EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000172534 (Gene tree)
Gene ID: 3054
Gene Symbol: HCFC1
Alias: HCF-1|HCF1|CFF|VCAF|MGC70925|PPP1R89|HFC1|MRX3
Full Name: host cell factor C1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 24,281 bases
Position: chrX:153,947,553-153,971,833
Accession: 4839
RBP type: non-canonical RBP
Summary: This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19292868	Novel genes in cell cycle control and lipid metabolism with dynamically regulated binding sites for sterol regulatory element-binding protein 1 and RNA polymerase II in HepG2 cells detected by chromatin immunoprecipitation with microarray detection.	FEBS J	2009 Apr	Motallebipour M	doi: 10.1111/j.1742-4658.2009.06914.x.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000444191	HCFC1-203	3624	-	ENSP00000399589	611 (aa)	-	H7C1C4
ENST00000461098	HCFC1-204	379	-	-	- (aa)	-	-
ENST00000310441	HCFC1-201	8869	XM_011531147	ENSP00000309555	2035 (aa)	XP_011529449	P51610
ENST00000369984	HCFC1-202	8375	XM_006724815	ENSP00000359001	2080 (aa)	XP_006724878	A6NEM2

Gene Model

Click here to download ENSG00000172534's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05168	Herpes simplex virus 1 infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172534's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000172534	HCFC1	100	93.164	ENSMUSG00000031386	Hcfc1	100	93.311	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISS	Process
GO:0000123	histone acetyltransferase complex	20018852.	IDA	Component
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	-	IEA	Function
GO:0001835	blastocyst hatching	-	IEA	Process
GO:0003682	chromatin binding	21285374.	IDA	Function
GO:0003713	transcription coactivator activity	10675337.23629655.	IMP	Function
GO:0005515	protein binding	9271389.10629049.10675337.10871379.10976766.12244100.12670868.14532282.15705566.15960975.17998332.18391022.18585351.19188440.19615732.19815555.20622854.21285374.21295698.21909281.23353889.23870121.24211834.27705803.	IPI	Function
GO:0005634	nucleus	7876203.10623756.19188440.20091349.21285374.23629655.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	18838386.	IDA	Component
GO:0005737	cytoplasm	10623756.20091349.	IDA	Component
GO:0006355	regulation of transcription, DNA-templated	12670868.	IDA	Process
GO:0007005	mitochondrion organization	-	TAS	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0010628	positive regulation of gene expression	21285374.	IDA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0019046	release from viral latency	10675337.	NAS	Process
GO:0030424	axon	-	IEA	Component
GO:0030425	dendrite	-	IEA	Component
GO:0030674	protein binding, bridging	23629655.	IPI	Function
GO:0032991	protein-containing complex	23629655.	IDA	Component
GO:0033613	activating transcription factor binding	9199328.	IPI	Function
GO:0042802	identical protein binding	12670868.	IPI	Function
GO:0043025	neuronal cell body	20091349.	IDA	Component
GO:0043254	regulation of protein complex assembly	10675337.	IDA	Process
GO:0043981	histone H4-K5 acetylation	20018852.	IDA	Process
GO:0043982	histone H4-K8 acetylation	20018852.	IDA	Process
GO:0043984	histone H4-K16 acetylation	20018852.	IDA	Process
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	20018852.	IDA	Function
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	20018852.	IDA	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045787	positive regulation of cell cycle	10623756.	TAS	Process
GO:0045893	positive regulation of transcription, DNA-templated	23629655.	IMP	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	20018852.	IDA	Function
GO:0048188	Set1C/COMPASS complex	17998332.18838538.	IDA	Component
GO:0050821	protein stabilization	21285374.	IDA	Process
GO:0070461	SAGA-type complex	18838386.	IDA	Component
GO:0071339	MLL1 complex	15960975.	IDA	Component
GO:0071407	cellular response to organic cyclic compound	-	IEA	Process
GO:1990837	sequence-specific double-stranded DNA binding	-	IEA	Function