EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000172667 (Gene tree)
Gene ID: 64393
Gene Symbol: ZMAT3
Alias: WIG1|MGC10613|FLJ12296|WIG-1|PAG608
Full Name: zinc finger matrin-type 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 55,057 bases
Position: chr3:179,017,223-179,072,279
Accession: 29983
RBP type: canonical RBP
Summary: This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000396506	zf-met	PF12874.7	3.6e-23	1	3
ENSP00000396506	zf-met	PF12874.7	3.6e-23	2	3
ENSP00000396506	zf-met	PF12874.7	3.6e-23	3	3
ENSP00000311221	zf-met	PF12874.7	3.6e-23	1	3
ENSP00000311221	zf-met	PF12874.7	3.6e-23	2	3
ENSP00000311221	zf-met	PF12874.7	3.6e-23	3	3
ENSP00000398920	zf-met	PF12874.7	2.8e-09	1	1
ENSP00000396506	zf-C2H2_jaz	PF12171.8	2.5e-22	1	3
ENSP00000396506	zf-C2H2_jaz	PF12171.8	2.5e-22	2	3
ENSP00000396506	zf-C2H2_jaz	PF12171.8	2.5e-22	3	3
ENSP00000311221	zf-C2H2_jaz	PF12171.8	2.5e-22	1	3
ENSP00000311221	zf-C2H2_jaz	PF12171.8	2.5e-22	2	3
ENSP00000311221	zf-C2H2_jaz	PF12171.8	2.5e-22	3	3
ENSP00000398920	zf-C2H2_jaz	PF12171.8	6.8e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24469038	Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3sigma.	Oncogene	2014 Aug 28	Bersani C	doi: 10.1038/onc.2013.594
19805223	The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element.	Proc Natl Acad Sci U S A	2009 Sep 15	Vilborg A	doi: 10.1073/pnas.0900862106
18519039	The p53 target protein Wig-1 binds hnRNP A2/B1 and RNA Helicase A via RNA.	FEBS Lett	2008 Jun 25	Prahl M	doi: 10.1016/j.febslet.2008.04.065
23085987	Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment.	EMBO J	2012 Nov 14	Kim BC	doi: 10.1038/emboj.2012.286
19127773	[Dicer interacts with Wig-1 protein].	Fen Zi Xi Bao Sheng Wu Xue Bao	2008 Oct	Huang J	-
20306257	Regulation of tumor suppressor p53 at the RNA level.	J Mol Med (Berl)	2010 Jul	Vilborg A	doi: 10.1007/s00109-010-0609-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000311417	ZMAT3-201	9406	XM_011513073	ENSP00000311221	289 (aa)	XP_011511375	Q9HA38
ENST00000414084	ZMAT3-202	743	-	ENSP00000398920	148 (aa)	-	C9J8H5
ENST00000432729	ZMAT3-203	2944	XM_005247706	ENSP00000396506	288 (aa)	XP_005247763	Q9HA38

Gene Model

Click here to download ENSG00000172667's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04115	p53 signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000172667	Platelet Function Tests	8.0700000E-006	-
ENSG00000172667	Platelet Function Tests	8.6500000E-006	-
ENSG00000172667	Platelet Function Tests	1.2462000E-005	-
ENSG00000172667	Stress Disorders, Post-Traumatic	2E-6	23726511

