00000514970	AFF1-210	582	-	ENSP00000424881	194 (aa)	-	H0Y9S4
ENST00000544085	AFF1-211	3644	XM_005263011	ENSP00000440843	1205 (aa)	XP_005263068	F5GXF9
ENST00000511996	AFF1-209	480	-	-	- (aa)	-	-
ENST00000395146	AFF1-202	9285	XM_005263007	ENSP00000378578	1218 (aa)	XP_005263064	P51825
ENST00000507468	AFF1-206	1486	-	ENSP00000427593	406 (aa)	-	E7ETI4
ENST00000504956	AFF1-205	1668	-	-	- (aa)	-	-
ENST00000307808	AFF1-201	9390	-	ENSP00000305689	1210 (aa)	-	P51825
ENST00000511442	AFF1-207	463	-	ENSP00000425755	52 (aa)	-	D6RIZ5

Gene Model

Click here to download ENSG00000172493's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05202	Transcriptional misregulation in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000172493	Personality	9.788e-005	-
ENSG00000172493	Personality	9.788e-005	-
ENSG00000172493	Insulin	2.179e-005	-
ENSG00000172493	Insulin	1.337e-005	-
ENSG00000172493	Insulin	2.179e-005	-
ENSG00000172493	Triglycerides	1E-18	24097068
ENSG00000172493	Triglycerides	2E-10	25961943
ENSG00000172493	Alzheimer Disease	2E-7	23535033
ENSG00000172493	Lupus Erythematosus, Systemic	8E-9	22291604
ENSG00000172493	Triglycerides	3E-10	20864672
ENSG00000172493	Triglycerides	9E-12	20686565

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000172493	rs443459	4	87054903	A	Mean corpuscular hemoglobin	27863252	[0.023-0.039] unit decrease	0.03119863	EFO_0004527
ENSG00000172493	rs13108043	4	87123184	A	Red blood cell count	27863252	[0.022-0.04] unit decrease	0.03093505	EFO_0004305
ENSG00000172493	rs6840258	4	87052516	T	Mean corpuscular volume	27863252	[0.026-0.044] unit decrease	0.03517071	EFO_0004526
ENSG00000172493	rs13120301	4	87065243	T	Mean platelet volume	27863252	[0.015-0.03] unit decrease	0.02267446	EFO_0004584
ENSG00000172493	rs2035403	4	87097839	G	Triglycerides	25961943	[0.027-0.051] s.d. increase	0.039	EFO_0004530
ENSG00000172493	rs340635	4	87010252	?	Alzheimer's disease (cognitive decline)	23535033	unit decrease	0.23	EFO_0000249
ENSG00000172493	rs442177	4	87109109	G	Triglycerides	24097068	[NR] mg/dL decrease	0.031	EFO_0004530
ENSG00000172493	rs5860048	4	86981006	T	Heel bone mineral density	28869591	[0.015-0.035] unit increase	0.0249099	EFO_0009270
ENSG00000172493	rs5860048	4	86981006	T	Heel bone mineral density	28869591	[0.013-0.026] unit increase	0.0196048	EFO_0009270
ENSG00000172493	rs28432336	4	87063179	?	Total bilirubin levels	29403010	[0.016-0.033] unit increase novel	0.02425	EFO_0004570
ENSG00000172493	rs1408	4	87136201	?	White blood cell count (basophil)	29403010	[0.021-0.043] unit decrease novel	0.03229	EFO_0005090
ENSG00000172493	rs1037814	4	87128698	?	Hemoglobin	29403010	[0.02-0.037] unit decrease novel	0.02849	EFO_0004509
ENSG00000172493	rs342437	4	87119757	?	Hematocrit	29403010	[0.022-0.039] unit decrease novel	0.03035	EFO_0004348
ENSG00000172493	rs17012216	4	86968285	?	Mean corpuscular volume	29403010	[0.018-0.036] unit decrease novel	0.02717	EFO_0004526
ENSG00000172493	rs6819155	4	87055026	?	Mean corpuscular hemoglobin	29403010	[0.017-0.034] unit decrease novel	0.02516	EFO_0004527
ENSG00000172493	rs60695258	4	87101557	T	Hematocrit	27863252	[0.022-0.037] unit decrease	0.02947209	EFO_0004348
ENSG00000172493	rs442177	4	87109109	T	Hemoglobin concentration	27863252	[0.024-0.038] unit decrease	0.03088176	EFO_0004509
ENSG00000172493	rs56390363	4	87021935	A	White blood cell count (basophil)	27863252	[0.037-0.054] unit decrease	0.04561271	EFO_0005090
ENSG00000172493	rs340637	4	87008040	T	Basophil percentage of white cells	27863252	[0.034-0.05] unit increase	0.04230716	EFO_0007992
