EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000172725 (Gene tree)
Gene ID: 57175
Gene Symbol: CORO1B
Alias: coronin-2
Full Name: coronin 1B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 8,312 bases
Position: chr11:67,435,510-67,443,821
Accession: 2253
RBP type: non-canonical RBP
Summary: Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000537042	CORO1B-204	1954	-	ENSP00000445330	282 (aa)	-	F5H390
ENST00000545016	CORO1B-207	551	-	ENSP00000438056	139 (aa)	-	F5H0D2
ENST00000545736	CORO1B-208	1037	-	-	- (aa)	-	-
ENST00000539970	CORO1B-206	220	-	-	- (aa)	-	-
ENST00000393893	CORO1B-202	1931	-	ENSP00000377471	489 (aa)	-	Q9BR76
ENST00000341356	CORO1B-201	1881	-	ENSP00000340211	489 (aa)	-	Q9BR76
ENST00000627576	CORO1B-210	960	-	ENSP00000486585	282 (aa)	-	F5H390
ENST00000539724	CORO1B-205	615	-	-	- (aa)	-	-
ENST00000616321	CORO1B-209	4464	-	ENSP00000479949	260 (aa)	-	A0A087WW53
ENST00000453768	CORO1B-203	1161	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000172725's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000172725	Depressive Disorder	1E-6	27622933
ENSG00000172725	Citalopram	1E-6	27622933
ENSG00000172725	Mood Disorders	1E-6	27622933

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172725's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000172725	CORO1B	99	98.551	ENSMUSG00000024835	Coro1b	100	98.266	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001725	stress fiber	16027158.22619279.	IDA	Component
GO:0005515	protein binding	16027158.17350576.21044950.26655834.	IPI	Function
GO:0005737	cytoplasm	23667561.25468996.	IDA	Component
GO:0005829	cytosol	22619279.	IDA	Component
GO:0005884	actin filament	18775315.	IDA	Component
GO:0005886	plasma membrane	15800061.	IDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0016477	cell migration	16027158.	IDA	Process
GO:0030027	lamellipodium	22619279.23667561.	IDA	Component
GO:0030036	actin cytoskeleton organization	18775315.	IDA	Process
GO:0031252	cell leading edge	16027158.17456547.	IDA	Component
GO:0031529	ruffle organization	16027158.	IDA	Process
GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	22619279.	IC	Process
GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation	17350576.18775315.	IDA	Process
GO:0035767	endothelial cell chemotaxis	23667561.	IDA	Process
GO:0035767	endothelial cell chemotaxis	23667561.	IMP	Process
GO:0036120	cellular response to platelet-derived growth factor stimulus	22619279.	IMP	Process
GO:0042060	wound healing	23667561.	IDA	Process
GO:0042802	identical protein binding	16027158.	IDA	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0048471	perinuclear region of cytoplasm	22619279.	IDA	Component
GO:0051015	actin filament binding	17456547.	IDA	Function
GO:0051015	actin filament binding	22364218.	IMP	Function
GO:0051017	actin filament bundle assembly	17456547.	IDA	Process
GO:0070062	extracellular exosome	19199708.23533145.	HDA	Component
GO:0071672	negative regulation of smooth muscle cell chemotaxis	22619279.	IMP	Process
GO:0071933	Arp2/3 complex binding	16027158.18775315.	IDA	Function
GO:0071933	Arp2/3 complex binding	22619279.	IPI	Function
GO:0071944	cell periphery	22619279.	IDA	Component
GO:0090135	actin filament branching	18775315.	IDA	Process
GO:1902463	protein localization to cell leading edge	17350576.	IDA	Process
GO:2000394	positive regulation of lamellipodium morphogenesis	17350576.	IDA	Process