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000172667	rs7641761	3	179022634	A	Mean corpuscular hemoglobin	27863252	[0.017-0.032] unit increase	0.02431824	EFO_0004527
ENSG00000172667	rs753173864	3	179031242	G	Mean corpuscular volume	27863252	[0.019-0.039] unit decrease	0.02898656	EFO_0004526
ENSG00000172667	rs4955793	3	179064233	?	Post-traumatic stress disorder (asjusted for relatedness)	23726511			EFO_0001358

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172667's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000172667	ZMAT3	86	63.462	ENSAPOG00000015037	zmat3	90	64.615	Acanthochromis_polyacanthus
ENSG00000172667	ZMAT3	100	95.848	ENSAMEG00000010742	ZMAT3	100	95.848	Ailuropoda_melanoleuca
ENSG00000172667	ZMAT3	97	68.966	ENSACIG00000023037	zmat3	82	65.882	Amphilophus_citrinellus
ENSG00000172667	ZMAT3	96	60.000	ENSAOCG00000017955	zmat3	78	68.966	Amphiprion_ocellaris
ENSG00000172667	ZMAT3	100	68.966	ENSAPEG00000014553	zmat3	89	65.354	Amphiprion_percula
ENSG00000172667	ZMAT3	95	62.637	ENSATEG00000022244	zmat3	93	64.093	Anabas_testudineus
ENSG00000172667	ZMAT3	100	83.045	ENSAPLG00000013292	ZMAT3	99	82.639	Anas_platyrhynchos
ENSG00000172667	ZMAT3	93	81.784	ENSACAG00000005005	ZMAT3	91	81.648	Anolis_carolinensis
ENSG00000172667	ZMAT3	100	92.568	ENSANAG00000035673	ZMAT3	96	95.238	Aotus_nancymaae
ENSG00000172667	ZMAT3	89	64.615	ENSACLG00000026272	zmat3	90	64.615	Astatotilapia_calliptera
ENSG00000172667	ZMAT3	97	64.138	ENSAMXG00000009798	zmat3	74	67.037	Astyanax_mexicanus
ENSG00000172667	ZMAT3	100	93.080	ENSBTAG00000012463	ZMAT3	100	93.080	Bos_taurus
ENSG00000172667	ZMAT3	100	95.156	ENSCJAG00000013399	ZMAT3	100	95.156	Callithrix_jacchus
ENSG00000172667	ZMAT3	100	94.810	ENSCAFG00000011081	ZMAT3	100	94.810	Canis_familiaris
ENSG00000172667	ZMAT3	100	94.810	ENSCAFG00020023107	ZMAT3	100	94.810	Canis_lupus_dingo
ENSG00000172667	ZMAT3	100	93.056	ENSCHIG00000025074	ZMAT3	100	93.056	Capra_hircus
ENSG00000172667	ZMAT3	100	95.833	ENSTSYG00000026546	ZMAT3	100	95.833	Carlito_syrichta
ENSG00000172667	ZMAT3	100	94.444	ENSCAPG00000014645	ZMAT3	99	94.444	Cavia_aperea
ENSG00000172667	ZMAT3	100	94.444	ENSCPOG00000003865	ZMAT3	100	94.444	Cavia_porcellus
ENSG00000172667	ZMAT3	100	93.772	ENSCCAG00000036721	ZMAT3	100	94.464	Cebus_capucinus
ENSG00000172667	ZMAT3	100	84.429	ENSCATG00000025137	ZMAT3	100	84.429	Cercocebus_atys
ENSG00000172667	ZMAT3	100	95.139	ENSCLAG00000013464	ZMAT3	100	95.139	Chinchilla_lanigera
ENSG00000172667	ZMAT3	100	98.611	ENSCSAG00000012935	ZMAT3	100	98.611	Chlorocebus_sabaeus
ENSG00000172667	ZMAT3	100	93.750	ENSCHOG00000005591	ZMAT3	100	93.750	Choloepus_hoffmanni