ENSG00000172493	rs151450	4	87095362	A	Basophil percentage of white cells	27863252	[0.031-0.045] unit decrease	0.03818492	EFO_0007992
ENSG00000172493	rs442177	4	87109109	G	Triglycerides	20686565	[1.51-2.99] mg/dL decrease	2.25	EFO_0004530
ENSG00000172493	rs442177	4	87109109	A	Triglycerides	20864672	[0.01-0.03] unit increase	0.02	EFO_0004530
ENSG00000172493	rs340630	4	87037243	A	Systemic lupus erythematosus	22291604	[1.14-1.30]	1.21	EFO_0002690
ENSG00000172493	rs6840258	4	87052516	T	Basophil percentage of granulocytes	27863252	[0.038-0.055] unit decrease	0.04634863	EFO_0007995
ENSG00000172493	rs7660883	4	87061724	C	HDL cholesterol levels	28334899	[0.03-0.066] unit decrease	0.048	EFO_0004612
ENSG00000172493	rs7660883	4	87061724	C	HDL cholesterol levels	28334899	[0.02-0.052] unit decrease	0.036	EFO_0004612
ENSG00000172493	rs236996	4	87084051	A	Triglyceride levels	28334899	[0.026-0.057] unit decrease	0.0413	EFO_0004530
ENSG00000172493	rs1037814	4	87128698	T	Triglyceride levels	28334899	[0.024-0.037] unit decrease (EA Beta values)	0.0307	EFO_0004530
ENSG00000172493	rs11539663	4	87140796	?	General cognitive ability	29844566	z-score increase	5.427	EFO_0004337
ENSG00000172493	rs5860048	4	86981006	?	Heel bone mineral density	30048462	[0.016-0.024] unit increase	0.0199992	EFO_0009270
ENSG00000172493	rs11434868	4	87035565	?	Heel bone mineral density	30048462	[0.018-0.026] unit increase	0.0220249	EFO_0009270
ENSG00000172493	rs1471251	4	87055207	A	Heel bone mineral density	30598549	[0.021-0.029] unit decrease	0.0250027	EFO_0009270
ENSG00000172493	rs2035403	4	87097839	A	High density lipoprotein cholesterol levels	29507422	unit increase	0.024	EFO_0004612
ENSG00000172493	rs2035403	4	87097839	A	High density lipoprotein cholesterol levels	29507422	unit increase	0.024	EFO_0004612
ENSG00000172493	rs442177	4	87109109	G	High density lipoprotein cholesterol levels	29507422	unit increase	0.022	EFO_0004612
ENSG00000172493	rs442177	4	87109109	G	High density lipoprotein cholesterol levels	29507422	unit increase	0.024	EFO_0004612
ENSG00000172493	rs2035403	4	87097839	A	Triglycerides	29507422	unit decrease	0.038	EFO_0004530
ENSG00000172493	rs2035403	4	87097839	A	Triglycerides	29507422	unit decrease	0.037	EFO_0004530
ENSG00000172493	rs442177	4	87109109	G	Triglycerides	29507422	unit decrease	0.033	EFO_0004530
ENSG00000172493	rs442177	4	87109109	G	Triglycerides	29507422	unit decrease	0.032	EFO_0004530
ENSG00000172493	rs442177	4	87109109	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000172493	rs17030453	4	87140201	?	Red blood cell count	30595370			EFO_0004305
ENSG00000172493	rs17012334	4	87059596	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000172493	rs1471251	4	87055207	?	Heel bone mineral density	30595370			EFO_0009270
ENSG00000172493	rs17605615	4	87075593	A	Triglycerides x physical activity interaction (2df test)	30670697			EFO_0004530\|EFO_0003940

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172493's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000172493	AFF1	72	60.204	ENSG00000072364	AFF4	59	35.865
ENSG00000172493	AFF1	56	56.818	ENSG00000144218	AFF3	92	49.112
ENSG00000172493	AFF1	96	32.530	ENSG00000155966	AFF2	89	32.624

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000172493	AFF1	78	37.372	ENSAPOG00000006096	aff4	99	34.519	Acanthochromis_polyacanthus
ENSG00000172493	AFF1	100	85.266	ENSAMEG00000003337	AFF1	100	79.919	Ailuropoda_melanoleuca
ENSG00000172493	AFF1	58	51.429	ENSACIG00000022732	aff2	54	51.429	Amphilophus_citrinellus