ENSG00000172667	ZMAT3	100	80.137	ENSCPBG00000026917	ZMAT3	99	78.694	Chrysemys_picta_bellii
ENSG00000172667	ZMAT3	100	98.962	ENSCANG00000029476	ZMAT3	100	98.962	Colobus_angolensis_palliatus
ENSG00000172667	ZMAT3	100	89.273	ENSCGRG00001012339	Zmat3	99	89.273	Cricetulus_griseus_chok1gshd
ENSG00000172667	ZMAT3	100	89.273	ENSCGRG00000011491	Zmat3	99	89.273	Cricetulus_griseus_crigri
ENSG00000172667	ZMAT3	81	68.240	ENSCSEG00000019463	zmat3	77	68.240	Cynoglossus_semilaevis
ENSG00000172667	ZMAT3	99	59.396	ENSCVAG00000011847	zmat3	79	67.660	Cyprinodon_variegatus
ENSG00000172667	ZMAT3	83	68.400	ENSDARG00000080021	zmat3	86	66.052	Danio_rerio
ENSG00000172667	ZMAT3	100	95.848	ENSDNOG00000012284	ZMAT3	100	95.848	Dasypus_novemcinctus
ENSG00000172667	ZMAT3	100	94.097	ENSDORG00000011801	Zmat3	100	94.097	Dipodomys_ordii
ENSG00000172667	ZMAT3	100	84.459	ENSETEG00000008883	ZMAT3	100	81.624	Echinops_telfairi
ENSG00000172667	ZMAT3	100	92.734	ENSEASG00005016887	ZMAT3	100	92.734	Equus_asinus_asinus
ENSG00000172667	ZMAT3	100	92.388	ENSECAG00000012784	ZMAT3	100	92.388	Equus_caballus
ENSG00000172667	ZMAT3	100	82.353	ENSEEUG00000001126	ZMAT3	100	82.353	Erinaceus_europaeus
ENSG00000172667	ZMAT3	83	70.161	ENSELUG00000010132	zmat3	66	70.161	Esox_lucius
ENSG00000172667	ZMAT3	100	94.118	ENSFCAG00000014578	ZMAT3	100	94.118	Felis_catus
ENSG00000172667	ZMAT3	100	81.315	ENSFALG00000008403	ZMAT3	99	80.556	Ficedula_albicollis
ENSG00000172667	ZMAT3	100	93.772	ENSFDAG00000013376	ZMAT3	100	93.772	Fukomys_damarensis
ENSG00000172667	ZMAT3	100	68.966	ENSFHEG00000003221	zmat3	95	61.538	Fundulus_heteroclitus
ENSG00000172667	ZMAT3	79	69.099	ENSGMOG00000008558	zmat3	95	69.099	Gadus_morhua
ENSG00000172667	ZMAT3	100	81.315	ENSGALG00000040948	ZMAT3	93	87.448	Gallus_gallus
ENSG00000172667	ZMAT3	72	65.169	ENSGAFG00000010485	zmat3	52	67.105	Gambusia_affinis
ENSG00000172667	ZMAT3	85	64.919	ENSGACG00000006175	zmat3	92	64.919	Gasterosteus_aculeatus
ENSG00000172667	ZMAT3	100	79.110	ENSGAGG00000009275	ZMAT3	99	77.663	Gopherus_agassizii
ENSG00000172667	ZMAT3	100	100.000	ENSGGOG00000009975	ZMAT3	100	100.000	Gorilla_gorilla
ENSG00000172667	ZMAT3	97	68.966	ENSHBUG00000004401	zmat3	80	68.831	Haplochromis_burtoni
ENSG00000172667	ZMAT3	100	94.792	ENSHGLG00000011523	ZMAT3	100	94.792	Heterocephalus_glaber_female
ENSG00000172667	ZMAT3	100	94.792	ENSHGLG00100012235	ZMAT3	100	94.792	Heterocephalus_glaber_male
ENSG00000172667	ZMAT3	79	69.163	ENSHCOG00000010624	zmat3	67	68.996	Hippocampus_comes
ENSG00000172667	ZMAT3	93	66.300	ENSIPUG00000003043	zmat3	94	68.605	Ictalurus_punctatus
ENSG00000172667	ZMAT3	100	96.528	ENSSTOG00000028436	ZMAT3	100	96.528	Ictidomys_tridecemlineatus
ENSG00000172667	ZMAT3	100	88.889	ENSJJAG00000004288	Zmat3	100	88.889	Jaculus_jaculus
ENSG00000172667	ZMAT3	80	68.103	ENSKMAG00000008962	zmat3	96	63.158	Kryptolebias_marmoratus
ENSG00000172667	ZMAT3	97	68.966	ENSLBEG00000001993	zmat3	87	65.476	Labrus_bergylta
ENSG00000172667	ZMAT3	95	63.423	ENSLACG00000015780	ZMAT3	75	69.118	Latimeria_chalumnae
ENSG00000172667	ZMAT3	84	72.441	ENSLOCG00000001108	zmat3	69	72.941	Lepisosteus_oculatus
ENSG00000172667	ZMAT3	100	95.156	ENSLAFG00000000897	ZMAT3	100	95.156	Loxodonta_africana
ENSG00000172667	ZMAT3	100	98.270	ENSMFAG00000021292	ZMAT3	100	98.270	Macaca_fascicularis
ENSG00000172667	ZMAT3	100	98.270	ENSMMUG00000003216	ZMAT3	100	98.270	Macaca_mulatta
ENSG00000172667	ZMAT3	100	98.616	ENSMNEG00000036725	ZMAT3	100	98.616	Macaca_nemestrina
ENSG00000172667	ZMAT3	100	97.917	ENSMLEG00000026279	ZMAT3	100	97.917	Mandrillus_leucophaeus
ENSG00000172667	ZMAT3	84	68.050	ENSMAMG00000012349	zmat3	76	68.050	Mastacembelus_armatus
ENSG00000172667	ZMAT3	97	68.966	ENSMZEG00005015427	zmat3	83	65.882	Maylandia_zebra
ENSG00000172667	ZMAT3	100	82.007	ENSMGAG00000009873	ZMAT3	99	81.250	Meleagris_gallopavo
ENSG00000172667	ZMAT3	100	89.236	ENSMAUG00000001986	Zmat3	99	89.236	Mesocricetus_auratus
ENSG00000172667	ZMAT3	100	93.772	ENSMICG00000049501	ZMAT3	100	93.772	Microcebus_murinus
ENSG00000172667	ZMAT3	100	89.583	ENSMOCG00000018844	Zmat3	100	89.583	Microtus_ochrogaster
ENSG00000172667	ZMAT3	86	65.587	ENSMMOG00000001603	zmat3	75	65.587	Mola_mola
ENSG00000172667	ZMAT3	96	76.344	ENSMODG00000021308	ZMAT3	94	76.344	Monodelphis_domestica
ENSG00000172667	ZMAT3	94	68.966	ENSMALG00000019683	zmat3	91	62.082	Monopterus_albus
ENSG00000172667	ZMAT3	100	87.197	MGP_CAROLIEiJ_G0024914	Zmat3	99	87.197	Mus_caroli
ENSG00000172667	ZMAT3	100	87.197	ENSMUSG00000027663	Zmat3	99	87.197	Mus_musculus
ENSG00000172667	ZMAT3	100	86.207	MGP_PahariEiJ_G0026359	Zmat3	99	86.207	Mus_pahari
ENSG00000172667	ZMAT3	100	86.851	MGP_SPRETEiJ_G0025848	Zmat3	99	86.851	Mus_spretus
ENSG00000172667	ZMAT3	100	94.444	ENSMPUG00000017206	ZMAT3	100	94.444	Mustela_putorius_furo
ENSG00000172667	ZMAT3	100	91.753	ENSMLUG00000013074	ZMAT3	100	91.753	Myotis_lucifugus
ENSG00000172667	ZMAT3	100	90.278	ENSNGAG00000023602	Zmat3	99	90.278	Nannospalax_galili
ENSG00000172667	ZMAT3	97	68.966	ENSNBRG00000020886	zmat3	80	68.831	Neolamprologus_brichardi
ENSG00000172667	ZMAT3	100	99.654	ENSNLEG00000005658	ZMAT3	100	99.654	Nomascus_leucogenys
ENSG00000172667	ZMAT3	100	78.007	ENSMEUG00000015724	ZMAT3	100	78.007	Notamacropus_eugenii
ENSG00000172667	ZMAT3	100	94.097	ENSODEG00000003313	ZMAT3	100	94.097	Octodon_degus