ENSG00000172493	AFF1	74	59.843	ENSACIG00000021066	-	91	57.812	Amphilophus_citrinellus
ENSG00000172493	AFF1	78	36.704	ENSAOCG00000008476	aff4	99	36.136	Amphiprion_ocellaris
ENSG00000172493	AFF1	78	36.906	ENSAPEG00000018275	aff4	99	36.672	Amphiprion_percula
ENSG00000172493	AFF1	55	55.263	ENSATEG00000010963	aff4	99	35.124	Anabas_testudineus
ENSG00000172493	AFF1	51	47.985	ENSAPLG00000003660	-	72	44.485	Anas_platyrhynchos
ENSG00000172493	AFF1	99	55.618	ENSAPLG00000004059	AFF1	100	55.105	Anas_platyrhynchos
ENSG00000172493	AFF1	99	37.803	ENSACAG00000022605	AFF4	59	34.951	Anolis_carolinensis
ENSG00000172493	AFF1	99	53.094	ENSACAG00000012192	AFF1	99	52.117	Anolis_carolinensis
ENSG00000172493	AFF1	100	97.810	ENSANAG00000017095	AFF1	100	92.717	Aotus_nancymaae
ENSG00000172493	AFF1	72	59.184	ENSANAG00000037761	AFF4	59	35.376	Aotus_nancymaae
ENSG00000172493	AFF1	78	36.842	ENSACLG00000011879	aff4	79	36.991	Astatotilapia_calliptera
ENSG00000172493	AFF1	97	36.296	ENSACLG00000002905	-	73	32.680	Astatotilapia_calliptera
ENSG00000172493	AFF1	77	37.267	ENSAMXG00000020137	aff4	57	33.803	Astyanax_mexicanus
ENSG00000172493	AFF1	99	86.441	ENSBTAG00000018488	AFF1	100	80.130	Bos_taurus
ENSG00000172493	AFF1	100	97.810	ENSCJAG00000006047	AFF1	100	91.358	Callithrix_jacchus
ENSG00000172493	AFF1	90	48.864	ENSCJAG00000013322	AFF4	59	35.664	Callithrix_jacchus
ENSG00000172493	AFF1	100	84.615	ENSCAFG00000009476	AFF1	100	80.327	Canis_familiaris
ENSG00000172493	AFF1	72	60.204	ENSCHIG00000015153	AFF4	59	34.740	Capra_hircus
ENSG00000172493	AFF1	99	86.441	ENSCHIG00000008450	AFF1	100	80.403	Capra_hircus
ENSG00000172493	AFF1	72	60.204	ENSTSYG00000014713	AFF4	61	35.221	Carlito_syrichta
ENSG00000172493	AFF1	51	40.824	ENSTSYG00000000526	AFF2	62	40.449	Carlito_syrichta
ENSG00000172493	AFF1	97	84.518	ENSTSYG00000002039	AFF1	100	80.518	Carlito_syrichta
ENSG00000172493	AFF1	99	68.148	ENSCAPG00000006540	AFF1	100	60.653	Cavia_aperea
ENSG00000172493	AFF1	99	66.260	ENSCPOG00000034568	AFF1	99	66.450	Cavia_porcellus
ENSG00000172493	AFF1	65	54.545	ENSCPOG00000006346	AFF3	74	56.000	Cavia_porcellus
ENSG00000172493	AFF1	72	58.163	ENSCPOG00000001814	AFF4	90	49.153	Cavia_porcellus
ENSG00000172493	AFF1	72	59.184	ENSCCAG00000030353	AFF4	97	40.554	Cebus_capucinus
ENSG00000172493	AFF1	96	33.494	ENSCCAG00000025994	AFF2	80	41.199	Cebus_capucinus
ENSG00000172493	AFF1	100	92.308	ENSCCAG00000027623	AFF1	99	93.970	Cebus_capucinus
ENSG00000172493	AFF1	100	100.000	ENSCATG00000039501	AFF1	100	96.478	Cercocebus_atys
ENSG00000172493	AFF1	72	60.204	ENSCATG00000044510	AFF4	59	36.262	Cercocebus_atys
ENSG00000172493	AFF1	96	37.500	ENSCLAG00000017100	AFF3	74	58.667	Chinchilla_lanigera
ENSG00000172493	AFF1	72	59.184	ENSCLAG00000013850	AFF4	60	35.624	Chinchilla_lanigera
ENSG00000172493	AFF1	83	84.472	ENSCLAG00000005537	AFF1	100	66.240	Chinchilla_lanigera
ENSG00000172493	AFF1	100	100.000	ENSCSAG00000004333	AFF1	100	96.376	Chlorocebus_sabaeus
ENSG00000172493	AFF1	72	59.184	ENSCSAG00000013682	AFF4	59	35.237	Chlorocebus_sabaeus
ENSG00000172493	AFF1	96	32.850	ENSCSAG00000007248	AFF2	51	40.824	Chlorocebus_sabaeus
ENSG00000172493	AFF1	72	60.204	ENSCHOG00000003138	AFF4	60	43.934	Choloepus_hoffmanni
ENSG00000172493	AFF1	99	88.889	ENSCHOG00000000041	AFF1	78	82.178	Choloepus_hoffmanni
ENSG00000172493	AFF1	100	60.308	ENSCPBG00000005382	AFF1	100	59.367	Chrysemys_picta_bellii
ENSG00000172493	AFF1	72	59.184	ENSCANG00000030350	AFF4	59	34.362	Colobus_angolensis_palliatus
ENSG00000172493	AFF1	100	100.000	ENSCANG00000037514	AFF1	100	95.967	Colobus_angolensis_palliatus
ENSG00000172493	AFF1	100	73.077	ENSCGRG00001015769	Aff1	100	71.302	Cricetulus_griseus_chok1gshd
ENSG00000172493	AFF1	72	58.163	ENSCGRG00001016680	Aff4	60	35.873	Cricetulus_griseus_chok1gshd
ENSG00000172493	AFF1	72	58.163	ENSCGRG00000008529	Aff4	60	35.873	Cricetulus_griseus_crigri
ENSG00000172493	AFF1	54	55.405	ENSCGRG00000003408	Aff3	74	56.000	Cricetulus_griseus_crigri
ENSG00000172493	AFF1	71	69.404	ENSCGRG00000004837	Aff1	100	68.243	Cricetulus_griseus_crigri
ENSG00000172493	AFF1	59	58.025	ENSCSEG00000017002	aff4	99	36.581	Cynoglossus_semilaevis
ENSG00000172493	AFF1	93	34.961	ENSCSEG00000000928	-	90	34.278	Cynoglossus_semilaevis
ENSG00000172493	AFF1	59	54.023	ENSDARG00000001857	aff4	89	62.500	Danio_rerio
ENSG00000172493	AFF1	78	86.916	ENSDNOG00000048783	-	100	81.443	Dasypus_novemcinctus
ENSG00000172493	AFF1	85	84.091	ENSDNOG00000040256	-	89	82.521	Dasypus_novemcinctus
ENSG00000172493	AFF1	96	83.461	ENSDORG00000013881	Aff1	100	79.917	Dipodomys_ordii
ENSG00000172493	AFF1	51	56.757	ENSDORG00000007294	Aff3	74	57.333	Dipodomys_ordii
ENSG00000172493	AFF1	91	92.308	ENSETEG00000014905	AFF1	91	95.745	Echinops_telfairi
ENSG00000172493	AFF1	89	49.593	ENSEBUG00000012097	aff4	67	37.681	Eptatretus_burgeri
ENSG00000172493	AFF1	72	61.224	ENSEASG00005018361	AFF4	61	34.740	Equus_asinus_asinus
ENSG00000172493	AFF1	100	88.462	ENSEASG00005012760	AFF1	100	79.805	Equus_asinus_asinus
ENSG00000172493	AFF1	72	60.204	ENSECAG00000011969	AFF4	61	34.880	Equus_caballus
ENSG00000172493	AFF1	100	88.462	ENSECAG00000003619	AFF1	100	79.968	Equus_caballus
ENSG00000172493	AFF1	74	95.000	ENSEEUG00000013664	-	74	95.000	Erinaceus_europaeus
ENSG00000172493	AFF1	67	55.714	ENSEEUG00000011214	AFF4	72	34.718	Erinaceus_europaeus
ENSG00000172493	AFF1	67	50.000	ENSELUG00000013368	aff2	78	34.770	Esox_lucius
ENSG00000172493	AFF1	95	88.831	ENSFCAG00000029806	AFF1	100	78.618	Felis_catus
ENSG00000172493	AFF1	87	56.522	ENSFALG00000008916	AFF4	64	59.091	Ficedula_albicollis
ENSG00000172493	AFF1	99	48.361	ENSFALG00000005554	AFF1	99	48.403	Ficedula_albicollis
ENSG00000172493	AFF1	100	71.154	ENSFDAG00000018846	AFF1	100	68.094	Fukomys_damarensis
ENSG00000172493	AFF1	95	32.763	ENSFDAG00000011981	AFF2	50	40.824	Fukomys_damarensis
ENSG00000172493	AFF1	72	57.143	ENSFDAG00000005342	AFF4	60	35.049	Fukomys_damarensis
ENSG00000172493	AFF1	78	38.002	ENSFHEG00000004526	aff4	54	40.909	Fundulus_heteroclitus
ENSG00000172493	AFF1	56	54.321	ENSGMOG00000008803	aff4	83	40.074	Gadus_morhua
ENSG00000172493	AFF1	72	58.654	ENSGALG00000030147	AFF4	62	34.874	Gallus_gallus
ENSG00000172493	AFF1	100	50.324	ENSGALG00000043935	AFF1	100	49.879	Gallus_gallus
ENSG00000172493	AFF1	83	58.209	ENSGACG00000020734	aff4	86	59.701	Gasterosteus_aculeatus
ENSG00000172493	AFF1	96	38.000	ENSGACG00000016333	-	100	37.594	Gasterosteus_aculeatus
ENSG00000172493	AFF1	71	54.167	ENSGAGG00000020214	AFF4	59	35.862	Gopherus_agassizii
ENSG00000172493	AFF1	94	53.401	ENSGAGG00000025416	-	96	55.025	Gopherus_agassizii
ENSG00000172493	AFF1	100	100.000	ENSGGOG00000008497	AFF1	100	99.344	Gorilla_gorilla
ENSG00000172493	AFF1	72	60.204	ENSGGOG00000011786	AFF4	88	32.630	Gorilla_gorilla
ENSG00000172493	AFF1	78	36.842	ENSHBUG00000021987	aff4	80	36.991	Haplochromis_burtoni
ENSG00000172493	AFF1	97	36.296	ENSHBUG00000005828	-	79	35.909	Haplochromis_burtoni
ENSG00000172493	AFF1	100	71.154	ENSHGLG00000001384	AFF1	100	68.357	Heterocephalus_glaber_female
ENSG00000172493	AFF1	66	57.895	ENSHGLG00000006661	AFF4	61	34.986	Heterocephalus_glaber_female