ENSG00000172667	ZMAT3	96	68.966	ENSONIG00000008388	zmat3	92	60.573	Oreochromis_niloticus
ENSG00000172667	ZMAT3	100	74.324	ENSOANG00000009901	ZMAT3	84	76.818	Ornithorhynchus_anatinus
ENSG00000172667	ZMAT3	100	94.444	ENSOCUG00000004658	ZMAT3	100	94.444	Oryctolagus_cuniculus
ENSG00000172667	ZMAT3	93	62.500	ENSOMEG00000011303	zmat3	85	62.963	Oryzias_melastigma
ENSG00000172667	ZMAT3	100	93.772	ENSOGAG00000003252	ZMAT3	100	93.772	Otolemur_garnettii
ENSG00000172667	ZMAT3	100	93.080	ENSOARG00000020713	ZMAT3	100	93.080	Ovis_aries
ENSG00000172667	ZMAT3	100	100.000	ENSPPAG00000035483	ZMAT3	100	100.000	Pan_paniscus
ENSG00000172667	ZMAT3	100	94.810	ENSPPRG00000004407	ZMAT3	100	94.810	Panthera_pardus
ENSG00000172667	ZMAT3	100	94.810	ENSPTIG00000009929	ZMAT3	100	94.810	Panthera_tigris_altaica
ENSG00000172667	ZMAT3	100	100.000	ENSPTRG00000015641	ZMAT3	100	100.000	Pan_troglodytes
ENSG00000172667	ZMAT3	100	97.924	ENSPANG00000023167	ZMAT3	100	97.924	Papio_anubis
ENSG00000172667	ZMAT3	84	71.951	ENSPKIG00000023370	zmat3	70	69.615	Paramormyrops_kingsleyae
ENSG00000172667	ZMAT3	100	79.110	ENSPSIG00000014839	ZMAT3	91	80.899	Pelodiscus_sinensis
ENSG00000172667	ZMAT3	97	60.284	ENSPMGG00000023924	zmat3	92	62.692	Periophthalmus_magnuspinnatus
ENSG00000172667	ZMAT3	100	87.847	ENSPEMG00000019154	Zmat3	99	87.847	Peromyscus_maniculatus_bairdii
ENSG00000172667	ZMAT3	80	66.260	ENSPFOG00000019206	zmat3	63	66.260	Poecilia_formosa
ENSG00000172667	ZMAT3	98	62.369	ENSPLAG00000022572	zmat3	91	64.179	Poecilia_latipinna
ENSG00000172667	ZMAT3	97	68.966	ENSPMEG00000004131	-	91	62.082	Poecilia_mexicana
ENSG00000172667	ZMAT3	98	62.630	ENSPREG00000022632	zmat3	83	69.787	Poecilia_reticulata
ENSG00000172667	ZMAT3	100	99.654	ENSPPYG00000014315	ZMAT3	100	99.654	Pongo_abelii
ENSG00000172667	ZMAT3	100	88.966	ENSPCAG00000008585	ZMAT3	100	88.621	Procavia_capensis
ENSG00000172667	ZMAT3	100	93.750	ENSPCOG00000022835	ZMAT3	100	93.750	Propithecus_coquereli
ENSG00000172667	ZMAT3	100	94.118	ENSPVAG00000004489	ZMAT3	100	94.118	Pteropus_vampyrus
ENSG00000172667	ZMAT3	97	68.966	ENSPNYG00000014350	zmat3	80	68.831	Pundamilia_nyererei
ENSG00000172667	ZMAT3	97	65.000	ENSPNAG00000015664	zmat3	74	68.613	Pygocentrus_nattereri
ENSG00000172667	ZMAT3	100	88.194	ENSRNOG00000010119	Zmat3	99	88.194	Rattus_norvegicus
ENSG00000172667	ZMAT3	100	98.270	ENSRBIG00000029622	ZMAT3	100	98.270	Rhinopithecus_bieti
ENSG00000172667	ZMAT3	100	98.270	ENSRROG00000038345	ZMAT3	100	98.270	Rhinopithecus_roxellana
ENSG00000172667	ZMAT3	100	94.464	ENSSBOG00000033332	ZMAT3	100	94.464	Saimiri_boliviensis_boliviensis