ENSG00000172493	AFF1	66	57.895	ENSHGLG00100018576	AFF4	64	34.986	Heterocephalus_glaber_male
ENSG00000172493	AFF1	100	71.154	ENSHGLG00100016607	AFF1	100	65.546	Heterocephalus_glaber_male
ENSG00000172493	AFF1	78	38.115	ENSHCOG00000016280	aff4	99	35.840	Hippocampus_comes
ENSG00000172493	AFF1	56	57.831	ENSIPUG00000011689	aff4	99	35.201	Ictalurus_punctatus
ENSG00000172493	AFF1	65	56.061	ENSSTOG00000012140	AFF3	69	58.667	Ictidomys_tridecemlineatus
ENSG00000172493	AFF1	100	86.747	ENSSTOG00000006530	AFF1	100	85.435	Ictidomys_tridecemlineatus
ENSG00000172493	AFF1	72	58.163	ENSSTOG00000026695	AFF4	57	58.571	Ictidomys_tridecemlineatus
ENSG00000172493	AFF1	55	53.333	ENSJJAG00000013155	Aff3	74	58.667	Jaculus_jaculus
ENSG00000172493	AFF1	99	72.934	ENSJJAG00000022877	Aff1	99	73.096	Jaculus_jaculus
ENSG00000172493	AFF1	72	59.184	ENSJJAG00000000912	Aff4	60	34.254	Jaculus_jaculus
ENSG00000172493	AFF1	97	35.593	ENSKMAG00000013113	-	70	35.817	Kryptolebias_marmoratus
ENSG00000172493	AFF1	78	37.079	ENSLBEG00000017778	aff4	79	38.193	Labrus_bergylta
ENSG00000172493	AFF1	99	35.646	ENSLACG00000008183	-	98	37.124	Latimeria_chalumnae
ENSG00000172493	AFF1	66	58.242	ENSLACG00000008849	AFF4	59	33.196	Latimeria_chalumnae
ENSG00000172493	AFF1	97	53.695	ENSLACG00000007303	AFF1	99	49.113	Latimeria_chalumnae
ENSG00000172493	AFF1	53	46.067	ENSLACG00000010860	aff2	63	46.825	Latimeria_chalumnae
ENSG00000172493	AFF1	64	54.839	ENSLOCG00000010610	aff4	58	33.152	Lepisosteus_oculatus
ENSG00000172493	AFF1	96	40.309	ENSLOCG00000004025	AFF1	60	37.500	Lepisosteus_oculatus
ENSG00000172493	AFF1	69	46.364	ENSLOCG00000015403	aff2	52	43.295	Lepisosteus_oculatus
ENSG00000172493	AFF1	72	59.184	ENSLAFG00000010555	AFF4	59	36.287	Loxodonta_africana
ENSG00000172493	AFF1	100	61.429	ENSLAFG00000015880	-	66	78.638	Loxodonta_africana
ENSG00000172493	AFF1	100	84.615	ENSLAFG00000027149	-	100	86.944	Loxodonta_africana
ENSG00000172493	AFF1	89	30.263	ENSLAFG00000018691	AFF2	87	39.041	Loxodonta_africana
ENSG00000172493	AFF1	100	100.000	ENSMFAG00000037700	AFF1	100	96.478	Macaca_fascicularis
ENSG00000172493	AFF1	72	59.184	ENSMFAG00000034615	AFF4	59	36.262	Macaca_fascicularis
ENSG00000172493	AFF1	72	59.184	ENSMMUG00000015640	AFF4	81	36.040	Macaca_mulatta
ENSG00000172493	AFF1	100	100.000	ENSMMUG00000014076	AFF1	100	97.608	Macaca_mulatta
ENSG00000172493	AFF1	72	59.184	ENSMNEG00000033381	AFF4	59	36.262	Macaca_nemestrina
ENSG00000172493	AFF1	95	33.570	ENSMNEG00000035909	AFF2	79	40.408	Macaca_nemestrina
ENSG00000172493	AFF1	100	100.000	ENSMNEG00000031536	AFF1	100	96.560	Macaca_nemestrina
ENSG00000172493	AFF1	100	100.000	ENSMLEG00000039099	AFF1	100	96.560	Mandrillus_leucophaeus
ENSG00000172493	AFF1	98	40.046	ENSMAMG00000016189	-	60	40.164	Mastacembelus_armatus
ENSG00000172493	AFF1	78	38.359	ENSMAMG00000021453	aff4	99	35.697	Mastacembelus_armatus
ENSG00000172493	AFF1	97	36.296	ENSMZEG00005020442	-	74	35.909	Maylandia_zebra
ENSG00000172493	AFF1	78	36.842	ENSMZEG00005003218	aff4	80	36.991	Maylandia_zebra
ENSG00000172493	AFF1	59	35.414	ENSMGAG00000008246	-	92	33.931	Meleagris_gallopavo
ENSG00000172493	AFF1	99	50.487	ENSMGAG00000007646	AFF1	99	49.798	Meleagris_gallopavo
ENSG00000172493	AFF1	90	42.623	ENSMGAG00000009144	AFF4	61	34.819	Meleagris_gallopavo
ENSG00000172493	AFF1	99	71.046	ENSMAUG00000010241	Aff1	99	70.154	Mesocricetus_auratus
ENSG00000172493	AFF1	72	53.061	ENSMAUG00000013669	Aff4	79	46.377	Mesocricetus_auratus
ENSG00000172493	AFF1	72	59.184	ENSMICG00000002753	-	62	36.389	Microcebus_murinus
ENSG00000172493	AFF1	100	59.615	ENSMICG00000028855	-	87	65.074	Microcebus_murinus