ENSG00000172667	ZMAT3	100	77.320	ENSSHAG00000016154	ZMAT3	100	77.320	Sarcophilus_harrisii
ENSG00000172667	ZMAT3	83	73.029	ENSSFOG00015006984	zmat3	83	73.061	Scleropages_formosus
ENSG00000172667	ZMAT3	96	59.459	ENSSMAG00000019540	-	53	66.255	Scophthalmus_maximus
ENSG00000172667	ZMAT3	96	61.888	ENSSDUG00000016188	zmat3	74	66.008	Seriola_dumerili
ENSG00000172667	ZMAT3	96	61.888	ENSSLDG00000018611	zmat3	74	66.008	Seriola_lalandi_dorsalis
ENSG00000172667	ZMAT3	100	91.892	ENSSARG00000004901	ZMAT3	100	91.781	Sorex_araneus
ENSG00000172667	ZMAT3	100	81.250	ENSSPUG00000014753	ZMAT3	99	80.556	Sphenodon_punctatus
ENSG00000172667	ZMAT3	96	61.348	ENSSPAG00000011062	zmat3	78	65.354	Stegastes_partitus
ENSG00000172667	ZMAT3	100	93.056	ENSSSCG00000033860	ZMAT3	100	93.056	Sus_scrofa
ENSG00000172667	ZMAT3	100	80.969	ENSTGUG00000010765	-	99	80.208	Taeniopygia_guttata
ENSG00000172667	ZMAT3	93	51.049	ENSTGUG00000018499	-	100	49.296	Taeniopygia_guttata
ENSG00000172667	ZMAT3	80	68.696	ENSTRUG00000004788	zmat3	88	65.234	Takifugu_rubripes
ENSG00000172667	ZMAT3	86	63.347	ENSTNIG00000006781	zmat3	87	63.347	Tetraodon_nigroviridis
ENSG00000172667	ZMAT3	65	94.304	ENSTBEG00000012359	ZMAT3	99	94.304	Tupaia_belangeri
ENSG00000172667	ZMAT3	100	91.892	ENSTTRG00000004923	ZMAT3	100	91.003	Tursiops_truncatus
ENSG00000172667	ZMAT3	100	94.595	ENSUAMG00000007623	ZMAT3	100	94.464	Ursus_americanus
ENSG00000172667	ZMAT3	100	94.595	ENSUMAG00000007847	ZMAT3	100	94.097	Ursus_maritimus
ENSG00000172667	ZMAT3	100	92.734	ENSVPAG00000006611	ZMAT3	100	92.734	Vicugna_pacos
ENSG00000172667	ZMAT3	100	94.464	ENSVVUG00000004729	ZMAT3	100	94.464	Vulpes_vulpes
ENSG00000172667	ZMAT3	100	66.330	ENSXETG00000007251	zmat3	84	73.684	Xenopus_tropicalis
ENSG00000172667	ZMAT3	88	65.019	ENSXCOG00000008397	zmat3	93	65.019	Xiphophorus_couchianus
ENSG00000172667	ZMAT3	96	59.933	ENSXMAG00000015188	zmat3	54	63.985	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	18519039.23085987.25416956.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006915	apoptotic process	-	IEA	Process
GO:0006974	cellular response to DNA damage stimulus	-	IEA	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0015031	protein transport	-	IEA	Process
GO:0040008	regulation of growth	-	IEA	Process
GO:0043065	positive regulation of apoptotic process	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr3	179030885	Missense_Mutation	novel	P129S	0.05
BLCA	chr3	179025201	Missense_Mutation	NA	R229L	0.15
BLCA	chr3	179030942	Missense_Mutation	novel	P110S	0.15
BRCA	chr3	179067709	Missense_Mutation	novel	P15H	0.09
BRCA	chr3	179027682	Missense_Mutation	novel	R174M	0.1
CESC	chr3	179024942	3'UTR	novel		0.21
CESC	chr3	179067705	Silent	novel	S16S	0.22
CESC	chr3	179024711	3'UTR	novel		0.15
COAD	chr3	179025195	Missense_Mutation	NA	R231I	0.19
COAD	chr3	179067494	Missense_Mutation	novel	A87S	0.1	zf-met
COAD	chr3	179030883	Silent	rs138510384	P129P	0.13
COAD	chr3	179025130	Missense_Mutation	NA	V253I	0.26
COAD	chr3	179067704	Missense_Mutation	NA	P17S	0.34
COAD	chr3	179025187	Missense_Mutation	rs774816930	R234C	0.3
COAD	chr3	179030915	Missense_Mutation	NA	P119S	0.3
COAD	chr3	179025177	Missense_Mutation	NA	A237V	0.2
COAD	chr3	179027788	Nonsense_Mutation	rs147086451	R139*	0.16
GBM	chr3	179030976	Silent	NA	L98L	0.41
GBM	chr3	179067765	5'UTR	novel		0.5
GBM	chr3	179027450	Missense_Mutation	novel	N211H	0.06
HNSC	chr3	179025189	Missense_Mutation	novel	P233L	0.09
KIRC	chr3	179030895	Frame_Shift_Del	novel	*P126Qfs15**	0.07
KIRP	chr3	179067599	Nonsense_Mutation	NA	E52*	0.35
LGG	chr3	179027458	Missense_Mutation	novel	N208S	0.33
LGG	chr3	179030982	Missense_Mutation	novel	K96N	0.41
LGG	chr3	179031000	Splice_Site	NA	X91_splice	0.37
LUAD	chr3	179030885	Missense_Mutation	novel	P129A	0.12
LUAD	chr3	179027471	Nonsense_Mutation	novel	K204*	0.17
LUAD	chr3	179067608	Missense_Mutation	NA	G49R	0.58
LUAD	chr3	179027780	Missense_Mutation	rs750676731	I141M	0.13
LUAD	chr3	179067583	Missense_Mutation	novel	G57V	0.19
LUAD	chr3	179030881	Missense_Mutation	NA	Q130L	0.17
LUSC	chr3	179067782	5'UTR	novel		0.32
LUSC	chr3	179025207	Missense_Mutation	rs151132491	R227H	0.26
LUSC	chr3	179067706	Missense_Mutation	novel	S16L	0.11
LUSC	chr3	179024993	3'UTR	novel		0.18
LUSC	chr3	179067699	Silent	NA	S18S	0.13
LUSC	chr3	179067490	Frame_Shift_Del	novel	*H88Lfs26**	0.05	zf-met
OV	chr3	179024954	3'UTR	novel		0.06
OV	chr3	179030908	In_Frame_Ins	novel	A121delinsGALGKIFLYLSSP	0.11
OV	chr3	179067533	Missense_Mutation	NA	L74V	0.14	zf-met
PAAD	chr3	179024995	3'UTR	novel		0.11
PAAD	chr3	179030974	Missense_Mutation	NA	R99Q	0.15
PAAD	chr3	179067657	Missense_Mutation	novel	Q32H	0.2
PAAD	chr3	179067699	Silent	rs779443540	S18S	0.21
READ	chr3	179030974	Missense_Mutation	NA	R99Q	0.31
READ	chr3	179025035	Missense_Mutation	NA	E284D	0.39
READ	chr3	179025196	Nonsense_Mutation	NA	R231*	0.22
READ	chr3	179025195	Missense_Mutation	NA	R231I	0.46
SARC	chr3	179067635	Missense_Mutation	novel	G40R	0.65
SKCM	chr3	179027508	Silent	novel	L191L	0.05
SKCM	chr3	179024986	3'UTR	novel		0.33
SKCM	chr3	179025104	Silent	novel	F261F	0.42
STAD	chr3	179067735	Silent	rs760329133	H6H	0.44
STAD	chr3	179030894	Missense_Mutation	NA	P126T	0.08
STAD	chr3	179067524	Missense_Mutation	NA	V77I	0.09	zf-met