ENSG00000172493	AFF1	72	59.184	ENSMOCG00000003884	Aff4	60	34.078	Microtus_ochrogaster
ENSG00000172493	AFF1	99	70.588	ENSMOCG00000017389	Aff1	99	69.782	Microtus_ochrogaster
ENSG00000172493	AFF1	52	67.742	ENSMMOG00000002118	-	58	67.742	Mola_mola
ENSG00000172493	AFF1	72	60.204	ENSMODG00000013842	AFF4	59	34.958	Monodelphis_domestica
ENSG00000172493	AFF1	100	78.102	ENSMODG00000020745	AFF1	97	57.294	Monodelphis_domestica
ENSG00000172493	AFF1	63	60.606	ENSMALG00000017690	aff4	71	60.606	Monopterus_albus
ENSG00000172493	AFF1	98	72.482	MGP_CAROLIEiJ_G0027469	Aff1	100	66.693	Mus_caroli
ENSG00000172493	AFF1	72	59.184	MGP_CAROLIEiJ_G0016331	Aff4	57	57.143	Mus_caroli
ENSG00000172493	AFF1	72	59.184	ENSMUSG00000049470	Aff4	57	57.143	Mus_musculus
ENSG00000172493	AFF1	99	35.663	ENSMUSG00000037138	Aff3	66	54.430	Mus_musculus
ENSG00000172493	AFF1	100	68.535	ENSMUSG00000029313	Aff1	100	67.734	Mus_musculus
ENSG00000172493	AFF1	72	59.184	MGP_PahariEiJ_G0017466	Aff4	57	57.143	Mus_pahari
ENSG00000172493	AFF1	98	72.973	MGP_PahariEiJ_G0017247	Aff1	100	68.780	Mus_pahari
ENSG00000172493	AFF1	96	41.958	MGP_SPRETEiJ_G0014867	Aff3	69	36.789	Mus_spretus
ENSG00000172493	AFF1	100	69.157	MGP_SPRETEiJ_G0028466	Aff1	97	78.723	Mus_spretus
ENSG00000172493	AFF1	72	59.184	MGP_SPRETEiJ_G0017175	Aff4	57	57.143	Mus_spretus
ENSG00000172493	AFF1	97	86.352	ENSMPUG00000002270	AFF1	99	79.143	Mustela_putorius_furo
ENSG00000172493	AFF1	53	56.818	ENSMLUG00000015255	AFF3	54	52.222	Myotis_lucifugus
ENSG00000172493	AFF1	97	83.251	ENSMLUG00000000293	AFF1	100	79.136	Myotis_lucifugus
ENSG00000172493	AFF1	96	78.000	ENSNGAG00000014096	-	96	77.627	Nannospalax_galili
ENSG00000172493	AFF1	69	59.596	ENSNGAG00000019867	Aff4	60	35.056	Nannospalax_galili
ENSG00000172493	AFF1	99	36.010	ENSNGAG00000002408	Aff3	66	55.696	Nannospalax_galili
ENSG00000172493	AFF1	100	100.000	ENSNLEG00000009429	AFF1	99	94.118	Nomascus_leucogenys
ENSG00000172493	AFF1	72	59.184	ENSNLEG00000012874	AFF4	59	35.865	Nomascus_leucogenys
ENSG00000172493	AFF1	93	33.967	ENSMEUG00000014599	AFF2	55	30.084	Notamacropus_eugenii
ENSG00000172493	AFF1	89	52.816	ENSMEUG00000003076	-	55	52.036	Notamacropus_eugenii
ENSG00000172493	AFF1	72	56.122	ENSMEUG00000006620	-	58	41.830	Notamacropus_eugenii
ENSG00000172493	AFF1	100	76.206	ENSOPRG00000017154	-	100	76.370	Ochotona_princeps
ENSG00000172493	AFF1	90	80.000	ENSODEG00000007407	AFF1	91	89.362	Octodon_degus
ENSG00000172493	AFF1	72	57.143	ENSODEG00000008137	AFF4	60	35.764	Octodon_degus
ENSG00000172493	AFF1	78	37.656	ENSONIG00000008446	aff4	99	36.093	Oreochromis_niloticus
ENSG00000172493	AFF1	100	58.757	ENSOANG00000013624	AFF1	100	58.529	Ornithorhynchus_anatinus
ENSG00000172493	AFF1	100	82.609	ENSOCUG00000002105	AFF1	97	79.397	Oryctolagus_cuniculus
ENSG00000172493	AFF1	78	36.233	ENSORLG00000001361	aff4	59	33.062	Oryzias_latipes
ENSG00000172493	AFF1	78	36.233	ENSORLG00020020601	aff4	59	33.062	Oryzias_latipes_hni
ENSG00000172493	AFF1	59	61.404	ENSORLG00020003991	-	54	60.606	Oryzias_latipes_hni
ENSG00000172493	AFF1	59	61.404	ENSORLG00015009287	-	51	60.606	Oryzias_latipes_hsok
ENSG00000172493	AFF1	78	35.971	ENSORLG00015004684	aff4	59	33.793	Oryzias_latipes_hsok
ENSG00000172493	AFF1	78	37.757	ENSOMEG00000005078	aff4	59	33.008	Oryzias_melastigma
ENSG00000172493	AFF1	79	71.429	ENSOGAG00000031211	-	99	68.677	Otolemur_garnettii
ENSG00000172493	AFF1	72	59.184	ENSOGAG00000028482	AFF4	59	35.196	Otolemur_garnettii
ENSG00000172493	AFF1	100	96.350	ENSOGAG00000009622	-	100	77.369	Otolemur_garnettii
ENSG00000172493	AFF1	97	86.070	ENSOARG00000004522	AFF1	98	77.409	Ovis_aries
ENSG00000172493	AFF1	72	60.204	ENSOARG00000013406	AFF4	59	34.880	Ovis_aries
ENSG00000172493	AFF1	72	60.204	ENSPPAG00000043255	AFF4	84	35.354	Pan_paniscus
ENSG00000172493	AFF1	100	100.000	ENSPPAG00000029196	AFF1	100	98.934	Pan_paniscus
ENSG00000172493	AFF1	95	88.312	ENSPPRG00000023590	AFF1	100	79.115	Panthera_pardus
ENSG00000172493	AFF1	95	88.052	ENSPTIG00000011838	AFF1	100	85.417	Panthera_tigris_altaica
ENSG00000172493	AFF1	72	60.204	ENSPTRG00000017228	AFF4	93	39.821	Pan_troglodytes
ENSG00000172493	AFF1	100	100.000	ENSPTRG00000016255	AFF1	100	98.852	Pan_troglodytes
ENSG00000172493	AFF1	72	60.204	ENSPTRG00000046486	-	93	39.821	Pan_troglodytes
ENSG00000172493	AFF1	72	59.184	ENSPANG00000007039	AFF4	59	36.262	Papio_anubis
ENSG00000172493	AFF1	100	100.000	ENSPANG00000016722	AFF1	99	91.946	Papio_anubis
ENSG00000172493	AFF1	83	56.522	ENSPKIG00000024325	AFF4	89	56.061	Paramormyrops_kingsleyae
ENSG00000172493	AFF1	80	35.343	ENSPKIG00000001556	aff2	62	32.859	Paramormyrops_kingsleyae
ENSG00000172493	AFF1	81	36.337	ENSPKIG00000024249	AFF4	58	33.004	Paramormyrops_kingsleyae
ENSG00000172493	AFF1	99	77.778	ENSPSIG00000003759	AFF1	100	55.997	Pelodiscus_sinensis
ENSG00000172493	AFF1	72	52.740	ENSPSIG00000013003	AFF4	58	36.453	Pelodiscus_sinensis
ENSG00000172493	AFF1	58	33.471	ENSPMGG00000006477	aff4	77	45.679	Periophthalmus_magnuspinnatus
ENSG00000172493	AFF1	100	67.894	ENSPEMG00000000785	Aff1	100	67.121	Peromyscus_maniculatus_bairdii
ENSG00000172493	AFF1	53	57.576	ENSPEMG00000014802	Aff3	74	54.667	Peromyscus_maniculatus_bairdii
ENSG00000172493	AFF1	59	54.321	ENSPMAG00000007807	aff4	57	31.199	Petromyzon_marinus
ENSG00000172493	AFF1	94	80.645	ENSPCIG00000011395	AFF1	99	80.645	Phascolarctos_cinereus
ENSG00000172493	AFF1	72	60.204	ENSPCIG00000000197	AFF4	59	36.893	Phascolarctos_cinereus
ENSG00000172493	AFF1	63	53.077	ENSPLAG00000005101	aff2	50	51.429	Poecilia_latipinna
ENSG00000172493	AFF1	72	59.184	ENSPPYG00000015775	AFF4	59	35.865	Pongo_abelii
ENSG00000172493	AFF1	100	100.000	ENSPPYG00000014910	AFF1	100	95.634	Pongo_abelii
ENSG00000172493	AFF1	89	90.164	ENSPCAG00000005658	AFF1	73	93.478	Procavia_capensis
ENSG00000172493	AFF1	77	57.143	ENSPCAG00000003995	AFF4	65	60.606	Procavia_capensis
ENSG00000172493	AFF1	99	36.010	ENSPCOG00000016986	AFF3	52	46.241	Propithecus_coquereli
ENSG00000172493	AFF1	72	59.184	ENSPCOG00000023876	AFF4	89	36.123	Propithecus_coquereli
ENSG00000172493	AFF1	100	88.462	ENSPCOG00000027339	AFF1	99	78.336	Propithecus_coquereli
ENSG00000172493	AFF1	100	80.769	ENSPVAG00000014455	AFF1	100	78.736	Pteropus_vampyrus
ENSG00000172493	AFF1	78	36.842	ENSPNYG00000014804	aff4	80	36.991	Pundamilia_nyererei
ENSG00000172493	AFF1	71	52.577	ENSPNAG00000005945	aff2	80	35.912	Pygocentrus_nattereri
ENSG00000172493	AFF1	66	62.222	ENSRNOG00000006965	Aff4	60	35.574	Rattus_norvegicus
ENSG00000172493	AFF1	100	68.675	ENSRNOG00000002232	Aff1	99	67.175	Rattus_norvegicus
ENSG00000172493	AFF1	100	31.057	ENSRNOG00000018830	Aff3	52	45.865	Rattus_norvegicus
ENSG00000172493	AFF1	81	31.844	ENSRBIG00000040484	-	97	30.749	Rhinopithecus_bieti
ENSG00000172493	AFF1	100	100.000	ENSRBIG00000032242	AFF1	100	95.823	Rhinopithecus_bieti
ENSG00000172493	AFF1	100	100.000	ENSRROG00000045716	AFF1	100	95.905	Rhinopithecus_roxellana
ENSG00000172493	AFF1	72	59.184	ENSRROG00000033812	AFF4	91	34.034	Rhinopithecus_roxellana
ENSG00000172493	AFF1	82	32.044	ENSRROG00000032529	-	82	32.044	Rhinopithecus_roxellana
ENSG00000172493	AFF1	100	97.080	ENSSBOG00000035401	AFF1	100	92.049	Saimiri_boliviensis_boliviensis