STAD	chr3	179067608	Missense_Mutation	NA	G49R	0.67
STAD	chr3	179030974	Missense_Mutation	NA	R99Q	0.29
STAD	chr3	179025011	3'UTR	novel		0.38
STAD	chr3	179024999	3'UTR	novel		0.21
STAD	chr3	179027765	Silent	NA	N146N	0.27
STAD	chr3	179024921	3'UTR	novel		0.51
UCEC	chr3	179025035	Missense_Mutation	NA	E284D	0.33
UCEC	chr3	179027775	Missense_Mutation	NA	A143D	0.6
UCEC	chr3	179027433	Missense_Mutation	novel	Q216H	0.4
UCEC	chr3	179067731	Missense_Mutation	rs761840300	V8M	0.2
UCEC	chr3	179027469	Missense_Mutation	NA	K204N	0.23
UCEC	chr3	179027676	Missense_Mutation	novel	R176Q	0.16
UCEC	chr3	179067599	Nonsense_Mutation	NA	E52*	0.26
UCEC	chr3	179027694	Missense_Mutation	NA	N170T	0.32
UCEC	chr3	179030974	Missense_Mutation	NA	R99Q	0.09
UCEC	chr3	179025195	Missense_Mutation	NA	R231I	0.41
UCEC	chr3	179027467	Missense_Mutation	novel	M205T	0.24
UCEC	chr3	179067574	Missense_Mutation	NA	D60V	0.12
UCEC	chr3	179025172	Missense_Mutation	novel	C239R	0.38
UCEC	chr3	179027438	Missense_Mutation	novel	V215I	0.25
UCEC	chr3	179030960	Missense_Mutation	novel	A104T	0.33
UCEC	chr3	179067767	5'UTR	novel		0.39
UCEC	chr3	179067597	Missense_Mutation	novel	E52D	0.32
UCEC	chr3	179067630	Silent	NA	Q41Q	0.37
UCEC	chr3	179030975	Nonsense_Mutation	rs763416591	R99*	0.3
UCEC	chr3	179024824	3'UTR	rs769996932		0.2
UCEC	chr3	179030974	Missense_Mutation	NA	R99Q	0.35
UCEC	chr3	179024827	3'UTR	novel		0.14
UCEC	chr3	179067731	Missense_Mutation	rs761840300	V8L	0.25
UCEC	chr3	179025226	Missense_Mutation	novel	G221S	0.33
UCEC	chr3	179030883	Silent	rs138510384	P129P	0.33
UCEC	chr3	179025035	Missense_Mutation	NA	E284D	0.27
UCEC	chr3	179030891	Missense_Mutation	rs763038459	V127I	0.17
UCEC	chr3	179024822	3'UTR	novel		0.46
UCEC	chr3	179067732	Frame_Shift_Del	novel	*V8Cfs72**	0.4
UCEC	chr3	179025055	Missense_Mutation	rs532278040	R278W	0.4
UCEC	chr3	179030911	Missense_Mutation	NA	A120V	0.3
UCEC	chr3	179024896	3'UTR	novel		0.59
UCS	chr3	179025118	Missense_Mutation	novel	E257K	0.32
UCS	chr3	179067592	Missense_Mutation	novel	S54L	0.15

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.451	0.0018563
BRCA	AMP	0.2648	2.264e-12
KIRC	AMP	0.1231	2.0306e-05
KIRP	AMP	0.3264	0.15981
LGG	AMP	0.0292	0.0013532
PAAD	AMP	0.1087	0.16151
SARC	DEL	0.1673	0.0086757
TGCT	AMP	0.2533	7.0307e-05

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0063	Kaplan-Meier Survival Analysis
BRCA	0.0045	Kaplan-Meier Survival Analysis
KIRP	0.043	Kaplan-Meier Survival Analysis
PCPG	0.04	Kaplan-Meier Survival Analysis
BLCA	0.022	Kaplan-Meier Survival Analysis
LAML	0.018	Kaplan-Meier Survival Analysis
LUAD	0.02	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742