ENSG00000172493	AFF1	99	49.265	ENSSBOG00000021562	AFF4	100	40.786	Saimiri_boliviensis_boliviensis
ENSG00000172493	AFF1	98	32.787	ENSSHAG00000009556	AFF2	99	31.016	Sarcophilus_harrisii
ENSG00000172493	AFF1	99	58.991	ENSSHAG00000004203	AFF1	99	57.259	Sarcophilus_harrisii
ENSG00000172493	AFF1	72	60.204	ENSSHAG00000013198	AFF4	60	35.014	Sarcophilus_harrisii
ENSG00000172493	AFF1	59	35.676	ENSSFOG00015000846	AFF4	89	33.520	Scleropages_formosus
ENSG00000172493	AFF1	73	52.000	ENSSFOG00015004020	aff2	98	34.653	Scleropages_formosus
ENSG00000172493	AFF1	83	60.000	ENSSFOG00015018646	aff4	86	60.000	Scleropages_formosus
ENSG00000172493	AFF1	97	41.262	ENSSMAG00000007062	-	93	37.811	Scophthalmus_maximus
ENSG00000172493	AFF1	83	62.500	ENSSMAG00000004734	aff4	84	36.462	Scophthalmus_maximus
ENSG00000172493	AFF1	78	36.633	ENSSDUG00000019498	aff4	81	36.985	Seriola_dumerili
ENSG00000172493	AFF1	78	36.633	ENSSLDG00000007683	aff4	81	36.985	Seriola_lalandi_dorsalis
ENSG00000172493	AFF1	84	54.118	ENSSARG00000013296	-	75	55.294	Sorex_araneus
ENSG00000172493	AFF1	99	41.259	ENSSPUG00000012215	AFF4	60	36.011	Sphenodon_punctatus
ENSG00000172493	AFF1	99	56.260	ENSSPUG00000001574	AFF1	100	55.219	Sphenodon_punctatus
ENSG00000172493	AFF1	65	34.143	ENSSPAG00000012370	aff4	99	34.889	Stegastes_partitus
ENSG00000172493	AFF1	100	78.846	ENSSSCG00000023593	AFF1	61	71.888	Sus_scrofa
ENSG00000172493	AFF1	98	59.701	ENSTGUG00000002726	AFF1	99	49.354	Taeniopygia_guttata
ENSG00000172493	AFF1	99	38.281	ENSTGUG00000000187	AFF4	60	34.777	Taeniopygia_guttata
ENSG00000172493	AFF1	78	38.383	ENSTRUG00000008087	aff4	97	35.864	Takifugu_rubripes
ENSG00000172493	AFF1	99	82.051	ENSTBEG00000007536	AFF1	100	81.886	Tupaia_belangeri
ENSG00000172493	AFF1	72	59.184	ENSTTRG00000014729	AFF4	59	35.162	Tursiops_truncatus
ENSG00000172493	AFF1	100	86.538	ENSTTRG00000005595	AFF1	100	82.881	Tursiops_truncatus
ENSG00000172493	AFF1	100	86.715	ENSUAMG00000001919	AFF1	99	80.378	Ursus_americanus
ENSG00000172493	AFF1	57	46.154	ENSUMAG00000017952	AFF4	90	35.616	Ursus_maritimus
ENSG00000172493	AFF1	100	86.538	ENSUMAG00000025433	AFF1	86	79.028	Ursus_maritimus
ENSG00000172493	AFF1	72	59.184	ENSVPAG00000007247	AFF4	59	35.021	Vicugna_pacos
ENSG00000172493	AFF1	100	86.747	ENSVVUG00000009263	AFF1	100	80.517	Vulpes_vulpes
ENSG00000172493	AFF1	72	60.204	ENSVVUG00000024524	AFF4	59	36.173	Vulpes_vulpes
ENSG00000172493	AFF1	99	45.521	ENSXETG00000019955	aff1	59	43.724	Xenopus_tropicalis
ENSG00000172493	AFF1	81	39.109	ENSXETG00000004169	aff4	59	33.427	Xenopus_tropicalis
ENSG00000172493	AFF1	89	44.195	ENSXETG00000019630	aff2	54	42.642	Xenopus_tropicalis
ENSG00000172493	AFF1	91	35.309	ENSXCOG00000001869	-	88	34.913	Xiphophorus_couchianus
ENSG00000172493	AFF1	59	33.699	ENSXCOG00000006385	aff4	54	38.361	Xiphophorus_couchianus
ENSG00000172493	AFF1	66	46.237	ENSXMAG00000015826	aff2	53	51.429	Xiphophorus_maculatus
ENSG00000172493	AFF1	97	37.349	ENSXMAG00000004657	-	77	36.596	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003690	double-stranded DNA binding	21873635.	IBA	Function
GO:0003700	DNA-binding transcription factor activity	21873635.	IBA	Function
GO:0005515	protein binding	21729782.22190034.23260655.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0006355	regulation of transcription, DNA-templated	-	IEA	Process
GO:0008023	transcription elongation factor complex	21873635.	IBA	Component
GO:0008023	transcription elongation factor complex	22195968.	IDA	Component
GO:0032783	ELL-EAF complex	21873635.	IBA	Component